Mechanisms of cardiotoxicity and the development of heart failure
Journal article
Lee, Christopher S.. (2015). Mechanisms of cardiotoxicity and the development of heart failure. Critical Care Nursing Clinics of North America. 27(4), pp. 469-481. https://doi.org/10.1016/j.cnc.2015.07.002
Authors | Lee, Christopher S. |
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Abstract | Key points • The term, cardiotoxicity, generally refers to toxicity of a substance that negatively affects the heart but also has been described using more precise clinical terms in cancer trials. • Common mechanisms of cardiotoxicity associated with cancer therapies include direct cardiomyocyte injury, thromboembolic events, and hypertension. • Anti–tumor necrosis factor (TNF)-α agents used in the treatment of rheumatoid arthritis may interfere with ischemic preconditioning or other roles of low levels of inflammation in cell repair. • Alcohol results in cardiotoxicity via oxidative stress, apoptosis, mitochondrial stress, and protein catabolism. • Cocaine is cardiotoxic primarily by means of sympathetic nervous system stimulation of heart and smooth muscle cells. |
Keywords | cardiotoxicity; heart failure; pathophysiology; cardiomyopathy; toxicity |
Year | 2015 |
Journal | Critical Care Nursing Clinics of North America |
Journal citation | 27 (4), pp. 469-481 |
Publisher | Elsevier Inc. |
ISSN | 0899-5885 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.cnc.2015.07.002 |
PubMed ID | 26567492 |
Scopus EID | 2-s2.0-84947302478 |
Page range | 469-481 |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 12 Nov 2015 |
Publication process dates | |
Deposited | 02 Jul 2025 |
Additional information | © 2015 Elsevier Inc. All rights reserved. |
https://acuresearchbank.acu.edu.au/item/92001/mechanisms-of-cardiotoxicity-and-the-development-of-heart-failure
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