Long-term effects of high-intensity resistance and endurance exercise on plasma leptin and ghrelin in overweight individuals: The RESOLVE Study

Journal article


Tremblay, Angelo, Dutheil, Frédéric, Drapeau, Vicky, Metz, Lore, Lesour, Bruno, Chapier, Robert, Pereira, Bruno, Verney, Julien, Baker, Julien S., Vinet, Agnes, Walther, Guillaume, Obert, Phillippe, Courteix, Daniel and Thivel, David. (2019). Long-term effects of high-intensity resistance and endurance exercise on plasma leptin and ghrelin in overweight individuals: The RESOLVE Study. Applied Physiology, Nutrition and Metabolism. 44(11), pp. 1172 - 1179. https://doi.org/10.1139/apnm-2019-0019
AuthorsTremblay, Angelo, Dutheil, Frédéric, Drapeau, Vicky, Metz, Lore, Lesour, Bruno, Chapier, Robert, Pereira, Bruno, Verney, Julien, Baker, Julien S., Vinet, Agnes, Walther, Guillaume, Obert, Phillippe, Courteix, Daniel and Thivel, David
Abstract

The objective of this study was to evaluate the effects of high-intensity resistance and endurance exercise on body composition and plasma leptin and ghrelin concentrations in overweight individuals. One hundred participants were randomly assigned to 3 exercise interventions: high-resistance–low-aerobic exercise (Re), low-resistance–high-aerobic exercise (rE), low-resistance–low-aerobic exercise (re). Interventions began with 3 weeks of residential supervision (phase 1) after which participants had to manage the physical activity programs individually (phase 2). Body composition and plasma variables were measured at baseline and after phase 1 as well as after 3, 6, and 12 months. Significant decreases in body weight and fat were observed after phase 1 (p < 0.001) and continued at a lower rate for up to 3 months and then remained stable for the rest of the protocol. Once a body weight plateau was reached, body fat loss after the Re and rE conditions exceeded the fat loss observed in the re condition by 1.5–2 kg (p < 0.05). Leptin was significantly decreased after day 21 and month 3 (p < 0.001) and remained stable for the rest of the study. Ghrelin was significantly increased after day 21 and month 3 (p < 0.001) and returned to a level comparable to baseline between month 6 and 12 when body weight and fat had reached a plateau. In conclusion, this study reinforces the idea that an increase in exercise intensity may accentuate body fat loss before the occurrence of a body weight plateau. Resistance to further fat loss was accompanied by a decrease in plasma leptin and an increase in plasma ghrelin.

Keywordsobesity; physical activity; energy; appetite; hormones; fat.
Year2019
JournalApplied Physiology, Nutrition and Metabolism
Journal citation44 (11), pp. 1172 - 1179
PublisherCanadian Science Publishing
ISSN1715-5320
Digital Object Identifier (DOI)https://doi.org/10.1139/apnm-2019-0019
Scopus EID2-s2.0-85074152345
Page range1172 - 1179
Research GroupSports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre
Publisher's version
File Access Level
Controlled
Place of publicationCanada
Permalink -

https://acuresearchbank.acu.edu.au/item/881x2/long-term-effects-of-high-intensity-resistance-and-endurance-exercise-on-plasma-leptin-and-ghrelin-in-overweight-individuals-the-resolve-study

Restricted files

Publisher's version

  • 145
    total views
  • 0
    total downloads
  • 2
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Muscle function and architecture in children with juvenile idiopathic arthritis
