Dietary Vitamin K1 intake is associated with lower long-term fracture-related hospitalization risk : The Perth longitudinal study of ageing women

Journal article


Sim, Marc, Strydom, Andre, Blekkenhorst, Lauren C., Bondonno, Nicola P., McCormick, Rachel, Lim, Wai H., Zhu, Kun, Byrnes, Elizabeth, Hodgson, Jonathan M., Lewis, Joshua R. and Prince, Richard L.. (2022). Dietary Vitamin K1 intake is associated with lower long-term fracture-related hospitalization risk : The Perth longitudinal study of ageing women. Food and Function. 13(20), pp. 10642-10650. https://doi.org/10.1039/d2fo02494b
AuthorsSim, Marc, Strydom, Andre, Blekkenhorst, Lauren C., Bondonno, Nicola P., McCormick, Rachel, Lim, Wai H., Zhu, Kun, Byrnes, Elizabeth, Hodgson, Jonathan M., Lewis, Joshua R. and Prince, Richard L.
Abstract

This study examined the association between dietary Vitamin K1 intake with fracture-related hospitalizations over 14.5 years in community-dwelling older Australian women (n = 1373, ≥70 years). Dietary Vitamin K1 intake at baseline (1998) was estimated using a validated food frequency questionnaire and a new Australian Vitamin K nutrient database, which was supplemented with published data. Over 14.5 years, any fracture (n = 404, 28.3%) and hip fracture (n = 153, 10.7%) related hospitalizations were captured using linked health data. Plasma Vitamin D status (25OHD) and the ratio of undercarboxylated osteocalcin (ucOC) to total osteocalcin (tOC) from serum was assessed at baseline. Estimates of dietary Vitamin K1 intake were supported by a significant inverse association with ucOC : tOC; a marker of Vitamin K status (r = −0.12, p < 0.001). Compared to women with the lowest Vitamin K1 intake (Quartile 1, <61 μg d−1), women with the highest Vitamin K1 intake (Quartile 4, ≥99 μg d−1) had lower hazards for any fracture- (HR 0.69 95%CI 0.52–0.91, p < 0.001) and hip fracture-related hospitalization (HR 0.51 95%CI 0.32–0.79, p < 0.001), independent of 25OHD levels, as part of multivariable-adjusted analysis. Spline analysis suggested a nadir in the relative hazard for any fracture-related hospitalizations at a Vitamin K1 intake of approximately 100 μg day−1. For hip fractures, a similar relationship was apparent. Higher dietary Vitamin K1 is associated with lower long-term risk for any fracture- and hip fracture-related hospitalizations in community-dwelling older women.

Year2022
JournalFood and Function
Journal citation13 (20), pp. 10642-10650
PublisherRoyal Society of Chemistry
ISSN2042-6496
Digital Object Identifier (DOI)https://doi.org/10.1039/d2fo02494b
Scopus EID2-s2.0-85140060158
Page range10642-10650
FunderHealthway, Western Australia
Western Australian Health Promotion Foundation
National Health and Medical Research Council (NHMRC)
Department of Health, Western Australia
Royal Perth Hospital
Western Australian Future Health and Innovation Fund
National Heart Foundation of Australia
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online12 Sep 2022
Publication process dates
Accepted12 Sep 2022
Deposited17 Jan 2023
Grant ID254627
303169
572604
CAF 130/2020
1172987
102498
1116973
102817
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https://acuresearchbank.acu.edu.au/item/8y99y/dietary-vitamin-k1-intake-is-associated-with-lower-long-term-fracture-related-hospitalization-risk-the-perth-longitudinal-study-of-ageing-women

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