Is short-term exposure to grass pollen adversely associated with lung function and airway inflammation in the community?

Journal article


Idrose, Nur Sabrina, Tham, Rachel C. A., Lodge, Caroline J., Lowe, Adrian J., Bui, Dinh, Perret, Jennifer L., Vicendese, Don, Newbigin, Edward J., Tang, Mimi L. K., Aldakheel, Fahad M., Waidyatillake, Nilakshi T., Douglass, Jo A., Abramson, Michael J., Walters, Eugene Haydn, Erbas, Bircan and Dharmage, Shyamali C.. (2021). Is short-term exposure to grass pollen adversely associated with lung function and airway inflammation in the community? Allergy. 76(4), pp. 1136-1146. https://doi.org/10.1111/all.14566
AuthorsIdrose, Nur Sabrina, Tham, Rachel C. A., Lodge, Caroline J., Lowe, Adrian J., Bui, Dinh, Perret, Jennifer L., Vicendese, Don, Newbigin, Edward J., Tang, Mimi L. K., Aldakheel, Fahad M., Waidyatillake, Nilakshi T., Douglass, Jo A., Abramson, Michael J., Walters, Eugene Haydn, Erbas, Bircan and Dharmage, Shyamali C.
Abstract

Background
The association between grass pollen exposure and early markers of asthma exacerbations such as lung function changes and increase in airway inflammation is limited. We investigated the associations between short-term grass pollen exposure and lung function and airway inflammation in a community-based sample, and whether any such associations were modified by current asthma, current hay fever, pollen sensitization, age, and other environmental factors.

Methods
Cross-sectional and short-term analyses of data from the Melbourne Atopy Cohort Study (MACS) participants (n = 936). Lung function was assessed using spirometry. Airway inflammation was assessed by fractional exhaled nitric oxide (FeNO) and exhaled breath condensate pH and nitrogen oxides (NOx). Daily pollen counts were collected using a volumetric spore trap. The associations were examined by linear regression.

Results
Higher ambient levels of grass pollen 2 days before (lag 2) were associated with lower mid-forced expiratory flow (FEF25%-75%) and FEV1/FVC ratio (Coef. [95% CI] = −119 [−226, −11] mL/s and −1.0 [−3.0, −0.03] %, respectively) and also 3 days before (lag 3). Increased levels of grass pollen a day before (lag 1) were associated with increased FeNO (4.35 [−0.1, 8.7] ppb) and also at lag 2. Adverse associations between pollen and multiple outcomes were greater in adults with current asthma, hay fever, and pollen sensitization.

Conclusion
Grass pollen exposure was associated with eosinophilic airway inflammation 1-2 days after exposure and airway obstruction 2-3 days after exposure. Adults and individuals with asthma, hay fever, and pollen sensitization may be at higher risk.

Keywordsairway inflammation; environmental health; grass; lung function; pollen
Year2021
JournalAllergy
Journal citation76 (4), pp. 1136-1146
PublisherJohn Wiley & Sons Ltd
ISSN0105-4538
Digital Object Identifier (DOI)https://doi.org/10.1111/all.14566
Scopus EID2-s2.0-85090977881
Open accessPublished as green open access
Page range1136-1146
FunderNational Health and Medical Research Council (NHMRC)
Author's accepted manuscript
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Open
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Output statusPublished
Publication dates
Online20 Aug 2020
Publication process dates
Accepted20 Aug 2020
Deposited11 Aug 2021
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