Safety, feasibility, and efficacy of an eccentric exercise intervention in people with multiple sclerosis with ankle contractures

Journal article


Psarakis, Michael, Lord, Stephen R. and Hoang, Phu D.. (2021). Safety, feasibility, and efficacy of an eccentric exercise intervention in people with multiple sclerosis with ankle contractures. International Journal of MS Care. 23(1), pp. 31-36. https://doi.org/10.7224/1537-2073.2019-022
AuthorsPsarakis, Michael, Lord, Stephen R. and Hoang, Phu D.
Abstract

Background:
The primary aim of this study was to investigate the safety and feasibility of an eccentric exercise program for people with multiple sclerosis (MS) who have ankle contractures, ie, reduced ankle range of motion (ROM). Secondary aims were to explore the efficacy of this eccentric exercise on ankle joint ROM and functional mobility.

Methods:
Five adults with MS with ankle contractures (three women and two men; mean ± SD age, 50.8 ± 9.4; MS duration, 7.6 ± 5.6 years) completed two eccentric exercise training sessions (10–45 minutes) per week for 12 weeks. The training involved walking backward downhill on an inclined treadmill (gradient, 10°–14°) at a self-selected pace. The intervention was assessed for safety (adverse events), feasibility (recruitment rates, adherence rates, enjoyment levels, difficulty, and discomfort), and clinical outcomes, including passive/active ankle ROM and distance walked in 6 minutes.

Results:
There were no adverse events during or after the eccentric exercise training. There was a 100% adherence rate. All participants enjoyed the training and experienced low levels of muscle soreness/discomfort. The training program improved passive/active ankle ROM in all participants; however, improvements did not translate to improvements in walking for all participants.

Conclusions:
Walking backward and downhill is a safe and feasible training modality for people with MS with ankle contractures. Clinical outcomes (greater passive/active ankle ROM) after this eccentric exercise training were evident. However, translation to clinically meaningful changes in walking function requires further examination.

Keywordsankle contracture; eccentric exercise; multiple sclerosis (MS); range of motion
Year2021
JournalInternational Journal of MS Care
Journal citation23 (1), pp. 31-36
PublisherDelaware Media Group
ISSN1537-2073
Digital Object Identifier (DOI)https://doi.org/10.7224/1537-2073.2019-022
Scopus EID2-s2.0-85102389291
Research or scholarlyResearch
Page range31-36
FunderNational Health and Medical Research Council (NHMRC)
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online2021
Publication process dates
Deposited06 Sep 2021
Grant IDNHMRC/1055084
Permalink -

https://acuresearchbank.acu.edu.au/item/8wv8w/safety-feasibility-and-efficacy-of-an-eccentric-exercise-intervention-in-people-with-multiple-sclerosis-with-ankle-contractures

