Physical activity is associated with attenuated disease progression in Chronic Obstructive Disease
Journal article
Demeyer, Heleen, Donaire-Gonzalez, David, Gimeno-Santos, Elena, Ramon, Maria A., de Battle, Jordie, Benet, Marta, Serra, Ignasi, Guerra, Stefano, Farrero, Eva, Rodriguez, Esther, Ferrer, Jaume, Sauleda, Jaume, Monso, Eduard, Gea, Joaquim, Rodriguez-Roisin, Robert, Agusti, Alvar, Antó, Josep M. and Garcia-Aymerich, Judith. (2019). Physical activity is associated with attenuated disease progression in Chronic Obstructive Disease. Medicine and Science in Sports and Exercise. 51(5), pp. 833 - 840. https://doi.org/10.1249/MSS.0000000000001859
Authors | Demeyer, Heleen, Donaire-Gonzalez, David, Gimeno-Santos, Elena, Ramon, Maria A., de Battle, Jordie, Benet, Marta, Serra, Ignasi, Guerra, Stefano, Farrero, Eva, Rodriguez, Esther, Ferrer, Jaume, Sauleda, Jaume, Monso, Eduard, Gea, Joaquim, Rodriguez-Roisin, Robert, Agusti, Alvar, Antó, Josep M. and Garcia-Aymerich, Judith |
---|---|
Abstract | Introduction: Chronic obstructive pulmonary disease (COPD) progression is variable and affects several disease domains, including decline in lung function, exercise capacity, muscle strength, and health status as well as changes in body composition. We aimed to assess the longitudinal association of physical activity (PA) with these a priori selected components of disease progression. Methods: We studied 114 COPD patients from the PAC-COPD cohort (94% male, mean [SD], 70 yr [8 yr] of age, 54 [16] forced expiratory volume in 1 s % predicted) at baseline and 2.6 yr (0.6 yr) later. Baseline PA was assessed by accelerometry. Multivariable general linear models were built to assess the association between PA and changes in lung function, functional exercise capacity, muscle strength, health status, and body composition. All models were adjusted for confounders and the respective baseline value of each measure. Results: Per each 1000 steps higher baseline PA, forced expiratory volume in 1 s declined 7 mL less (P < 0.01), forced vital capacity 9 mL less (P = 0.03) and carbon monoxide diffusing capacity 0.10 mL[middle dot]min-1[middle dot]mm Hg-1 less (P = 0.04), while the St George's Respiratory Questionnaire symptom domain deteriorated 0.4 points less (P = 0.03), per year follow-up. Physical activity was not associated with changes in functional exercise capacity, muscle strength, other domains of health status or body composition. Conclusions: Higher PA is associated with attenuated decline in lung function and reduced health status (symptoms domain) deterioration in moderate-to-very severe COPD patients. |
Keywords | longitudinal analysis; lung function; muscle strength; health status; exercise capacity |
Year | 2019 |
Journal | Medicine and Science in Sports and Exercise |
Journal citation | 51 (5), pp. 833 - 840 |
Publisher | Lippincott Williams & Wilkins |
ISSN | 0195-9131 |
Digital Object Identifier (DOI) | https://doi.org/10.1249/MSS.0000000000001859 |
Scopus EID | 2-s2.0-85064198220 |
Open access | Published as green open access |
Page range | 833 - 840 |
Research Group | Mary MacKillop Institute for Health Research |
Author's accepted manuscript | License File Access Level Open |
Publisher's version | License All rights reserved File Access Level Controlled |
Place of publication | United States of America |
https://acuresearchbank.acu.edu.au/item/8721w/physical-activity-is-associated-with-attenuated-disease-progression-in-chronic-obstructive-disease
Download files
Author's accepted manuscript
AM_Demeyer_2019_Physical_activity_is_associated_with_attenuated.pdf | |
License: CC BY-NC | |
File access level: Open |
Restricted files
Publisher's version
281
total views147
total downloads4
views this month2
downloads this month