Sequential release of BMP-7 and VEGF from the PLGA/AK-Gelatin composite scaffolds

Journal article


Liu, G., Fan, W., Miao, X., Xiao, Y., Good, David Andrew and Wei, M.. (2011). Sequential release of BMP-7 and VEGF from the PLGA/AK-Gelatin composite scaffolds. Journal of Biomimetics, Biomaterials, and Tissue Engineering (online version). 11, pp. 81 - 91. https://doi.org/10.4028/www.scientific.net/JBBTE.11.81
AuthorsLiu, G., Fan, W., Miao, X., Xiao, Y., Good, David Andrew and Wei, M.
Abstract

Vascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMP-7) are key regulators of angiogenesis and osteogenesis during bone regeneration. The aim of this study was to investigate the possibility of realizing sequential release of the two growth factors using a novel composite scaffold. Poly(lactic-co-glycolic acid) (PLGA)-Akermanite (AK) microspheres were used to make the composite scaffold, which was then loaded with BMP-7, followed by embedding in a gelatin hydrogel matrix loaded with VEGF. The release profiles of the growth factors were studied and selected osteogenic related markers of bone marrow stromal cells (BMSCs) were analysed. It was shown that the composite scaffolds exhibited a fast initial burst release of VEGF within the first 3 days and a sustained slow release of BMP-7 over the full period of 20 days. The in vitro proliferation and differentiation of the BMSCs cultured in the osteogenic medium were enhanced by 1 to 2 times, resulting from the additionally and sequentially release of growth factors from the PLGA-AK/gelatin composite scaffolds.

Year2011
JournalJournal of Biomimetics, Biomaterials, and Tissue Engineering (online version)
Journal citation11, pp. 81 - 91
ISSN1662-100X
Digital Object Identifier (DOI)https://doi.org/10.4028/www.scientific.net/JBBTE.11.81
Scopus EID2-s2.0-80053520408
Page range81 - 91
Research GroupSchool of Allied Health
Permalink -

https://acuresearchbank.acu.edu.au/item/87970/sequential-release-of-bmp-7-and-vegf-from-the-plga-ak-gelatin-composite-scaffolds

  • 109
    total views
  • 0
    total downloads
  • 1
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Immunotherapy for non-small cell lung cancer (NSCLC), as a stand-alone and in combination therapy
Kaur, Jasmine, Elms, Jackson, Munn, Alan L., Good, David and Wei, Ming Q.. (2021). Immunotherapy for non-small cell lung cancer (NSCLC), as a stand-alone and in combination therapy. Critical Reviews in Oncology Hematology. 164, p. Article: 103417. https://doi.org/10.1016/j.critrevonc.2021.103417
Significance of LL-37 on Immunomodulation and Disease Outcome
Binbin Yang, David Good, Tamim Mosaiab, Wei Liu, Guoying Ni, Jasmine Kaur, Xiaosong Liu, Calvin Jessop, Lu Yang, Rushdi Fadhil, Zhengjun Yi and Ming Q. Wei. (2020). Significance of LL-37 on Immunomodulation and Disease Outcome. BioMed Research International. 2020(8349712), pp. 1-16. https://doi.org/10.1155/2020/8349712
Salivary microRNA miR-let-7a-5p and miR-3928 could be used as potential diagnostic bio-markers for head and neck squamous cell carcinoma
Fadhil, Rushdi S., Wei, Ming Q., Nikolarakos, Dimitrios, Good, David and Nair, Raj G.. (2020). Salivary microRNA miR-let-7a-5p and miR-3928 could be used as potential diagnostic bio-markers for head and neck squamous cell carcinoma. PLoS ONE. 15(3), pp. 1 - 12. https://doi.org/10.1371/journal.pone.0221779
Vaccinations for colorectal cancer: Progress, strategies, and novel adjuvants
Stephen Jiang, David Good and Ming Q. Wei. (2019). Vaccinations for colorectal cancer: Progress, strategies, and novel adjuvants. International Journal of Molecular Sciences. 20(14), pp. 1-15. https://doi.org/10.3390/ijms20143403
Therapeutic Effects of Ten Commonly Used Chinese Herbs and Their Bioactive Compounds on Cancers
Liu Wei, Binbin Yang, Lu Yang, Jasmine Kaur, Calvin Jessop, Rushdi Fadhil, David Good, Guoying Ni, Xiaosong Liu, Tamim Mosaiab, Zhengjun Yi and Ming Wei. (2019). Therapeutic Effects of Ten Commonly Used Chinese Herbs and Their Bioactive Compounds on Cancers. Evidence-Based Complementary and Alternative Medicine. (6057837), pp. 1-10. https://doi.org/10.1155/2019/6057837
