Exercise-induced natural killer cell activation is driven by epigenetic modifications

Journal article

Zimmer, Philipp, Bloch, Wilhelm, Schenk, Alexander, Zopf, Eva M., Hildebrandt, U., Streckmann, F., Beulertz, J., Koliamitra, C., Schollmayer, Friederike and Baumann, F.. (2015). Exercise-induced natural killer cell activation is driven by epigenetic modifications. International Journal of Sports Medicine. 36(6), pp. 510 - 515. https://doi.org/10.1055/s-0034-1398531
AuthorsZimmer, Philipp, Bloch, Wilhelm, Schenk, Alexander, Zopf, Eva M., Hildebrandt, U., Streckmann, F., Beulertz, J., Koliamitra, C., Schollmayer, Friederike and Baumann, F.
Abstract

Exercise has been proven to reduce the risk and progression of various diseases, such as cancer, diabetes and neurodegenerative disorders. Increasing evidence suggests that exercise affects the cytokine profile and changes distribution and function of tumor-competitive immune cells. Initial studies have shown that different exercise interventions are associated with epigenetic modifications in different tissues and cell types, such as muscle, fat, brain and blood. The present investigation examines the effect of an intense endurance run (half marathon) on global epigenetic modifications in natural killer (NK) cells in 14 cancer patients compared to 14 healthy controls. We were able to show that histone acetylation and NKG2D expression, a functional NK cell marker, were elevated for at least 24 h after the run. Thus, this is the first study to present a potential mechanism of how exercise may impact NK cell activity on the subcellular level. Further studies should focus on epigenetic mechanisms and dose-dependent effects of exercise.

Keywordssports; tumor; acetylation; NK-cell; NKG2D; exercise
Year2015
JournalInternational Journal of Sports Medicine
Journal citation36 (6), pp. 510 - 515
PublisherGeorg Thieme Verlag
ISSN0172-4622
Digital Object Identifier (DOI)https://doi.org/10.1055/s-0034-1398531
Scopus EID2-s2.0-84930380222
Page range510 - 515
Research GroupInstitute for Health and Ageing
Publisher's version
File Access Level
Controlled
Place of publicationGermany
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