Percutaneous transluminal angioplasty and stenting for symptomatic intracranial arterial stenosis : A systematic review and meta-analysis

Journal article

Tsivgoulis, Georgios, Katsanos, Aristeidis H., Magoufis, Georgios, Kargiotis, Odysseas, Papadimitropoulos, Georgios, Vadikolias, Konstantinos, Karapanayiotides, Theodoros, Ellul, John, Alexandrov, Anne W., Mitsias, Panayiotis D. and Alexandrov, Andrei V.. (2016). Percutaneous transluminal angioplasty and stenting for symptomatic intracranial arterial stenosis : A systematic review and meta-analysis. Therapeutic Advances in Neurological Disorders. 9(5), pp. 351-358. https://doi.org/10.1177/1756285616650357
AuthorsTsivgoulis, Georgios, Katsanos, Aristeidis H., Magoufis, Georgios, Kargiotis, Odysseas, Papadimitropoulos, Georgios, Vadikolias, Konstantinos, Karapanayiotides, Theodoros, Ellul, John, Alexandrov, Anne W., Mitsias, Panayiotis D. and Alexandrov, Andrei V.
Abstract

Objectives:
The cumulative safety and efficacy measures of percutaneous transluminal angioplasty and stenting (PTAS) for secondary stroke prevention in patients with symptomatic intracranial arterial stenosis (sICAS) have not previously been evaluated using a meta-analytical approach.

Methods:
We conducted a systematic review and random effects meta-analysis of all available randomized controlled trials (RCTs) evaluating the safety and efficacy of PTAS (in comparison with medical therapy) for sICAS.

Results:
Three RCTs (678 total patients) were included in the quantitative analysis. PTAS was associated with a higher risk of recurrent ischemic stroke in the territory of qualifying artery both within 30 days [risk ratio (RR) = 2.21, 95% confidence interval (CI) 1.10–4.43] and 1 year (RR = 1.92, 95% CI 1.10–3.36). PTAS was also related to a higher risk of any ischemic stroke within 30 days from the index event (RR = 2.08, 95% CI 1.17–3.71). The risk for intracranial hemorrhage was found to be higher in PTAS patients both within 30 days (RR = 10.60, 95% CI 1.98–56.62) and 1 year (RR = 8.15, 95% CI 1.50–44.34). The composite outcome of any stroke or death within 1 year (RR = 2.29, 95% CI 1.13–4.66) and 2 years (RR = 1.52, 95% CI 1.04–2.21) was higher in PTAS than in medical therapy. PTAS was associated with a higher risk of any stroke or death within 2 years in the sICAS subgroup located in posterior circulation (RR = 2.37, 95% CI 1.27–4.42).

Conclusions:
PTAS is associated with adverse early and long-term outcomes and should not be recommended in patients with sICAS. Further research to identify subgroups of patients who could also serve as candidates for future interventional trials along with efforts to reduce procedure-related complications are needed.

Keywordsischemic stroke; percutaneous transluminal angioplasty; stenting; symptomatic intracranial arterial stenosis
Year2016
JournalTherapeutic Advances in Neurological Disorders
Journal citation9 (5), pp. 351-358
PublisherSage Publications Ltd.
ISSN1756-2856
Digital Object Identifier (DOI)https://doi.org/10.1177/1756285616650357
Scopus EID2-s2.0-84982176723
Research or scholarlyResearch
Page range351-358
Publisher's version
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All rights reserved
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Controlled
Output statusPublished
Publication dates
Online22 May 2016
Publication process dates
Deposited19 Nov 2021
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