Prediction of incident heart failure by serum amino-terminal pro-B-type natriuretic peptide level in a community-based cohort

Journal article


Campbell, Duncan J., Gong, Fei Fei, Jelinek, Michael V., Castro, Julian M., Coller, Jennifer M., McGrady, Michele, Boffa, Umberto, Shiel, Louise, Wang, Bing H., Liew, Danny, Wolfe, Rory, Stewart, Simon, Owen, Alice J., Krum, Henry, Reid, Christopher M. and Prior, David L.. (2019) Prediction of incident heart failure by serum amino-terminal pro-B-type natriuretic peptide level in a community-based cohort. European Journal of Heart Failure. 21, pp. 449-459. https://doi.org/10.1002/ejhf.1381
AuthorsCampbell, Duncan J., Gong, Fei Fei, Jelinek, Michael V., Castro, Julian M., Coller, Jennifer M., McGrady, Michele, Boffa, Umberto, Shiel, Louise, Wang, Bing H., Liew, Danny, Wolfe, Rory, Stewart, Simon, Owen, Alice J., Krum, Henry, Reid, Christopher M. and Prior, David L.
Abstract

Aims
We investigated which serum amino-terminal pro-B-type-natriuretic peptide (NT-proBNP) levels inform heart failure (HF) risk in a community-based population at increased cardiovascular disease (CVD) risk.

Methods and results
Inclusion criteria were age ≥ 60 years with one or more of self-reported hypertension, diabetes, heart disease, abnormal heart rhythm, cerebrovascular disease, or renal impairment. Exclusion criteria were known HF, ejection fraction (EF) < 50%, or more than mild valve abnormality. NT-proBNP levels were measured in 3842 participants on enrolment. HF was diagnosed in 162 participants at a median of 4.5 (interquartile range 2.7–5.4) years after enrolment, 73 with HF with preserved EF (HFpEF), 53 with HF with reduced EF (HFrEF), and 36 with valvular HF (VHF). Areas under the receiver operating characteristic curve (AUC) for 5-year prediction of total HF were similar for NT-proBNP alone (0.79, 95% confidence interval 0.74–0.83) and a 7-parameter multivariable model (0.82, 0.77–0.86, P = 0.035). NT-proBNP cut-points of 11, 16, and 25 pmol/L for individuals aged 60–69, 70–79, and ≥ 80 years, respectively, achieved sensitivities > 76% and specificities of 47–69% for 5-year prediction of total HF in men and women in all three age groups. Sensitivities were ≥ 75% in most subgroups according to body mass index, estimated glomerular filtration rate, and the presence or absence of atrial fibrillation, pacemaker, or CVD, and for the prediction of HFpEF, HFrEF and VHF.

Conclusion
Age-specific serum NT-proBNP levels inform prognosis, and hence therapeutic decisions, regarding HF risk in individuals at increased CVD risk.

KeywordsNT-proBNP; natriuretic peptides; incident heart failure; prevention; epidemiology •risk factors
Year2019
JournalEuropean Journal of Heart Failure
Journal citation21, pp. 449-459
PublisherThe European Society of Cardiology
ISSN1388-9842
Digital Object Identifier (DOI)https://doi.org/10.1002/ejhf.1381
Scopus EID2-s2.0-85060202426
Research or scholarlyResearch
Page range449-459
Publisher's version
Output statusPublished
Publication dates
Print18 Jan 2019
Publication process dates
Accepted11 Nov 2018
Deposited03 Jun 2021
Permalink -

https://acuresearchbank.acu.edu.au/item/8w27z/prediction-of-incident-heart-failure-by-serum-amino-terminal-pro-b-type-natriuretic-peptide-level-in-a-community-based-cohort

