Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: A systematic analysis for the Global Burden of Disease Study 2016

Journal article


GBD 2016 Mortality Collaborators, , Wang, Haidong, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abera, Semaw Ferede, Abraha, Haftom Niguse, Abu-Raddad, Laith J., Abu-Rmeileh, Niveen M. E., Adedeji, Isaac Akinkunmi, Adedoyin, Rufus Adesoji, Adetifa, Ifedayo Morayo O., Adetokunboh, Olatunji, Afshin, Ashkan, Aggarwal, Rakesh, Agrawal, Anurag, Agrawal, Sutapa, ... GBD 2016 Mortality Collaborators. (2017) Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970-2016: A systematic analysis for the Global Burden of Disease Study 2016. The Lancet. 390(10100), pp. 1084 - 1150. https://doi.org/10.1016/S0140-6736(17)31833-0
AuthorsGBD 2016 Mortality Collaborators, , Wang, Haidong, Abajobir, Amanuel Alemu, Abate, Kalkidan Hassen, Abbafati, Cristiana, Abbas, Kaja M., Abd-Allah, Foad, Abera, Semaw Ferede, Abraha, Haftom Niguse, Abu-Raddad, Laith J., Abu-Rmeileh, Niveen M. E., Adedeji, Isaac Akinkunmi, Adedoyin, Rufus Adesoji, Adetifa, Ifedayo Morayo O., Adetokunboh, Olatunji, Afshin, Ashkan, Aggarwal, Rakesh, Agrawal, Anurag, Agrawal, Sutapa, Kiadaliri, Aliasghar Ahmad, Ahmed, Muktar Beshir, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Eddine, Aiyar, Sneha, Akanda, Ali Shafqat, Akinyemiju, Tomi F., Akseer, Nadia, Al-Eyadhy, Ayman, Al Lami, Faris Hasan, Szoeke, Cassandra E. I. and GBD 2016 Mortality Collaborators
Abstract

Background Detailed assessments of mortality patterns, particularly age-specific mortality, represent a crucial input that enables health systems to target interventions to specific populations. Understanding how all-cause mortality has changed with respect to development status can identify exemplars for best practice. To accomplish this, the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) estimated age-specific and sex-specific all-cause mortality between 1970 and 2016 for 195 countries and territories and at the subnational level for the five countries with a population greater than 200 million in 2016. Methods We have evaluated how well civil registration systems captured deaths using a set of demographic methods called death distribution methods for adults and from consideration of survey and census data for children younger than 5 years. We generated an overall assessment of completeness of registration of deaths by dividing registered deaths in each location-year by our estimate of all-age deaths generated from our overall estimation process. For 163 locations, including subnational units in countries with a population greater than 200 million with complete vital registration (VR) systems, our estimates were largely driven by the observed data, with corrections for small fluctuations in numbers and estimation for recent years where there were lags in data reporting (lags were variable by location, generally between 1 year and 6 years). For other locations, we took advantage of different data sources available to measure under-5 mortality rates (U5MR) using complete birth histories, summary birth histories, and incomplete VR with adjustments; we measured adult mortality rate (the probability of death in individuals aged 15–60 years) using adjusted incomplete VR, sibling histories, and household death recall. We used the U5MR and adult mortality rate, together with crude death rate due to HIV in the GBD model life table system, to estimate age-specific and sex-specific death rates for each location-year. Using various international databases, we identified fatal discontinuities, which we defined as increases in the death rate of more than one death per million, resulting from conflict and terrorism, natural disasters, major transport or technological accidents, and a subset of epidemic infectious diseases; these were added to estimates in the relevant years. In 47 countries with an identified peak adult prevalence for HIV/AIDS of more than 0·5% and where VR systems were less than 65% complete, we informed our estimates of age-sex-specific mortality using the Estimation and Projection Package (EPP)-Spectrum model fitted to national HIV/AIDS prevalence surveys and antenatal clinic serosurveillance systems. We estimated stillbirths, early neonatal, late neonatal, and childhood mortality using both survey and VR data in spatiotemporal