Hepcidin is a better predictor of iron stores in premenopausal women than blood loss or dietary intake

Journal article


Lim, Karen, Booth, Alison O., Nowson, Carol, Szymlek-Gay, Ewa A., Irving, David O. and Riddell, Lynn J.. (2016). Hepcidin is a better predictor of iron stores in premenopausal women than blood loss or dietary intake. Nutrients. 8(9), pp. 1 - 15. https://doi.org/10.3390/nu8090540
AuthorsLim, Karen, Booth, Alison O., Nowson, Carol, Szymlek-Gay, Ewa A., Irving, David O. and Riddell, Lynn J.
Abstract

The relationship between dietary intake, circulating hepcidin and iron status in free-living premenopausal women has not been explored. This cross-sectional study aimed to identify dietary determinants of iron stores after accounting for blood loss and to determine whether iron intake predicts iron stores independently of hepcidin in a sample of Australian women. Three hundred thirty eight women aged 18–50 years were recruited. Total intake and food sources of iron were determined via food frequency questionnaire; the magnitude of menstrual losses was estimated by self-report; and blood donation volume was quantified using blood donation records and self-reported donation frequency. Serum samples were analysed for ferritin, hepcidin and C-reactive protein concentrations. Linear regression was used to investigate associations. Accounting for blood loss, each 1 mg/day increase in dietary iron was associated with a 3% increase in iron stores (p = 0.027); this association was not independent of hepcidin. Hepcidin was a more influential determinant of iron stores than blood loss and dietary factors combined (R2 of model including hepcidin = 0.65; R2 of model excluding hepcidin = 0.17, p for difference < 0.001), and increased hepcidin diminished the positive association between iron intake and iron stores. Despite not being the biggest contributor to dietary iron intake, unprocessed meat was positively associated with iron stores, and each 10% increase in consumption was associated with a 1% increase in iron stores (p = 0.006). No other dietary factors were associated with iron stores. Interventions that reduce hepcidin production combined with dietary strategies to increase iron intake may be important means of improving iron status in women with depleted iron stores.

Year2016
JournalNutrients
Journal citation8 (9), pp. 1 - 15
PublisherMDPI AG
ISSN2072-6643
Digital Object Identifier (DOI)https://doi.org/10.3390/nu8090540
Scopus EID2-s2.0-84986000524
Open accessOpen access
Page range1 - 15
Research GroupMary MacKillop Institute for Health Research
Publisher's version
License
Place of publicationSwitzerland
EditorsJonathan
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