Higher dietary Vitamin K intake is associated with better physical function and lower long-term injurious falls risk in community-dwelling older women

Journal article


Sim, Marc, Smith, Cassandra, Bondonno, Nicola P., Radavelli-Bagatini, S., Blekkenhorst, Lauren C., Dalla Via, J., McCormick, Rachel, Zhu, K., Hodgson, Jonathan M., Prince, R. L. and Lewis, Joshua R.. (2023). Higher dietary Vitamin K intake is associated with better physical function and lower long-term injurious falls risk in community-dwelling older women. Journal of Nutrition, Health and Aging. 27(1), pp. 38-45. https://doi.org/10.1007/s12603-022-1866-9
AuthorsSim, Marc, Smith, Cassandra, Bondonno, Nicola P., Radavelli-Bagatini, S., Blekkenhorst, Lauren C., Dalla Via, J., McCormick, Rachel, Zhu, K., Hodgson, Jonathan M., Prince, R. L. and Lewis, Joshua R.
Abstract

Background
In recent years, a potential beneficial role of Vitamin K in neuromuscular function has been recognised. However, the optimal dietary intake of Vitamin K to support muscle function in the context of falls prevention remains unknown.

Objective
To examine the relationship of dietary Vitamin K1 and K2 with muscle function and long-term injurious fall-related hospitalisations in older women.
Design

Cohort study.
Participants
1347 community-dwelling older Australian women ≥70 years.

Measurements
A new Australian Vitamin K nutrient database, supplemented with published data, was used to calculate Vitamin K1 and K2 intake from a validated food frequency questionnaire at baseline (1998). Muscle function (grip strength and timed-up-and-go; TUG) as well plasma Vitamin D status (25OHD) were also assessed at baseline. Fall-related hospitalisations over 14.5 years were obtained from linked health records. Multivariable-adjusted logistic regression and Cox-proportional hazard models were used to analyse the data.

Results
Over 14.5 years of follow-up (14,774 person-years), 535 (39.7%) women experienced a fall-related hospitalisation. Compared to women with the lowest Vitamin K1 intake (Quartile 1, median 49 µg/d), those with the highest intake (Quartile 4, median 120 µg/d) had 29% lower odds (OR 0.71 95%CI 0.52–0.97) for slow TUG performance (>10.2 s), and 26% lower relative hazards of a fall-related hospitalisation (HR 0.74 95%CI 0.59–0.93) after multivariable adjustment. These associations were non-linear and plateaued at moderate intakes of ∼70–100 µg/d. There was no relation to grip strength. Vitamin K2 intakes were not associated with muscle function or falls.

Conclusion
A higher habitual Vitamin K1 intake was associated with better physical function and lower long-term injurious falls risk in community-dwelling older women. In the context of musculoskeletal health, Vitamin K1 found abundantly in green leafy vegetables should be promoted.

Keywordsphylloquinone; menaquinone; muscle function; injury; nutrition
Year2023
JournalJournal of Nutrition, Health and Aging
Journal citation27 (1), pp. 38-45
PublisherSpringer
ISSN1760-4788
Digital Object Identifier (DOI)https://doi.org/10.1007/s12603-022-1866-9
PubMed ID36651485
Scopus EID2-s2.0-85145940662
Open accessPublished as ‘gold’ (paid) open access
Page range38-45
FunderHealthway, Western Australia
Western Australian Health Promotion Foundation
National Health and Medical Research Council (NHMRC)
Department of Health, Western Australia
Royal Perth Hospital
Western Australian Future Health and Innovation Fund
Australia Emerging Leadership Investigator Grant
National Heart Foundation of Australia
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online04 Jan 2024
Publication process dates
Accepted27 Oct 2022
Deposited24 Apr 2025
Grant ID254627
303169
572604
CAF 130/2020
1172987
102498
1116973
102817
Additional information

This article is distributed under the terms of the Creative Commons https://creativecommons.org/licenses/by/4.0/ which permits use, duplication, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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