Bridging the gap in heart failure prevention: Rationale and design of the Nurse-led intervention for Less Chronic Heart Failure (NiL-CHF) Study
Journal article
Carrington, Melinda J. and Stewart, Simon. (2010). Bridging the gap in heart failure prevention: Rationale and design of the Nurse-led intervention for Less Chronic Heart Failure (NiL-CHF) Study. European Journal of Heart Failure. 12(1), pp. 82 - 88. https://doi.org/10.1093/eurjhf/hfp161
Authors | Carrington, Melinda J. and Stewart, Simon |
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Abstract | Aims The primary objective of the Nurse-led Intervention for Less Chronic Heart Failure (NIL-CHF) Study is to develop a programme of care that cost-effectively prevents the development of chronic heart failure (CHF). Methods NIL-CHF is a randomized controlled trial of a hybrid, home- and clinic-based, nurse-led multidisciplinary intervention targeting hospitalized patients at risk of developing CHF. A target of 750 patients aged ≥45 years will be exposed to usual post-discharge care or the NIL-CHF intervention. The composite primary endpoint is all-cause mortality or CHF-related admission during 3–5 years of follow-up. After 12 months recruitment, ∼300 eligible patients (40% of target) have been randomized. Overall, 73% are male and the mean age is 65 ± 10 years. The most common antecedents for CHF thus far are hypertension (70%, 95% CI, 64–75%), coronary artery disease (51%, 95% CI, 31–41%), and type 2 diabetes (26%, 95% CI, 21–31%), whereas 76% (95% CI, 69–82%) of patients have diastolic dysfunction, 29% (95% CI, 23–36%) left ventricular hypertrophy, 71% (95% CI, 64–78%) mitral valve dysfunction, and 7% (95% CI, 4–12%) have a left ventricular ejection fraction ≤45%. Conclusion As one of the largest randomized studies of its kind, NIL-CHF will ultimately provide important insights into the potential to prevent CHF via prolonged and intensive disease management. |
Keywords | Chronic heart failure; Prevention; Disease management; Hypertension |
Year | 2010 |
Journal | European Journal of Heart Failure |
Journal citation | 12 (1), pp. 82 - 88 |
ISSN | 1388-9842 |
Digital Object Identifier (DOI) | https://doi.org/10.1093/eurjhf/hfp161 |
Scopus EID | 2-s2.0-72649091075 |
Page range | 82 - 88 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Grant ID | nhmrc/472662 |
https://acuresearchbank.acu.edu.au/item/88561/bridging-the-gap-in-heart-failure-prevention-rationale-and-design-of-the-nurse-led-intervention-for-less-chronic-heart-failure-nil-chf-study
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