Noncoding variations in the gene encoding ceramide synthase 6 are associated with type 2 diabetes in a large Indigenous Australian pedigree
Good, David A., Duffy, David L., Good, Manuela, Guo, Cheng Xia, Busfield, Frances, Shaw, Anthony and Shaw, Joanne T. E.. (2019). Noncoding variations in the gene encoding ceramide synthase 6 are associated with type 2 diabetes in a large Indigenous Australian pedigree. Twin Research and Human Genetics. 22(2), pp. 79 - 87. https://doi.org/10.1017/thg.2019.13
Factors influencing self-management priority setting and decision-making among Chinese patients with acute coronary syndrome and type 2 diabetes mellitus
Liu, Xian-Liang, Willis, Karen, Fulbrook, Paul, Wu, Jo, Shi, Yan and Johnson, Maree. (2019). Factors influencing self-management priority setting and decision-making among Chinese patients with acute coronary syndrome and type 2 diabetes mellitus. European Journal of Cardiovascular Nursing. 18(8), pp. 700 - 710. https://doi.org/10.1177/1474515119863178
Preparing Chinese patients with comorbid heart disease and diabetes for home management: A mixed methods study
Liu, Xian-Liang, Willis, Karen, Wu, Chiung-Jung Jo, Fulbrook, Paul, Shi, Yan and Johnson, Maree. (2019). Preparing Chinese patients with comorbid heart disease and diabetes for home management: A mixed methods study. BMJ Open. 9, pp. 1 - 13. https://doi.org/10.1136/bmjopen-2019-029816
The dosage of the Derivative of Clostridium Ghonii (DCG) spores dictates whether an IFNγ/IL-9 or a strong IFNγ response is elicited in TC-1 tumour bearing mice
Ni, Guoying, Wang, Yong, Good, David, Yuan, Jianwei, Pan, Xuan, Wei, Jou, Liu, Xiaosong and Wei, Ming Q.. (2019). The dosage of the Derivative of Clostridium Ghonii (DCG) spores dictates whether an IFNγ/IL-9 or a strong IFNγ response is elicited in TC-1 tumour bearing mice. BioMed Research International. 2019, pp. 1 - 10. https://doi.org/10.1155/2019/1395138
Exploring Health Education Delivered to Patients with Acute Coronary Syndrome and Type 2 Diabetes Mellitus Admitted to a Shanghai Hospital
Liu, Xian-Liang. (2018). Exploring Health Education Delivered to Patients with Acute Coronary Syndrome and Type 2 Diabetes Mellitus Admitted to a Shanghai Hospital [Thesis]. https://doi.org/10.26199/5c8aec7ccdcbf
The impact of inpatient education on self-management for patients with acute coronary syndrome and type 2 diabetes mellitus: a cross-sectional study in China
Liu, Xian-Liang, Wu, Chiung-Jung Jo, Willis, Karen, Shi, Yan and Johnson, Maree. (2018). The impact of inpatient education on self-management for patients with acute coronary syndrome and type 2 diabetes mellitus: a cross-sectional study in China. Health Education Research. 33(5), pp. 389 - 401. https://doi.org/10.1093/her/cyy023
The development of toad toxins as potential therapeutic agents
Qi, Ji, Zulfiker, Abu Hasanat, Li, Chun, Good, David and Wei, Ming Q.. (2018). The development of toad toxins as potential therapeutic agents. Toxins. 10(8), pp. 1 - 14. https://doi.org/10.3390/toxins10080336
'Better to save one life than build a seven-storied pagoda': A qualitative study of health education for patients with acute coronary syndrome and type 2 diabetes mellitus in Shanghai, China
Liu, Xian-Liang, Willis, Karen, Wu, Chiung-Jung (Jo), Shi, Yan and Johnson, Maree. (2018). 'Better to save one life than build a seven-storied pagoda': A qualitative study of health education for patients with acute coronary syndrome and type 2 diabetes mellitus in Shanghai, China. BMJ Open. 8(8), pp. 1 - 11. https://doi.org/10.1136/bmjopen-2017-019351
Cane toad skin extract-induced upregulation and increased interaction of serotonin 2A and D2 receptors via Gq/11 signaling pathway in CLU213 cells
