Morning exercise mitigates the impact of prolonged sitting on cerebral blood flow in older adults
Journal article
Wheeler, Michael J., Dunstan, David W., Smith, Brianne, Smith, Kurt J., Scheer, Anna, Lewis, Jaye, Naylor, Louise H., Heinonen, Ilkka, Ellis, Kathryn A., Cerin, Ester, Ainslie, Philip N. and Green, Daniel J.. (2019). Morning exercise mitigates the impact of prolonged sitting on cerebral blood flow in older adults. Journal of Applied Physiology. 126(4), pp. 1049-1055. https://doi.org/10.1152/japplphysiol.00001.2019
Authors | Wheeler, Michael J., Dunstan, David W., Smith, Brianne, Smith, Kurt J., Scheer, Anna, Lewis, Jaye, Naylor, Louise H., Heinonen, Ilkka, Ellis, Kathryn A., Cerin, Ester, Ainslie, Philip N. and Green, Daniel J. |
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Abstract | Preventing declines in cerebral blood flow is important for maintaining optimal brain health with aging. We compared the effects of a morning bout of moderate-intensity exercise, with and without subsequent light-intensity walking breaks from sitting, on cerebral blood velocity over 8 h in older adults. In a randomized crossover trial, overweight/obese older adults (n = 12, 70 ± 7 yr; 30.4 ± 4.3 kg/m2), completed three acute conditions (6-day washout); SIT: prolonged sitting (8 h, control); EX+SIT: sitting (1 h), moderate-intensity walking (30 min), followed by uninterrupted sitting (6.5 h); and EX + BR: sitting (1 h), moderate-intensity walking (30 min), followed by sitting (6.5 h) interrupted with 3 min of light-intensity walking every 30 min. Bilateral middle cerebral artery velocities (MCAv) were determined using transcranial Doppler at 13 time points across the day. The temporal pattern and average MCAv over 8 h was determined. The pattern of MCAv over 8 h was a negative linear trend in SIT (P < 0.001), but a positive quadratic trend in EX + SIT (P < 0.001) and EX + BR (P < 0.01). Afternoon time points in SIT were lower than baseline within condition (P ≤ 0.001 for all). A morning dip in MCAv was observed in EX + SIT and EX + BR (P < 0.05 relative to baseline), but afternoon time points were not significantly lower than baseline. The average MCAv over 8 h was higher in EX + SIT than SIT (P = 0.007) or EX + BR (P = 0.024). Uninterrupted sitting should be avoided, and moderate-intensity exercise should be encouraged for the daily maintenance of cerebral blood flow in older adults. The clinical implications of maintaining adequate cerebral blood flow include the delivery of vital oxygen and nutrients to the brain. |
Keywords | acute exercise; brain health; older adults; sedentary behavior; transcranial Doppler |
Year | 2019 |
Journal | Journal of Applied Physiology |
Journal citation | 126 (4), pp. 1049-1055 |
Publisher | American Physiological Society |
ISSN | 8750-7587 |
Digital Object Identifier (DOI) | https://doi.org/10.1152/japplphysiol.00001.2019 |
Scopus EID | 2-s2.0-85064950079 |
Open access | Published as green open access |
Page range | 1049-1055 |
Funder | National Health and Medical Research Council (NHMRC) |
University of Western Australia | |
Baker Heart and Diabetes Institute | |
University of Turku (UTU) | |
Hospital District of South-West Finland | |
Juho Vainio Foundation | |
Australian Research Council (ARC) | |
Canada Research Chairs Program | |
Research Group | Mary MacKillop Institute for Health Research |
Author's accepted manuscript | License All rights reserved File Access Level Open |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 07 Feb 2019 |
Publication process dates | |
Accepted | 01 Feb 2019 |
ARC Funded Research | This output has been funded, wholly or partially, under the Australian Research Council Act 2001 |
Grant ID | 1062338 |
1078360 | |
FT140100085 | |
1080914 |
https://acuresearchbank.acu.edu.au/item/899qx/morning-exercise-mitigates-the-impact-of-prolonged-sitting-on-cerebral-blood-flow-in-older-adults
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File access level: Open |
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