Bourdier, Pierre, Birat, Anthony, Rochette, Emmanuelle, Doré, Éric, Courteix, Daniel, Dutheil, Frédéric, Pereira, Bruno, Ratel, Sébastien, Merlin, Etienne and Duché, Pascale. (2021). Muscle function and architecture in children with juvenile idiopathic arthritis. Acta Paediatrica. 110(1), pp. 280-287. https://doi.org/10.1111/apa.15335
Heart rate variability as a possible predictor of sport performance in junior rhythmic gymnastics
Urzeala, Constanta, Bota, Aura, Serbanoiu, Sorin, Mezei, Mariana, Dutheil, Frederic and Courteix, Daniel. (2020). Heart rate variability as a possible predictor of sport performance in junior rhythmic gymnastics. Isokinetics and Exercise Science. 28(2), pp. 171-179. https://doi.org/10.3233/IES-192222
Cognitive restriction accentuates the increased energy intake response to a 10-month multidisciplinary weight loss program in adolescents with obesity
Miguet, M., Masurier, J., Chaput, J. P., Pereira, B., Lambert, C., Dâmaso, A. R., Courteix, D., Duclos, M., Boirie, Y. and Thivel, D.. (2019). Cognitive restriction accentuates the increased energy intake response to a 10-month multidisciplinary weight loss program in adolescents with obesity. Appetite. 134, pp. 125-134. https://doi.org/10.1016/j.appet.2018.12.015
Effects of a short residential thermal spa program to prevent work-related stress/burnout on stress biomarkers: The thermstress proof of concept study
Dutheil, Frederic, Chaplais, Elodie, Vilmant, Audrey, Lanoir, Denise, Courteix, Daniel, Duche, Pascale, Abergel, Armand, Pfabigan, Daniela M., Han, Shihui, Mondillon, Laurie, Vallet, Guillaume, Mermillod, Martial, Boudet, Gil, Obert, Phillippe, Izem, Omar, Boirie, Yves, Pereira, Bruno and Lesage, Francois-Xavier. (2019). Effects of a short residential thermal spa program to prevent work-related stress/burnout on stress biomarkers: The thermstress proof of concept study. Journal of International Medical Research. 47(10), pp. 5130 - 5145. https://doi.org/10.1177/0300060519859119
Regional myocardial function abnormalities are associated with macro- and microcirculation dysfunction in the metabolic syndrome: the RESOLVE study
Phillippe Obert, Guillaume Walther, Frederic Dutheil, Bruno Lesourd, Robert Chapier, Daniel Courteix and Agnes Vinet. (2018). Regional myocardial function abnormalities are associated with macro- and microcirculation dysfunction in the metabolic syndrome: the RESOLVE study. Heart and Vessels: an international journal. 33(6), pp. 688-694. https://doi.org/10.1007/s00380-017-1108-y
Different modalities of exercise improve macrovascular function but not microvascular function in metabolic syndrome: The RESOLVE randomized trial
Agnes Vinet, Phillippe Obert, Daniel Courteix, Robert Chapier, Bruno Lesourd, Julien Verney, Frederic Dutheil and Guillaume Walther. (2018). Different modalities of exercise improve macrovascular function but not microvascular function in metabolic syndrome: The RESOLVE randomized trial. International Journal of Cardiology. 267, pp. 165-170. https://doi.org/10.1016/j.ijcard.2018.05.073
Cardiovascular risk of adipokines: A review
Frederic Dutheil, Brett Ashley Gordon, Geraldine Naughton, Edward Crendal, Daniel Courteix, Elodie Chaplais, David Thivel, Gerard Lac and Amanda Benson. (2018). Cardiovascular risk of adipokines: A review. Journal of International Medical Research. 46(6), pp. 2082-2095. https://doi.org/10.1177/0300060517706578
Effects of interventions with a physical activity component on bone health in obese children and adolescents: a systematic review and meta-analysis
