Carl R. Walkley
| Contact category | Researcher (past) |
|---|---|
| Job title | Associate Professor |
| Research institute | Mary MacKillop Institute for Health Research |
| Faculty of Health Sciences |
Research outputs
Direct identification of A-to-I editing sites with nanopore native RNA sequencing
Nguyen, Tram, Heng, Jia, Kaewsapsak, Pornchai, Kok, Eng, Stanojevic, Dominik, Liu, Hao, Cardilla, Angelysia, Praditya, Albert, Yi, Zirong, Lin, Mingwan, Aw, Jong, Ho, Yin, Peh, Kai, Wang, Yuanming, Zhong, Qixing, Heraud-Farlow, Jacki, Xue, Shifeng, Reversade, Bruno, Walkley, Carl Richard, ... Tan, Meng. (2022). Direct identification of A-to-I editing sites with nanopore native RNA sequencing. Nature Methods. 19, pp. 833-844. https://doi.org/10.1038/s41592-022-01513-3Journal article
ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis
Zhang, Ting, Yin, Chaoran, Fedorov, Aleksandr, Qiao, Liangjun, Bao, Hongliang, Beknazarov, Nazar, Wang, Shiyu, Gautam, Avishekh, Williams, Riley M., Crawford, Jeremy Chase, Peri, Suraj, Studitsky, Vasily, Beg, Amer A., Thomas, Paul G., Walkley, Carl, Xu, Yan, Poptsova, Maria, Herbert, Alan and Balachandran, Siddharth. (2022). ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis. Nature. 606, pp. 594-602. https://doi.org/10.1038/s41586-022-04753-7Journal article
Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation
Xu, Jane Jialu, Chalk, Alistair M., Nikolic, Iva, Simpson, Kaylene J., Smeets, Monique F. and Walkley, Carl R.. (2022). Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation. Blood Advances. 6(7), pp. 2092-2106. https://doi.org/10.1182/bloodadvances.2021004571Journal article
Osteosarcoma in the Post Genome Era: Preclinical Models and Approaches to Identify Tractable Therapeutic Targets
Wilson Castillo-Tandazo, Anthony J. Mutsaers and Carl R. Walkley. (2019). Osteosarcoma in the Post Genome Era: Preclinical Models and Approaches to Identify Tractable Therapeutic Targets. Current Osteoporosis Reports. 17(5), pp. 343-352. https://doi.org/10.1007/s11914-019-00534-wJournal article
Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia
Vu, Therese, Straube, Jasmin, Porter, Amy H., Bywater, Megan, Song, Axia, Ling, Victoria, Cooper, Leanne, Pali, Gabor, Bruedigam, Claudia, Jacquelin, Sebastien, Green, Joanne, Magor, Graham, Perkins, Andrew, Chalk, Alistair M., Walkley, Carl R., Heidel, Florian H., Mukhopadhyay, Pamela, Cloonan, Nicole, Gröschel, Stefan, ... Lane, Steven W.. (2020). Hematopoietic stem and progenitor cell-restricted Cdx2 expression induces transformation to myelodysplasia and acute leukemia. Nature Communications. 11, pp. 1-15. https://doi.org/10.1038/s41467-020-16840-2Journal article
Rothmund-Thomson syndrome-like RECQL4 truncating mutations cause a haploinsufficient low-bone-mass phenotype in mice
Castillo-Tandazo, Wilson, Frazier, Ann E., Sims, Natalie A., Smeets, Monique F. and Walkley, Carl R.. (2021). Rothmund-Thomson syndrome-like RECQL4 truncating mutations cause a haploinsufficient low-bone-mass phenotype in mice. Molecular and Cellular Biology. 41(3), pp. Article e00590-20. https://doi.org/10.1128/MCB.00590-20Journal article
Enhancing mitochondrial function in vivo rescues MDS-like anemia induced by pRb deficiency
Sen, Taha, Jain, Mayur, Gram, Magnus, Mattebo, Alexander, Soneji, Shamit, Walkley, Carl R. and Singbrant, Sofie. (2020). Enhancing mitochondrial function in vivo rescues MDS-like anemia induced by pRb deficiency. Experimental Hematology. 88, pp. 28-41. https://doi.org/10.1016/j.exphem.2020.06.006Journal article
What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs
Heraud-Farlow, Jacki E. and Walkley, Carl R.. (2020). What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs. Open Biology. 10(7), p. 200085. https://doi.org/10.1098/rsob.200085Journal article
Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction
Marshall, Paul R., Zhao, Qiongyi, Li, Xiang, Wei, Wei, Periyakaruppiah, Ambika, Zajaczkowski, Esmi L., J. Leighton, Laura, Madugalle, Sachithrani U., Basic, Dean, Wang, Ziqi, Yin, Jiayu, Liau, Wei-Siang, Gupte, Ankita, Walkley, Carl R. and Bredy, Timothy W.. (2020). Dynamic regulation of Z-DNA in the mouse prefrontal cortex by the RNA-editing enzyme Adar1 is required for fear extinction. Nature Neuroscience. 23(6), pp. 718-729. https://doi.org/10.1038/s41593-020-0627-5Journal article
Murine models of bone sarcomas
Jacques, Camille, Renema, Nathalie, Ory, Benjamin, Walkley, Carl R., Grigoriadis, Agamemnon E. and Heymann, Dominique. (2019). Murine models of bone sarcomas. In In Idris, Aymen I. (Ed.). Bone research protocols pp. 331-342 Humana Press. https://doi.org/10.1007/978-1-4939-8997-3_18Book chapter
Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway
Walkley, Carl R. and Kile, Benjamin T.. (2019). Cell death following the loss of ADAR1 mediated A-to-I RNA editing is not effected by the intrinsic apoptosis pathway. Cell Death and Disease. 10, pp. 1 - 5. https://doi.org/10.1038/s41419-019-2160-6Journal article
Defining the functions of adenosine-to-inosine RNA editing through hematology
Heraud-Farlow, Jacki E., Chalk, Alistair M. and Walkley, Carl R.. (2019). Defining the functions of adenosine-to-inosine RNA editing through hematology. Current Opinion in Hematology. 26(4), pp. 241 - 248. https://doi.org/10.1097/MOH.0000000000000514Journal article
Modeling human RNA spliceosome mutations in the mouse: Not all mice were created equal
Xu, Jane Jialu, Smeets, Monique F., Tan, Shuh Ying, Wall, Meaghan, Purton, Louise E. and Walkley, Carl R.. (2019). Modeling human RNA spliceosome mutations in the mouse: Not all mice were created equal. Experimental Hematology. 70, pp. 10 - 23. https://doi.org/10.1016/j.exphem.2018.11.001Journal article
Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly
Ku, Matthew, MacKinnon, Ruth N., Wall, Meaghan, Narayan, Nisha, Walkley, Carl, Cheng, Heung-Chin, Campbell, Lynda J., Purton, Louise E. and Nandurkar, Harshal. (2019). Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly. Scientific Reports. 9(1), pp. 1 - 11. https://doi.org/10.1038/s41598-019-43373-6Journal article
ATP-dependent helicase activity is dispensable for the physiological functions of Recql4
Castillo-Tandazo, Wilson, Smeets, Monique F., Murphy, Vincent, Liu, Rui, Hodson, Charlotte, Heierhorst, Jörg, Deans, Andrew J. and Walkley, Carl R.. (2019). ATP-dependent helicase activity is dispensable for the physiological functions of Recql4. PLoS Genetics. 15(7), pp. 1 - 19. https://doi.org/10.1371/journal.pgen.1008266Journal article
The majority of A-to-I RNA editing is not required for mammalian homeostasis
Chalk, Alistair M., Taylor, Scott, Heraud-Farlow, Jacki E. and Walkley, Carl. (2019). The majority of A-to-I RNA editing is not required for mammalian homeostasis. Genome Biology. 20, pp. 1 - 14. https://doi.org/10.1186/s13059-019-1873-2Journal article
Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice
Shekhar, Tanmay M., Burvenich, Ingrid J. G., Harris, Michael A., Rigopoulos, Angela, Zanker, Damien, Spurling, Alex, Parker, Belinda S., Walkley, Carl R., Scott, Andrew M. and Hawkins, Christine J.. (2019). Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice. BMC Cancer. 19, pp. 1 - 18. https://doi.org/10.1186/s12885-019-6103-5Journal article
Srsf2P95H initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells
Smeets, Monique F., Tan, Shuh Ying, Xu, Jane Jialu, Anande, Govardhan, Unnikrishnan, Ashwin, Chalk, Alistair M., Taylor, Scott, Pimanda, John E., Wall, Meaghan, Purton, L. E. and Walkley, Carl. (2018). Srsf2P95H initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells. Blood. 132(6), pp. 608 - 621. https://doi.org/10.1182/blood-2018-04-845602Journal article
Small animal models for the study of bone sarcoma pathogenesis: characteristics, therapeutic interests and limitations
Jacques, Camille, Renema, Nathalie, Lezot, Frederic, Ory, Benjamin, Walkley, Carl, Grigoriadis, Agi E. and Heymann, Dominique. (2018). Small animal models for the study of bone sarcoma pathogenesis: characteristics, therapeutic interests and limitations. Journal of Bone Oncology. 12, pp. 7 - 13. https://doi.org/10.1016/j.jbo.2018.02.004Journal article
ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity
Nakahama, Taisuke, Kato, Yuki, Kim, Jung In, Vongpipatana, Tuangtong, Suzuki, Yutaka, Walkley, Carl R. and Kawahara, Yukio. (2018). ADAR1-mediated RNA editing is required for thymic self-tolerance and inhibition of autoimmunity. EMBO Reports. 19(12), pp. 1 - 18. https://doi.org/10.15252/embr.201846303Journal article
mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis
Martin, Sally K., Fitter, Stephen, El Khawanky, Nadia, Grose, Randall H., Walkley, Carl, Purton, Louise E., Ruegg, Markus A., Hall, Michael N., Gronthos, Stan and Zannettino, Andrew C. W.. (2018). mTORC1 plays an important role in osteoblastic regulation of B-lymphopoiesis. Scientific Reports. 8(1), pp. 1 - 10. https://doi.org/10.1038/s41598-018-32858-5Journal article
Adar3 is involved in learning and memory in mice
Mladenova, Dessislava, Barry, Guy, Konen, Lyndsey M., Pineda, Sandy S., Guennewig, Boris, Avesson, Lotta, Zinn, Raphael, Schonrock, Nicole, Bitar, Maina, Jonkhout, Nicky, Crumlish, Lauren, Kaczorowski, Dominik C., Gong, Andrew, Pinese, Mark, Franco, Gloria R., Walkley, Carl R., Vissel, Bryce and Mattick, John S.. (2018). Adar3 is involved in learning and memory in mice. Frontiers in Neuroscience. 12, pp. 1 - 17. https://doi.org/10.3389/fnins.2018.00243Journal article
Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53
Walia, Mannu K., Taylor, Scott, Ho, Patricia M.W., Martin, John and Walkley, Carl. (2018). Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53. Cell Death and Disease. 9(9), pp. 1 - 17. https://doi.org/10.1038/s41419-018-0944-8Journal article
The asymmetric cell division regulators par3, scribble and PINS/GPSM2 are not essential for erythroid development or enucleation
Wölwer, Christina B., Gödde, Nathan, Pase, Luke B., Elsum, Imogen A., Lim, Krystle Y. B., Sacirbegovic, Faruk, Walkley, Carl, Ellis, Sharon, Ohno, Shigeo, Matsuzaki, Fumio, Russell, Sarah M. and Humbert, Patrick O.. (2017). The asymmetric cell division regulators par3, scribble and PINS/GPSM2 are not essential for erythroid development or enucleation. PLoS ONE. 12(1), pp. 1 - 14. https://doi.org/10.1371/journal.pone.0170295Journal article
mTORC1 plays an important role in skeletal development by controlling preosteoblast differentiation
Fitter, Stephen, Mathews, Mary P., Martin, Sally K., Xie, Jianling, Ooi, Soo Siang, Walkley, Carl, Codrington, John D., Ruegg, Markus A., Hall, Michael N., Proud, Christopher G., Gronthos, Stan and Zannettino, Andrew C. W.. (2017). mTORC1 plays an important role in skeletal development by controlling preosteoblast differentiation. Molecular and Cellular Biology. 37(7), pp. 1 - 20. https://doi.org/10.1128/MCB.00668-16Journal article
Murine models of osteosarcoma: A piece of the translational puzzle
Walia, Mannu K., Castillo-Tandazo, Wilson, Mutsaers, Anthony J., Martin, T. John and Walkley, Carl. (2017). Murine models of osteosarcoma: A piece of the translational puzzle. Journal of Cellular Biochemistry. 119(6), pp. 4241 - 4250. https://doi.org/10.1002/jcb.26601Journal article
Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress
Shi, Wei, Vu, Therese, Boucher, Didier, Biernacka, Anna, Nde, Jules, Pandita, Raj K., Straube, Jasmin, Boyle, Glen M., Al-Ejeh, Fares, Nag, Purba, Jeffery, Jessie, Harris, Janelle L., Bain, Amanda L., Grzelak, Marta, Skrzypczak, Magdalena, Mitra, Abhishek, Dojer, Norbert, Crosetto, Nicola, Cloonan, Nicole, ... Khanna, Kum Kum. (2017). Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress. Blood. 129(18), pp. 2479 - 2492. https://doi.org/10.1182/blood-2016-06-725093Journal article
Dynamic landscape and regulation of RNA editing in mammals
Tan, Meng How, Li, Qin, Shanmugam, Raghuvaran, Piskol, Robert, Kohler, Jennefer, Young, Amy N., Liu, Kaiwen Ivy, Zhang, Rui, Ramaswami, Gokul, Ariyoshi, Kentaro, Gupte, Ankita, Keegan, Liam P., George, Cyril X., Ramu, Avinash, Huang, Ni, Pollina, Elizabeth A., Leeman, Dena S., Rustighi, Alessandra, Sharon Goh, Y. P., ... GTEx Consortium. (2017). Dynamic landscape and regulation of RNA editing in mammals. Nature. 550, pp. 249 - 254. https://doi.org/10.1038/nature24041Journal article
Design, synthesis, and biological activity of 1,2,3-triazolobenzodiazepine BET bromodomain inhibitors
Sharp, Phillip P., Garnier, Jean-Marc, Hatfaludi, Tamas, Xu, Zhen, Segal, David, Jarman, Kate E., Jousset, Hélène, Garnham, Alexandra, Feutrill, John T., Cuzzupe, Anthony, Hall, Peter, Taylor, Scott, Walkley, Carl, Tyler, Dean, Dawson, Mark A., Czabotar, Peter, Wilks, Andrew F., Glaser, Stefan, Huang, David C. S. and Burns, Christopher J.. (2017). Design, synthesis, and biological activity of 1,2,3-triazolobenzodiazepine BET bromodomain inhibitors. ACS Medicinal Chemistry Letters. 8(12), pp. 1298-1303. https://doi.org/10.1021/acsmedchemlett.7b00389Journal article
Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis
Heraud-Farlow, Jacki E., Chalk, Alistair M., Linder, Sandra, Li, Qin, Taylor, Scott, White, Joshua M., Pang, Lokman, Liddicoat, Brian J., Gupte, Ankita, Li, Jin Billy and Walkley, Carl. (2017). Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis. Genome Biology. 18(1), pp. 1 - 18. https://doi.org/10.1186/s13059-017-1301-4Journal article
Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs
Walkley, Carl and Li, Jin Billy. (2017). Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs. Genome Biology. 18(1), pp. 1 - 13. https://doi.org/10.1186/s13059-017-1347-3Journal article
ADAR1, inosine and the immune sensing system: Distinguishing self from non-self
Liddicoat, Brian J., Chalk, Alistair M. and Walkley, Carl R.. (2016). ADAR1, inosine and the immune sensing system: Distinguishing self from non-self. Wiley Interdisciplinary Reviews: RNA. 7(2), pp. 157 - 172. https://doi.org/10.1002/wrna.1322Journal article
PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells
Chandrakanthan, Vashe, Yeola, Avani, Kwan, Jair C., Oliver, Rema A., Qiao, Qiao, Kang, Young Chan, Zarzour, Peter, Beck, Dominik, Boelen, Lies, Unnikrishnan, Ashwin, Villanueva, Jeanette E., Nunez, Andrea C., Knezevic, Kathy, Palu, Cintia, Nasrallah, Rabab, Carnell, Michael, Macmillan, Alex, Whan, Renee, Yu, Yan, ... Pimanda, John E.. (2016). PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells. Proceedings of the National Academy of Sciences of USA. 113(16), pp. E2306 - E2315. https://doi.org/10.1073/pnas.1518244113Journal article
Defining the minimal factors required for erythropoiesis through direct lineage conversion
