Interrupting prolonged sitting in type 2 diabetes: nocturnal persistence of improved glycaemic control
Journal article
Dempsey, Paddy C., Blankenship, Jennifer M., Larsen, Robyn, Sacre, Julian W., Sethi, Parneet, Straznicky, Nora E., Cohen, N., Cerin, Ester, Lambert, Gavin, Owen, Neville, Kingwell, Bronwyn A. and Dunstan, David. (2017). Interrupting prolonged sitting in type 2 diabetes: nocturnal persistence of improved glycaemic control. Diabetologia. 60(3), pp. 499 - 507. https://doi.org/10.1007/s00125-016-4169-z
Authors | Dempsey, Paddy C., Blankenship, Jennifer M., Larsen, Robyn, Sacre, Julian W., Sethi, Parneet, Straznicky, Nora E., Cohen, N., Cerin, Ester, Lambert, Gavin, Owen, Neville, Kingwell, Bronwyn A. and Dunstan, David |
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Abstract | Aims/hypothesis We aimed to examine the effect of interrupting 7 h prolonged sitting with brief bouts of walking or resistance activities on 22 h glucose homeostasis (including nocturnal-to-following morning hyperglycaemia) in adults with type 2 diabetes. Methods This study is an extension of a previously published randomised crossover trial, which included 24 inactive overweight/obese adults with type 2 diabetes (14 men; 62± 6 years) who completed three 7 h laboratory conditions, separated by 6–14 day washout periods: SIT: (1) prolonged sitting (control); (2) light-intensity walking (LW): sitting plus 3 min bouts of light-intensity walking at 3.2 km/h every 30 min; (3) simple resistance activities (SRA): sitting plus 3 min bouts of simple resistance activities (alternating half-squats, calf raises, brief gluteal contractions and knee raises) every 30 min. In the present study, continuous glucose mon-itoring was performed for 22 h, encompassing the 7 h labora-tory trial, the evening free-living period after leaving the lab-oratory and sleeping periods. Meals and meal times were standardised across conditions for all participants. Results Compared with SIT, both LW and SRA reduced 22 h glucose [SIT: 11.6 ± 0.3 mmol/l, LW: 8.9 ± 0.3 mmol/l, SRA: 8.7 ± 0.3 mmol/l; p < 0.001] and nocturnal mean glucose con-centrations [SIT: 10.6 ± 0.4 mmol/l, LW: 8.1 ± 0.4 mmol/l, SRA: 8.3 ± 0.4 mmol/l; p < 0.001]. Furthermore, mean glucose concentrations were sustained nocturnally at a lower level until the morning following the intervention for both LW and SRA (waking glucose both −2.7 ± 0.4 mmol/l compared with SIT; p < 0.001). Conclusions/interpretation Interrupting 7 h prolonged sitting time with either LW or SRA reduced 22 h hyperglycaemia. The glycaemic improvements persisted after these laboratory conditions and nocturnally, until waking the following morn-ing. These findings may have implications for adults with relatively well-controlled type 2 diabetes who engage in prolonged periods of sitting, for example, highly desk-bound workers. Trial registration: anzctr.org.au ACTRN12613000576729 Funding: This research was supported by a National Health and Medical Research Council (NHMRC) project grant (no. 1081734) and the Victorian Government Operational Infrastructure Support scheme. |
Keywords | Cardiometabolic risk; Diabetes; Glycaemic control; Glycaemic variability; Nocturnal glycaemia; Physical activity; Resistance exercise; Sedentary behaviour; Sitting; Walking |
Year | 2017 |
Journal | Diabetologia |
Journal citation | 60 (3), pp. 499 - 507 |
Publisher | Springer |
ISSN | 0012-186X |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s00125-016-4169-z |
Scopus EID | 2-s2.0-85003874468 |
Page range | 499 - 507 |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | File Access Level Controlled |
Place of publication | Germany |
Editors | S. Marshall |
https://acuresearchbank.acu.edu.au/item/89vxw/interrupting-prolonged-sitting-in-type-2-diabetes-nocturnal-persistence-of-improved-glycaemic-control
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