Associations of neighborhood environment with brain imaging outcomes in the Australian imaging, biomarkers and lifestyle cohort
Journal article
Cerin, Ester, Rainey-Smith, Stephanie R., Ames, David, Lautenschlager, Nicola T., Macaulay, Stuart Lance, Fowler, Chris J., Robertson, Jane M., Rowe, Christopher C., Maruff, Paul Thomas, Martins, Ralph N., Masters, Colin L. and Ellis, Kathryn A.. (2017). Associations of neighborhood environment with brain imaging outcomes in the Australian imaging, biomarkers and lifestyle cohort. Alzheimer's and Dementia. 13(4), pp. 388 - 398. https://doi.org/10.1016/j.jalz.2016.06.2364
Authors | Cerin, Ester, Rainey-Smith, Stephanie R., Ames, David, Lautenschlager, Nicola T., Macaulay, Stuart Lance, Fowler, Chris J., Robertson, Jane M., Rowe, Christopher C., Maruff, Paul Thomas, Martins, Ralph N., Masters, Colin L. and Ellis, Kathryn A. |
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Abstract | Introduction: “Walkable” neighborhoods offer older adults opportunities for activities that may benefit cognition-related biological mechanisms. These have not previously been examined in this context. Methods: We objectively assessed neighborhood walkability for participants (n 5 146) from the Australian Imaging, Biomarkers and Lifestyle study with apolipoprotein E (APOE) genotype and two 18-month-apart brain volumetric and/or amyloid b burden assessments. Linear mixed models estimated associations of neighborhood walkability with levels and changes in brain imaging outcomes, the moderating effect of APOE ε4 status, and the extent to which associations were explained by physical activity. Results: Cross-sectionally, neighborhood walkability was predictive of better neuroimaging outcomes except for left hippocampal volume. These associations were to a small extent explained by physical activity. APOE ε4 carriers showed slower worsening of outcomes if living in walkable neighborhoods. Discussion: These findings indicate associations between neighborhood walkability and brain imaging measures (especially in APOE ε4 carriers) minimally attributable to physical activity. |
Year | 2017 |
Journal | Alzheimer's and Dementia |
Journal citation | 13 (4), pp. 388 - 398 |
Publisher | Elsevier Inc. |
ISSN | 1552-5260 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.jalz.2016.06.2364 |
Scopus EID | 2-s2.0-85000605936 |
Page range | 388 - 398 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | United States |
Editors | Z. S. Khachaturian |
https://acuresearchbank.acu.edu.au/item/876vx/associations-of-neighborhood-environment-with-brain-imaging-outcomes-in-the-australian-imaging-biomarkers-and-lifestyle-cohort
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