Elodie, Chaplais, Naughton, Geraldine, Greene, David, Dutheil, Frederic, Pereira, Bruno, Thivel, David and Courteix, Daniel. (2018). Effects of interventions with a physical activity component on bone health in obese children and adolescents: a systematic review and meta-analysis. Journal of Bone and Mineral Metabolism. 36(1), pp. 12 - 30. https://doi.org/10.1007/s00774-017-0858-z
Geometric and mechanical bone response to a multidisciplinary weight loss intervention in adolescents with obesity: The ADIBOX Study
Chaplais, Elodie, Naughton, Geraldine, Dutheil, Frederic, Masurier, Julie, Greene, David, Pereira, Bruno, Duclos, Martine, Thivel, David and Courteix, Daniel. (2018). Geometric and mechanical bone response to a multidisciplinary weight loss intervention in adolescents with obesity: The ADIBOX Study. Journal of Clinical Densitometry. 23(2), pp. 254 - 263. https://doi.org/10.1016/j.jocd.2018.06.002
Longitudinal determinants of 12-month changes on bone health in adolescent male athletes
Ubago-Guisado, Esther, Vlachopoulos, Dimitris, Fatouros, Ioannis G., Deli, Chariklia K., Leontsini, Diamanda, Moreno, Luis A., Courteix, Daniel and Gracia-Marco, Luis. (2018). Longitudinal determinants of 12-month changes on bone health in adolescent male athletes. Archives of Osteoporosis. 13(1), pp. 1 - 9. https://doi.org/10.1007/s11657-018-0519-4
Total and regional bone mineral and tissue composition in female adolescent athletes: Comparison between volleyball players and swimmers
Valente-dos-Santos, João, Tavares, Óscar M., Duarte, João P., Sousa-e-Silva, Paulo M., Rama, Luís M., Casanova, José M., Fontes-Ribeiro, Carlos A., Marques, Elisa A., Courteix, Daniel, Ronque, Enio R. V., Cyrino, Edilson S., Conde, Jorge and Coelho-e-Silva, Manuel J.. (2018). Total and regional bone mineral and tissue composition in female adolescent athletes: Comparison between volleyball players and swimmers. BMC Pediatrics. 18(1), pp. 1 - 11. https://doi.org/10.1186/s12887-018-1182-z
Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis
Tournadre, Anne, Pereira, Bruno, Dutheil, Fréderic, Giraud, Charlotte, Courteix, Daniel, Sapin, Vincent, Frayssac, Thomas, Mathieu, Sylvain, Malochet-Guinamand, Sandrine and Soubrier, Martin. (2017). Changes in body composition and metabolic profile during interleukin 6 inhibition in rheumatoid arthritis. Journal of Cachexia, Sarcopenia and Muscle. 8(4), pp. 639 - 646. https://doi.org/10.1002/jcsm.12189
Paradoxical dissociation between heart rate and heart rate variability following different modalities of exercise in individuals with metabolic syndrome: The RESOLVE study
Boudet, Gil, Walther, Guillaume, Courteix, Daniel, Obert, Phillippe, Lesourd, Bruno, Pereira, Bruno, Chapier, Robert, Vinet, Agnès, Chamoux, Alain, Naughton, Geraldine, Poirier, Paul and Dutheil, Frédéric. (2017). Paradoxical dissociation between heart rate and heart rate variability following different modalities of exercise in individuals with metabolic syndrome: The RESOLVE study. European Journal of Preventative Cardiology. 24(3), pp. 281 - 296. https://doi.org/10.1177/2047487316679523
Long-term cost reduction of routine medications following a residential programme combining physical activity and nutrition in the treatment of type 2 diabetes: a prospective cohort study
Lanhers, Charlotte, Walther, Guillaume, Chapier, Robert, Lesourd, Bruno, Naughton, Geraldine, Pereira, Bruno, Duclos, Martine, Vinet, Agnes, Obert, Phillippe, Courteix, Daniel and Dutheil, Frederic. (2017). Long-term cost reduction of routine medications following a residential programme combining physical activity and nutrition in the treatment of type 2 diabetes: a prospective cohort study. BMJ Open. 7(4), pp. 1 - 10. https://doi.org/10.1136/bmjopen-2016-013763
