Recapitulating the liver niche in vitro

Book chapter


Yap, Kiryu and Mitchell, Geraldine. (2022). Recapitulating the liver niche in vitro. In In Nilsson, Susie (Ed.). Recapitulating the Stem Cell Niche Ex Vivo pp. 1 Elsevier Science BV. https://doi.org/10.1016/bs.asn.2021.10.002
AuthorsYap, Kiryu and Mitchell, Geraldine
EditorsNilsson, Susie
Abstract

The liver is a structurally and functionally complex organ, and its unique microenvironment is critical for this. Methods to recreate this niche requires careful consideration of the cell composition, source of cells, media ingredients, extracellular matrix, and bio-engineered technologies such as scaffolds, 3D bio-printing, perfusion bioreactors, and microfluidic systems. The field has transitioned from being reliant on rodent cells, to a focus on generating human liver constructs using primary human liver cells and human induced pluripotent stem cell-derived cells, increasing the clinical relevance of these products. More complex models with greater fidelity to native liver tissue and its microenvironment is expected in the future, incorporating further cell types and structures, and using strategies such as designer matrices. These bio-engineered liver platforms are useful for studying liver development and biology, and can also be used to model disease conditions, identify new therapeutic targets, and play a major role in drug development.

Keywordsliver; liver niche; in vitro; stem cell; bioengineering; organoid; primary human liver cells
Page range1
55
Year01 Jan 2022
Book titleRecapitulating the Stem Cell Niche Ex Vivo
PublisherElsevier Science BV
Place of publicationUnited Kingdom
SeriesAdvances in Stem Cells and their Niches : Vol. 6
ISBN9780323910927
Digital Object Identifier (DOI)https://doi.org/10.1016/bs.asn.2021.10.002
Web address (URL)https://www.sciencedirect.com/science/article/abs/pii/S2468509721000208?via%3Dihub
Open accessPublished as non-open access
Research or scholarlyResearch
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Output statusPublished
Publication dates
Print11 Jul 2022
Online03 Dec 2021
Publication process dates
Deposited29 Oct 2024
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Copyright © 2022 Elsevier Inc. All rights reserved.

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