Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD

Journal article

Ramon, Maria A., Ferrer, Jaume, Gimeno-Santos, Elena, Donaire-Gonzalez, David, Rodríguez, Esther, Balcells, Eva, de Batlle, Jordi, Benet, Marta, Guerra, Stefano, Sauleda, Jaume, Ferrer, Antoni, Farrero, Eva, Gea, Joaquim, Barberà, Joan A., Agustí, Àlvar, Rodriguez-Roisin, Robert, Antó, Josep M. and Garcia-Aymerich, Judith. (2016). Inspiratory capacity-to-total lung capacity ratio and dyspnoea predict exercise capacity decline in COPD. Respirology. 21(3), pp. 476 - 482. https://doi.org/10.1111/resp.12723
AuthorsRamon, Maria A., Ferrer, Jaume, Gimeno-Santos, Elena, Donaire-Gonzalez, David, Rodríguez, Esther, Balcells, Eva, de Batlle, Jordi, Benet, Marta, Guerra, Stefano, Sauleda, Jaume, Ferrer, Antoni, Farrero, Eva, Gea, Joaquim, Barberà, Joan A., Agustí, Àlvar, Rodriguez-Roisin, Robert, Antó, Josep M. and Garcia-Aymerich, Judith
Abstract

Background and objective: Exercise capacity decline is a predictor of mortality in patients with chronic obstructive pulmonary disease (COPD). Static pulmonary hyperinflation is a key determinant of exercise performance, but its effect on the longitudinal decline in exercise capacity remains unknown. We aimed to study the relationship between the inspiratory capacity‐to‐total lung capacity (IC/TLC) ratio and exercise capacity decline in COPD. Methods: We measured IC/TLC and other relevant clinical and functional variables in 342 clinically stable patients with COPD. The 6‐min walk distance (6MWD) was determined at recruitment and after a mean ± SD of 1.7 ± 0.3 years. The annual rate of change in 6MWD was calculated. Multiple imputation to account for losses during follow up was implemented, and multivariate regression was used to analyze predictive factors of 6MWD decline. Results: Mean decline rate in the 6MWD was 21.9 ± 34.1 m/year. In the bivariate analysis, patients with lower levels of IC/TLC had greater 6MWD decline (−27.4 ± 42.5, −24.9 ± 36.5 and −13.4 ± 39.9 m/year in the first, second and third tertile of IC/TLC, respectively; P‐for‐trend = 0.018). From other potential risk factors considered, dyspnoea, health status, serum C‐reactive protein and Borg dyspnoea score at the end of the exercise test were related to exercise capacity decline. In the multivariate regression model, only IC/TLC (β = 0.7 m/year per each percentage unit of IC/TLC; P = 0.007) and dyspnoea (mMRC ≥ 2) (β = −14.6 m/year; P = 0.013) were associated with the annual rate of 6MWD change. Conclusion: IC/TLC and dyspnoea in clinically stable patients with COPD predict their exercise capacity decline and may help to guide early therapeutic interventions.

Keywordschronic obstructive pulmonary disease; cohort study; disease progression; exercise capacity; 6-min walk distance
Year2016
JournalRespirology
Journal citation21 (3), pp. 476 - 482
PublisherWiley-Blackwell Publishing Asia
ISSN1323-7799
Digital Object Identifier (DOI)https://doi.org/10.1111/resp.12723
Scopus EID2-s2.0-84952815409
Page range476 - 482
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Place of publicationAustralia
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Acute respiratory response to traffic-related air pollution during physical activity performance
Matt, Florian, Cole-Hunter, Tom, Donaire-Gonzalez, David, Kubesch, Nadine, Martínez, David, Carrasco-Turigas, Glòria and Nieuwenhuijsen, Mark. (2016). Acute respiratory response to traffic-related air pollution during physical activity performance. Environment International. 97, pp. 45 - 55. https://doi.org/10.1016/j.envint.2016.10.011
Spatiotemporally resolved black carbon concentration, schoolchildren's exposure and dose in Barcelona
Rivas, Ioar, Donaire-Gonzalez, David, Bouso, L., Esnaola, Mikel, Pandolfi, M., de Castro, Montserrat, Viana, M., Alvarez-Pedrerol, Mar, Nieuwenhuijsen, Mark J., Alastuey, A., Sunyer, Jordi and Querol, Xavier. (2016). Spatiotemporally resolved black carbon concentration, schoolchildren's exposure and dose in Barcelona. Indoor Air. 26(3), pp. 391 - 402. https://doi.org/10.1111/ina.12214