Zulfiker, Abu Hasanat, Hashimi, Saeed M., Good, David A., Grice, I. Darren and Wei, Ming Q.. (2017). Cane toad skin extract-induced upregulation and increased interaction of serotonin 2A and D2 receptors via Gq/11 signaling pathway in CLU213 cells. Journal of Cellular Biochemistry. 118(5), pp. 979 - 993. https://doi.org/10.1002/jcb.25627
Health education for patients with acute coronary syndrome and type 2 diabetes mellitus: an umbrella review of systematic reviews and meta-analyses
Liu, Xian-Liang, Shi, Yan, Willis, Karen, Wu, Chiung-Jung Jo and Johnson, Maree. (2017). Health education for patients with acute coronary syndrome and type 2 diabetes mellitus: an umbrella review of systematic reviews and meta-analyses. BMJ Open. 7(10), pp. 1 - 30. https://doi.org/10.1136/bmjopen-2017-016857
Acupuncture-point stimulation for postoperative pain control : A systematic review and meta-analysis of randomized controlled trials
Liu, Xian-Liang, Tan, Jing Yu, Molassiotis, Alex, Suen, Lorna K. P. and Shi, Yan. (2015). Acupuncture-point stimulation for postoperative pain control : A systematic review and meta-analysis of randomized controlled trials. Evidence-Based Complementary and Alternative Medicine. 2015, p. Article 657809. https://doi.org/10.1155/2015/657809
Metacognitive functioning in individuals at clinical high risk for psychosis
Barbato, M, Penn, David, Perkins, D, Woods, Scott, Liu, Li and Addington, Jean. (2014). Metacognitive functioning in individuals at clinical high risk for psychosis. Behavioural and Cognitive Psychotherapy. 42(5), pp. 526 - 534. https://doi.org/10.1017/S1352465813000167
Toad glandular secretions and skin extractions as anti-inflammatory and anticancer agents
Qi, Ji, Tan, CK, Hashimi, Saeed, Zulfiker, Abu Hasanat, Good, David and Wei, Ming. (2014). Toad glandular secretions and skin extractions as anti-inflammatory and anticancer agents. Hindawi. 2014(312684), pp. 1 - 9. https://doi.org/10.1155/2014/312684
The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells
Li, Chun, Hashimi, Saeed M., Cao, Siyu, Mellick, Albert S., Duan, Wei and Good, David. (2013). The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2013, pp. 1 - 11. https://doi.org/10.1155/2013/849054
Apoptosis and microRNA aberrations in cancer
Li, Chun, Hashimi, Saeed M., Good, David A., Cao, Siyu, Duan, Wei, Plummer, Prue N., Mellick, Albert S. and Wei, Ming Q.. (2012). Apoptosis and microRNA aberrations in cancer. Clinical and Experimental Pharmacology & Physiology. 39(8), pp. 739 - 746. https://doi.org/10.1111/j.1440-1681.2012.05700.x
Clostridial spores for cancer therapy : Targeting solid tumour microenvironment
Umer, Brittany, Good, David, Anne, Jozef, Duan, Wei and Wei, Ming. (2012). Clostridial spores for cancer therapy : Targeting solid tumour microenvironment. Journal of Toxicology. 2012, pp. 1 - 8. https://doi.org/10.1155/2012/862764
A Combination of a Fluorescent Dye and Zn-S Nanocluster and Its Biological Application on Stain Bacteria
Xie, Jingli, Cao, Siyu, Good, David Andrew, Wei, Mingqian and Ren, Xiaoming. (2010). A Combination of a Fluorescent Dye and Zn-S Nanocluster and Its Biological Application on Stain Bacteria. Inorganic Chemistry. 49(4), pp. 1319 - 1321. https://doi.org/10.1021/ic9023629
Neuroprotective effects of a standardized flavonoid extract from diospyros kaki leaves
Bei, Weijian, Zang, Linquan, Guo, Jiao, Peng, Wenlie, Xu, Anlong, Good, David, Hu, Yinming, Wu, Wei, Hu, Dehui, Zhu, Xinghong, Wei, Ming and Li, Chuyuan. (2009). Neuroprotective effects of a standardized flavonoid extract from diospyros kaki leaves. Journal of Ethnopharmacology. 126(1), pp. 134 - 142. https://doi.org/10.1016/j.jep.2009.07.034
Differential transcriptional responses between the interferon-gamma-induction and iron-limitation models of persistence for chlamydia pneumoniae
Tim, Peter, Good, David, Wan, C., Theodoropoulos, Christina, Mukhopadhyay, Sanghamitra, Summersgill, James and Mathews, Sarah. (2009). Differential transcriptional responses between the interferon-gamma-induction and iron-limitation models of persistence for chlamydia pneumoniae. Journal of Microbiology Immunology and Infection. 42(1), pp. 27 - 37.
