Exogenous glucose oxidation is reduced with carbohydrate feeding during exercise after starvation

Journal article


Rowlands, David S., Johnson, Nathan A., Thomson, Jasmine A., Chapman, Phil and Stannard, Stephen R.. (2009) Exogenous glucose oxidation is reduced with carbohydrate feeding during exercise after starvation. Metabolism: Clinical and experimental. 58(8), pp. 1161 - 1169. https://doi.org/10.1016/j.metabol.2009.03.016
AuthorsRowlands, David S., Johnson, Nathan A., Thomson, Jasmine A., Chapman, Phil and Stannard, Stephen R.
Abstract

Lean healthy individuals are characterized by the ability to rapidly adapt metabolism to acute changes in substrate availability and metabolic rate. However, in glucose-intolerance/insulin-resistant conditions, such as that induced by starvation, the flexibility of tissues to rapidly respond to change in substrate availability is diminished. We asked whether the conundrum of increased glucose demand by the contracting skeletal muscle during prolonged exercise and the glucose intolerance of starvation would result in the obstruction of oxidative disposal of ingested 13C-labeled glucose during exercise. Seven lean, healthy, physically active individuals (2 women, 5 men) completed a randomized crossover study comparing the effects of the normal-fed condition vs a 67-hour water-only fast on the metabolic response to carbohydrate ingestion during 80 minutes of exercise at 56% of maximum oxygen uptake. Compared with the normal condition, fasting resulted in a large overall increase in the rate of fat oxidation (mean effect, 71%; 95% confidence limit, ±22%) and moderate reductions in both exogenous (−54%, ±10%) and endogenous (−40%, ±19%) glucose oxidation rates during exercise. Over the course of exercise, fat oxidation was impermeable to change in the fasting condition, but increased moderately (33%, ±19%) in the normal condition. These changes were associated with a large increase in plasma free fatty-acid concentration (120%, ±64%) and a moderate increase in blood lactate concentration (58%, ±50%). In contrast, large reductions in resting blood glucose (−21%, ±14%) and moderate reductions in plasma insulin concentrations (−47%, ±26%) were observed in the fast condition; but this effect was reversed for glucose (30%, ± 24%) and negated for insulin by the end of exercise. To conclude, a 67-hour fast leads to an impermeable increase in fat oxidation, suppression of both exogenous and endogenous carbohydrate oxidation, and a metabolic response consistent with resistance to contraction-induced exogenous glucose uptake and oxidation.

Year2009
JournalMetabolism: Clinical and experimental
Journal citation58 (8), pp. 1161 - 1169
PublisherElsevier
ISSN0026-0495
Digital Object Identifier (DOI)https://doi.org/10.1016/j.metabol.2009.03.016
Page range1161 - 1169
Research GroupSports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre
Place of publicationOxford, United Kingdom
Permalink -

https://acuresearchbank.acu.edu.au/item/867x2/exogenous-glucose-oxidation-is-reduced-with-carbohydrate-feeding-during-exercise-after-starvation

  • 10
    total views
  • 0
    total downloads
  • 8
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

