Significance of LL-37 on Immunomodulation and Disease Outcome

Journal article


Binbin Yang, David Good, Tamim Mosaiab, Wei Liu, Guoying Ni, Jasmine Kaur, Xiaosong Liu, Calvin Jessop, Lu Yang, Rushdi Fadhil, Zhengjun Yi and Ming Q. Wei. (2020). Significance of LL-37 on Immunomodulation and Disease Outcome. BioMed Research International. 2020(8349712), pp. 1-16. https://doi.org/10.1155/2020/8349712
AuthorsBinbin Yang, David Good, Tamim Mosaiab, Wei Liu, Guoying Ni, Jasmine Kaur, Xiaosong Liu, Calvin Jessop, Lu Yang, Rushdi Fadhil, Zhengjun Yi and Ming Q. Wei
Abstract

LL-37, also called cathelicidin, is an important part of the human immune system, which can resist various pathogens. A plethora of experiments have demonstrated that it has the multifunctional effects of immune regulation, in addition to antimicrobial activity. Recently, there have been increasing interest in its immune function. It was found that LL-37 can have two distinct functions in different tissues and different microenvironments. Thus, it is necessary to investigate LL-37 immune functions from the two sides of the same coin. On the one side, LL-37 promotes inflammation and immune response and exerts its anti-infective and antitumor effects; on the other side, it has the ability to inhibit inflammation and promote carcinogenesis. This review presents a brief summary of its expression, structure, and immunomodulatory effects as well as brief discussions on the role of this small peptide as a key factor in the development and treatment of various inflammation-related diseases and cancers.

Year2020
JournalBioMed Research International
Journal citation2020 (8349712), pp. 1-16
PublisherHindawi Publishing Corporation
ISSN2314-6141
Digital Object Identifier (DOI)https://doi.org/10.1155/2020/8349712
Scopus EID2-s2.0-85086296634
Open accessPublished as ‘gold’ (paid) open access
Publisher's version
File Access Level
Open
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Deposited30 Apr 2021
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