Endovascular thrombectomy with or without systemic thrombolysis?

Journal article

Georgios Tsivgoulis, Aristeidis H Katsanos, Dimitris Mavridis, Anne Alexandrov, Georgios Magoufis, Adam Arthur, Valeria Caso, Peter D. Schellinger and Andrei V. Alexandrov. (2017). Endovascular thrombectomy with or without systemic thrombolysis? Therapeutic Advances in Neurological Disorders. 10(3), pp. 151-160. https://doi.org/10.1177/1756285616680549
AuthorsGeorgios Tsivgoulis, Aristeidis H Katsanos, Dimitris Mavridis, Anne Alexandrov, Georgios Magoufis, Adam Arthur, Valeria Caso, Peter D. Schellinger and Andrei V. Alexandrov
Abstract

Objectives:
Current recommendations advocate that pretreatment with intravenous thrombolysis (IVT) should first be offered to all eligible patients with emergent large vessel occlusion (ELVO) before an endovascular thrombectomy (ET) procedure. However, there are observational data that question the safety and efficacy of IVT pretreatment in patients with ELVO.

Methods:
We performed a meta-analysis of the included subgroups from ET randomized controlled trials (RCTs) to evaluate the comparative efficacy between direct ET without IVT pretreatment and bridging therapy (IVT and ET) in patients with ELVO.

Results:
We included a total of seven RCTs, including 1764 patients with ELVO (52.8% men). Patients receiving bridging therapy (IVT followed by ET) had lower rates (p = 0.041) of 90-day death/severe dependency (modified Rankin Scale-score of 5–6; 19.0%, 95% CI: 14.1–25.1%) compared with patients receiving only ET (31.0%, 95% CI: 21.2–42.9%). Moreover, patients receiving IVT and ET had a nonsignificant (p = 0.389) trend towards higher 90-day functional independence rates (51.4%, 95% CI: 42.5–60.1%) compared with patients undergoing only ET (41.7%, 95% CI: 24.1–61.7%). Finally, shift-analysis uncovered a nonsignificant trend towards functional improvement at 90 days for bridging therapy over ET (cOR = 1.28, 95% CI: 0.91–1.89; p = 0.155). It should be noted that patients included in the present meta-analysis were not randomized to receive IVT, and thus the two groups (bridging therapy versus ET monotherapy) may differ in terms of baseline characteristics and, in particular, in terms of onset to groin puncture time and thus the risk of confounding bias cannot be ruled out.

Conclusion:
Despite the limitations and the risk of confounding bias, our findings contradict the recent notion regarding potential equality between ET and bridging therapy in ELVO patients and suggest that IVT and ET are complementary therapies that should be pursued in a parallel and noncompeting fashion.

Keywordsacute ischemic stroke; emergent large vessel occlusion; intravenous thrombolysis; mechanical thrombectomy; meta-analysis
Year2017
JournalTherapeutic Advances in Neurological Disorders
Journal citation10 (3), pp. 151-160
PublisherSage Publications Ltd.
ISSN1756-2856
Digital Object Identifier (DOI)https://doi.org/10.1177/1756285616680549
Scopus EID2-s2.0-85015003307
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Controlled
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Deposited14 May 2021
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