Endothelial precursor cells home to a vascularized tissue engineering chamber by application of the angiogenic chemokine cxcl12

Journal article


Simcock, Jeremy W., Penington, Anthony, Morrison, Wayne A., Thompson, Erik W. and Mitchell, Geraldine. (2009). Endothelial precursor cells home to a vascularized tissue engineering chamber by application of the angiogenic chemokine cxcl12. Tissue Engineering Part A: Tissue Engineering. 15(3), pp. 655 - 664. https://doi.org/10.1089/ten.tea.2007.0438
AuthorsSimcock, Jeremy W., Penington, Anthony, Morrison, Wayne A., Thompson, Erik W. and Mitchell, Geraldine
Abstract

Tissue engineering of vascularized constructs has great utility in reconstructive surgery. While we have been successful in generating vascularized granulation-like tissue and adipose tissue in an in vivo tissue engineering chamber, production of other differentiated tissues in a stable construct remains a challenge. One approach is to utilize potent differentiation factors, which can influence the base tissue. Endothelial precursor cells (EPCs) have the ability to both carry differentiation factors and home to developing vasculature. In this study, proof-of-principle experiments demonstrate that such cells can be recruited from the circulation into an in vivo tissue engineering chamber. CXC chemokine ligand 12 (CXCL12)/stromal cell–derived factor 1 was infused into the chamber through Alzet osmotic pumps and chamber cannulation between days 0 and 7, and facilitated recruitment of systemically inoculated exogenous human EPCs injected on day 6. CXCL12 infusion resulted in an eightfold increase in EPC recruitment, 2 (p = 0.03) and 7 days postinfusion (p = 0.008). Delivery of chemotactic/proliferation and/or differentiation factors and appropriately timed introduction of effective cells may allow us to better exploit the regenerative potential of the established chamber construct.

Year2009
JournalTissue Engineering Part A: Tissue Engineering
Journal citation15 (3), pp. 655 - 664
PublisherMary Ann Liebert, Inc. Publishers
ISSN1937-3341
Digital Object Identifier (DOI)https://doi.org/10.1089/ten.tea.2007.0438
Page range655 - 664
Place of publicationUnited States of America
Permalink -

https://acuresearchbank.acu.edu.au/item/86455/endothelial-precursor-cells-home-to-a-vascularized-tissue-engineering-chamber-by-application-of-the-angiogenic-chemokine-cxcl12