Capellera-Garcia, Sandra, Pulecio, Julian, Dhulipala, Kishori, Siva, Kavitha, Rayon-Estrada, Violeta, Singbrant, Sofie, Sommarin, Mikael N. E., Walkley, Carl R., Soneji, Shamit, Karlsson, Göran, Raya, Ángel, Sankaran, Vijay G. and Flygare, Johan. (2016). Defining the minimal factors required for erythropoiesis through direct lineage conversion. Cell Reports. 15(11), pp. 2550 - 2562. https://doi.org/10.1016/j.celrep.2016.05.027Journal article
Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis
Liddicoat, Brian J., Hartner, Jochen C., Piskol, Robert, Ramaswami, Gokul, Chalk, Alistair M., Kingsley, Paul D., Sankaran, Vijay G., Wall, Meaghan, Purton, Louise E., Seeburg, Peter H., Palis, James, Orkin, Stuart H., Lu, Jun, Li, Jin Billy and Walkley, Carl R.. (2016). Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis. Experimental Hematology. 44(10), pp. 947 - 963. https://doi.org/10.1016/j.exphem.2016.06.250Journal article
Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development
Nguyen, Thao M., Arthur, Agnieszka, Paton, Sharon, Hemming, Sarah, Panagopoulos, Romana, Codrington, John D., Walkley, Carl R., Zannettino, Andrew C. W. and Gronthos, Stan. (2016). Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development. Bone. 93, pp. 12 - 21. https://doi.org/10.1016/j.bone.2016.09.009Journal article
Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death
Bhattacharya, S., Chalk, Alistair M., Ng, A. J. M., Martin, T. John, Zannettino, Andrew C. W., Purton, L. E., Lu, J., Baker, E. K. and Walkley, Carl R.. (2016). Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death. Oncogene. 35(40), pp. 5282 - 5294. https://doi.org/10.1038/onc.2016.68Journal article
The transcription factor ASCIZ and its target DYNLL1 are essential for the development and expansion of MYC-driven B cell lymphoma
Wong, David M., Li, ngli Li, Jurado, Sabine, King, Ashleigh, Bamford, Rebecca, Wall, Meaghan, Walia, Mannu K., Kelly, Gemma L., Walkley, Carl R., Tarlinton, David M., Strasser, Andreas and Heierhorst, Jörg. (2016). The transcription factor ASCIZ and its target DYNLL1 are essential for the development and expansion of MYC-driven B cell lymphoma. Cell Reports. 14(6), pp. 1488 - 1499. https://doi.org/10.1016/j.celrep.2016.01.012Journal article
The role of RNA editing by ADAR1 in prevention of innate immune sensing of self-RNA
Heraud-Farlow, Jacki E. and Walkley, Carl R.. (2016). The role of RNA editing by ADAR1 in prevention of innate immune sensing of self-RNA. Journal of Molecular Medicine. 94(10), pp. 1095 - 1102. https://doi.org/10.1007/s00109-016-1416-1Journal article
Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance
Walia, Mannu K., Ho, Patricia M. W., Taylor, Scott, Ng, Alvin J. M., Gupte, Ankita, Chalk, Alistair M., Zannettino, Andrew C. W., Martin, T. John and Walkley, Carl R.. (2016). Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance. eLife. 5(April), pp. 1 - 31. https://doi.org/10.7554/eLife.13446Journal article
IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα
Shekhar, Tanmay M., Miles, Mark A., Gupte, Ankita, Taylor, Scott, Tascone, Brianna, Walkley, Carl R. and Hawkins, Christine J.. (2016). IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα. Oncotarget. 7(23), pp. 33866 - 33886. https://doi.org/10.18632/oncotarget.8980Journal article
Systematic screening identifies dual PI3K and mTOR inhibition as a conserved therapeutic vulnerability in osteosarcoma
Gupte, Ankita, Baker, E. K., Wan, Soo-San, Stewart, Elizabeth, Loh, Amos, Shelat, Anang A., Gould, Cathryn M., Chalk, Alistair M., Taylor, Scott, Lackovic, Kurt, Karlström, Åsa, Mutsaers, Anthony J., Desai, Jayesh, Madhamshettiwar, Piyush B., Zannettino, Andrew C. W., Burns, Christopher J., Huang, David C. S., Dyer, Michael A., Simpson, Kaylene J. and Walkley, Carl. (2015). Systematic screening identifies dual PI3K and mTOR inhibition as a conserved therapeutic vulnerability in osteosarcoma. Clinical Cancer Research. 21(14), pp. 3216 - 3229. https://doi.org/10.1158/1078-0432.CCR-14-3026Journal article
Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma
Baker, Emma K., Taylor, Scott, Gupte, Ankita, Chalk, Alistair M., Bhattacharya, Shreya, Green, Alanna C., Martin, T. John, Strbenac, Dario, Robinson, Mark D., Purton, Louise E. and Walkley, Carl R.. (2015). Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma. Bone. 73, pp. 223 - 232. https://doi.org/10.1016/j.bone.2014.12.063Journal article
Src family kinases and their role in hematological malignancies
Ku, Matthew, Wall, Meaghan, MacKinnon, Ruth N., Walkley, Carl R., Purton, Louise E., Tam, Constantine, Izon, David, Campbell, Lynda, Cheng, Heung-Chin and Nandurkar, Harshal. (2015). Src family kinases and their role in hematological malignancies. Leukemia and Lymphoma. 56(3), pp. 577 - 586. https://doi.org/10.3109/10428194.2014.907897Journal article
HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α
Forristal, C. E., Nowlan, B., Jacobsen, R. N., Barbier, V., Walkinshaw, G., Walkley, Carl, Winkler, I. G. and Levesque, J. P.. (2015). HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α. Leukemia. 29(6), pp. 1366 - 1378. https://doi.org/10.1038/leu.2015.8Journal article
The DNA Helicase Recql4 is required for normal osteoblast expansion and osteosarcoma formation
Ng, A. J. M., Walia, Mannu K., Smeets, Monique F., Mutsaers, Anthony J., Sims, Natalie A., Purton, L. E., Walsh, Nicole C., Martin, T. John and Walkley, Carl. (2015). The DNA Helicase Recql4 is required for normal osteoblast expansion and osteosarcoma formation. PLoS Genetics. 11(4), pp. 1 - 25. https://doi.org/10.1371/journal.pgen.1005160Journal article
BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells
Baker, E. K., Taylor, Scott, Gupte, Ankita, Sharp, Phillip P., Walia, Mannu K., Walsh, Nicole C., Zannettino, Andrew C. W., Chalk, Alistair M., Burns, Christopher J. and Walkley, Carl. (2015). BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells. Scientific Reports. 5, pp. 1 - 14. https://doi.org/10.1038/srep10120Journal article
RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself
Liddicoat, Brian J., Piskol, Robert, Chalk, Alistair M., Ramaswami, Gokul, Higuchi, Miyoko, Hartner, Jochen C., Li, Jin Billy, Seeburg, Peter H. and Walkley, Carl. (2015). RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself. Science. 349(6252), pp. 1115 - 1120. https://doi.org/10.1126/science.aac7049Journal article
Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo
Ho, P. W. M., Goradia, A., Russell, M. R., Chalk, Alistair M., Milley, K. M., Baker, E. K., Danks, J. A., Slavin, John, Walia, Mannu K., Crimeen-Irwin, B., Dickins, R. A., Martin, T. John and Walkley, Carl. (2015). Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo. Oncogene. 34(22), pp. 2922 - 2933. https://doi.org/10.1038/onc.2014.217Journal article
RARγ is a negative regulator of osteoclastogenesis
Green, Alanna C., Poulton, Ingrid J., Vrahnas, Christina, Häusler, Karl D., Walkley, Carl, Wu, Joy Y., Martin, T. John, Gillespie, Matthew T., Chandraratna, Roshantha A. S., Quinn, Julian M. W., Sims, Natalie A. and Purton, L. E.. (2015). RARγ is a negative regulator of osteoclastogenesis. The Journal of Steroid Biochemistry and Molecular Biology. 150, pp. 46 - 53. https://doi.org/10.1016/j.jsbmb.2015.03.005Journal article
Brief report: The differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation
Martin, Sally K., Fitter, Stephen, Dutta, Ankit K., Matthews, Mary P., Walkley, Carl, Hall, Michael N., Ruegg, Markus A., Gronthos, Stan and Zannettino, Andrew C. W.. (2015). Brief report: The differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation. Stem Cells. 33(4), pp. 1359 - 1365. https://doi.org/10.1002/stem.1931Journal article
Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure
Askmyr, Maria, White, Kirby E., Jovic, Tanja, King, Hannah A., Quach, Julie M., Maluenda, Ana C., Baker, E. K., Smeets, Monique F., Walkley, Carl and Purton, L. E.. (2015). Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure. Scientific Reports. 5, pp. 1 - 13. https://doi.org/10.1038/srep15529Journal article
PTHrP, its receptor, and protein kinase A activation in osteosarcoma
Walkley, Carl, Walia, Mannu K., Ho, P.W.M. and Martin, T. J.. (2014). PTHrP, its receptor, and protein kinase A activation in osteosarcoma. Molecular & Cellular Oncology. 1(4), pp. 1 - 3. https://doi.org/10.4161/23723548.2014.965624Journal article
Gene expression profiling to define the cell intrinsic role of the SKI proto-oncogene in hematopoiesis and myeloid neoplsms
Chalk, Alistair M., Liddicoat, Brian J., Walkley, Carl and Singbrant, Sofie. (2014). Gene expression profiling to define the cell intrinsic role of the SKI proto-oncogene in hematopoiesis and myeloid neoplsms. Genomics Data. 2, pp. 189 - 191. https://doi.org/10.1016/j.gdata.2014.06.022Journal article
The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease
Singbrant, Sofie, Wall, Meaghan, Moody, Jennifer, Karlsson, Göran, Chalk, Alistair M., Liddicoat, Brian J., Russell, Megan R., Walkley, Carl R. and Karlsson, Stefan. (2014). The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease. Haematologica. 99(4), pp. 647 - 655. https://doi.org/10.3324/haematol.2013.093971Journal article
The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis
Smeets, Monique F., DeLuca, Elisabetta, Wall, Meaghan, Quach, Julie M., Chalk, Alistair M., Deans, Andrew J., Heierhorst, Jörg, Purton, Louise E., Izon, David J. and Walkley, Carl R.. (2014). The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis. Journal of Clinical Investigation. 124(8), pp. 3551 - 3565. https://doi.org/10.1172/JCI75334Journal article
Cells of origin in osteosarcoma: Mesenchymal stem cells or osteoblast committed cells?
Mutsaers, Anthony J. and Walkley, Carl R.. (2014). Cells of origin in osteosarcoma: Mesenchymal stem cells or osteoblast committed cells? Bone. 62, pp. 56 - 63. https://doi.org/10.1016/j.bone.2014.02.003Journal article
Immune response to rb1-regulated senescence limits radiation-Induced osteosarcoma formation
Kansara, Maya, Leong, Huei San, Lin, Dan Mei, Popkiss, Sophie, Pang, Puiyi, Garsed, Dale W., Walkley, Carl R., Cullinane, Carleen, Ellul, Jason, Haynes, Nicole M., Hicks, Rod, Kuijjer, Marieke L., Cleton-Jansen, Anne-Marie, Hinds, Philip W., Smyth, Mark J. and Thomas, David M.. (2013). Immune response to rb1-regulated senescence limits radiation-Induced osteosarcoma formation. Journal of Clinical Investigation. 123(12), pp. 5351 - 5360. https://doi.org/10.1172/JCI70559Journal article
Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors
Dewamitta, Sita R., Joseph, Chacko, Purton, Louise E. and Walkley, Carl R.. (2013). Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors. British Journal of Haematology. 164(2), pp. 280 - 285. https://doi.org/10.1111/bjh.12578Journal article
Modeling distinct osteosarcoma subtypes in vivo using Cre: Lox and lineage-restricted transgenic shRNA
Mutsaers, Anthony J., Ng, Alvin J. M., Baker, Emma K., Russell, Megan R., Chalk, Alistair M., Wall, Meaghan, Liddicoat, Brian J. J., Ho, Patricia W. M., Slavin, John L., Goradia, Ankita, Martin, T. John, Purton, Louise E., Dickins, Ross A. and Walkley, Carl R.. (2013). Modeling distinct osteosarcoma subtypes in vivo using Cre: Lox and lineage-restricted transgenic shRNA. Bone. 55(1), pp. 166 - 178. https://doi.org/10.1016/j.bone.2013.02.016Journal article
Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone marrow microenvironment
Dewamitta, Sita R., Russell, Megan R., Nandurkar, Harshal and Walkley, Carl R.. (2013). Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone marrow microenvironment. Haematologica. 98(5), pp. 686 - 690. https://doi.org/10.3324/haematol.2012.078709Journal article
Deciphering hematopoietic stem cells in their niches: A critical appraisal of genetic models, lineage tracing, and imaging strategies
Joseph, Chacko, Quach, Julie M., Walkley, Carl R., Lane, Steven W., Celso, Cristina Lo and Purton, Louise E.. (2013). Deciphering hematopoietic stem cells in their niches: A critical appraisal of genetic models, lineage tracing, and imaging strategies. Cell Stem Cell. 13(5), pp. 520 - 533. https://doi.org/10.1016/j.stem.2013.10.010Journal article
The zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim
Jurado, Sabine, Gleeson, Kimberly, O’Donnell, Kristy, Izon, David J., Walkley, Carl R., Strasser, Andreas, Tarlinton, David M. and Heierhorst, Jörg. (2012). The zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim. Journal of Experimental Medicine. 209(9), pp. 1629-1639. https://doi.org/10.1084/jem.20120785Journal article
Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion
Lu, Jiayun, Sun, Yan, Nombela-Arrieta, Cesar, Du, Karrie P., Park, Shin-Young, Chai, Li, Walkley, Carl, Luo, Hongbo R. and Silberstein, Leslie E.. (2012). Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion. Experimental Hematology. 40(4), pp. 307-317. https://doi.org/10.1016/j.exphem.2011.11.010Journal article
Defining the hematopoietic stem cell niche : The chicken and the egg conundrum
Singbrant, Sofie, Askmyr, Maria, Purton, Louise E. and Walkley, Carl R.. (2011). Defining the hematopoietic stem cell niche : The chicken and the egg conundrum. Journal of Cellular Biochemistry. 112(6), pp. 1486-1490. https://doi.org/10.1002/jcb.23085Journal article
Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment
Singbrant, Sofie, Russell, Megan R., Jovic, Tanja, Liddicoat, Brian, Izon, David J., Purton, Louise E., Sims, Natalie A., Martin, T. John, Sankaran, Vijay G. and Walkley, Carl R.. (2011). Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment. Blood. 117(21), pp. 5631-5642. https://doi.org/10.1182/blood-2010-11-320564Journal article
Erythropoiesis, anemia and the bone marrow microenvironment
Walkley, Carl R.. (2011). Erythropoiesis, anemia and the bone marrow microenvironment. International Journal of Hematology. 93, pp. 10-13. https://doi.org/10.1007/s12185-010-0759-6Journal article
Hematopoietic AMPK beta1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
Galic, Sandra, Fullerton, Morgan, Schertzer, Jonathan, Sikkema, Sarah, Marcinko, Katarina, Walkley, Carl, Izon, David, Honeyman, Jane, Chen, Zhi-Ping, Van Denderen, Bryce, Kemp, Bruce and Steinberg, Gregory. (2011). Hematopoietic AMPK beta1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. Journal of Clinical Investigation. 121(12), pp. 4903 - 4915. https://doi.org/10.1172/JCI58577Journal article
Hematopoietic AMPK Beta ß1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity
Galic, Sandra, Fullerton, Morgan D., Schertzer, Jonathan D., Sikkema, Sarah, Marcinko, Katarina, Walkley, Carl R., Izon, David, Honeyman, Jane, Chen, Zhi-Ping, van Denderen, Bryce J., Kemp, Bruce Ernest and Steinberg, Gregory R.. (2011). Hematopoietic AMPK Beta ß1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity. Journal of Clinical Investigation. 121(12), pp. 4903 - 4915. https://doi.org/10.1172/JCI58577Journal article
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