Dietary Vitamin K1 intake is associated with lower long-term fracture-related hospitalization risk : The Perth longitudinal study of ageing women
Journal article
Sim, Marc, Strydom, Andre, Blekkenhorst, Lauren C., Bondonno, Nicola P., McCormick, Rachel, Lim, Wai H., Zhu, Kun, Byrnes, Elizabeth, Hodgson, Jonathan M., Lewis, Joshua R. and Prince, Richard L.. (2022). Dietary Vitamin K1 intake is associated with lower long-term fracture-related hospitalization risk : The Perth longitudinal study of ageing women. Food and Function. 13(20), pp. 10642-10650. https://doi.org/10.1039/d2fo02494b
Authors | Sim, Marc, Strydom, Andre, Blekkenhorst, Lauren C., Bondonno, Nicola P., McCormick, Rachel, Lim, Wai H., Zhu, Kun, Byrnes, Elizabeth, Hodgson, Jonathan M., Lewis, Joshua R. and Prince, Richard L. |
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Abstract | This study examined the association between dietary Vitamin K1 intake with fracture-related hospitalizations over 14.5 years in community-dwelling older Australian women (n = 1373, ≥70 years). Dietary Vitamin K1 intake at baseline (1998) was estimated using a validated food frequency questionnaire and a new Australian Vitamin K nutrient database, which was supplemented with published data. Over 14.5 years, any fracture (n = 404, 28.3%) and hip fracture (n = 153, 10.7%) related hospitalizations were captured using linked health data. Plasma Vitamin D status (25OHD) and the ratio of undercarboxylated osteocalcin (ucOC) to total osteocalcin (tOC) from serum was assessed at baseline. Estimates of dietary Vitamin K1 intake were supported by a significant inverse association with ucOC : tOC; a marker of Vitamin K status (r = −0.12, p < 0.001). Compared to women with the lowest Vitamin K1 intake (Quartile 1, <61 μg d−1), women with the highest Vitamin K1 intake (Quartile 4, ≥99 μg d−1) had lower hazards for any fracture- (HR 0.69 95%CI 0.52–0.91, p < 0.001) and hip fracture-related hospitalization (HR 0.51 95%CI 0.32–0.79, p < 0.001), independent of 25OHD levels, as part of multivariable-adjusted analysis. Spline analysis suggested a nadir in the relative hazard for any fracture-related hospitalizations at a Vitamin K1 intake of approximately 100 μg day−1. For hip fractures, a similar relationship was apparent. Higher dietary Vitamin K1 is associated with lower long-term risk for any fracture- and hip fracture-related hospitalizations in community-dwelling older women. |
Year | 2022 |
Journal | Food and Function |
Journal citation | 13 (20), pp. 10642-10650 |
Publisher | Royal Society of Chemistry |
ISSN | 2042-6496 |
Digital Object Identifier (DOI) | https://doi.org/10.1039/d2fo02494b |
Scopus EID | 2-s2.0-85140060158 |
Page range | 10642-10650 |
Funder | Healthway, Western Australia |
Western Australian Health Promotion Foundation | |
National Health and Medical Research Council (NHMRC) | |
Department of Health, Western Australia | |
Royal Perth Hospital | |
Western Australian Future Health and Innovation Fund | |
National Heart Foundation of Australia | |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 12 Sep 2022 |
Publication process dates | |
Accepted | 12 Sep 2022 |
Deposited | 17 Jan 2023 |
Grant ID | 254627 |
303169 | |
572604 | |
CAF 130/2020 | |
1172987 | |
102498 | |
1116973 | |
102817 |
https://acuresearchbank.acu.edu.au/item/8y99y/dietary-vitamin-k1-intake-is-associated-with-lower-long-term-fracture-related-hospitalization-risk-the-perth-longitudinal-study-of-ageing-women
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