Effects of lifestyle intervention on left ventricular regional myocardial function in metabolic syndrome patients from the RESOLVE randomized trial

Journal article


Serrano-Ferrer, Juan, Crendal, Edward, Walther, Guillaume, Vinet, Agnes, Dutheil, Frederic, Naughton, Geraldine Ann, Lesourd, Bruno, Chapier, Robert, Courteix, Daniel and Obert, Philippe. (2016). Effects of lifestyle intervention on left ventricular regional myocardial function in metabolic syndrome patients from the RESOLVE randomized trial. Metabolism. 65(9), pp. 1350 - 1360. https://doi.org/10.1016/j.metabol.2016.05.006
AuthorsSerrano-Ferrer, Juan, Crendal, Edward, Walther, Guillaume, Vinet, Agnes, Dutheil, Frederic, Naughton, Geraldine Ann, Lesourd, Bruno, Chapier, Robert, Courteix, Daniel and Obert, Philippe
Abstract

Aims: The purpose of our study was to determine the effect of lifestyle intervention on left ventricular (LV) regional myocardial function in patients with metabolic syndrome (MetS) and investigate the relationships of the changes in myocardial function to changes in epicardial adipose tissue (EAT), inflammatory profile and MetS components. Methods: Eighty-seven MetS patients were enrolled in a 6 month lifestyle intervention program based on dietary management and increased physical activity, and compared with 44 aged and sex-matched healthy controls. MetS individuals were allocated to different groups randomized (computer-generated randomization) on exercise modalities (high-intensity dominant resistance or aerobic training, and moderate-intensity of both modes). EAT was measured by transthoracic echocardiography and LV longitudinal strains and strain rates were obtained using vector velocity imaging. Blood chemistry allowed assessments of adipocytokines (TNF-α: tumor necrosis factor α, PAI active: active plasminogen activator inhibitor-1 and adiponectin) and glucose tolerance markers. Results: Regardless of exercise training modalities, lifestyle intervention improved significantly LV strains and strain rates (p < 0.001) as well as metabolic and inflammatory profiles. Stepwise multiple regression analyses revealed EAT (β = 0.73, p < 0.01), log adiponectin (β = − 0.13, p < 0.05) and log TNF-α (β = 0.15, p < 0.05) as independent predictors of LV longitudinal strain (R2 = 0.74, p < 0.001) while myocardial function improvement consecutive to lifestyle intervention was explained by EAT changes only (R2 = 0.54, p < 0.001). Conclusion: The mechanisms through which regional myocardial function is impaired in MetS and improved consecutive to intervention involved EAT, possibly via paracrine effects of adipocytokines. EAT should be considered as a future therapeutic target of interest in the treatment of metabolic-related cardiac diseases.

Keywordsmetabolic syndrome; epicardial fat; inflammation; myocardial dysfunction; lifestyle intervention
Year2016
JournalMetabolism
Journal citation65 (9), pp. 1350 - 1360
PublisherChurchill Livingstone
ISSN0026-0495
Digital Object Identifier (DOI)https://doi.org/10.1016/j.metabol.2016.05.006
Page range1350 - 1360
Research GroupSports Performance, Recovery, Injury and New Technologies (SPRINT) Research Centre
Publisher's version
File Access Level
Controlled
Place of publicationUnited Kingdom
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Tavares, Óscar M., Valente-dos-Santos, João, Duarte, João P., Póvoas, Susana C., Gobbo, Luís A., Fernandes, Rômulo A., Marinho, Daniel Almeida, Casanova, José M., Sherar, Lauren B., Courteix, Daniel and Coelho-e-Silva, Manuel J.. (2016). Concurrent agreement between an anthropometric model to predict thigh volume and dual-energy X-Ray absorptiometry assessment in female volleyball players aged 14-18 years. BMC Pediatrics. 16(190), pp. 1 - 10. https://doi.org/10.1186/s12887-016-0730-7
Are nurses burned out?