  • 47
    total views
  • 0
    total downloads
  • 0
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Liver sinusoidal endothelial cells promote the differentiation and survival of mouse vascularised hepatobiliary organoids
Yap, Kiryu K., Gerrand, Yi-Wen, Dingle, Aaron M., Yeoh, George C., Morrison, Wayne A. and Mitchell, Geraldine M.. (2020). Liver sinusoidal endothelial cells promote the differentiation and survival of mouse vascularised hepatobiliary organoids. Biomaterials. 251, p. 120091. https://doi.org/10.1016/j.biomaterials.2020.120091
Vascular pedicle and microchannels : Simple methods toward effective in vivo vascularization of 3D scaffolds
Rnjak-Kovacina, Jelena, Gerrand, Yi-wen, Wray, Lindsay S., Tan, Beryl, Joukhdar, Habib, Kaplan, David L., Morrison, Wayne A. and Mitchell, Geraldine M.. (2019). Vascular pedicle and microchannels : Simple methods toward effective in vivo vascularization of 3D scaffolds. Advanced Healthcare Materials. 8(24), p. 1901106. https://doi.org/10.1002/adhm.201901106
Generation of a nitric oxide signaling pathway in mesenchymal stem cells promotes endothelial lineage commitment
Bandara, Nadeeka, Gurusinghe, Saliya, Kong, Anne, Mitchell, Geraldine, Wang, Le-Xin, Lim, Shiang Y. and Strappe, Padraig. (2019). Generation of a nitric oxide signaling pathway in mesenchymal stem cells promotes endothelial lineage commitment. Journal of Cellular Physiology. 234(11), pp. 20392-20407. https://doi.org/10.1002/jcp.28640
Bio-engineering a tissue flap utilizing a porous scaffold incorporating a human induced pluripotent stem cell-derived endothelial cell capillary network connected to a vascular pedicle
Kong, Anne M., Yap, Kiryu K., Lim, Shiang Y., Marre, Diego, Pébay, Alice, Gerrand, Yi-wen, Lees, Jarmon G., Palmer, Jason A., Morrison, Wayne A. and Mitchell, Geraldine M.. (2019). Bio-engineering a tissue flap utilizing a porous scaffold incorporating a human induced pluripotent stem cell-derived endothelial cell capillary network connected to a vascular pedicle. Acta Biomaterialia. 94, pp. 281-294. https://doi.org/10.1016/j.actbio.2019.05.067
Epigenetic and transcriptome profiling identifies a population of visceral adipose-derived progenitor cells with the potential to differentiate into an endocrine pancreatic lineage
Williams, Michael D., Joglekar, Mugdha V., Satoor, Sarang N., Wong, Wilson, Keramidaris, Effie, Rixon, Amanda, O’Connell, Philip, Hawthorne, Wayne J., Mitchell, Geraldine M. and Hardikar, Anandwardhan A.. (2019). Epigenetic and transcriptome profiling identifies a population of visceral adipose-derived progenitor cells with the potential to differentiate into an endocrine pancreatic lineage. Cell Transplantation. 28(1), pp. 89-104. https://doi.org/10.1177/0963689718808472
Melatonin promotes survival of nonvascularized fat grafts and enhances the viability and migration of human adipose-derived stem cells via down-regulation of acute inflammatory cytokines
Tan, Shaun S., Zhan, Weiqing, Poon, Christopher J., Han, Xiaolian, Marre, Diego, Boodhun, Sholeh, Palmer, Jason A., Mitchell, Geraldine M. and Morrison, Wayne A.. (2018). Melatonin promotes survival of nonvascularized fat grafts and enhances the viability and migration of human adipose-derived stem cells via down-regulation of acute inflammatory cytokines. Journal of Tissue Engineering and Regenerative Medicine. 12(2), pp. 382-392. https://doi.org/10.1002/term.2463
The Vascularised Chamber as an In Vivo Bioreactor
Kiryu K. Yap, George Yeoh, Wayne Morrison and Geraldine Mitchell. (2018). The Vascularised Chamber as an In Vivo Bioreactor. Trends in Biotechnology. 36(10), pp. 1011-1024. https://doi.org/10.1016/j.tibtech.2018.05.009
Characterization of isolated liver sinusoidal endothelial cells for liver bioengineering
Aaron M. Dingle, Kiryu K. Yap, Yi-Wen Gerrand, Carolyn Taylor, Efthimia Keramidaris, Zerina Lokmic, A.M. Kong, H.L. Peters, Wayne Morrison and Geraldine Mitchell. (2018). Characterization of isolated liver sinusoidal endothelial cells for liver bioengineering. Angiogenesis. 21(3), pp. 581-597. https://doi.org/10.1007/s10456-018-9610-0
The adipogenic potential of various extracellular matrices under the influence of an angiogenic growth factor combination in a mouse tissue engineering chamber
Ting, Adrian, Craft, Randall, Palmer, Jason, Gerrand, Yi-Wen, Penington, Anthony, Morrison, Wayne and Mitchell, Geraldine. (2014). The adipogenic potential of various extracellular matrices under the influence of an angiogenic growth factor combination in a mouse tissue engineering chamber. Acta Biomaterialia. 10(5), pp. 1907 - 1918. https://doi.org/10.1016/j.actbio.2013.11.019
