The dosage of the Derivative of Clostridium Ghonii (DCG) spores dictates whether an IFNγ/IL-9 or a strong IFNγ response is elicited in TC-1 tumour bearing mice

Journal article


Ni, Guoying, Wang, Yong, Good, David, Yuan, Jianwei, Pan, Xuan, Wei, Jou, Liu, Xiaosong and Wei, Ming Q.. (2019). The dosage of the Derivative of Clostridium Ghonii (DCG) spores dictates whether an IFNγ/IL-9 or a strong IFNγ response is elicited in TC-1 tumour bearing mice. BioMed Research International. 2019, pp. 1 - 10. https://doi.org/10.1155/2019/1395138
AuthorsNi, Guoying, Wang, Yong, Good, David, Yuan, Jianwei, Pan, Xuan, Wei, Jou, Liu, Xiaosong and Wei, Ming Q.
Abstract

Background. Anaerobic Clostridial spores (CG) cause significant oncolysis in hypoxic tumour microenvironment and result in tumour regression in both animal models and clinical trials. The immune mediated response plays a critical role in the antitumour effect by the anaerobic spore treatment. Method. Human papillomavirus 16 E6/E7 transformed TC-1 tumour bearing mice were intravenously administered with low (1 × 108 CFU/kg) or high dosage (3 × 108 CFU/kg) of Derivative Clostridial spore (DCG). Results. Intravenous administration of the derivative of Clostridial ghonii (DCG) spores leads to both tumour and systemic inflammatory responses characterized by increased IFNγ/IL-9 secreting T cells in the spleen and the tumour. Low numbers of antigen specific T cells (<20/106 spleen cells) in the spleen of the tumour bearing mice are also detected after intravenous DCG delivery. Interestingly, our results showed that a mixed IL-9/IFNγ secreting T cell response was induced when the tumour bearing mice received a low dose of DCG spore (1 × 108 CFU/kg), while a strong IFNγ response was elicited with a high dosage of DCG spore (3 × 108 CFU/kg). Conclusion. The dosage of DCG spore will determine the types of the DCG induced immune responses.

Year2019
JournalBioMed Research International
Journal citation2019, pp. 1 - 10
PublisherHindawi
ISSN2314-6133
Digital Object Identifier (DOI)https://doi.org/10.1155/2019/1395138
Scopus EID2-s2.0-85066084500
Open accessOpen access
Page range1 - 10
Research GroupSchool of Allied Health
Publisher's version
License
Place of publicationUnited Kingdom
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