A low-carbohydrate ketogenic diet reduces body mass without compromising performance in powerlifting and Olympic weightlifting athletes
Greene, David A., Varley, Benjamin J., Hartwig, Timothy B., Chapman, Phillip and Rigney, Michael. (2018) A low-carbohydrate ketogenic diet reduces body mass without compromising performance in powerlifting and Olympic weightlifting athletes. Journal of Strength and Conditioning Research. 32(12), pp. 3373 - 3382. https://doi.org/10.1519/JSC.0000000000002904
The effect of nitrate supplementation on muscle contraction in healthy adults
Hoon, Matthew W., Fornusek, Che, Chapman, Phillip Grant and Johnson, Nathan A.. (2016) The effect of nitrate supplementation on muscle contraction in healthy adults. European Journal of Sport Science. 15(8), pp. 712 - 719. https://doi.org/10.1080/17461391.2015.1053418
The influence of ice slushy on voluntary contraction force following exercise-induced hyperthermia
Burdon, Catriona, Easthope, Chris, Johnson, Nathan, Chapman, Phillip and O'Connor, Helen. (2014) The influence of ice slushy on voluntary contraction force following exercise-induced hyperthermia. Applied Physiology, Nutrition and Metabolism. 39(7), pp. 781 - 786. https://doi.org/10.1139/apnm-2013-0394
Indirect measures of substrate utilisation following exercise-induced muscle damage
Hughes, Jonathan, Chapman, Phillip, Brown, Stephen, Johnson, Nathan and Stannard, Stephen. (2013) Indirect measures of substrate utilisation following exercise-induced muscle damage. European Journal of Sport Science. https://doi.org/10.1080/17461391.2012.755570
The effect of ice slushy ingestion and mouthwash on thermoregulation and endurance performance in the heat
Burdon, Catriona, Hoon, Matthew, Johnson, Nathan, Chapman, Phillip and O'Connor, Helen. (2013) The effect of ice slushy ingestion and mouthwash on thermoregulation and endurance performance in the heat. International Journal of Sport Nutrition and Exercise Metabolism. https://doi.org/10.1123/ijsnem.23.5.458
Physiological and physical characteristics of elite dragon boat paddlers
Ho, Sarah, Smith, Richard, Chapman, Phillip, Sinclair, Peter and Funato, Kazuo. (2013) Physiological and physical characteristics of elite dragon boat paddlers. Journal of Strength and Conditioning Research. https://doi.org/10.1519/JSC.0b013e318252f612
Case study : Beverage temperature at aid stations on Ironman traithlon
Burdon, Catriona, Johnson, Nathan, Chapman, Phillip, Ahmad Munir, Che Muhamed and O'Connor, Helen. (2013) Case study : Beverage temperature at aid stations on Ironman traithlon. International Journal of Sport Nutrition and Exercise Metabolism. https://doi.org/10.1123/ijsnem.23.4.418
Influence of beverage temperature on palatability and fluid ingestion during endurance exercise : A systematic review
Burdon, Catriona, Johnson, Nathan, Chapman, Phillip and O'Connor, Helen. (2012) Influence of beverage temperature on palatability and fluid ingestion during endurance exercise : A systematic review. International Journal of Sport Nutrition and Exercise Metabolism. 22(3), pp. 199 - 211. https://doi.org/10.1123/ijsnem.22.3.199
Effect of prolonged exercise and pre-exercise dietary manipulation on hepatic triglycerides in trained men
Johnson, Nathan, van Overbeek, Danielle, Chapman, Phillip, Thompson, Martin, Sachinwalla, Toos and George, Jacob. (2012) Effect of prolonged exercise and pre-exercise dietary manipulation on hepatic triglycerides in trained men. European Journal of Applied Physiology. 112(5), pp. 1817 - 1825. https://doi.org/10.1007/s00421-011-2158-y
Gender relations, prostate cancer and diet :Re-inscribing hetero-normative food practices
Mroz, L, Chapman, G, Oliffe, J and Bottorff, Joan. (2011) Gender relations, prostate cancer and diet :Re-inscribing hetero-normative food practices. Social Science & Medicine. 72(9), pp. 1499 - 1506. https://doi.org/10.1016/j.socscimed.2011.03.012