Effects of lifestyle intervention on left ventricular regional myocardial function in metabolic syndrome patients from the RESOLVE randomized trial
Serrano-Ferrer, Juan, Crendal, Edward, Walther, Guillaume, Vinet, Agnes, Dutheil, Frederic, Naughton, Geraldine Ann, Lesourd, Bruno, Chapier, Robert, Courteix, Daniel and Obert, Philippe. (2016). Effects of lifestyle intervention on left ventricular regional myocardial function in metabolic syndrome patients from the RESOLVE randomized trial. Metabolism. 65(9), pp. 1350 - 1360. https://doi.org/10.1016/j.metabol.2016.05.006
Concurrent agreement between an anthropometric model to predict thigh volume and dual-energy X-Ray absorptiometry assessment in female volleyball players aged 14-18 years
Tavares, Óscar M., Valente-dos-Santos, João, Duarte, João P., Póvoas, Susana C., Gobbo, Luís A., Fernandes, Rômulo A., Marinho, Daniel Almeida, Casanova, José M., Sherar, Lauren B., Courteix, Daniel and Coelho-e-Silva, Manuel J.. (2016). Concurrent agreement between an anthropometric model to predict thigh volume and dual-energy X-Ray absorptiometry assessment in female volleyball players aged 14-18 years. BMC Pediatrics. 16(190), pp. 1 - 10. https://doi.org/10.1186/s12887-016-0730-7
Cross-sectional and longitudinal study protocols of the 'ADIposity and BOne metabolism: Effects of eXercise-induced weight loss in obese adolescents' (ADIBOX) project
Chaplais, Elodie, Dutheil, Frederic, Naughton, Geraldine Ann, Greene, David Anthony, Pereira, Bruno, Thivel, David and Courteix, Daniel. (2016). Cross-sectional and longitudinal study protocols of the 'ADIposity and BOne metabolism: Effects of eXercise-induced weight loss in obese adolescents' (ADIBOX) project. BMJ Open. 6, pp. 1 - 9. https://doi.org/10.1136/bmjopen-2016-011407
Multilevel approach of a 1-year program of dietary and exercise interventions on bone mineral content and density in metabolic syndrome - the RESOLVE randomized controlled trial
Courteix, Daniel, Valente-dos-Santos, Joao, Ferry, Beatrice, Lac, Gerard, Lesourd, Bruno, Chapier, Robert, Naughton, Geraldine, Marceau, Geoffroy, Coelho-E-Silva, Manuel, Vinet, Agnes, Walther, Guillaume, Obert, Philippe and Dutheil, Frederic. (2015). Multilevel approach of a 1-year program of dietary and exercise interventions on bone mineral content and density in metabolic syndrome - the RESOLVE randomized controlled trial. PLoS One (online). 10(9), pp. 1 - 20. https://doi.org/10.1371/journal.pone.0136491
Bone-adiposity cross-talk: implications for pediatric obesity
Chaplais, Elodie, Thivel, David, Greene, David, Dutheil, Frederic, Duche, Pascale, Naughton, Geraldine and Courteix, Daniel. (2015). Bone-adiposity cross-talk: implications for pediatric obesity. Journal of Bone and Mineral Metabolism. 33(6), pp. 592 - 602. https://doi.org/10.1007/s00774-015-0654-6
Smartphone interventions for weight treatment and behavioral change in pediatric obesity : A systematic review
Chaplais, Elodie, Naughton, Geraldine, Thivel, David, Courteix, Daniel and Greene, David. (2015). Smartphone interventions for weight treatment and behavioral change in pediatric obesity : A systematic review. Telemedicine and e-Health (print). 21(10), pp. 822 - 830. https://doi.org/10.1089/tmj.2014.0197
Metabolic syndrome individuals with and without type 2 diabetes mellitus present generalized vascular dysfunction : Cross-sectional study
