Sedentary behavior and lifespan brain health

Journal article


Zou, Liye, Herold, Fabian, Cheval, Boris, Wheeler, Michael, Pindus, Dominika M., Erickson, Kirk I., Raichlen, David A., Alexander, Gene E., Müller, Notger G., Dunstan, David W., Kramer, Arthur F., Hillman, Charles H., Hallgren, Mats, Ekelund, Ulf, Maltagliati, Silvio and Owen, Neville. (2024). Sedentary behavior and lifespan brain health. Trends in Cognitive Sciences. 28(4), pp. 369-382. https://doi.org/10.1016/j.tics.2024.02.003
AuthorsZou, Liye, Herold, Fabian, Cheval, Boris, Wheeler, Michael, Pindus, Dominika M., Erickson, Kirk I., Raichlen, David A., Alexander, Gene E., Müller, Notger G., Dunstan, David W., Kramer, Arthur F., Hillman, Charles H., Hallgren, Mats, Ekelund, Ulf, Maltagliati, Silvio and Owen, Neville
Abstract

Higher levels of physical activity are known to benefit aspects of brain health across the lifespan. However, the role of sedentary behavior (SB) is less well understood. In this review we summarize and discuss evidence on the role of SB on brain health (including cognitive performance, structural or functional brain measures, and dementia risk) for different age groups, critically compare assessment approaches to capture SB, and offer insights into emerging opportunities to assess SB via digital technologies. Across the lifespan, specific characteristics of SB (particularly whether they are cognitively active or cognitively passive) potentially act as moderators influencing the associations between SB and specific brain health outcomes. We outline challenges and opportunities for future research aiming to provide more robust empirical evidence on these observations.

Keywordsprolonged sitting; cognition; dementia; children; adolescents; aging
Year2024
JournalTrends in Cognitive Sciences
Journal citation28 (4), pp. 369-382
PublisherCell Press
ISSN1364-6613
Digital Object Identifier (DOI)https://doi.org/10.1016/j.tics.2024.02.003
PubMed ID38431428
Scopus EID2-s2.0-85186949920
PubMed Central IDPMC11778811
Page range369-382
FunderShenzhen Educational Research Funding
Shenzhen Science and Technology Innovation Commission
Ministry of Education of China
National Center for Mental Health of China
Shenzhen University
National Institute for Health Research (NIHR)
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online02 Apr 2024
Publication process dates
Deposited27 Mar 2025
Grant IDzdzb2014
202307313000096
23YJA880093
2022M711174
Z014
ZYZD2305
AG072445
AG067200
AG064587
AG072980
AG019610
Permalink -

https://acuresearchbank.acu.edu.au/item/9180z/sedentary-behavior-and-lifespan-brain-health