Gaussian process regression models. We estimated abridged life tables for all location-years using age-specific death rates. We grouped locations into development quintiles based on the Socio-demographic Index (SDI) and analysed mortality trends by quintile. Using spline regression, we estimated the expected mortality rate for each age-sex group as a function of SDI. We identified countries with higher life expectancy than expected by comparing observed life expectancy to anticipated life expectancy on the basis of development status alone. Findings Completeness in the registration of deaths increased from 28% in 1970 to a peak of 45% in 2013; completeness was lower after 2013 because of lags in reporting. Total deaths in children younger than 5 years decreased from 1970 to 2016, and slower decreases occurred at ages 5–24 years. By contrast, numbers of adult deaths increased in each 5-year age bracket above the age of 25 years. The distribution of annualised rates of change in age-specific mortality rate differed over the period 2000 to 2016 compared with earlier decades: increasing annualised rates of change were less frequent, although rising annualised rates of change still occurred in some locations, particularly for adolescent and younger adult age groups. Rates of stillbirths and under-5 mortality both decreased globally from 1970. Evidence for global convergence of death rates was mixed; although the absolute difference between age-standardised death rates narrowed between countries at the lowest and highest levels of SDI, the ratio of these death rates—a measure of relative inequality—increased slightly. There was a strong shift between 1970 and 2016 toward higher life expectancy, most noticeably at higher levels of SDI. Among countries with populations greater than 1 million in 2016, life expectancy at birth was highest for women in Japan, at 86·9 years (95% UI 86·7–87·2), and for men in Singapore, at 81·3 years (78·8–83·7) in 2016. Male life expectancy was generally lower than female life expectancy between 1970 and 2016, and the gap between male and female life expectancy increased with progression to higher levels of SDI. Some countries with exceptional health performance in 1990 in terms of the difference in observed to expected life expectancy at birth had slower progress on the same measure in 2016. Interpretation Globally, mortality rates have decreased across all age groups over the past five decades, with the largest improvements occurring among children younger than 5 years. However, at the national level, considerable heterogeneity remains in terms of both level and rate of changes in age-specific mortality; increases in mortality for certain age groups occurred in some locations. We found evidence that the absolute gap between countries in age-specific death rates has declined, although the relative gap for some age-sex groups increased. Countries that now lead in terms of having higher observed life expectancy than that expected on the basis of development alone, or locations that have either increased this advantage or rapidly decreased the deficit from expected levels, could provide insight into the means to accelerate progress in nations where progress has stalled. Funding Bill & Melinda Gates Foundation, and the National Institute on Aging and the National Institute of Mental Health of the National Institutes of Health.

Year2017
JournalThe Lancet
Journal citation390 (10100), pp. 1084 - 1150
PublisherLancet Publishing Group
ISSN0140-6736
Digital Object Identifier (DOI)https://doi.org/10.1016/S0140-6736(17)31833-0
Scopus EID2-s2.0-85031719180
Open accessOpen access
Page range1084 - 1150
Research GroupSchool of Philosophy
Publisher's version
License
Grant IDNHMRC/1056929
Additional information

Please refer to the full article for a complete list of the GBD 2016 Mortality Collaborators.

Place of publicationUnited Kingdom
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Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: A systematic analysis for the Global Burden of Disease Study 2015
