Tibolone
Book chapter
McClung, M. R.. (2013). Tibolone. In In Genazzani, Andrea R. (Ed.). Postmenopausal osteoporosis : Hormones and other therapies pp. 233-238 Taylor & Francis. https://doi.org/10.1201/b14631-28
Authors | McClung, M. R. |
---|---|
Editors | Genazzani, Andrea R. |
Abstract | MECHANISM OF ACTION Tibolone is a synthetic steroid substance that has little if any inherent estrogenic effect6. However, it is converted to two 3-OH-metabolites that bind to and activate the estrogen receptor (ER). The metabolites preferentially interact with the ERα receptor, accounting for the estrogen-like activity of tibolone on bone metabolism. In breast tissue, metabolites of tibolone inhibit proliferation of and stimulate apoptosis of breast tissue cells7. In the uterus, the peripheral metabolite of tibolone (∆4-isomer) has progestational and possibly androgenic effects. This allows tibolone to be administered without concomitant progestin in women without an intact uterus. Studies with specific inhibitors of estrogenic, progestogenic and androgenic action have documented that the effects of tibolone on bone are mediated through the estrogen receptor8. |
Page range | 233-238 |
Year | 2013 |
Book title | Postmenopausal osteoporosis : Hormones and other therapies |
Publisher | Taylor & Francis |
Place of publication | London, United Kingdom |
New York, New York | |
ISBN | 9780429095337 |
9780203007402 | |
Digital Object Identifier (DOI) | https://doi.org/10.1201/b14631-28 |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 11 Nov 2015 |
2013 | |
Publication process dates | |
Deposited | 04 Oct 2023 |
https://acuresearchbank.acu.edu.au/item/8zq8z/tibolone
Restricted files
Publisher's version
48
total views0
total downloads0
views this month0
downloads this month