Significance of LL-37 on Immunomodulation and Disease Outcome

Journal article

Binbin Yang, David Good, Tamim Mosaiab, Wei Liu, Guoying Ni, Jasmine Kaur, Xiaosong Liu, Calvin Jessop, Lu Yang, Rushdi Fadhil, Zhengjun Yi and Ming Q. Wei. (2020). Significance of LL-37 on Immunomodulation and Disease Outcome. BioMed Research International. 2020(8349712), pp. 1-16. https://doi.org/10.1155/2020/8349712
AuthorsBinbin Yang, David Good, Tamim Mosaiab, Wei Liu, Guoying Ni, Jasmine Kaur, Xiaosong Liu, Calvin Jessop, Lu Yang, Rushdi Fadhil, Zhengjun Yi and Ming Q. Wei
Abstract

LL-37, also called cathelicidin, is an important part of the human immune system, which can resist various pathogens. A plethora of experiments have demonstrated that it has the multifunctional effects of immune regulation, in addition to antimicrobial activity. Recently, there have been increasing interest in its immune function. It was found that LL-37 can have two distinct functions in different tissues and different microenvironments. Thus, it is necessary to investigate LL-37 immune functions from the two sides of the same coin. On the one side, LL-37 promotes inflammation and immune response and exerts its anti-infective and antitumor effects; on the other side, it has the ability to inhibit inflammation and promote carcinogenesis. This review presents a brief summary of its expression, structure, and immunomodulatory effects as well as brief discussions on the role of this small peptide as a key factor in the development and treatment of various inflammation-related diseases and cancers.

Year2020
JournalBioMed Research International
Journal citation2020 (8349712), pp. 1-16
PublisherHindawi Publishing Corporation
ISSN2314-6141
Digital Object Identifier (DOI)https://doi.org/10.1155/2020/8349712
Scopus EID2-s2.0-85086296634
Open accessPublished as ‘gold’ (paid) open access
Publisher's version
File Access Level
Open
Publication process dates
Deposited30 Apr 2021
Permalink -

https://acuresearchbank.acu.edu.au/item/8vyy3/significance-of-ll-37-on-immunomodulation-and-disease-outcome

Log in to edit

Download files

Publisher's version
OA_Yang_2020_Significance_of_LL_37_on_Immunomodulation.pdf
File access level: Open

