Efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus : A randomized SHAM-controlled trial

Journal article


Coombes, Jeff S., Dias, Katrin A., Lal, Ravin, Fassett, Robert G., Wallen, Matthew P., Ramos, Joyce S., Russell, Suzanna, Vear, Natalie K., Gajanand, Trishan, Bailey, Tom G., Green, Daniel J., Coombes, Brooke K. and Roberts, Llion A.. (2023). Efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus : A randomized SHAM-controlled trial. Diabetes Research and Clinical Practice. 200, p. Article 110701. https://doi.org/10.1016/j.diabres.2023.110701
AuthorsCoombes, Jeff S., Dias, Katrin A., Lal, Ravin, Fassett, Robert G., Wallen, Matthew P., Ramos, Joyce S., Russell, Suzanna, Vear, Natalie K., Gajanand, Trishan, Bailey, Tom G., Green, Daniel J., Coombes, Brooke K. and Roberts, Llion A.
Abstract

Aims
To determine the efficacy of two doses of external counterpulsation (ECP) on glycemic control in people with type 2 diabetes mellitus (T2D), and any persistent benefits 7 weeks following treatment.

Methods
50 participants with T2D were randomly assigned to either 1) 20x45-minute ECP sessions over 7 weeks (ECP45), 2) 20x30-minute ECP sessions over 7 weeks (ECP30) or 3) SHAM control. Outcomes were assessed at baseline, after 7 weeks of the intervention and 7 weeks after the interventions finished. Efficacy was determined from changes in HbA1c.

Results
After 7 weeks, there were significant between-group differences, with ECP45 lowering HbA1c compared to SHAM (mean [95% CI] −0.7 [-0.1 to −1.3] %; −7 [-1 to −15] mmol/mol). Within group changes were; ECP45 (mean ± SD −0.8 ± 0.8%; −8 ± 8 mmol/mol), ECP30 (-0.2 ± 0.5%; −2 ± 6 mmol/mol) and SHAM (-0.1 ± 0.9%; −1 ± 10 mmol/mol). HbA1c in the ECP45 group remained lower 7 weeks after completing the intervention; ECP45 (7.0 ± 1.1%; 53 ± 26 mmol/mol), ECP30 (7.7 ± 1.4%; 60 ± 16 mmol/mol) and SHAM (7.7 ± 1.0%; 60 ± 10 mmol/mol).

Conclusions
In people with T2D, ECP45 for 7 weeks improved glycemic control when compared to ECP30 and a SHAM control group.

KeywordsHbA1c; insulin resistance; insulin sensitivity; beta cell function; basal disposition index
Year2023
JournalDiabetes Research and Clinical Practice
Journal citation200, p. Article 110701
PublisherElsevier B.V.
ISSN0168-8227
Digital Object Identifier (DOI)https://doi.org/10.1016/j.diabres.2023.110701
PubMed ID37172647
Scopus EID2-s2.0-85159602549
Page range1-9
FunderRenew Group Private Ltd
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online10 May 2023
Publication process dates
Accepted05 May 2023
Deposited07 Aug 2023
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