Choron, Guillame, Dutheil, Frederic and Lesage, Francois-Xavier. (2016). Are nurses burned out? International Journal of Nursing Studies. 58, pp. 80 - 81. https://doi.org/10.1016/j.ijnurstu.2016.02.002
Validation of the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS) in French psychiatric and general populations
Trousselard, Marion, Steiler, Dominique, Dutheil, Frederic, Claverie, Damien, Canini, Frédéric, Fenouillet, Fabien, Naughton, Geraldine Ann, Stewart-Brown, Sarah and Franck, Nicolas. (2016). Validation of the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS) in French psychiatric and general populations. Psychiatry Research. 245, pp. 282 - 290. https://doi.org/10.1016/j.psychres.2016.08.050
Stress among nurses working in emergency, anesthesiology and intensive care units depends on qualification: a Job Demand-Control survey
Trousselard, Marion, Dutheil, Frederic, Naughton, Geraldine Ann, Cosserant, Sylvie, Amadon, Sylvie, Christian, Duale and Schoeffler, Pierre. (2016). Stress among nurses working in emergency, anesthesiology and intensive care units depends on qualification: a Job Demand-Control survey. International Archives of Occupational and Environmental Health. https://doi.org/10.1007/s00420-015-1065-7
Cross-sectional and longitudinal study protocols of the 'ADIposity and BOne metabolism: Effects of eXercise-induced weight loss in obese adolescents' (ADIBOX) project
Chaplais, Elodie, Dutheil, Frederic, Naughton, Geraldine Ann, Greene, David Anthony, Pereira, Bruno, Thivel, David and Courteix, Daniel. (2016). Cross-sectional and longitudinal study protocols of the 'ADIposity and BOne metabolism: Effects of eXercise-induced weight loss in obese adolescents' (ADIBOX) project. BMJ Open. 6, pp. 1 - 9. https://doi.org/10.1136/bmjopen-2016-011407
Multilevel approach of a 1-year program of dietary and exercise interventions on bone mineral content and density in metabolic syndrome - the RESOLVE randomized controlled trial
Courteix, Daniel, Valente-dos-Santos, Joao, Ferry, Beatrice, Lac, Gerard, Lesourd, Bruno, Chapier, Robert, Naughton, Geraldine, Marceau, Geoffroy, Coelho-E-Silva, Manuel, Vinet, Agnes, Walther, Guillaume, Obert, Philippe and Dutheil, Frederic. (2015). Multilevel approach of a 1-year program of dietary and exercise interventions on bone mineral content and density in metabolic syndrome - the RESOLVE randomized controlled trial. PLoS One (online). 10(9), pp. 1 - 20. https://doi.org/10.1371/journal.pone.0136491
Creatine supplementation and lower limb strength performance : A systematic review and meta-analyses
Lanhers, Charlotte, Pereira, Bruno, Naughton, Geraldine, Trousselard, Marion, Lesage, Francois-Xavier and Dutheil, Frederic. (2015). Creatine supplementation and lower limb strength performance : A systematic review and meta-analyses. Sports Medicine: reviews of applied medicine and science in sport and exercise. 45(9), pp. 1285 - 1294. https://doi.org/10.1007/s40279-015-0337-4
Electronic cigarettes: The resistance value of the heating filament could be the key to lung toxicity
Chausse, Pierre, Naughton, Geraldine and Dutheil, Frederic. (2015). Electronic cigarettes: The resistance value of the heating filament could be the key to lung toxicity. Chest. 148(1), pp. e29 - e30. https://doi.org/10.1378/chest.15-0497
Bone-adiposity cross-talk: implications for pediatric obesity
Chaplais, Elodie, Thivel, David, Greene, David, Dutheil, Frederic, Duche, Pascale, Naughton, Geraldine and Courteix, Daniel. (2015). Bone-adiposity cross-talk: implications for pediatric obesity. Journal of Bone and Mineral Metabolism. 33(6), pp. 592 - 602. https://doi.org/10.1007/s00774-015-0654-6
Smartphone interventions for weight treatment and behavioral change in pediatric obesity : A systematic review
Chaplais, Elodie, Naughton, Geraldine, Thivel, David, Courteix, Daniel and Greene, David. (2015). Smartphone interventions for weight treatment and behavioral change in pediatric obesity : A systematic review. Telemedicine and e-Health (print). 21(10), pp. 822 - 830. https://doi.org/10.1089/tmj.2014.0197
Metabolic syndrome individuals with and without type 2 diabetes mellitus present generalized vascular dysfunction : Cross-sectional study
Walther, Guillaume, Obert, Philippe, Dutheil, Frederic, Chapier, Robert, Lesourd, Bruno, Naughton, Geraldine, Courteix, Daniel and Vinet, Agnes. (2015). Metabolic syndrome individuals with and without type 2 diabetes mellitus present generalized vascular dysfunction : Cross-sectional study. Arteriosclerosis Thrombosis and Vascular Biology. 35(4), pp. 1022 - 1029. https://doi.org/10.1161/ATVBAHA.114.304591
Chest CT Scan Screening for Lung Cancer in Asbestos Occupational Exposure : A Systematic Review and Meta-analysis