  • 109
    total views
  • 18
    total downloads
  • 4
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Immunotherapy for non-small cell lung cancer (NSCLC), as a stand-alone and in combination therapy
Kaur, Jasmine, Elms, Jackson, Munn, Alan L., Good, David and Wei, Ming Q.. (2021). Immunotherapy for non-small cell lung cancer (NSCLC), as a stand-alone and in combination therapy. Critical Reviews in Oncology Hematology. 164, p. Article: 103417. https://doi.org/10.1016/j.critrevonc.2021.103417
Salivary microRNA miR-let-7a-5p and miR-3928 could be used as potential diagnostic bio-markers for head and neck squamous cell carcinoma
Fadhil, Rushdi S., Wei, Ming Q., Nikolarakos, Dimitrios, Good, David and Nair, Raj G.. (2020). Salivary microRNA miR-let-7a-5p and miR-3928 could be used as potential diagnostic bio-markers for head and neck squamous cell carcinoma. PLoS ONE. 15(3), pp. 1 - 12. https://doi.org/10.1371/journal.pone.0221779
Vaccinations for colorectal cancer: Progress, strategies, and novel adjuvants
Stephen Jiang, David Good and Ming Q. Wei. (2019). Vaccinations for colorectal cancer: Progress, strategies, and novel adjuvants. International Journal of Molecular Sciences. 20(14), pp. 1-15. https://doi.org/10.3390/ijms20143403
Therapeutic Effects of Ten Commonly Used Chinese Herbs and Their Bioactive Compounds on Cancers
Liu Wei, Binbin Yang, Lu Yang, Jasmine Kaur, Calvin Jessop, Rushdi Fadhil, David Good, Guoying Ni, Xiaosong Liu, Tamim Mosaiab, Zhengjun Yi and Ming Wei. (2019). Therapeutic Effects of Ten Commonly Used Chinese Herbs and Their Bioactive Compounds on Cancers. Evidence-Based Complementary and Alternative Medicine. (6057837), pp. 1-10. https://doi.org/10.1155/2019/6057837
Noncoding variations in the gene encoding ceramide synthase 6 are associated with type 2 diabetes in a large Indigenous Australian pedigree
Good, David A., Duffy, David L., Good, Manuela, Guo, Cheng Xia, Busfield, Frances, Shaw, Anthony and Shaw, Joanne T. E.. (2019). Noncoding variations in the gene encoding ceramide synthase 6 are associated with type 2 diabetes in a large Indigenous Australian pedigree. Twin Research and Human Genetics. 22(2), pp. 79 - 87. https://doi.org/10.1017/thg.2019.13
The dosage of the Derivative of Clostridium Ghonii (DCG) spores dictates whether an IFNγ/IL-9 or a strong IFNγ response is elicited in TC-1 tumour bearing mice
Ni, Guoying, Wang, Yong, Good, David, Yuan, Jianwei, Pan, Xuan, Wei, Jou, Liu, Xiaosong and Wei, Ming Q.. (2019). The dosage of the Derivative of Clostridium Ghonii (DCG) spores dictates whether an IFNγ/IL-9 or a strong IFNγ response is elicited in TC-1 tumour bearing mice. BioMed Research International. 2019, pp. 1 - 10. https://doi.org/10.1155/2019/1395138
The development of toad toxins as potential therapeutic agents
Qi, Ji, Zulfiker, Abu Hasanat, Li, Chun, Good, David and Wei, Ming Q.. (2018). The development of toad toxins as potential therapeutic agents. Toxins. 10(8), pp. 1 - 14. https://doi.org/10.3390/toxins10080336
Cane toad skin extract-induced upregulation and increased interaction of serotonin 2A and D2 receptors via Gq/11 signaling pathway in CLU213 cells
Zulfiker, Abu Hasanat, Hashimi, Saeed M., Good, David A., Grice, I. Darren and Wei, Ming Q.. (2017). Cane toad skin extract-induced upregulation and increased interaction of serotonin 2A and D2 receptors via Gq/11 signaling pathway in CLU213 cells. Journal of Cellular Biochemistry. 118(5), pp. 979 - 993. https://doi.org/10.1002/jcb.25627
Toad glandular secretions and skin extractions as anti-inflammatory and anticancer agents
Qi, Ji, Tan, CK, Hashimi, Saeed, Zulfiker, Abu Hasanat, Good, David and Wei, Ming. (2014). Toad glandular secretions and skin extractions as anti-inflammatory and anticancer agents. Hindawi. 2014(312684), pp. 1 - 9. https://doi.org/10.1155/2014/312684
The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells
Li, Chun, Hashimi, Saeed M., Cao, Siyu, Mellick, Albert S., Duan, Wei and Good, David. (2013). The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2013, pp. 1 - 11. https://doi.org/10.1155/2013/849054
Apoptosis and microRNA aberrations in cancer
Li, Chun, Hashimi, Saeed M., Good, David A., Cao, Siyu, Duan, Wei, Plummer, Prue N., Mellick, Albert S. and Wei, Ming Q.. (2012). Apoptosis and microRNA aberrations in cancer. Clinical and Experimental Pharmacology & Physiology. 39(8), pp. 739 - 746. https://doi.org/10.1111/j.1440-1681.2012.05700.x
Clostridial spores for cancer therapy : Targeting solid tumour microenvironment
Umer, Brittany, Good, David, Anne, Jozef, Duan, Wei and Wei, Ming. (2012). Clostridial spores for cancer therapy : Targeting solid tumour microenvironment. Journal of Toxicology. 2012, pp. 1 - 8. https://doi.org/10.1155/2012/862764
Sequential release of BMP-7 and VEGF from the PLGA/AK-Gelatin composite scaffolds