Neuromuscular function following prolonged intense self-paced exercise in hot climatic conditions
Périard, J., Cramer, M. N., Chapman, Phillip G., Caillaud, C. and Thompson, M. W.. (2011) Neuromuscular function following prolonged intense self-paced exercise in hot climatic conditions. European Journal of Applied Physiology (print version). 111(8), pp. 1561 - 1569. https://doi.org/10.1007/s00421-010-1781-3
Cardiovascular strain impairs prolonged self-paced exercise in the heat
Periard, J., Cramer, M., Chapman, Phil, Caillaud, C. and Thompson, M. W.. (2011) Cardiovascular strain impairs prolonged self-paced exercise in the heat. Experimental Physiology. 96(2), pp. 134 - 144. https://doi.org/10.1113/expphysiol.2010.054213
Men, food, and prostate cancer :Gender influences on men's diets
Mroz, L, Chapman, G, Oliffe, J and Bottorff, Joan. (2011) Men, food, and prostate cancer :Gender influences on men's diets. American Journal of Men's Health. 5(2), pp. 177 - 187. https://doi.org/10.1177/1557988310379152
Effect of acute exercise and dietary manipulation on hepatic triglycerides
Johnson, Nathan and Chapman, Phil. (2010) Effect of acute exercise and dietary manipulation on hepatic triglycerides. Australian Conference of Science and Medicine in Sport. Australia: Elsevier. pp. 89 - 89
Beverage temperatures at aid stations: Port Macquarie Ironman.
O'Connor, Helen, Johnson, Nathan and Chapman, Phil. (2010) Beverage temperatures at aid stations: Port Macquarie Ironman. Australian Conference of Science and Medicine in Sport. Australia: Elsevier. pp. 87 - 87
The limits to prolonged exercise in the heat: Heart or brain?
Chapman, Phil. (2010) The limits to prolonged exercise in the heat: Heart or brain? Australian Conference of Science and Medicine in Sport. Australia: Elsevier. pp. 60 - 60
Prostate cancer, masculinity and food. Rationales for perceived diet change
Mroz, L, Chapman, G, Oliffe, J and Bottorff, Joan. (2010) Prostate cancer, masculinity and food. Rationales for perceived diet change. Appetite. 55(3), pp. 398 - 406. https://doi.org/10.1016/j.appet.2010.07.009
Effect of drink temperature on core temperature and endurance cycling performance in warm, humid conditions
Burdon, Catriona, O'Connor, Helen, Gifford, Janelle, Shirreffs, S, Chapman, Phillip and Johnson, Nathan. (2010) Effect of drink temperature on core temperature and endurance cycling performance in warm, humid conditions. Journal of Sports Sciences. 28(11), pp. 1147 - 1156. https://doi.org/10.1080/02640414.2010.489197
Effect of altered pre-exercise carbohydrate availability on selection and perception of effort during prolonged cycling
Johnson, Nathan, Stannard, Stephen, Chapman, Phil and Thompson, Martin. (2006) Effect of altered pre-exercise carbohydrate availability on selection and perception of effort during prolonged cycling. European Journal of Applied Physiology. 98(1), pp. 62 - 70. https://doi.org/10.1007/s00421-006-0243-4
Short-term suppression of plasma free fatty acids fails to improve insulin sensitivity when intramyocellular lipid is elevated
Johnson, Nathan, Stannard, Stephen, Rowlands, David, Chapman, Phil, Thompson, Campbell, Sachinwalla, Toos and Thompson, Martin. (2006) Short-term suppression of plasma free fatty acids fails to improve insulin sensitivity when intramyocellular lipid is elevated. Diabetic Medicine. 23(10), pp. 1061 - 1068. https://doi.org/10.1111/j.1464-5491.2006.01952.x
Effect of short-term starvation versus high-fat diet on intramyocellular triglyceride accumulation and insulin resistance in physically fit men
Johnson, Nathan, Stannard, Stephen, Rowlands, David, Chapman, Phil, Thompson, Campbell, O'Connor, Helen, Sachinwalla, Toos and Thompson, Martin. (2006) Effect of short-term starvation versus high-fat diet on intramyocellular triglyceride accumulation and insulin resistance in physically fit men. Experimental Physiology. 91(4), pp. 693 - 703. https://doi.org/10.1113/expphysiol.2006.033399