Ollier, Marie, Chamoux, Alain, Naughton, Geraldine, Pereira, Bruno and Dutheil, Frederic. (2014). Chest CT Scan Screening for Lung Cancer in Asbestos Occupational Exposure : A Systematic Review and Meta-analysis. Chest. 145(6), pp. 1339 - 1346. https://doi.org/10.1378/chest.13-2181
Left ventricular myocardial dyssynchrony is already present in nondiabetic patients with metabolic syndrome
Crendal, Edward, Walther, Guillaume, Dutheil, Frederic, Courteix, Daniel, Lesourd, Bruno, Chapier, Robert, Naughton, Geraldine A., Vinet, Agnes and Obert, Phillippe. (2014). Left ventricular myocardial dyssynchrony is already present in nondiabetic patients with metabolic syndrome. Canadian Journal of Cardiology. 30(3), pp. 320 - 324. https://doi.org/10.1016/j.cjca.2013.10.019
Increased myocardial dysfunction, dyssynchrony, and epicardial fat across the lifespan in healthy males
Crendal, Edward, Dutheil, Fred, Naughton, Geraldine, McDonald, Tracey and Obert, Philippe. (2014). Increased myocardial dysfunction, dyssynchrony, and epicardial fat across the lifespan in healthy males. BMC Cardiovascular Disorders. 14(95), pp. 1 - 10. https://doi.org/10.1186/1471-2261-14-95
Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet - the RESOLVE trial
Dutheil, Frederic, Walther, Guillame, Chapier, Robert, Mnatzaganian, George, Lesourd, Bruno, Naughton, Geraldine, Verney, Julien, Fogli, Anne, Sapin, Vincent, Duclos, Martine, Vinet, Agnes, Obert, Philippe, Courteix, Daniel and Lac, Gerard. (2014). Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet - the RESOLVE trial. Lipids in Health and Disease. 13(1). https://doi.org/10.1186/1476-511X-13-112
Comparison of the ultra-low-dose Veo algorithm with the gold standard filtered back projection for detecting pulmonary asbestos-related conditions : A clinical observational study
Tekath, Marielle, Dutheil, Frederic, Bellini, Romain, Roche, Antoine, Pereira, Bruno, Naughton, Geraldine, Chamoux, Alain and Michel, Jean-Luc. (2014). Comparison of the ultra-low-dose Veo algorithm with the gold standard filtered back projection for detecting pulmonary asbestos-related conditions : A clinical observational study. BMJ Open. 4(5), pp. 1 - 8. https://doi.org/10.1136/bmjopen-2014-004980
Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: Effects of a 3-month lifestyle intervention program
Serrano-Ferrer, Juan, Walther, Guillaume, Crendal, Edward, Vinet, Agnes, Dutheil, Frederic, Naughton, Geraldine A., Lesourd, Bruno, Chapier, Robert, Courteix, Daniel and Obert, Philippe. (2014). Right ventricle free wall mechanics in metabolic syndrome without type-2 diabetes: Effects of a 3-month lifestyle intervention program. Cardiovascular Diabetology. 13(1), pp. 1 - 11. https://doi.org/10.1186/s12933-014-0116-9
Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet : the RESOLVE trial
Dutheil, Frederic, Walther, Guillaume, Chapier, Robert, Mnatzaganian, George, Lesourd, Bruno, Naughton, Geraldine, Verney, Julien, Fogli, Anne, Sapin, Vincent and Duclose, Martine. (2014). Atherogenic subfractions of lipoproteins in the treatment of metabolic syndrome by physical activity and diet : the RESOLVE trial. Lipids in Health and Disease. 13(112), pp. 1 - 9. https://doi.org/10.1186/1476-511X-13-112
Myocardial deformation and twist mechanics in adults with metabolic syndrome : Impact of cumulative metabolic burden
Crendal, Edward, Walther, Guillaume, Vinet, Agnes, Dutheil, Frederic, Naughton, Geraldine, Lesourd, Bruno, Chapier, Robert, Rupp, Thomas, Courteix, Daniel and Obert, Philippe. (2013). Myocardial deformation and twist mechanics in adults with metabolic syndrome : Impact of cumulative metabolic burden. Obesity: a resourch journal. https://doi.org/10.1002/oby.20537
Urinary Interleukin-8 is a biomarker of stress in emergency physicians, especially with advancing age: The JOBSTRESS* randomized trial
Dutheil, Frederic, Trousselard, Marion, Perrier, Christophe, Lac, Gerard, Chamoux, Alain, Duclos, Martine, Naughton, Geraldine, Mnatzaganian, George and Schmidt, Jeannot. (2013). Urinary Interleukin-8 is a biomarker of stress in emergency physicians, especially with advancing age: The JOBSTRESS* randomized trial. PLoS ONE. 8(8), pp. 1 - 7. https://doi.org/10.1371/journal.pone.0071658
Gymnastics participation is associated with skeletal benefits in the distal forearm : a 6-month study using peripheral Quantitative Computed Tomography
Burt, Lauren, Ducher, Gaele, Naughton, Geraldine, Courteix, Daniel and Greene, David. (2013). Gymnastics participation is associated with skeletal benefits in the distal forearm : a 6-month study using peripheral Quantitative Computed Tomography. The Journal of Musculoskeletal and Neuronal Interactions.