  • 0
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Mild depression predicts long-term mortality after acute myocardial infarction : A 25-year follow-up
Worcester, Marian U., Goble, Alan J., Elliott, Peter C., Froelicher, Erika S., Murphy, Barbara M., Beauchamp, Alison J., Jelinek, Michael V. and Hare, David L.. (2019) Mild depression predicts long-term mortality after acute myocardial infarction : A 25-year follow-up. Heart Lung and Circulation. 28, pp. 1812-1818. https://doi.org/10.1016/j.hlc.2018.11.013
Implications of Cardio-Respiratory Fitness on the Performance of Exercise Tests
Michael Jelinek and Kenneth Hossack. (2019) Implications of Cardio-Respiratory Fitness on the Performance of Exercise Tests. Heart Lung and Circulation. 28(4), pp. 64-66. https://doi.org/10.1016/j.hlc.2018.07.015
Coaching Patients Saves Lives and Money
Joshua Byrnes, Thomas Elliott, Margarite Vale, Michael Jelinek and Paul Scuffham. (2018) Coaching Patients Saves Lives and Money. American Journal of Medicine. 131(4), pp. 415-422. https://doi.org/10.1016/j.amjmed.2017.10.019
Risk factors for incident heart failure with preserved or reduced ejection fraction, and valvular heart failure, in a community-based cohort
Gong, Fei Fei, Jelinek, Michael, Castro, Julian M., Coller, Jennifer M., McGrady, Michele, Boffa, Umberto, Shiel, Louise, Liew, Danny, Wolfe, R., Stewart, Simon, Owen, Alice J., Krum, Henry, Reid, Christopher, Prior, David and Campbell, Duncan J.. (2018) Risk factors for incident heart failure with preserved or reduced ejection fraction, and valvular heart failure, in a community-based cohort. Open Heart. 5(2), pp. 1 - 11. https://doi.org/10.1136/openhrt-2018-000782
Cardiac Society of Australia and New Zealand position statement executive summary: coronary artery calcium scoring
Christian R. Hamilton-Craig, Clara Chow, John F. Younger, Michael Jelinek, Jonathan Chan and Gary Y. H. Liew. (2017) Cardiac Society of Australia and New Zealand position statement executive summary: coronary artery calcium scoring. Medical Journal of Australia. 207(8), pp. 357-361. https://doi.org/10.5694/mja16.01134
SMARTphone-based, early cardiac REHABilitation in patients with acute coronary syndromes [SMART-REHAB Trial]: A randomized controlled trial protocol
Yudi, Matias B., Clark, David J., Tsang, David, Jelinek, Michael, Kalten, Katie, Joshi, Subodh, Phan, Khoa, Nasis, Arthur, Amerena, John, Arunothayaraj, Sandeep, Reid, Chris and Farouque, Omar. (2016) SMARTphone-based, early cardiac REHABilitation in patients with acute coronary syndromes [SMART-REHAB Trial]: A randomized controlled trial protocol. BMC Cardiovascular Disorders. 16(170), pp. 1 - 8. https://doi.org/10.1186/s12872-016-0356-6
Improving access and equity in reducing cardiovascular risk : The Queensland Health Model
Ski, Chantal, Vale, Margarite, Bennett, Gary, Chalmers, Victoria, McFarlane, Kim, Jelinek, Michael, Scott, Ian and Thompson, David. (2015) Improving access and equity in reducing cardiovascular risk : The Queensland Health Model. Medical Journal of Australia. 202(3), pp. 148 - 152. https://doi.org/10.5694/mja14.00575
Reversing social disadvantage in secondary prevention of coronary heart disease
Jelinek, Michael, Santamaria, John, Best, James, Thompson, David R., Tonkin, Andrew and Vale, Margarite. (2014) Reversing social disadvantage in secondary prevention of coronary heart disease. International Journal of Cardiology. 171(3), pp. 346 - 350. https://doi.org/10.1016/j.ijcard.2013.12.022
'FIT FOR PURPOSE'. The COACH program improves lifestyle and biomedical cardiac risk factors
Jelinek, Michael, Santamaria, John, Thompson, David and Vale, Margarite. (2012) 'FIT FOR PURPOSE'. The COACH program improves lifestyle and biomedical cardiac risk factors. Heart. 98(21), pp. 1608 - 1608. https://doi.org/10.1136/heartjnl-2012-302723
Reconciling systematic reviews of exercise-based cardiac rehabilitation and secondary prevention programmes for coronary heart disease
Jelinek, Michael, Clark, Alexander, Oldridge, Neil, Briffa, Thomas and Thompson, David Robert. (2011) Reconciling systematic reviews of exercise-based cardiac rehabilitation and secondary prevention programmes for coronary heart disease. European Journal of Cardiovascular Prevention & Rehabilitation. 18(2), pp. 147 - 149. https://doi.org/10.1177/1741826710389388
Screening for depression in coronary heart disease: The perfect Hegelian dialectic? A short commentary on ''Beyond the blues: The need for integrated care pathways''
Jelinek, Michael. (2011) Screening for depression in coronary heart disease: The perfect Hegelian dialectic? A short commentary on ''Beyond the blues: The need for integrated care pathways''. European Journal of Cardiovascular Prevention & Rehabilitation. 18(2), pp. 222 - 223. https://doi.org/10.1177/1741826710389411