Recapitulating the liver niche in vitro
Book chapter
Yap, Kiryu and Mitchell, Geraldine. (2022). Recapitulating the liver niche in vitro. In In Nilsson, Susie (Ed.). Recapitulating the Stem Cell Niche Ex Vivo pp. 1 Elsevier Science BV. https://doi.org/10.1016/bs.asn.2021.10.002
Authors | Yap, Kiryu and Mitchell, Geraldine |
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Editors | Nilsson, Susie |
Abstract | The liver is a structurally and functionally complex organ, and its unique microenvironment is critical for this. Methods to recreate this niche requires careful consideration of the cell composition, source of cells, media ingredients, extracellular matrix, and bio-engineered technologies such as scaffolds, 3D bio-printing, perfusion bioreactors, and microfluidic systems. The field has transitioned from being reliant on rodent cells, to a focus on generating human liver constructs using primary human liver cells and human induced pluripotent stem cell-derived cells, increasing the clinical relevance of these products. More complex models with greater fidelity to native liver tissue and its microenvironment is expected in the future, incorporating further cell types and structures, and using strategies such as designer matrices. These bio-engineered liver platforms are useful for studying liver development and biology, and can also be used to model disease conditions, identify new therapeutic targets, and play a major role in drug development. |
Keywords | liver; liver niche; in vitro; stem cell; bioengineering; organoid; primary human liver cells |
Page range | 1 |
55 | |
Year | 01 Jan 2022 |
Book title | Recapitulating the Stem Cell Niche Ex Vivo |
Publisher | Elsevier Science BV |
Place of publication | United Kingdom |
Series | Advances in Stem Cells and their Niches : Vol. 6 |
ISBN | 9780323910927 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/bs.asn.2021.10.002 |
Web address (URL) | https://www.sciencedirect.com/science/article/abs/pii/S2468509721000208?via%3Dihub |
Open access | Published as non-open access |
Research or scholarly | Research |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
11 Jul 2022 | |
Online | 03 Dec 2021 |
Publication process dates | |
Deposited | 29 Oct 2024 |
Additional information | Copyright © 2022 Elsevier Inc. All rights reserved. |
No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found at our website: www.elsevier.com/permissions. |
https://acuresearchbank.acu.edu.au/item/91071/recapitulating-the-liver-niche-in-vitro
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