Regular activity breaks combined with physical activity improve postprandial plasma triglyceride, nonesterified fatty acid, and insulin responses in healthy, normal weight adults : A randomised crossover trial

Journal article


Homer, Ashleigh R., Fenemor, Stephen P., Perry, Tracy L., Rehrer, Nancy J., Cameron, Claire M., Skeaff, C. Murrary and Peddie, Meredith C.. (2017). Regular activity breaks combined with physical activity improve postprandial plasma triglyceride, nonesterified fatty acid, and insulin responses in healthy, normal weight adults : A randomised crossover trial. Journal of Clinical Lipidology. 11(5), pp. 1268-1279. https://doi.org/10.1016/j.jacl.2017.06.007
AuthorsHomer, Ashleigh R., Fenemor, Stephen P., Perry, Tracy L., Rehrer, Nancy J., Cameron, Claire M., Skeaff, C. Murrary and Peddie, Meredith C.
Abstract

Background
Compared with prolonged sitting, regular activity breaks immediately lower postprandial glucose and insulin, but not triglyceride responses. Postprandial triglycerides can be lowered by physical activity but the effect is often delayed by ∼12 to 24 hours.

Objective
The objective of the study was to determine whether regular activity breaks affect postprandial triglyceride response in a delayed manner similar to physical activity.

Methods
In a randomized crossover trial, 36 adults (body mass index 23.9 kg/m2 [standard deviation 3.9]) completed four 2-day interventions: (1) prolonged sitting (SIT); (2) prolonged sitting with 30 minutes of continuous walking (60% VO2max), at the end of Day 1 (SIT + PAD1); (3) Sitting with 2 minutes of walking (60% VO2max) every 30 minutes (RAB); (4) A combination of the continuous walking and regular activity breaks in 2 and 3 above (RAB + PAD1). Postprandial plasma triglyceride, nonesterified fatty acids, glucose, and insulin responses were measured in venous blood over 5 hours on Day 2.

Results
Compared with SIT, both RAB (difference: −43.61 mg/dL·5 hours; 95% confidence interval [CI] −83.66 to −2.67; P = .035) and RAB + PAD1 (−65.86 mg/dL·5 hours; 95% CI −112.14 to −19.58; P = .005) attenuated triglyceride total area under the curve (tAUC). RAB + PAD1 produced the greatest reductions in insulin tAUC (−23%; 95% CI −12% to −31%; P < .001), whereas RAB resulted in the largest increase in nonesterified fatty acids (tAUC, 10.08 mg/dL·5 hours; 95% CI 5.60–14.84; P < .001). There was no effect on glucose tAUC (P = .290).

Conclusions
Postprandial triglyceride response is attenuated by regular activity breaks, when measured ∼24 hours after breaks begin. Combining regular activity breaks with 30 minutes of continuous walking further improves insulinemic and lipidemic responses.

Keywordssedentary behaviour; sedentary lifestyle; physical activity; postprandial metabolism
Year2017
JournalJournal of Clinical Lipidology
Journal citation11 (5), pp. 1268-1279
PublisherElsevier Inc.
ISSN1933-2874
Digital Object Identifier (DOI)https://doi.org/10.1016/j.jacl.2017.06.007
Scopus EID2-s2.0-85021685410
Page range1268-1279
FunderNational Heart Foundation of New Zealand
Lotteries Health Research
University of Otago
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online19 Jun 2017
Publication process dates
Accepted07 Jun 2017
Deposited25 Jan 2023
Grant ID1527
326803
1518
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https://acuresearchbank.acu.edu.au/item/8yq04/regular-activity-breaks-combined-with-physical-activity-improve-postprandial-plasma-triglyceride-nonesterified-fatty-acid-and-insulin-responses-in-healthy-normal-weight-adults-a-randomised-crossover

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