Liu, G., Fan, W., Miao, X., Xiao, Y., Good, David Andrew and Wei, M.. (2011). Sequential release of BMP-7 and VEGF from the PLGA/AK-Gelatin composite scaffolds. Journal of Biomimetics, Biomaterials, and Tissue Engineering (online version). 11, pp. 81 - 91. https://doi.org/10.4028/www.scientific.net/JBBTE.11.81
A Combination of a Fluorescent Dye and Zn-S Nanocluster and Its Biological Application on Stain Bacteria
Xie, Jingli, Cao, Siyu, Good, David Andrew, Wei, Mingqian and Ren, Xiaoming. (2010). A Combination of a Fluorescent Dye and Zn-S Nanocluster and Its Biological Application on Stain Bacteria. Inorganic Chemistry. 49(4), pp. 1319 - 1321. https://doi.org/10.1021/ic9023629
Neuroprotective effects of a standardized flavonoid extract from diospyros kaki leaves
Bei, Weijian, Zang, Linquan, Guo, Jiao, Peng, Wenlie, Xu, Anlong, Good, David, Hu, Yinming, Wu, Wei, Hu, Dehui, Zhu, Xinghong, Wei, Ming and Li, Chuyuan. (2009). Neuroprotective effects of a standardized flavonoid extract from diospyros kaki leaves. Journal of Ethnopharmacology. 126(1), pp. 134 - 142. https://doi.org/10.1016/j.jep.2009.07.034
Differential transcriptional responses between the interferon-gamma-induction and iron-limitation models of persistence for chlamydia pneumoniae
Tim, Peter, Good, David, Wan, C., Theodoropoulos, Christina, Mukhopadhyay, Sanghamitra, Summersgill, James and Mathews, Sarah. (2009). Differential transcriptional responses between the interferon-gamma-induction and iron-limitation models of persistence for chlamydia pneumoniae. Journal of Microbiology Immunology and Infection. 42(1), pp. 27 - 37.
New approaches in developing gene transfer vectors for the therapy of solid tumours
Wei, Ming, Yao, Qin, Cao, Siyu, Li, Chun, Li, Kang, Good, David and Anne, Jozef. (2009). New approaches in developing gene transfer vectors for the therapy of solid tumours. Journal of Gene Medicine. 11, pp. 843 - 843.
Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models
Yao, Qin, Qu, Xun, Yang, Qifeng, Good, David, Dai, Shuzhen, Kong, Beihua and Wei, Ming. (2009). Blockage of transdifferentiation from fibroblast to myofibroblast in experimental ovarian cancer models. Molecular Cancer. 8(78), pp. 1 - 8. https://doi.org/10.1186/1476-4598-8-78
Clostridial spores as live 'trojan horse' vectors for cancer gene therapy: Comparison with viral delivery systems
Wei, Ming, Ren, Ruimei, Good, David and Anne, Jozef. (2008). Clostridial spores as live 'trojan horse' vectors for cancer gene therapy: Comparison with viral delivery systems. Genetic Vaccines and Therapy. 6(8), pp. 1 - 12. https://doi.org/10.1186/1479-0556-6-8
Bacterial targeted tumour therapy-dawn of a new era
Wei, Ming W., Mengesha, Asferd, Good, David Andrew and Anne, Jozef. (2008). Bacterial targeted tumour therapy-dawn of a new era. Cancer Letters. 259(1), pp. 16 - 27. https://doi.org/10.1016/j.canlet.2007.10.034
Susceptibility to insulin resistance in indigenous Australians may be down stream of resistin
Good, David, Cardinal, John, Ware, Robert, Marks, Lisa, Kesting, Janine, Chan, Lionel and Shaw, Joanne. (2008). Susceptibility to insulin resistance in indigenous Australians may be down stream of resistin. International Journal of Diabetes and Metabolism. 16, pp. 1 - 6.
Association between anthropometric measures of obesity and cardiovascular risk markers in a self-selected group of indigenous Australians
Chan, Lionel, Ware, Robert, Kesting, Janine, Marczak, Maureen, Good, David and Shaw, Joanne. (2007). Association between anthropometric measures of obesity and cardiovascular risk markers in a self-selected group of indigenous Australians. European Journal of Preventative Cardiology. 14(4), pp. 515 - 517. https://doi.org/10.1097/HJR.0b013e3280117257
Short term efficacy of a lifestyle intervention programme on cardiovascular health outcome in overweight Indigenous Australians with and without type 2 diabetes mellitus. The healthy lifestyle programme (HELP)
Chan, Lionel, Ware, Robert, Kesting, Janine, Marczak, Maureen, Good, David and Shaw, Joanne. (2007). Short term efficacy of a lifestyle intervention programme on cardiovascular health outcome in overweight Indigenous Australians with and without type 2 diabetes mellitus. The healthy lifestyle programme (HELP). Diabetes Research and Clinical Practice. 75(7), pp. 65 - 71. https://doi.org/10.1016/j.diabres.2006.04.012
Association between anthropometric measures of obesity and insulin resistance in a self-selected group of Indigenous Australians
Chan, Lionel, Ware, Robert, Kesting, Janine, Marczak, Maureen, Good, David and Shaw, Joanne. (2007). Association between anthropometric measures of obesity and insulin resistance in a self-selected group of Indigenous Australians. Heart, Lung and Circulation. 16(4), pp. 303 - 304. https://doi.org/10.1016/j.hlc.2007.01.006