Short-term planning and policy interventions to promote cycling in urban centers: Findings from a commute mode choice analysis in Barcelona, Spain
Braun, Lindsay M., Rodríguez, Daniel A., Cole-Hunter, Tom, Ambros, Albert, Donaire-Gonzalez, David, Jerrett, Michael, Mendez, Michelle A., Nieuwenhuijsen, Mark J. and de Nazelle, Audrey. (2016). Short-term planning and policy interventions to promote cycling in urban centers: Findings from a commute mode choice analysis in Barcelona, Spain. Transportation Research Part A. 89, pp. 164 - 183. https://doi.org/10.1016/j.tra.2016.05.007
Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation
Balcells, Eva, Gimeno-Santos, Elena, de Batlle, Jordi, Ramon, Maria Antonia, Rodríguez, Esther, Benet, Marta, Farrero, Eva, Ferrer, Antoni, Guerra, Stefano, Ferrer, Jaume, Sauleda, Jaume, Barberà, Joan A., Agustí, Àlvar, Rodriguez-Roisin, Robert, Gea, Joaquim, Antó, Josep M., Garcia-Aymerich, Judith, the, P. A. C. Copd Study Group and Donaire Gonzalez, David. (2015). Characterisation and prognosis of undiagnosed chronic obstructive pulmonary disease patients at their first hospitalisation. BMC Pulmonary Medicine. 15(1), p. Article 4. https://doi.org/10.1186/1471-2466-15-4
The added benefit of bicycle commuting on the regular amount of physical activity performed
Donaire-Gonzalez, David, de Nazelle, Audrey, Cole-Hunter, Tom, Curto, Ariadna, Rodríguez, Daniel A., Mendez, Michelle A., Garcia-Aymerich, Judith, Basagaña, Xavier, Ambros, Albert, Jerrett, Michael and Nieuwenhuijsen, Mark J.. (2015). The added benefit of bicycle commuting on the regular amount of physical activity performed. American Journal of Preventive Medicine. 49(6), pp. 842 - 849. https://doi.org/10.1016/j.amepre.2015.03.036
Objective correlates and determinants of bicycle commuting propensity in an urban environment
Cole-Hunter, Tom, Donaire-Gonzalez, David, Curto, A., Ambros, Albert, Valentín, Antònia, Garcia-Aymerich, J., Martínez, David, Braun, Lindsay M., Mendez, Michelle, Jerrett, Michael, Rodríguez, Daniel A., de Nazelle, Audrey and Nieuwenhuijsen, Mark J.. (2015). Objective correlates and determinants of bicycle commuting propensity in an urban environment. Transportation Research Part D. 40, pp. 132 - 143. https://doi.org/10.1016/j.trd.2015.07.004
Benefits of physical activity on COPD hospitalisation depend on intensity
Donaire-Gonzalez, David, Gimeno-Santos, Elena, Balcells, Eva, De Batlle, Jordi, Ramon, Maria A., Rodriguez, Esther, Farrero, Eva, Benet, Marta, Guerra, Stefano, Sauleda, Jaume, Ferrer, Antoni, Barberà, Joan A., Rodriguez-Roisin, Robert, Gea, Joaquim, Agusti, Alvar, Antó, Josep M., Garcia-Aymerich, Judith, PAC-COPD Study Group, , Ferrer, Jaume and PAC-COPD Study Group. (2015). Benefits of physical activity on COPD hospitalisation depend on intensity. European Respiratory Journal. 46(5), pp. 1281 - 1289. https://doi.org/10.1183/13993003.01699-2014
Positive health effects of the natural outdoor environment in typical populations in different regions in Europe (PHENOTYPE): A study programme protocol
Nieuwenhuijsen, Mark J., Kruize, Hanneke, Gidlow, Christopher, Andrusaityte, Sandra, Antó, Josep M., Basagaña, Xavier, Cirach, Marta, Dadvand, Payam, Danileviciute, Asta, Donaire-Gonzalez, David, Garcia, Judith, Jerrett, Michael, Jones, Marc V., Julvez, Jordi, van Kempen, Elise, van Kamp, Irene, Maas, Jolanda, Seto, Edmund, Smith, Graham, ... Gražulevičienė, Regina. (2014). Positive health effects of the natural outdoor environment in typical populations in different regions in Europe (PHENOTYPE): A study programme protocol. BMJ Open. 4(4), pp. 1 - 11. https://doi.org/10.1136/bmjopen-2014-004951
Lifetime occupational exposure to dusts, gases and fumes is associated with bronchitis symptoms and higher diffusion capacity in COPD patients