Different modalities of exercise to reduce visceral fat mass and cardiovascular risk in metabolic syndrome : the RESOLVE* randomized trial
Dutheil, Frederic, Lac, Gerard, Lesourd, Bruno, Chapier, Robert, Walther, Guillaume, Vinet, Agnes, Sapin, Vincent, Verney, Julien, Ouchchane, Lemlih and Duclos, Martine. (2013). Different modalities of exercise to reduce visceral fat mass and cardiovascular risk in metabolic syndrome : the RESOLVE* randomized trial. International Journal of Cardiology. https://doi.org/10.1016/j.ijcard.2013.05.012
The long-term effects of occupational exposure to vinyl chloride monomer on microcirculation : a cross-sectional study 15 years after retirement
Lopez, Vincent, Chamoux, Alain, Tempier, Marion, Thiel, Helene, Ughetto, Sylvie, Trousselard, Marion, Naughton, Geraldine and Dutheil, Frederic. (2013). The long-term effects of occupational exposure to vinyl chloride monomer on microcirculation : a cross-sectional study 15 years after retirement. BMJ Open. https://doi.org/10.1136/bmjopen-2013-002785
Non-elite gymnastics participation is associated with greater bone strength, muscle size, and function in pre- and early pubertal girls
Burt, Lauren, Naughton, Geraldine, Greene, David and Courteix, Daniel. (2012). Non-elite gymnastics participation is associated with greater bone strength, muscle size, and function in pre- and early pubertal girls. Osteoporosis International. 23(4), pp. 1277 - 1286. https://doi.org/10.1007/s00198-011-1677-z
Treatment of Metabolic syndrome by combination of physical activity and diet needs an optimal protein intake: a randomized controlled trial
Dutheil, Frederic, Lac, Gerard, Courteix, Daniel, Dore, Eric, Chapier, Robert, Roszyk, Laurence, Sapin, Vincent and Lesourd, Bruno. (2012). Treatment of Metabolic syndrome by combination of physical activity and diet needs an optimal protein intake: a randomized controlled trial. Nutrition Journal. 11(1). https://doi.org/10.1186/1475-2891-11-72
Bone geometry and strength adaptations to physical constraints inherent in different sports: Comparison between elite female soccer players and swimmers
Ferry, B., Duclos, M., Burt, Lauren A., Therre, P., Le Gall, F., Jaffré, C. and Courteix, D.. (2011). Bone geometry and strength adaptations to physical constraints inherent in different sports: Comparison between elite female soccer players and swimmers. Journal of Bone and Mineral Metabolism (print version). 29(3), pp. 342 - 351. https://doi.org/10.1007/s00774-010-0226-8
Bone geometry and strength adaptations to physical constraints inherent in different sports: comparison between elite female soccer players and swimmers
Ferry, Beatrice, Duclos, Martine, Burt, Lauren, Therre, Perrine, Le Gall, Franck, Jaffre, Christelle and Courteix, Daniel. (2011). Bone geometry and strength adaptations to physical constraints inherent in different sports: comparison between elite female soccer players and swimmers. Journal of Bone and Mineral Metabolism. 29(3). https://doi.org/10.1007/s00774-010-0226-8
Effect of a six-month training programme on the physical capacities of Romanian schoolchildren
Greene, David, Serbescu, Carmen, Flora, D., Hantiu, Iacob, Benhamou, Claude Laurent and Courteix, Daniel. (2006). Effect of a six-month training programme on the physical capacities of Romanian schoolchildren. Acta Paediatrica. 10(10), pp. 1258 - 1265. https://doi.org/10.1080/08035250600599719