Walther, Guillaume, Obert, Philippe, Dutheil, Frederic, Chapier, Robert, Lesourd, Bruno, Naughton, Geraldine, Courteix, Daniel and Vinet, Agnes. (2015). Metabolic syndrome individuals with and without type 2 diabetes mellitus present generalized vascular dysfunction : Cross-sectional study. Arteriosclerosis Thrombosis and Vascular Biology. 35(4), pp. 1022 - 1029. https://doi.org/10.1161/ATVBAHA.114.304591
Effects of a multi-disciplinary lifestyle intervention on cardiometabolic risk factors in young women with abdominal obesity: A randomised controlled trial
Share, Bianca, Naughton, Geraldine, Obert, Phillippe, Peat, Jennifer, Aumand, Elizabeth and Kemp, Justin. (2015). Effects of a multi-disciplinary lifestyle intervention on cardiometabolic risk factors in young women with abdominal obesity: A randomised controlled trial. PLoS One (online). 10(6), pp. 1 - 15. https://doi.org/10.1371/journal.pone.0130270
Left ventricular myocardial dyssynchrony is already present in nondiabetic patients with metabolic syndrome
Crendal, Edward, Walther, Guillaume, Dutheil, Frederic, Courteix, Daniel, Lesourd, Bruno, Chapier, Robert, Naughton, Geraldine A., Vinet, Agnes and Obert, Phillippe. (2014). Left ventricular myocardial dyssynchrony is already present in nondiabetic patients with metabolic syndrome. Canadian Journal of Cardiology. 30(3), pp. 320 - 324. https://doi.org/10.1016/j.cjca.2013.10.019
Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet - the RESOLVE trial
Dutheil, Frederic, Walther, Guillame, Chapier, Robert, Mnatzaganian, George, Lesourd, Bruno, Naughton, Geraldine, Verney, Julien, Fogli, Anne, Sapin, Vincent, Duclos, Martine, Vinet, Agnes, Obert, Philippe, Courteix, Daniel and Lac, Gerard. (2014). Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet - the RESOLVE trial. Lipids in Health and Disease. 13(1). https://doi.org/10.1186/1476-511X-13-112
Cardiometabolic and behavioural risk factors in young overweight women identified with simple anthropometric measures
Share, Bianca L., Naughton, Geraldine A., Obert, Phillippe, Peat, Jennifer K. and Kemp, Justin G.. (2014). Cardiometabolic and behavioural risk factors in young overweight women identified with simple anthropometric measures. Journal of Science and Medicine in Sport. 17(6), pp. 656 - 661. https://doi.org/10.1016/j.jsams.2013.09.011
Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: Effects of a 3-month lifestyle intervention program
Serrano-Ferrer, Juan, Walther, Guillaume, Crendal, Edward, Vinet, Agnes, Dutheil, Frederic, Naughton, Geraldine A., Lesourd, Bruno, Chapier, Robert, Courteix, Daniel and Obert, Philippe. (2014). Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: Effects of a 3-month lifestyle intervention program. Cardiovascular Diabetology. 13(1), pp. 1 - 11. https://doi.org/10.1186/s12933-014-0116-9
Myocardial deformation and twist mechanics in adults with metabolic syndrome : Impact of cumulative metabolic burden
Crendal, Edward, Walther, Guillaume, Vinet, Agnes, Dutheil, Frederic, Naughton, Geraldine, Lesourd, Bruno, Chapier, Robert, Rupp, Thomas, Courteix, Daniel and Obert, Philippe. (2013). Myocardial deformation and twist mechanics in adults with metabolic syndrome : Impact of cumulative metabolic burden. Obesity: a resourch journal. https://doi.org/10.1002/oby.20537
Gymnastics participation is associated with skeletal benefits in the distal forearm : a 6-month study using peripheral Quantitative Computed Tomography
Burt, Lauren, Ducher, Gaele, Naughton, Geraldine, Courteix, Daniel and Greene, David. (2013). Gymnastics participation is associated with skeletal benefits in the distal forearm : a 6-month study using peripheral Quantitative Computed Tomography. The Journal of Musculoskeletal and Neuronal Interactions.