New approaches in developing gene transfer vectors for the therapy of solid tumours
Wei, Ming, Yao, Qin, Cao, Siyu, Li, Chun, Li, Kang, Good, David and Anne, Jozef. (2009). New approaches in developing gene transfer vectors for the therapy of solid tumours. Journal of Gene Medicine. 11, pp. 843 - 843.
Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models
Yao, Qin, Qu, Xun, Yang, Qifeng, Good, David, Dai, Shuzhen, Kong, Beihua and Wei, Ming. (2009). Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models. Molecular Cancer. 8(78), pp. 1 - 8. https://doi.org/10.1186/1476-4598-8-78
Clostridial spores as live 'trojan horse' vectors for cancer gene therapy: Comparison with viral delivery systems
Wei, Ming, Ren, Ruimei, Good, David and Anne, Jozef. (2008). Clostridial spores as live 'trojan horse' vectors for cancer gene therapy: Comparison with viral delivery systems. Genetic Vaccines and Therapy. 6(8), pp. 1 - 12. https://doi.org/10.1186/1479-0556-6-8
Bacterial targeted tumour therapy-dawn of a new era
Wei, Ming W., Mengesha, Asferd, Good, David Andrew and Anne, Jozef. (2008). Bacterial targeted tumour therapy-dawn of a new era. Cancer Letters. 259(1), pp. 16 - 27. https://doi.org/10.1016/j.canlet.2007.10.034
Susceptibility to insulin resistance in indigenous Australians may be down stream of resistin
Good, David, Cardinal, John, Ware, Robert, Marks, Lisa, Kesting, Janine, Chan, Lionel and Shaw, Joanne. (2008). Susceptibility to insulin resistance in indigenous Australians may be down stream of resistin. International Journal of Diabetes and Metabolism. 16, pp. 1 - 6.
Association between anthropometric measures of obesity and cardiovascular risk markers in a self-selected group of indigenous Australians
Chan, Lionel, Ware, Robert, Kesting, Janine, Marczak, Maureen, Good, David and Shaw, Joanne. (2007). Association between anthropometric measures of obesity and cardiovascular risk markers in a self-selected group of indigenous Australians. European Journal of Preventative Cardiology. 14(4), pp. 515 - 517. https://doi.org/10.1097/HJR.0b013e3280117257
Short term efficacy of a lifestyle intervention programme on cardiovascular health outcome in overweight Indigenous Australians with and without type 2 diabetes mellitus. The healthy lifestyle programme (HELP)
Chan, Lionel, Ware, Robert, Kesting, Janine, Marczak, Maureen, Good, David and Shaw, Joanne. (2007). Short term efficacy of a lifestyle intervention programme on cardiovascular health outcome in overweight Indigenous Australians with and without type 2 diabetes mellitus. The healthy lifestyle programme (HELP). Diabetes Research and Clinical Practice. 75(7), pp. 65 - 71. https://doi.org/10.1016/j.diabres.2006.04.012
Association between anthropometric measures of obesity and insulin resistance in a self-selected group of Indigenous Australians
Chan, Lionel, Ware, Robert, Kesting, Janine, Marczak, Maureen, Good, David and Shaw, Joanne. (2007). Association between anthropometric measures of obesity and insulin resistance in a self-selected group of Indigenous Australians. Heart, Lung and Circulation. 16(4), pp. 303 - 304. https://doi.org/10.1016/j.hlc.2007.01.006