Exercise and heat stress : Inflammation and the iron regulatory response

Journal article


McKay, Alannah K. A., McCormick, Rachel, Tee, Nicolin and Peeling, Peter. (2021). Exercise and heat stress : Inflammation and the iron regulatory response. International Journal of Sport Nutrition and Exercise Metabolism. 31(6), pp. 460-465. https://doi.org/10.1123/ijsnem.2021-0080
AuthorsMcKay, Alannah K. A., McCormick, Rachel, Tee, Nicolin and Peeling, Peter
Abstract

This study determined the impact of heat stress on postexercise inflammation and hepcidin levels. Twelve moderately trained males completed three, 60-min treadmill running sessions under different conditions: (a) COOL, 18 °C with speed maintained at 80% maximum heart rate; (b) HOTHR, 35 °C with speed maintained at 80% maximum heart rate; and (c) HOTPACE, 35 °C completed at the average running speed from the COOL trial. Venous blood samples were collected pre-, post-, and 3-hr postexercise and analyzed for serum ferritin, interleukin-6 (IL-6), and hepcidin concentrations. Average HR was highest during HOTPACE compared with HOTHR and COOL (p < .001). Running speed was slowest in HOTHR compared with COOL and HOTPACE (p < .001). The postexercise increase in IL-6 was greatest during HOTPACE (295%; p = .003). No differences in the IL-6 response immediately postexercise between COOL (115%) and HOTHR (116%) were evident (p = .992). No differences in hepcidin concentrations between the three trials were evident at 3 hr postexercise (p = .407). Findings from this study suggest the IL-6 response to exercise is greatest in hot compared with cool conditions when the absolute running speed was matched. No differences in IL-6 between hot and cool conditions were evident when HR was matched, suggesting the increased physiological strain induced from training at higher intensities in hot environments, rather than the heat per se, is likely responsible for this elevated response. Environmental temperature had no impact on hepcidin levels, indicating that exercising in hot conditions is unlikely to further impact transient alterations in iron regulation, beyond that expected in temperate conditions.

Keywordsathlete; heat training; hepcidin; hot environments; iron metabolism; temperature
Year2021
JournalInternational Journal of Sport Nutrition and Exercise Metabolism
Journal citation31 (6), pp. 460-465
PublisherHuman Kinetics Publishers
ISSN1526-484X
Digital Object Identifier (DOI)https://doi.org/10.1123/ijsnem.2021-0080
Scopus EID2-s2.0-85117800630
Research or scholarlyResearch
Page range460-465
Publisher's version
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All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online29 Jul 2021
Publication process dates
Deposited25 Aug 2022
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