Restricted files

Publisher's version

  • 95
    total views
  • 0
    total downloads
  • 1
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Exercise and Sports Science Australia (ESSA) position statement on exercise for people with mild to moderate multiple sclerosis
Hoang, Phu D., Lord, Stephen, Gandevia, Simon and Menant, Jasmine. (2022). Exercise and Sports Science Australia (ESSA) position statement on exercise for people with mild to moderate multiple sclerosis. Journal of Science and Medicine in Sport. 25(2), pp. 146-154. https://doi.org/10.1016/j.jsams.2021.08.015
Brief report : Passive mechanical properties of gastrocnemius in multiple sclerosis and ankle contracture
Hoang, Phu D., Psarakis, Michael, Kwah, Li Khim, Clarke, Jillian L., Gandevia, Simon C. and Diong, Joanna. (2021). Brief report : Passive mechanical properties of gastrocnemius in multiple sclerosis and ankle contracture. Clinical Biomechanics. 84, p. Article 105338. https://doi.org/10.1016/j.clinbiomech.2021.105338
Ankle contractures in people with multiple sclerosis : Implications, measurement and treatment
Psarakis, Michael. (2020). Ankle contractures in people with multiple sclerosis : Implications, measurement and treatment [PhD Thesis]. Australian Catholic University School of Behavioural and Health Sciences https://doi.org/10.26199/acu.8vywz
The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue : A single centre experience
Lin, Sophia D., Butler, Jane E., Boswell-Ruys, Claire L., Phu, Hoang, Jarvis, Tom, Gandevia, Simon C. and McCaughey, Euan J.. (2019). The frequency of bowel and bladder problems in multiple sclerosis and its relation to fatigue : A single centre experience. PLoS ONE. 14(9), p. Article e0222731. https://doi.org/10.1371/journal.pone.0222731
Cold Water Ingestion Improves Exercise Tolerance of Heat-Sensitive People with MS
Georgia K. Chaseling, Davide Filingeri, Michael Barnett, Phu Hoang, Scott L. Davis and Ollie Jay. (2018). Cold Water Ingestion Improves Exercise Tolerance of Heat-Sensitive People with MS. Medicine and Science in Sports and Exercise. 50(4), pp. 643-649. https://doi.org/10.1249/MSS.0000000000001496
Between session reliability of heel-to-toe progression measurements in the stance phase of gait
Vanessa Ade, Dale Schalkwijk, Michael Psarakis, Michael D. Laporte, Timothy J. Faras, Remi Sandoval, Fadi Najjar and Peter Stubbs. (2018). Between session reliability of heel-to-toe progression measurements in the stance phase of gait. PLoS ONE. 13(7), pp. 1-6. https://doi.org/10.1371/journal.pone.0200436
Relationship between physiological and perceived fall risk in people with multiple sclerosis: Implications for assessment and management
Gunn, Hilary, Cameron, Michelle, Hoang, Phu, Lord, Stephen R., Shaw, Steve and Freeman, Jennifer. (2018). Relationship between physiological and perceived fall risk in people with multiple sclerosis: Implications for assessment and management. Archives of Physical Medicine and Rehabilitation. 99(10), pp. 2022 - 2029. https://doi.org/10.1016/j.apmr.2018.03.019
Wearable technology reveals gait compensations, unstable walking patterns and fatigue in people with multiple sclerosis
Psarakis, Michael, Greene, David A., Cole, Michael H., Lord, Stephen R., Hoang, Phu and Brodie, Matthew A. D.. (2018). Wearable technology reveals gait compensations, unstable walking patterns and fatigue in people with multiple sclerosis. Physiological Measurement. 39(7), pp. 1 - 13. https://doi.org/10.1088/1361-6579/aac0a3
Afferent thermosensory function in relapsing–remitting multiple sclerosis following exercise-induced increases in body temperature
Filingeri, Davide, Chaseling, Georgia K., Hoang, Phu, Barnett, Michael, Davis, Scott L. and Jay, Ollie. (2017). Afferent thermosensory function in relapsing–remitting multiple sclerosis following exercise-induced increases in body temperature. Experimental Physiology. 102(8), pp. 887 - 893. https://doi.org/10.1113/EP086320
Impaired heel to toe progression during gait is related to reduced ankle range of motion in people with Multiple Sclerosis
Psarakis, Michael, Greene, David, Moresi, Mark, Baker, Michael, Stubbs, Peter, Brodie, Matthew, Lord, Stephen and Hoang, Phu. (2017). Impaired heel to toe progression during gait is related to reduced ankle range of motion in people with Multiple Sclerosis. Clinical Biomechanics. 49, pp. 96-100. https://doi.org/10.1016/j.clinbiomech.2017.08.012
A simple test of choice stepping reaction time for assessing fall risk in people with multiple sclerosis
Tijsma, Mylou, Vister, Eva, Hoang, Phu and Lord, Stephen R.. (2017). A simple test of choice stepping reaction time for assessing fall risk in people with multiple sclerosis. Disability and Rehabilitation. 39(6), pp. 601 - 607. https://doi.org/10.3109/09638288.2016.1148784
Effects of a home-based step training programme on balance, stepping, cognition and functional performance in people with multiple sclerosis - A randomized controlled trial
Hoang, Phu, Schoene, Daniel, Gandevia, Simon C., Smith, Stuart T. and Lord, Stephen R.. (2016). Effects of a home-based step training programme on balance, stepping, cognition and functional performance in people with multiple sclerosis - A randomized controlled trial. Multiple Sclerosis Journal. 22(1), pp. 94 - 103. https://doi.org/10.1177/1352458515579442
Gyroscopic corrections improve wearable sensor data prior to measuring dynamic sway in the gait of people with Multiple Sclerosis
Brodie, Matthew A. D., Psarakis, Michael and Hoang, Phu. (2016). Gyroscopic corrections improve wearable sensor data prior to measuring dynamic sway in the gait of people with Multiple Sclerosis. Computer Methods in Biomechanics and Biomedical Engineering. 19(12), pp. 1339 - 1346. https://doi.org/10.1080/10255842.2016.1140747
Medications are associated with falls in people with multiple sclerosis - A Prospective Cohort study
Cameron, Michelle H., Karstens, Lisa, Hoang, Phu, Bourdette, Dennis and Lord, Stephen R.. (2015). Medications are associated with falls in people with multiple sclerosis - A Prospective Cohort study. International Journal of MS Care. 17(5), pp. 207 - 214. https://doi.org/10.7224/1537-2073.2014-076
Falls in people with MS - An individual data meta-analysis from studies from Australia, Sweden, United Kingdom and the United States
Nilsagård, Ylva E., Gunn, Hilary, Freeman, Jennifer, Hoang, Phu, Lord, Stephen R., Mazumder, Rajarshi and Cameron, Michelle. (2015). Falls in people with MS - An individual data meta-analysis from studies from Australia, Sweden, United Kingdom and the United States. Multiple Sclerosis Journal. 21(1), pp. 92 - 100. https://doi.org/10.1177/1352458514538884
Neuromuscular electrical stimulation cycling exercise for persons with advanced multiple sclerosis
Fornusek, Ché and Hoang, Phu. (2014). Neuromuscular electrical stimulation cycling exercise for persons with advanced multiple sclerosis. Journal of Rehabilitation Medicine. 46(7), pp. 698 - 702. https://doi.org/10.2340/16501977-1792
Passive mechanical properties of the gastrocnemius after spinal cord injury
Diong, Joanna, Herbert, Robert, Harvey, Lisa, Kwah, Li, Clark, Jillian, Hoang, Phu, Martin, Josh, Clarke, E, Bilston, L and Gandevia, S. (2012). Passive mechanical properties of the gastrocnemius after spinal cord injury. Muscle & Nerve. 46(2), pp. 237 - 245. https://doi.org/10.1002/mus.23356