Wang, Haidong, Naghavi, Mohsen, Allen, Christine, Barber, Ryan M., Bhutta, Zulfiqar A., Carter, Austin, Casey, Daniel C., Charlson, Fiona J., Chen, Alan Zian, Coates, Matthew M., Coggeshall, Megan, Dandona, Lalit, Dicker, Daniel J., Erskine, Holly E., Ferrari, Alize J., Fitzmaurice, Christina, Foreman, Kyle, Forouzanfar, Mohammad H., Fraser, Maya S., ... GBD 2015 Mortality and Causes of Death Collaborators. (2016) Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: A systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 388(10053), pp. 1459 - 1544. https://doi.org/10.1016/S0140-6736(16)31012-1
Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990--2015: a systematic analysis for the Global Burden of Disease Study 2015
Vos, Theo, Allen, Christine, Arora, Megha, Barber, Ryan M., Bhutta, Zulfiqar A., Brown, Alexandria, Carter, Austin, Casey, Daniel C., Charlson, Fiona J., Chen, Alan Z., Coggeshall, Megan, Cornaby, Leslie, Dandona, Lalit, Dicker, Daniel J., Dilegge, Tina, Erskine, Holly E., Ferrari, Alize J., Fitzmaurice, Christina, Fleming, Tom, ... Murray, Christopher J. L.. (2016) Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990--2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 388(10053), pp. 1545 - 1602. https://doi.org/10.1016/S0140-6736(16)31678-6
Phenomenological characterization of memory complaints in preclinical and prodromal Alzheimer's disease
Buckley, Rachel F., Ellis, Kathryn A., Ames, David, Rowe, Christopher C., Lautenschlager, Nicola T., Maruff, Paul Thomas, Villemagne, Victor L., Macaulay, S. Lance, Szoeke, Cassandra, Martins, Ralph N., Masters, Colin L., Savage, Greg, Rainey-Smith, Stephanie R., Rembach, Alan R. and Saling, Michael M.. (2015) Phenomenological characterization of memory complaints in preclinical and prodromal Alzheimer's disease. Neuropsychology. https://doi.org/10.1037/neu0000156
Grandparenting predicts late-life cognition: Results from the Women's Healthy Ageing Project
Burn, Katherine F. and Szoeke, Cassandra. (2015) Grandparenting predicts late-life cognition: Results from the Women's Healthy Ageing Project. Maturitas. https://doi.org/10.1016/j.maturitas.2015.03.013
Longitudinal cognitive decline in the AIBL cohort: The role of APOE E4 status
Albrecht, Matthew A., Szoeke, Cassandra, Maruff, Paul Thomas, Savage, Greg, Lautenschlager, Nicola T., Ellis, Kathryn A., Taddei, Kevin, Martins, Ralph N., Masters, Colin L., Ames, David and Foster, Jonathan K.. (2015) Longitudinal cognitive decline in the AIBL cohort: The role of APOE E4 status. Neuropsychologia. https://doi.org/10.1016/j.jalz.2014.04.303
Evaluating the effects of increasing physical activity to optimize rehabilitation outcomes in hospitalized older adults (MOVE Trial): Study protocol for a randomized controlled trial
Said, Catherine M., Morris, Meg E., McGinley, Jennifer L., Szoeke, Cassandra, Workman, Barbara, Liew, Danny, Hill, Keith David, Woodward, Michael Clifford, Wittwer, Joanne E., Churilov, Leonid, Ventura, Cameron and Bernhardt, Julie. (2015) Evaluating the effects of increasing physical activity to optimize rehabilitation outcomes in hospitalized older adults (MOVE Trial): Study protocol for a randomized controlled trial. Trials. 16(1), pp. 1 - 9. https://doi.org/10.1186/s13063-014-0531-y
Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease
Kerestes, Rebecca, Phal, Pramit M., Steward, Chris, Moffat, Bradford A., Salinas, Simon, Cox, Kay L., Ellis, Kathryn A., Cyarto, Elizabeth V., Ames, David, Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Sharman, Matthew J., Salvado, Oliver, Szoeke, Cassandra, Lai, Michelle, Lautenschlager, Nicola T. and Desmond, Patricia M.. (2015) Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease. BJPsych Open. 1(2), pp. 139 - 148. https://doi.org/10.1192/bjpo.bp.115.001339
Is grandparenting a form of social engagement that benefits cognition in ageing?
Burn, Katherine F. and Szoeke, Cassandra. (2015) Is grandparenting a form of social engagement that benefits cognition in ageing? Maturitas. 80(2), pp. 122 - 125. https://doi.org/10.1016/j.maturitas.2014.10.017
Semi-automated hippocampal segmentation in people with cognitive impairment using an age appropriate template for registration
Merkel, Bernd, Steward, Christopher, Vivash, Lucy, Malpas, Charles B., Phal, Pramit, Moffat, Bradford A., Cox, Kay L., Ellis, Kathryn A., Ames, David J., Cyarto, Elizabeth V., Lai, Michelle M. Y., Sharman, Matthew J., Szoeke, Cassandra, Masters, Colin L., Lautenschlager, Nicola T. and Desmond, Patricia. (2015) Semi-automated hippocampal segmentation in people with cognitive impairment using an age appropriate template for registration. Journal of Magnetic Resonance Imaging. https://doi.org/10.1002/jmri.24966
