Sequential release of BMP-7 and VEGF from the PLGA/AK-Gelatin composite scaffolds

Journal article


Liu, G., Fan, W., Miao, X., Xiao, Y., Good, David Andrew and Wei, M.. (2011) Sequential release of BMP-7 and VEGF from the PLGA/AK-Gelatin composite scaffolds. Journal of Biomimetics, Biomaterials, and Tissue Engineering (online version). 11, pp. 81 - 91. https://doi.org/10.4028/www.scientific.net/JBBTE.11.81
AuthorsLiu, G., Fan, W., Miao, X., Xiao, Y., Good, David Andrew and Wei, M.
Abstract

Vascular endothelial growth factor (VEGF) and bone morphogenetic proteins (BMP-7) are key regulators of angiogenesis and osteogenesis during bone regeneration. The aim of this study was to investigate the possibility of realizing sequential release of the two growth factors using a novel composite scaffold. Poly(lactic-co-glycolic acid) (PLGA)-Akermanite (AK) microspheres were used to make the composite scaffold, which was then loaded with BMP-7, followed by embedding in a gelatin hydrogel matrix loaded with VEGF. The release profiles of the growth factors were studied and selected osteogenic related markers of bone marrow stromal cells (BMSCs) were analysed. It was shown that the composite scaffolds exhibited a fast initial burst release of VEGF within the first 3 days and a sustained slow release of BMP-7 over the full period of 20 days. The in vitro proliferation and differentiation of the BMSCs cultured in the osteogenic medium were enhanced by 1 to 2 times, resulting from the additionally and sequentially release of growth factors from the PLGA-AK/gelatin composite scaffolds.

Year2011
JournalJournal of Biomimetics, Biomaterials, and Tissue Engineering (online version)
Journal citation11, pp. 81 - 91
ISSN1662-100X
Digital Object Identifier (DOI)https://doi.org/10.4028/www.scientific.net/JBBTE.11.81
Scopus EID2-s2.0-80053520408
Page range81 - 91
Research GroupSchool of Allied Health
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