Enhanced liver progenitor cell survival and differentiation in vivo by spheroid implantation in a vascularized tissue engineering chamber
Yap, Kiryu, Dingle, Aaron, Palmer, Jason, Dillon, Raminder, Lokmic, Zerina, Penington, Anthony, Yeoh, George, Morrison, Wayne and Mitchell, Geraldine. (2013). Enhanced liver progenitor cell survival and differentiation in vivo by spheroid implantation in a vascularized tissue engineering chamber. Biomaterials. 34(16), pp. 3992 - 4001. https://doi.org/10.1016/j.biomaterials.2013.02.011
An adipoinductive role of inflammation in adipose tissue engineering : key factors in the early development of engineered soft tissues
Lilja, Heidi, Morrison, Wayne, Han, Xiao-Lian, Palmer, Jason, Taylor, Caroline, Tee, Richard, Moller, Andreas, Thompson, Erik and Abberton, Keren. (2013). An adipoinductive role of inflammation in adipose tissue engineering : key factors in the early development of engineered soft tissues. Stem Cells and Development. https://doi.org/10.1089/scd.2012.0451
MicroRNAs in insulin resistance and obesity
Williams, Michael and Mitchell, Geraldine. (2012). MicroRNAs in insulin resistance and obesity. Experimental Diabetes Research. 2012, pp. 1 - 8. https://doi.org/10.1155/2012/484696
Stem cells: Epigenetic basis of differentiation
Williams, Michael D., Mitchell, Geraldine and Hardikar, Anandwardhan. (2011). Stem cells: Epigenetic basis of differentiation. The Open Stem Cell Journal. 3(1), pp. 28 - 33. https://doi.org/10.2174/1876893801103010028
Intrinsics and dynamics of fat grafts: An in vitro study
Stillaert, Filip B., Abberton, Keren, Keramidaris, Efthimia, Thompson, Erik, Blondeel, Phillip Nicholas V. and Morrison, Wayne. (2010). Intrinsics and dynamics of fat grafts: An in vitro study. Plastic and Reconstructive Surgery. 126(4), pp. 1155 - 1162. https://doi.org/10.1097/PRS.0b013e3181ebe224
Implanted Myoblast Survival Is Dependent on the Degree of Vascularization in a NovelDelayed Implantation/Prevascularization Tissue Engineering Model
Tilkorn, Daniel J., Bedogni, Alberto, Keramidaris, Efthimia, Han, Xiao-Lian, Palmer, Jason, Dingle, Aaron M., Cowling, Belinda Simone, Williams, Michael D., McKay, Sue M., Pepe, Liliana, Deftereos, Anna, Morrison, Wayne, Penington, Tony and Mitchell, Geraldine. (2010). Implanted Myoblast Survival Is Dependent on the Degree of Vascularization in a NovelDelayed Implantation/Prevascularization Tissue Engineering Model. Tissue Engineering Part A. 16(1), pp. 165 - 178. https://doi.org/10.1089/ten.tea.2009.0075
Myogel supports the ex-vivo amplification of corneal epithelial cells
Francis, Dorthe J., Abberton, Keren, Thompson, Erik and Daniell, Mark D.. (2009). Myogel supports the ex-vivo amplification of corneal epithelial cells. Experimental Eye Research. 88(3), pp. 339 - 346. https://doi.org/10.1016/j.exer.2008.06.016
Zymosan-induced inflammation stimulates neo-adipogenesis
Thomas, Gregory P., Hemmrich, Karsten, Abberton, Keren, McCombe, David B., Penington, Tony, Thompson, Erik and Morrison, Wayne. (2008). Zymosan-induced inflammation stimulates neo-adipogenesis. International Journal of Obesity. 32(2), pp. 239 - 248. https://doi.org/10.1038/sj.ijo.0803702
An endogenously deposited fibrin scaffold determines construct size in the surgicallycreated arteriovenous loop chamber model of tissue engineering
Lokmic, Zerina, Thomas, James L., Morrison, Wayne, Thompson, Erik and Mitchell, Geraldine. (2008). An endogenously deposited fibrin scaffold determines construct size in the surgicallycreated arteriovenous loop chamber model of tissue engineering. Journal of Vascular Surgery. 48(4), pp. 974 - 985. https://doi.org/10.1016/j.jvs.2008.05.021
Myogel, a novel, basement membrane-rich, extracellular matrix derived from skeletal muscle, is highly adipogenic in vivo and in vitro
Abberton, Keren, Bortolotto, Susan K., Woods, Alan A., Findlay, Michael W., Morrison, Wayne, Thompson, Erik and Messina, Aurora. (2008). Myogel, a novel, basement membrane-rich, extracellular matrix derived from skeletal muscle, is highly adipogenic in vivo and in vitro. Cells, Tissues, Organs: in vivo, in vitro. 188(4), pp. 347 - 358. https://doi.org/10.1159/000121575
Adipose differentiation of bone marrow-derived mesenchymal stem cells using Pluronic F-127 hydrogel in vitro
Vashi, Aditya V., Keramidaris, Efthimia, Abberton, Keren, Morrison, Wayne, Wilson, Jeremy L., O'Connor, Andrea J., Cooper-White, Justin J. and Thompson, Erik. (2008). Adipose differentiation of bone marrow-derived mesenchymal stem cells using Pluronic F-127 hydrogel in vitro. Biomaterials. 29(5), pp. 573 - 579. https://doi.org/10.1016/j.biomaterials.2007.10.017