Rodríguez, Esther, Ferrer, Jaume, Zock, Jan-Paul, Serra, Ignasi, Antó, Josep M., De Batlle, Jordi, Kromhout, Hans, Vermeulen, Roel, Donaire-Gonzalez, David, Benet, Marta, Balcells, Eva, Monso, Eduard, Gayete, Angel, Garcia-Aymerich, J., Guerra, Stefano, Gea, Joaquim, Orozco-Levi, Mauricio, Vollmer, Ivan, Barberà, Joan A., ... Belda, José. (2014). Lifetime occupational exposure to dusts, gases and fumes is associated with bronchitis symptoms and higher diffusion capacity in COPD patients. PLoS ONE. 9(2), pp. 1 - 7. https://doi.org/10.1371/journal.pone.0088426
Using personal sensors to assess the exposome and acute health effects
Nieuwenhuijsen, Mark J., Donaire-Gonzalez, David, Foraster, Maria, Martínez, David and Cisneros, Andres. (2014). Using personal sensors to assess the exposome and acute health effects. International Journal of Environmental Research and Public Health. 11(8), pp. 7805 - 7819. https://doi.org/10.3390/ijerph110807805
Physical activity in COPD patients : Patterns and bouts
Donaire-Gonzalez, David, Gimeno-Santos, Elena, Balcells, Eva, Rodríguez, Diego A., Farrero, Eva, de Batlle, Jordi, Benet, Marta, Ferrer, Antoni, Barberà, Joan A., Gea, Joaquim, Rodriguez-Roisin, Robert, Antó, Josep M. and Garcia-Aymerich, Judith. (2013). Physical activity in COPD patients : Patterns and bouts. European Respiratory Journal. 42(4), pp. 993-1002. https://doi.org/10.1183/09031936.00101512
Comparison of physical activity measures using mobile phone-based calfit and actigraph
Donaire-Gonzalez, David, de Nazelle, Audrey, Seto, Edmund, Mendez, Michelle, Nieuwenhuijsen, Mark J. and Jerrett, Michael. (2013). Comparison of physical activity measures using mobile phone-based calfit and actigraph. Journal of Medical Internet Research. 15(6), p. e111. https://doi.org/10.2196/jmir.2470
Improving estimates of air pollution exposure through ubiquitous sensing technologies
de Nazelle, Audrey, Seto, Edmund, Donaire-Gonzalez, David, Mendez, Michelle, Matamala, Jaume, Nieuwenhuijsen, Mark J. and Jerrett, Michael. (2013). Improving estimates of air pollution exposure through ubiquitous sensing technologies. Environmental Pollution. 176, pp. 92 - 99. https://doi.org/10.1016/j.envpol.2012.12.032
Effect of bronchial colonisation on airway and systemic inflammation in stable COPD
Marin, Alicia, Garcia-Aymerich, Judith, Sauleda, Jaume, Belda, Jose, Millares, Laura, García-Núñez, Marian, Serra, Ignasi, Benet, Marta, Agustí, Alvar, Antó, Josep M., Monsó, Eduard, PAC-COPD Study Group and Donaire-Gonzalez, David. (2012). Effect of bronchial colonisation on airway and systemic inflammation in stable COPD. COPD. 9(2), pp. 121-130. https://doi.org/10.3109/15412555.2011.636407
Cured meat consumption increases risk of readmission in COPD patients
Jordi de Batlle, Mendez, Michelle, Romieu, Isabelle, Balcells, Eva, Benet, Marta, Donaire-Gonzalez, David, Ferrer, Jaume J., Orozco-Levi, Mauricio, Antó, Josep M., Garcia-Aymerich, Judith and PAC-COPD Study Group. (2012). Cured meat consumption increases risk of readmission in COPD patients. European Respiratory Journal. 40(3), pp. 555-560. https://doi.org/10.1183/09031936.00116911
Specific IgA and metalloproteinase activity in bronchial secretions from stable chronic obstructive pulmonary disease patients colonized by Haemophilus influenzae
Millares, Laura, Marin, Alicia, Garcia-Aymerich, J., Sauleda, Jaume, Belda, José, Monso, Eduard, Antó, Josep M., Benet, Marta, De Batlle, Jordi, Serra, Ignasi, Donaire Gonzalez, David, Guerra, Stefano, Gea, Joaquim, Balcells, Eva, Gayete, ADavidngel, Orozco-Levi, Mauricio, Vollmer, Ivan, Barberà, Joan A., Gomez, Federico P., ... Pallissa, Esther. (2012). Specific IgA and metalloproteinase activity in bronchial secretions from stable chronic obstructive pulmonary disease patients colonized by Haemophilus influenzae. Respiratory Research. 13(1). https://doi.org/10.1186/1465-9921-13-113
Validation of the Yale Physical Activity Survey in Chronic Obstructive Pulmonary Disease Patients
Donaire-Gonzalez, David, Gimeno-Santos, Elena, Serra, Ignasi, Roca, Josep, Balcells, Eva, Rodríguez, Esther, Farrero, Eva, Antó, Josep M. and Garcia-Aymerich, Judith. (2011). Validation of the Yale Physical Activity Survey in Chronic Obstructive Pulmonary Disease Patients. Archivos de Bronconeumología. 47(11), pp. 552-560.