Fluoromica nanoparticle cytotoxicity in macrophages decreases with size and extent of uptake

Journal article


Tee, Nicolin, Zhu, Yingdong, Mortimer, Gysell, Martin, Darren and Minchin, Rodney. (2015). Fluoromica nanoparticle cytotoxicity in macrophages decreases with size and extent of uptake. International Journal of Nanomedicine. 10(1), pp. 2363-2375. https://doi.org/10.2147/IJN.S80655
AuthorsTee, Nicolin, Zhu, Yingdong, Mortimer, Gysell, Martin, Darren and Minchin, Rodney
Abstract

Polyurethanes are widely used in biomedical devices such as heart valves, pacemaker leads, catheters, vascular devices, and surgical dressings because of their excellent mechanical properties and good biocompatibility. Layered silicate nanoparticles can significantly increase tensile strength and breaking strain of polyurethanes potentially increasing the life span of biomedical devices that suffer from wear in vivo. However, very little is known about how these nanoparticles interact with proteins and cells and how they might exert unwanted effects. A series of fluoromica nanoparticles ranging in platelet size from 90 to over 600 nm in diameter were generated from the same base material ME100 by high energy milling and differential centrifugation. The cytotoxicity of the resulting particles was dependent on platelet size but in a manner that is opposite to many other types of nanomaterials. For the fluoromicas, the smaller the platelet size, the less toxicity was observed. The small fluoromica nanoparticles (,200 nm) were internalized by macrophages via scavenger receptors, which was dependent on the protein corona formed in serum. This internalization was associated with apoptosis in RAW cells but not in dTHP-1 cells. The larger particles were not internalized efficiently but mostly decorated the surface of the cells, causing membrane disruption, even in the presence of 80% serum. This work suggests the smaller fluoromica platelets may be safer for use in humans but their propensity to recognize macrophage scavenger receptors also suggests that they will target the reticulo-endoplasmic system in vivo.

Keywordslayered silicates,; accumulation; phagocytosis; high energy milling
Year01 Jan 2015
JournalInternational Journal of Nanomedicine
Journal citation10 (1), pp. 2363-2375
PublisherDove Medical Press Ltd. (Dovepress)
ISSN1176-9114
Digital Object Identifier (DOI)https://doi.org/10.2147/IJN.S80655
Web address (URL)https://www.dovepress.com/fluoromica-nanoparticle-cytotoxicity-in-macrophages-decreases-with-siz-peer-reviewed-fulltext-article-IJN
Open accessOpen access
Research or scholarlyResearch
Page range2363-2375
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online26 Mar 2015
Publication process dates
Accepted24 Feb 2015
Deposited06 Jun 2024
Additional information

© 2015 Tee et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.php

Place of publicationNew Zealand
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