Exercise-induced cardioprotection: A role for eNOS uncoupling and NO metabolites
Farah, C., Kleindienst, Adrien, Bolea, G., Meyer, G., Gayrard, Sandrine, Geny, B., Obert, Phillippe, Cazorla, O., Tanguy, Stephane and Reboul, Cyril. (2013). Exercise-induced cardioprotection: A role for eNOS uncoupling and NO metabolites. Basic Research in Cardiology. 108(6), pp. 1 - 13. https://doi.org/10.1007/s00395-013-0389-2
Non-elite gymnastics participation is associated with greater bone strength, muscle size, and function in pre- and early pubertal girls
Burt, Lauren, Naughton, Geraldine, Greene, David and Courteix, Daniel. (2012). Non-elite gymnastics participation is associated with greater bone strength, muscle size, and function in pre- and early pubertal girls. Osteoporosis International. 23(4), pp. 1277 - 1286. https://doi.org/10.1007/s00198-011-1677-z
Treatment of Metabolic syndrome by combination of physical activity and diet needs an optimal protein intake: a randomized controlled trial
Dutheil, Frederic, Lac, Gerard, Courteix, Daniel, Dore, Eric, Chapier, Robert, Roszyk, Laurence, Sapin, Vincent and Lesourd, Bruno. (2012). Treatment of Metabolic syndrome by combination of physical activity and diet needs an optimal protein intake: a randomized controlled trial. Nutrition Journal. 11(1). https://doi.org/10.1186/1475-2891-11-72
Beta-Adrenergic receptors desensitization is not involved in exercise-induced cardiac fatigue: NADPH oxidase-induced oxidative stress as a new trigger
Vitiello, Damien, Boissiere, Julien, Doucende, Gregory, Gayrard, Sandrine, Polge, Anne, Faure, Patrice, Goux, Aurelie, Tanguy, Stephane, Obert, Phillippe, Reboul, Cyril and Nottin, Stephane. (2011). Beta-Adrenergic receptors desensitization is not involved in exercise-induced cardiac fatigue: NADPH oxidase-induced oxidative stress as a new trigger. Journal of Applied Physiology. 111(5), pp. 1242 - 1248. https://doi.org/10.1152/japplphysiol.00449.2011
Bone geometry and strength adaptations to physical constraints inherent in different sports: Comparison between elite female soccer players and swimmers
Ferry, B., Duclos, M., Burt, Lauren A., Therre, P., Le Gall, F., Jaffré, C. and Courteix, D.. (2011). Bone geometry and strength adaptations to physical constraints inherent in different sports: Comparison between elite female soccer players and swimmers. Journal of Bone and Mineral Metabolism (print version). 29(3), pp. 342 - 351. https://doi.org/10.1007/s00774-010-0226-8
Carbon monoxide pollution impairs myocardial perfusion reserve: Implication of coronary endothelial dysfunction
Meyer, G., Boissiere, Julien, Tanguy, Stephane, Rugale, C., Gayrard, Sandrine, Jover, Bernard, Obert, Phillippe and Reboul, Cyril. (2011). Carbon monoxide pollution impairs myocardial perfusion reserve: Implication of coronary endothelial dysfunction. Cardiovascular Toxicology. 11(4), pp. 334 - 340. https://doi.org/10.1007/s12012-011-9125-z
Bone geometry and strength adaptations to physical constraints inherent in different sports: comparison between elite female soccer players and swimmers
Ferry, Beatrice, Duclos, Martine, Burt, Lauren, Therre, Perrine, Le Gall, Franck, Jaffre, Christelle and Courteix, Daniel. (2011). Bone geometry and strength adaptations to physical constraints inherent in different sports: comparison between elite female soccer players and swimmers. Journal of Bone and Mineral Metabolism. 29(3). https://doi.org/10.1007/s00774-010-0226-8
Effect of a six-month training programme on the physical capacities of Romanian schoolchildren
Greene, David, Serbescu, Carmen, Flora, D., Hantiu, Iacob, Benhamou, Claude Laurent and Courteix, Daniel. (2006). Effect of a six-month training programme on the physical capacities of Romanian schoolchildren. Acta Paediatrica. 10(10), pp. 1258 - 1265. https://doi.org/10.1080/08035250600599719