Restricted files

Publisher's version

  • 0
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Type 2 Diabetes Mellitus and Sarcopenia as Comorbid Chronic Diseases in Older Adults : Established and Emerging Treatments and Therapies
Mesinovic, Jakub, Fyfe, Jackson, Talevski, Jason, Wheeler, Michael, Leung, Gloria K W, George, Elena S., Hunegnaw, Melkamu T., Glavas, Costas, Jansons, Paul, Daly, Rob and Scott, David. (2023). Type 2 Diabetes Mellitus and Sarcopenia as Comorbid Chronic Diseases in Older Adults : Established and Emerging Treatments and Therapies. Diabetes and Metabolism Journal. 47(6), pp. 719-742. https://doi.org/10.4093/dmj.2023.0112
Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates : A randomized control trial
Parr, Evelyn B., Kouw, Imre W. K., Wheeler, Michael J., Radford, Bridget E., Hall, Rebecca C., Senden, Joan M., Goessens, Joy P. B., Van Loon, Luc J. C. and Hawley, John A.. (2023). Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates : A randomized control trial. Obesity. 31(S1), pp. 116-126. https://doi.org/10.1002/oby.23637
Eating disorders are associated with increased risk of fall injury and fracture in Swedish men and women
Axelsson, K. F., Woessner, M. N., Litsne, H., Wheeler, M., Flehr, A., King, A. J., Kalén, M., Vandenput, L. and Lorentzon, M.. (2022). Eating disorders are associated with increased risk of fall injury and fracture in Swedish men and women. Osteoporosis International. 33(6), pp. 1347-1355. https://doi.org/10.1007/s00198-022-06312-2
Development of a novel method to measure bone marrow fat fraction in older women using high-resolution peripheral quantitative computed tomography
Flehr, Alison, Källgård, Julius, Alvén, Jennifer, Lagerstrand, Kerstin, Papalini, Evin, Wheeler, Michael, Vandenput, Liesbeth, Kahl, Fredrik, Axelsson, Kristian F., Sundh, Daniel, Mysore, Raghunath Shirish and Lorentzon, Mattias. (2022). Development of a novel method to measure bone marrow fat fraction in older women using high-resolution peripheral quantitative computed tomography. Osteoporosis International. 33(7), pp. 1545-1556. https://doi.org/10.1007/s00198-021-06224-7
Different frequencies of active interruptions to sitting have distinct effects on 22 h glycemic control in type 2 diabetes
Homer, Ashleigh R., Taylor, Frances C., Dempsey, Paddy C., Wheeler, Michael J., Sethi, Parneet, Grace, Megan S., Green, Daniel J., Cohen, Neale D., Larsen, Robyn N., Kingwell, Bronwyn A., Owen, Neville and Dunstan, David W.. (2021). Different frequencies of active interruptions to sitting have distinct effects on 22 h glycemic control in type 2 diabetes. Nutrition Metabolism and Cardiovascular Diseases. 31(10), pp. 2969-2978. https://doi.org/10.1016/j.numecd.2021.07.001
Frequency of interruptions to sitting time : Benefits for postprandial metabolism in type 2 diabetes
Homer, Ashleigh R., Taylor, Frances C., Dempsey, Paddy C., Wheeler, Michael J., Sethi, Parneet, Townsend, Melanie K., Grace, Megan S., Green, Daniel J., Cohen, Neale D., Larsen, Robyn N., Kingwell, Bronwyn A., Owen, Neville and Dunstan, David W.. (2021). Frequency of interruptions to sitting time : Benefits for postprandial metabolism in type 2 diabetes. Diabetes Care. 44(6), pp. 1-10. https://doi.org/10.2337/dc20-1410
Acute effects of interrupting prolonged sitting on vascular function in type 2 diabetes
Dunstan, D., Homer, A., Wheeler, M. and Maniar, N.. (2021). Acute effects of interrupting prolonged sitting on vascular function in type 2 diabetes. American Journal of Physiology: Heart and Circulatory Physiology. 320(1), pp. H393-H403. https://doi.org/10.1152/ajpheart.00422.2020
Combined effects of continuous exercise and intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides in adults with obesity : A randomized crossover trial
Wheeler, Michael J., Green, Daniel J., Cerin, Ester, Ellis, Kathryn A., Heinonen, Ilkka, Lewis, Jaye, Naylor, Louise H., Cohen, Neale, Larsen, Robyn, Dempsey, Paddy C., Kingwell, Bronwyn A., Owen, Neville and Dunstan, David W.. (2020). Combined effects of continuous exercise and intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides in adults with obesity : A randomized crossover trial. International Journal of Behavioral Nutrition and Physical Activity. 17(1), p. 152. https://doi.org/10.1186/s12966-020-01057-9
Phenotypic responses to a lifestyle intervention do not account for inter-individual variability in glucose tolerance for individuals at high risk of type 2 diabetes
O'Donoghue, Grainne, Kennedy, Aileen, Andersen, Gregers S., Carr, Bernadette, Cleary, Stephen, Durkan, Eoin, Davis, Heidi, Faerch, Kristine, Fitzpatrick, Paula, Kenny, Helena, McCaffrey, Noel, Monedero, Javier, Murphy, Enda, Noone, John, Suvitaival, Tommi, Thybo, Tanja, Wheeler, Michael, Vistissen, Dorte, Nolan, John J. and O'Gorman, Donal J.. (2019). Phenotypic responses to a lifestyle intervention do not account for inter-individual variability in glucose tolerance for individuals at high risk of type 2 diabetes. Frontiers in Physiology. 10(317), pp. 1 - 12. https://doi.org/10.3389/fphys.2019.00317
Study design and methods for the ACTIVity And TEchnology (ACTIVATE) trial
Brigid M Lynch, Nga Nguyen, Marina M. Reeves, Melissa Moore, Dori E Rosenberg, Michael Wheeler, Terry Boyle, Jeff K. Vallance, Christine M Friedenreich and Dallas English. (2018). Study design and methods for the ACTIVity And TEchnology (ACTIVATE) trial. Contemporary Clinical Trials. 64, pp. 112-117. https://doi.org/10.1016/j.cct.2017.10.015
Interacting effects of exercise with breaks in sitting time on cognitive and metabolic function in older adults: rationale and design of a randomised crossover trial
Dunstan, David, Wheeler, Michael, Ellis, Kathryn A.H., Cerin, Ester and Green, Daniel. (2018). Interacting effects of exercise with breaks in sitting time on cognitive and metabolic function in older adults: rationale and design of a randomised crossover trial. Mental Health and Physical Activity. 15, pp. 11 - 16. https://doi.org/10.1016/j.mhpa.2018.05.003
Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health
Wheeler, Michael, Dempsey, Paddy C., Grace, Megan S., Ellis, Kathryn A., Gardiner, Paul A., Green, Daniel and Dunstan, David. (2017). Sedentary behavior as a risk factor for cognitive decline? A focus on the influence of glycemic control in brain health. Alzheimer's and Dementia: Translational Research and Clinical Interventions. 3(3), pp. 291 - 300. https://doi.org/10.1016/j.trci.2017.04.001
In search of the big fish: Investigating the coexistence of the big-fish-little-pond effect with the positive effects of upward comparisons
Seaton, Marjorie, Marsh, Herb, Dumas, F., Huguet, P., Monteil, J. M., Regner, I., Blanton, H., Buunk, A. P., Gibbons, F. X., Kuyper, H., Suls, J. and Wheeler, L.. (2008). In search of the big fish: Investigating the coexistence of the big-fish-little-pond effect with the positive effects of upward comparisons. British Journal of Social Psychology. 47(1), pp. 73 - 103. https://doi.org/10.1348/014466607X202309