Cardiovascular risk of adipokines: A review
Journal article
Frederic Dutheil, Brett Ashley Gordon, Geraldine Naughton, Edward Crendal, Daniel Courteix, Elodie Chaplais, David Thivel, Gerard Lac and Amanda Benson. (2018). Cardiovascular risk of adipokines: A review. Journal of International Medical Research. 46(6), pp. 2082-2095. https://doi.org/10.1177/0300060517706578
Authors | Frederic Dutheil, Brett Ashley Gordon, Geraldine Naughton, Edward Crendal, Daniel Courteix, Elodie Chaplais, David Thivel, Gerard Lac and Amanda Benson |
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Abstract | Over the last two decades, the understanding of adipose tissue has undergone radical change. The perception has evolved from an inert energy storage tissue to that of an active endocrine organ. Adipose tissue releases a cluster of active molecules named adipokines. The severity of obesity-related diseases does not necessarily correlate with the extent of body fat accumulation but is closely related to body fat distribution, particularly to visceral localization. There is a distinction between the metabolic function of central obesity (visceral abdominal) and peripheral obesity (subcutaneous) in the production of adipokines. Visceral fat accumulation, linked with levels of some adipokines, induces chronic inflammation and metabolic disorders, including glucose intolerance, hyperlipidaemia, and arterial hypertension. Together, these conditions contribute to a diagnosis of metabolic syndrome, directly associated with the onset of cardiovascular disease. If it is well known that adipokines contribute to the inflammatory profile and appetite regulation, this review is novel in synthesising the current state of knowledge of the role of visceral adipose tissue and its secretion of adipokines in cardiovascular risk. |
Keywords | metabolic syndrome; central obesity; adipokines; visceral adipose tissue; cardiovascular disease; appetite; inflammation |
Year | 2018 |
Journal | Journal of International Medical Research |
Journal citation | 46 (6), pp. 2082-2095 |
Publisher | Sage Publications Ltd. |
ISSN | 0300-0605 |
Digital Object Identifier (DOI) | https://doi.org/10.1177/0300060517706578 |
Scopus EID | 2-s2.0-85044510294 |
Open access | Published as ‘gold’ (paid) open access |
Publisher's version | License File Access Level Open |
Publication process dates | |
Deposited | 22 Apr 2021 |
https://acuresearchbank.acu.edu.au/item/8vxqq/cardiovascular-risk-of-adipokines-a-review
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Publisher's version
OA_Dutheil_2018_Cardiovascular_risk_of_adipokines_a_review.pdf | |
License: CC BY-NC 3.0 | |
File access level: Open |
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