Investigating acute satiation and meal termination effects of a commercial lipid emulsion : A breakfast meal study

Journal article


Poppitt, Sally, Han, Shuang, Strik, Caroline, Kindleysides, Sophie and Chan, Yih-Kai. (2015). Investigating acute satiation and meal termination effects of a commercial lipid emulsion : A breakfast meal study. Physiology & Behavior. 152, pp. 20 - 25. https://doi.org/10.1016/j.physbeh.2015.09.008
AuthorsPoppitt, Sally, Han, Shuang, Strik, Caroline, Kindleysides, Sophie and Chan, Yih-Kai
Abstract

Background: Early clinical studies showed the commercial lipid emulsion Fabuless™ to decrease energy intake (EI) and prevent weight regain, but later studies have failed to confirm this finding. Where appetite suppression has been observed it is commonly attributed to the ileal brake, where emulsified fats pass undigested to the distal small intestine and promote later satiety, but satiety profiles suggest possible transient effects within 15 min. The aim of this study was to determine whether this emulsion promotes short-term satiation and meal termination. Methods: In a randomised cross-over intervention 18 lean men were given 4 lipid preloads immediately prior to a breakfast meal, during which ad libitum food consumption, time to meal termination and VAS-rated appetite scores were measured. Preloads were given as lipid emulsion and lipid control, both alone as a ‘shot’ and combined with a dairy yoghurt: (i) lipid emulsion alone (LE, Fabuless™ 4.2g lipid, 0.2 MJ), (ii) lipid control alone (LC, 4 .2g lipid, 0.2 MJ), (iii) LE + yoghurt (1.2 MJ), (iv) LC + yoghurt (1.2 MJ). Results: Whilst both yoghurt preloads suppressed EI at breakfast relative to the ‘shots’, as expected, neither lipid emulsion suppressed EI or triggered more rapid meal termination when compared to energy matched lipid controls (P > 0.05). There was also no difference in VAS-assessed appetite scores between emulsion and control, for either preload. Conclusions: When consumed with a meal there was no evidence in lean men that this commercial lipid emulsion promotes satiation or suppresses short-term food intake.

Year2015
JournalPhysiology & Behavior
Journal citation152, pp. 20 - 25
ISSN0031-9384
Digital Object Identifier (DOI)https://doi.org/10.1016/j.physbeh.2015.09.008
Page range20 - 25
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
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Effect of high-fat meals and fatty acid saturation on postprandial levels of the hormones ghrelin and leptin in healthy men
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Molecular changes evoked by triethylenetetramine treatment in the extracellular matrix of the heart and aorta in diabetic rats
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Demonstratuon of hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation
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Regeneration of the heart in diabetes by selective copper chelation
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