Dietary patterns and cognitive decline in an Australian study of ageing
Gardener, S. L., Rainey-Smith, Stephanie R., Barnes, Margaret, Sohrabi, H. R., Weinborn, M., Lim, Yen Ying, Harrington, Karra D., Taddei, Kevin, Gu, Yian, Rembach, Alan R., Szoeke, Cassandra, Ellis, Kathryn A., Masters, C. L., Macaulay, Stuart Lance, Rowe, Christopher C., Ames, David, Keogh, Jennifer B., Scarmeas, Nikolaos and Martins, Ralph N.. (2015) Dietary patterns and cognitive decline in an Australian study of ageing. Molecular Psychiatry. https://doi.org/10.1038/mp.2014.79
Prehypertension in midlife is associated with worse cognition a decade later in middle-aged and older women
Chen, Karen, Henderson, Victor, Stolwyk, Rene, Dennerstein, Lorraine and Szoeke, Cassandra. (2015) Prehypertension in midlife is associated with worse cognition a decade later in middle-aged and older women. Age and Ageing. https://doi.org/10.1093/ageing/afv026
Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study
Pietrzak, Robert H., Scott, James, Neumeister, Alexander, Lim, Yen Ying, Ames, David, Ellis, Kathryn A., Harrington, Karra D., Lautenschlager, Nicola T., Szoeke, Cassandra, Martins, Ralph N., Masters, Colin L., Villemagne, Victor L., Rowe, Christopher C. and Maruff, Paul Thomas. (2014) Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study. British Journal of Psychiatry. https://doi.org/10.1192/bjp.bp.113.134239
Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL)
Ellis, Kathryn A., Szoeke, Cassandra, Bush, Ashley I., Darby, David, Graham, Petra, Lautenschlager, Nicola T., Macaulay, S Lance, Martins, Ralph N., Maruff, Paul Thomas, Masters, Colin L., McBride, Simon J., Pike, Kerryn E., Rainey-Smith, Stephanie R., Rembach, Alan R., Robertson, Joanne, Rowe, Christopher C., Savage, Greg, Villemagne, Victor L., Woodward, Michael Clifford, ... Ames, David. (2014) Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL). International Psychogeriatrics. https://doi.org/10.1017/S1041610213001956
Aß and cognitive change: Examining the preclinical and prodromal stages of Alzheimer's disease
Lim, Yen Ying, Maruff, Paul Thomas, Pietrzak, Robert H., Ellis, Kathryn A., Darby, David, -, David Ames, Harrington, Karra J., Martins, Ralph N., Masters, Colin L., Szoeke, Cassandra, Savage, Greg, Villemagne, Victor L. and Rowe, Christopher C.. (2014) Aß and cognitive change: Examining the preclinical and prodromal stages of Alzheimer's disease. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2013.11.005
Incidence of cerebral microbleeds in preclinical Alzheimer disease
Yates, Paul A., Desmond, Patricia M., Phal, Pramit M., Steward, Christopher, Szoeke, Cassandra, Salvado, Olivier, Ellis, Kathryn A., Martins, Ralph N., Masters, Colin L., Ames, David, Villemagne, Victor L. and Rowe, Christopher C.. (2014) Incidence of cerebral microbleeds in preclinical Alzheimer disease. Neurology. https://doi.org/10.1212/WNL.0000000000000285
Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: Combined data from three cohorts
Moore, Eileen, Ames, David, Mander, Alastair, Carne, Ross, Brodaty, Henry, Woodward, Michael Clifford, Boundy, Karen, Ellis, Kathryn A., Bush, Ashley I., Faux, Noel G., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Szoeke, Cassandra and Watters, David. (2014) Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: Combined data from three cohorts. Journal of Alzheimer's Disease. https://doi.org/10.3233/JAD-131265
Associations between gonadotropins, testosterone and ß amyloid in men at risk of Alzheimer's disease
Verdile, G., Laws, S. M., Henley, D., Ames, David, Bush, A. I., Ellis, Kathryn A., Faux, N. G., Gupta, V. B., Li, Q., Masters, C L., Pike, K E., Rowe, C. C., Szoeke, Cassandra, Taddei, K., Villemagne, V. L. and Martins, R. N.. (2014) Associations between gonadotropins, testosterone and ß amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry. https://doi.org/10.1038/mp.2012.147
Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease
Lim, Yen Ying, Maruff, Paul Thomas, Pietrzak, Robert H., Ames, David, Ellis, Kathryn A., Harrington, Karra J., Lautenschlager, Nicola T., Szoeke, Cassandra, Martins, Ralph N., Masters, Colin L., Villemagne, Victor L. and Rowe, Christopher C.. (2014) Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease. Brain. 137(1), pp. 221 - 231. https://doi.org/10.1093/brain/awt286
Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults
Buckley, Rachel F., Saling, Michael M., Irish, Muireann, Ames, David, Rowe, Christopher C., Villemagne, Victor L., Lautenschlager, Nicola T., Maruff, Paul Thomas, Macaulay, S Lance, Martins, Ralph N., Szoeke, Cassandra, Masters, Colin L., Rainey-Smith, Stephanie R., Rembach, Alan R., Savage, Greg and Ellis, Kathryn A.. (2014) Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults. International Psychogeriatrics. https://doi.org/10.1017/S1041610214001136
Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease
Rembach, Alan R., Gaux, Noel G., Watt, Andrew D., Pertile, Kelly Kathleen, Rumble, Rebecca L., Trounson, Brett O., Fowler, Christopher J., Roberts, Blaine R., Perez, Keyla A., Li, Qiaoxin, Laws, Simon M., Taddei, Kevin, Rainey-Smith, Stephanie R., Robertson, Joanne, Vandijck, Manu LJ, Vanderstichele, Hugo M. J., Barnham, Kevin Jeffrey, Ellis, Kathryn A., Szoeke, Cassandra, ... Masters, Colin L.. (2014) Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2012.12.006
Genetic algorithm with logistic regression for prediction of progression to Alzheimer's disease
Johnson, Piers, Vandewater, Luke, Wilson, William, Maruff, Paul Thomas, Savage, Greg, Graham, Petra, Macaulay, Lance S., Ellis, Kathryn A., Szoeke, Cassandra, Martins, Ralph N., Rowe, Christopher C., Masters, Colin L., Ames, David and Zhang, Ping. (2014) Genetic algorithm with logistic regression for prediction of progression to Alzheimer's disease. BMC Bioinformatics. 15(S11), pp. 1 - 14. https://doi.org/10.1186/1471-2105-15-S16-S11
Dehydroepiandrosterone sulfate and cognition in midlife, post-menopausal women
Chua, Catherine K.Z., Henderson, Victor W., Dennerstein, Lorraine, Ames, David and Szoeke, Cassandra. (2014) Dehydroepiandrosterone sulfate and cognition in midlife, post-menopausal women. Neurobiology of Aging. 35(7), pp. 1654 - 1655. https://doi.org/10.1016/j.neurobiolaging.2014.01.140
The Women's Healthy Ageing Project: Fertile ground for investigation of healthy participants 'at risk' for dementia
Szoeke, Cassandra, Robertson, Joanne, Rowe, Christopher C., Yates, Paul A., Campbell, Katherine, Masters, C. L., Ames, David, Dennerstein, L. and Desmond, P.. (2013) The Women's Healthy Ageing Project: Fertile ground for investigation of healthy participants 'at risk' for dementia. International Review of Psychiatry. https://doi.org/10.3109/09540261.2013.873394
Lack of reliable evidence for a distinctive e4-related cognitive phenotype that is independent from clinical diagnostic status: Findings from the Australian Imaging, Biomarkers and Lifestyle Study
Foster, Jonathan, Albrecht, Matthew A., Savage, Greg, Lautenschlager, Nicola T., Ellis, Kathryn A., Maruff, Paul Thomas, Szoeke, Cassandra, Taddei, Kevin, Martins, Ralph N., Masters, Colin L. and Ames, David. (2013) Lack of reliable evidence for a distinctive e4-related cognitive phenotype that is independent from clinical diagnostic status: Findings from the Australian Imaging, Biomarkers and Lifestyle Study. Brain. https://doi.org/10.1093/brain/awt127
Aß amyloid, cognition, and APOE genotype in healthy older adults
Lim, Yen Ying, Ellis, Kathryn A., Ames, David, Darby, David, Harrington, Karra J., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg, Szoeke, Cassandra, Villemagne, Victor L. and Maruff, Paul Thomas. (2013) Aß amyloid, cognition, and APOE genotype in healthy older adults. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2012.07.004
Physical activity and amyloid-Beta plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing
Brown, Belinda M., Peiffer, J. J., Taddei, Kevin, Lui, J. K., Laws, Simon M., Gupta, V. B., Taddei, Tania, Ward, Vanessa K., Rodrigues, Mark A., Burnham, Samantha, Rainey-Smith, Stephanie R., Villemagne, Victor L., Bush, Ashley I., Ellis, Kathryn A., Masters, Colin L., Ames, David, Macaulay, S. Lance, Szoeke, Cassandra, Rowe, Christopher C. and Martins, Ralph N.. (2013) Physical activity and amyloid-Beta plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry. https://doi.org/10.1038/mp.2012.107
Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease
Frost, Shaun M., Kanagasinam, Yogesan, Sohrabi, Hamid R., Vignarajan, Janardhan, Bourgeat, Pierrick T., Salvado, Oliver, Villemagne, Victor Luis, Rowe, Christopher C., Macaulay, S. Lance, Szoeke, Cassandra, Ellis, Kathryn A., Ames, David, Masters, Colin L., Rainey-Smith, Stephanie R. and Martins, Ralph N.. (2013) Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease. Translational Psychiatry. https://doi.org/10.1038/tp.2012.150
Normative Data for the Tower Of London Performance in Australian Midlife Women
Lee, Young Eun C., Anderson, Jacqueline F., Dennerstein, Lorraine, Henderson, Victor W. and Szoeke, Cassandra. (2013) Normative Data for the Tower Of London Performance in Australian Midlife Women. Australian Psychologist. https://doi.org/10.1111/ap.12033
Factors affecting subjective memory complaints in the AIBL aging study: Biomarkers, memory, affect, and age
Buckley, Rachel F., Saling, Michael M., Ames, David, Rowe, Christopher C., Lautenschlager, Nicola T., Macaulay, S. Lance, Martins, Ralph N., Masters, Colin L., O'Meara, T., Savage, Greg, Szoeke, Cassandra, Villemagne, Victor L. and Ellis, Kathryn A.. (2013) Factors affecting subjective memory complaints in the AIBL aging study: Biomarkers, memory, affect, and age. International Psychogeriatrics. https://doi.org/10.1017/S1041610213000665
Predicting Alzheimer disease with beta-amyloid imaging: Results from the Australian imaging, biomarkers, and lifestyle study of ageing
Rowe, Christopher C., Bourgeat, Pierrick, Ellis, Kathryn A., Brown, Belinda M., Lim, Yen Ying, Mulligan, Rachel, Jones, Gareth, Maruff, Paul Thomas, Woodward, Michael Clifford, Price, Roger Ian, Robins, Peter, Tochon-Danguy, Henri, O'Keefe, Graeme, Pike, Kerryn E., Yates, Patsy, Szoeke, Cassandra, Salvado, Olivier, Macaulay, S. Lance, O'Meara, Timothy, ... Villemagne, Victor L.. (2013) Predicting Alzheimer disease with beta-amyloid imaging: Results from the Australian imaging, biomarkers, and lifestyle study of ageing. Annals of Neurology. https://doi.org/10.1002/ana.24040
Cognitive consequences of high Aß amyloid in mild cognitive impairment and healthy older adults: Implications for early detection of alzheimer's disease
Lim, Yen Ying, Ellis, Kathryn A., Harrington, Karra J., Kamer, Adrian, Pietrzak, Robert H., Bush, Ashley I., Darby, David G., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg R., Szoeke, Cassandra, Villemagne, Victor L., Ames, David and Maruff, Paul Thomas. (2013) Cognitive consequences of high Aß amyloid in mild cognitive impairment and healthy older adults: Implications for early detection of alzheimer's disease. Neuropsychology. https://doi.org/10.1037/a0032321
Research and standardization in Alzheimer's trials: Reaching international consensus
Carillo, Maria C., Rowe, Christopher C., Szoeke, Cassandra, Masters, Colin L., Ames, David, O'Meara, Timothy, Macaulay, S Lance, Milner, Andrew, Ellis, Kathryn A., Maruff, Paul Thomas, Rainey-Smith, Stephanie R., Martins, Ralph N., Bain, Lisa J. and Head, Richard. (2013) Research and standardization in Alzheimer's trials: Reaching international consensus. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2012.10.006
Cognitive decline in adults with amnestic mild cognitive impairment and high amyloid-: Prodromal Alzheimer's disease?
Lim, Yen Ying, Ellis, Kathryn A., Harrington, Karra J., Pietrzak, Robert H., Gale, Joanne, Ames, David, Bush, Ashley I., -, David Darby, Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg, Szoeke, Cassandra, Villemagne, Victor L. and Maruff, Paul Thomas. (2013) Cognitive decline in adults with amnestic mild cognitive impairment and high amyloid-: Prodromal Alzheimer's disease? Journal of Alzheimer's Disease. https://doi.org/10.3233/JAD-121771
Three-month stability of the cogstate brief battery in healthy older adults, mild cognitive impairment, and alzheimer's disease: Results from the Australian imaging, biomarkers, and lifestyle-rate of change substudy (AIBL-ROCS)
Lim, Yen Ying, Jaeger, Judith, Harrington, Karra J., Ashwood, Tim J., Ellis, Kathryn A., Stoffler, Albrecht, Szoeke, Cassandra, -, Rebecca Lachovitzki, Martins, Ralph N., Villemagne, Victor L., Bush, Ashley I., Masters, Colin L., Rowe, Christopher C., Ames, David, Darby, David and Maruff, Paul Thomas. (2013) Three-month stability of the cogstate brief battery in healthy older adults, mild cognitive impairment, and alzheimer's disease: Results from the Australian imaging, biomarkers, and lifestyle-rate of change substudy (AIBL-ROCS). Archives of Clinical Neuropsychology. https://doi.org/10.1093/arclin/act021
