Nutritional interventions for preventing and treating pressure ulcers
Journal article
Langer, Gero, Wan, Ching Shan, Fink, Astrid, Schwingshackl, Lukas and Schoberer, Daniela. (2024). Nutritional interventions for preventing and treating pressure ulcers. Cochrane Database of Systematic Reviews. 2024(2), p. Article CD003216. https://doi.org/10.1002/14651858.CD003216.pub3
Authors | Langer, Gero, Wan, Ching Shan, Fink, Astrid, Schwingshackl, Lukas and Schoberer, Daniela |
---|---|
Abstract | Background Objectives Search methods Selection criteria Data collection and analysis Main results Pressure ulcer prevention Eleven studies (with 12 arms) compared six types of nutritional interventions for the prevention of pressure ulcers. Compared to standard diet, energy, protein and micronutrient supplements may result in little to no difference in the proportion of participants developing a pressure ulcer (energy, protein and micronutrient supplements 248 per 1000, standard diet 269 per 1000; RR 0.92, 95% CI 0.71 to 1.19; 3 studies, 1634 participants; low‐certainty evidence). Compared to standard diet, protein supplements may result in little to no difference in pressure ulcer incidence (protein 21 per 1000, standard diet 28 per 1000; RR 0.75, 95% CI 0.49 to 1.14; 4 studies, 4264 participants; low‐certainty evidence). The evidence is very uncertain about the gastrointestinal side effects of these supplements (protein 109 per 1000, standard diet 155 per 1000; RR 0.70, 95% CI 0.06 to 7.96; 2 studies, 140 participants, very low‐certainty evidence). The evidence is very uncertain about the effects of protein, arginine, zinc and antioxidants; L‐carnitine, L‐leucine, calcium, magnesium and vitamin D; EPA, GLA and antioxidants; disease‐specific supplements on pressure ulcer incidence when compared to standard diet (1 study each; very low‐certainty evidence for all comparisons). Pressure ulcer treatment Twenty‐four studies (with 27 arms) compared 10 types of nutritional interventions or supplements for treatment of pressure ulcers. Compared to standard diet, energy, protein and micronutrient supplements may slightly increase the number of healed pressure ulcers (energy, protein and micronutrients 366 per 1000, standard diet 253 per 1000; RR 1.45, 95% CI 1.14 to 1.85; 3 studies, 577 participants, low‐certainty evidence). The evidence is very uncertain about the effect of these supplements on gastrointestinal side effects. Compared to standard diet, the evidence is very uncertain about the effect of protein, arginine, zinc and antioxidant supplements on pressure ulcer healing (pressure ulcer area: mean difference (MD) 2 cm² smaller, 95% CI 4.54 smaller to 0.53 larger; 2 studies, 71 participants, very low‐certainty evidence). The evidence on side effects of these supplements is very uncertain. Compared to standard diet, supplements with arginine and micronutrients may not increase the number of healed pressure ulcers, but the evidence suggests a slight reduction in pressure ulcer area (MD 15.8% lower, 95% CI 25.11 lower to 6.48 lower; 2 studies, 231 participants, low‐certainty evidence). The evidence is very uncertain about changes in pressure ulcer scores, acceptability, and side effects of these supplements. Compared to placebo, collagen supplements probably improve the mean change in pressure ulcer area (MD 1.81 cm² smaller, 95% CI 3.36 smaller to 0.26 smaller; 1 study, 74 participants, moderate‐certainty evidence). The evidence is very uncertain about the effect of these supplements on side effects. The evidence is very uncertain about the effects of vitamin C, different doses of arginine; EPA, GLA (special dietary fatty acids) and antioxidants; protein; a specialized amino acid mixture; ornithine alpha‐ketoglutarate and zinc supplements on pressure ulcer healing (1 or 2 studies each; very low‐certainty evidence). Authors' conclusions |
Year | 2024 |
Journal | Cochrane Database of Systematic Reviews |
Journal citation | 2024 (2), p. Article CD003216 |
Publisher | John Wiley & Sons Ltd |
ISSN | 1469-493X |
Digital Object Identifier (DOI) | https://doi.org/10.1002/14651858.CD003216.pub3 |
PubMed ID | 38345088 |
Scopus EID | 2-s2.0-85185137637 |
PubMed Central ID | PMC10860148 |
Open access | Open access |
Page range | 1-176 |
Publisher's version | License All rights reserved File Access Level Open |
Output status | Published |
Publication dates | |
Online | 12 Feb 2024 |
Publication process dates | |
Deposited | 26 May 2025 |
Additional information | Bronze open access. |
Copyright © 2024 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. |
https://acuresearchbank.acu.edu.au/item/91x10/nutritional-interventions-for-preventing-and-treating-pressure-ulcers
Download files
Publisher's version
Langer_2024_Nutritional_interventions_for_preventing_and_treating.pdf | |
License: All rights reserved | |
File access level: Open |
2
total views1
total downloads0
views this month0
downloads this month