Off-label prescribing of psychotropics in a psychiatric patient population in Australia

Journal article

Kyrios, Mietta, Levido, Jesse, Talbot, Daniel and Harris, Anthony. (2024). Off-label prescribing of psychotropics in a psychiatric patient population in Australia. Australasian Psychiatry. 32(3), pp. 196-200. https://doi.org/10.1177/10398562241237659

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Authors	Kyrios, Mietta, Levido, Jesse, Talbot, Daniel and Harris, Anthony
Abstract	Background This study aimed to investigate the practice of off-label prescribing in both in- and outpatient psychiatry practice. Methods One-hundred inpatient and 100 outpatient medical records from adult patients of an Australian psychiatry service from 2020 to 2021 were examined to determine the prevalence of off-label prescribing as defined by Therapeutic Goods Administration (TGA) indications, adherence to Royal Australian and New Zealand College of Psychiatrists (RANZCP) treatment guidelines, frequency of off-label prescription, and the quality of documentation and informed consent process. Results Most prescribing events in both in- and outpatient settings were either on-label or off-label but consistent with RANZCP guidelines. Patients with a schizoaffective disorder diagnosis or displaying aggression were most likely to receive off-label prescriptions. There was no significant difference between in- and outpatient groups in the quality of documentation or consent process. Conclusions In general, off-label prescribing across groups was common, but many decisions were then in line with RANZCP recommendations. That there is a discrepancy between clinical and regulatory bodies has implications for how off-label status is decided.
Year	2024
Journal	Australasian Psychiatry
Journal citation	32 (3), pp. 196-200
Publisher	SAGE Publications
ISSN	1039-8562
Digital Object Identifier (DOI)	https://doi.org/10.1177/10398562241237659
PubMed ID	38427939
Scopus EID	2-s2.0-85186539440
Page range	196-200
Publisher's version	License All rights reserved File Access Level Controlled
Output status	Published
Online	01 Mar 2024
Publication process dates
Deposited	13 Jun 2025
Additional information	© The Royal Australian and New Zealand College of Psychiatrists 2024.

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