Amyloid ß deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study
Villemagne, Victor L., Burnham, Samantha, Bourgeat, Pierrick, Brown, Belinda M., Ellis, Kathryn A., Salvado, Olivier, Szoeke, Cassandra, Macaulay, S. Lance, Martins, Ralph N., Maruff, Paul Thomas, Ames, David, Rowe, Christopher C. and Masters, Colin L.. (2013) Amyloid ß deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study. The Lancet Neurology. https://doi.org/10.1016/S1474-4422(13)70044-9
The association of ABeta amyloid and composite cognitive measures in healthy older adults and MCI
Harrington, Karra J., Lim, Yen Ying, Ellis, Kathryn A., Copolov, Carly, Darby, D, Weinborn, M., Ames, David, Martins, R. N., Savage, G., Szoeke, Cassandra, Rowe, C. C., Villemagne, V. L., Masters, C. L. and Maruff, Paul Thomas. (2013) The association of ABeta amyloid and composite cognitive measures in healthy older adults and MCI. International Psychogeriatrics. https://doi.org/10.1017/S1041610213001087
Increased risk of cognitive impairment in patients with diabetes is associated with metformin
Moore, Eileen, Mander, Alastair, Ames, David, Kotowicz, Mark A., Carne, Ross, Brodaty, Henry, Woodward, Michael Clifford, Boundy, Karen, Ellis, Kathryn A., Bush, Ashley I., Faux, Noel G., Martins, Ralph N., Szoeke, Cassandra, Rowe, Christopher C. and Watters, David. (2013) Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes Care. https://doi.org/10.2337/dc13-0229
Decline in cognitive function over 18 months in healthy older adults with high amyloid-beta
Ellis, Kathryn A., Lim, Yen Ying, Harrington, Karra J., Ames, David, Bush, Ashley I., Darby, David, Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg, Szoeke, Cassandra, Villemagne, Victor L. and Maruff, Paul Thomas. (2013) Decline in cognitive function over 18 months in healthy older adults with high amyloid-beta. Journal of Alzheimer's Disease. https://doi.org/10.3233/JAD-122170
Intense physical activity is associated with cognitive performance in the elderly
Brown, Belinda M., Peiffer, John, Sohrabi, Hamid R., Mondal, Alinda, Gupta, Veer B. A., Rainey-Smith, Stephanie R., Taddei, Kevin, Burnham, Samantha C., Ellis, Kathryn A., Szoeke, Cassandra, Masters, Colin L., Ames, David, Rowe, Christopher C. and Martins, Ralph N.. (2012) Intense physical activity is associated with cognitive performance in the elderly. Translational Psychiatry. https://doi.org/10.1038/tp.2012.118
Oestrogen alpha-receptor variant and two-year memory decline in midlife Australian women
Bousman, Chad, Szoeke, Cassandra, Chen, Karen, Dennerstein, Lorraine, Henderson, Victor W. and Everall, Ian P.. (2012) Oestrogen alpha-receptor variant and two-year memory decline in midlife Australian women. Neuropsychobiology. https://doi.org/10.1159/000341879
Cortical surface mapping using topology correction, partial flattening and 3D shape context-based non-rigid registration for use in quantifying atrophy in Alzheimer's disease
Acosta, Oscar, Fripp, Jurgen, Dore, Vincent, Bourgeat, Pierrick, Favreau, Jean-Marie, Chetelat, Gael, Rueda, Andrea, Villemagne, Victor L., Szoeke, Cassandra, Ames, David, Ellis, Kathryn A., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Bonner, Erik, Gris, Florence, Xiao, Di, Raniga, Parnesh, Barra, Vincent and Salvado, Olivier. (2012) Cortical surface mapping using topology correction, partial flattening and 3D shape context-based non-rigid registration for use in quantifying atrophy in Alzheimer's disease. Journal of Neuroscience Methods. https://doi.org/10.1016/j.jneumeth.2011.12.011
Blood-based protein biomarkers for diagnosis of Alzheimer disease
Doecke, James D., Laws, Simon M., Faux, Noel G., Wilson, William, Burnham, Samantha, Lam, Chiou Peng, Mondal, Alinda, Bedo, Justin, Bush, Ashley I., Brown, Belinda M., De Ruyck, Karl, Ellis, Kathryn A., Fowler, Christopher J., Gupta, V. B., Head, Richard, Macaulay, S. Lance, Pertile, Kelly K., Rowe, Christopher C., Rembach, Alan R., ... Martins, Ralph N.. (2012) Blood-based protein biomarkers for diagnosis of Alzheimer disease. Archives of Neurology. https://doi.org/10.1001/archneurol.2012.1282
Predictors of rapid cognitive decline in Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing
Sona, Alessano, Zhang, Ping, Ames, David, Bush, Ashley I., Lautenschlager, Nicola T., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Szoeke, Cassandra, Taddei, Kevin and Ellis, Kathryn A.. (2012) Predictors of rapid cognitive decline in Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing. International Psychogeriatrics. https://doi.org/10.1017/S1041610211001335
Hormone levels and cognitive function in postmenopausal midlife women
Ryan, Joanne L., Stanczyk, Frank Z., Dennerstein, Lorraine, Mack, Wendy J., Clark, Margaret S., Szoeke, Cassandra, Kildea, Daniel George and Henderson, Victor W.. (2012) Hormone levels and cognitive function in postmenopausal midlife women. Neurobiology of Aging. 33(3), pp. 617.e11 - 617.e22. https://doi.org/10.1016/j.neurobiolaging.2010.07.014
Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults
Lim, Yen Ying, Ellis, Kathryn A., Pietrzak, Robert H., Ames, David, Darby, David, Harrington, Karra J., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg, Szoeke, Cassandra, Villemagne, Victor L. and Maruff, Paul Thomas. (2012) Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults. Neurology. https://doi.org/10.1212/WNL.0b013e31826e9ae6
Use of the CogState Brief Battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study
Lim, Yen Ying, Ellis, Kathryn A., Harrington, Karra J., Ames, David, Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg, Szoeke, Cassandra, Darby, David and Maruff, Paul Thomas. (2012) Use of the CogState Brief Battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Clinical and Experimental Neuropsychology. https://doi.org/10.1080/13803395.2011.643227
Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population
Gardener, Samantha L., Gu, Yian, Rainey-Smith, Stephanie R., Keogh, Jennifer B., Clifton, Peter Marshall, Mathieson, S. L., Taddei, Kevin, Mondal, Alinda, Ward, Vanessa K., Scarmeas, Nikolaos, Barnes, Margaret, Ellis, Kathryn A., Head, Richard, Masters, Colin L., Ames, David, Macaulay, Stuart Lance, Rowe, Christopher C., Szoeke, Cassandra and Martins, Ralph N.. (2012) Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population. Translational Psychiatry. https://doi.org/10.1038/tp.2012.91
Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study
Pike, Kerryn E., Ellis, Kathryn A., Villemagne, Victor L., Good, Norm, Chetelat, Gael, Ames, David, Szoeke, Cassandra, Laws, Simon M., Verdile, Giuseppe, Martins, Ralph N., Masters, Colin L. and Rowe, Christopher C.. (2011) Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study. Neuropsychologia. https://doi.org/10.1016/j.neuropsychologia.2011.04.012
Advances in structural and molecular neuroimaging in Alzheimer's disease
Ellis, Kathryn A., Rowe, Christopher C., Szoeke, Cassandra E. I., Villemagne, Victor L., Ames, David, Chetelat, Gael, Martins, Ralph N., Masters, Colin L., Fripp, Jurgen, Acosta, Oscar, Raniga, Parnesh, Bourgeat, Pierrick T. and Salvado, Olivier. (2011) Advances in structural and molecular neuroimaging in Alzheimer's disease. Medical Journal of Australia.
Effects of anticholinergic drugs on cognitive function in older Australians: Results from the AIBL study
Sittironnarit, Gobhathai, Ames, David, Bush, Ashley I., Faux, Noel G., Flicker, Leon, Foster, Jonathan, Hilmer, Sarah, Lautenschlager, Nicola T., Maruff, Paul Thomas, Masters, Colin L., Martins, Ralph N., Rowe, Christopher C., Szoeke, Cassandra and Ellis, Kathryn A.. (2011) Effects of anticholinergic drugs on cognitive function in older Australians: Results from the AIBL study. Dementia and Geriatric Cognitive Disorders. https://doi.org/10.1159/000325171
Plasma apolipoprotein E and Alzheimer disease risk: The AIBL study of aging
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Association of plasma Aß peptides with blood pressure in the elderly
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Executive functions in recently postmenopausal women: Absence of strong association with serum gonadal steroids
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Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: Baseline characteristics in subjects of the Australian imaging biomarker lifestyle study
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A web-based normative data tool for assessing cognitive performance in healthy older Australians
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Independent contribution of temporal beta-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease
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