Factors associated with improved walking in older people during hospital rehabilitation : Secondary analysis of a randomized controlled trial

Journal article

Said, Catherine M., McGinley, Jennifer L., Szoeke, Cassandra, Workman, Barbara, Hill, Keith D., Wittwer, Joanne E., Woodward, Michael, Liew, Danny, Churilov, Leonid, Bernhardt, Julie and Morris, Meg E.. (2021). Factors associated with improved walking in older people during hospital rehabilitation : Secondary analysis of a randomized controlled trial. BMC Geriatrics. 21, p. Article 90. https://doi.org/10.1186/s12877-021-02016-0
AuthorsSaid, Catherine M., McGinley, Jennifer L., Szoeke, Cassandra, Workman, Barbara, Hill, Keith D., Wittwer, Joanne E., Woodward, Michael, Liew, Danny, Churilov, Leonid, Bernhardt, Julie and Morris, Meg E.
Abstract

Background
Older people are often admitted for rehabilitation to improve walking, yet not everyone improves. The aim of this study was to determine key factors associated with a positive response to hospital-based rehabilitation in older people.

Methods
This was a secondary data analysis from a multisite randomized controlled trial. Older people (n= 198, median age 80.9 years, IQR 76.6- 87.2) who were admitted to geriatric rehabilitation wards with a goal to improve walking were recruited. Participants were randomized to receive additional daily physical therapy focused on mobility (n = 99), or additional social activities (n = 99). Self-selected gait speed was measured on admission and discharge. Four participants withdrew. People who changed gait speed ≥0.1 m/s were classified as ‘responders’ (n = 130); those that changed <0.1m/s were classified as ‘non-responders’ (n = 64). Multivariable logistic regression explored the association of six pre-selected participant factors (age, baseline ambulation status, frailty, co-morbidities, cognition, depression) and two therapy factors (daily supervised upright activity time, rehabilitation days) and response.

Results
Responding to rehabilitation was associated with the number of days in rehabilitation (OR 1.04; 95% CI 1.00 to 1.08; p = .039) and higher Mini Mental State Examination scores (OR 1.07, 95% CI 1.00 – 1.14; p = .048). No other factors were found to have association with responding to rehabilitation.

Conclusion
In older people with complex health problems or multi-morbidities, better cognition and a longer stay in rehabilitation were associated with a positive improvement in walking speed. Further research to explore who best responds to hospital-based rehabilitation and what interventions improve rehabilitation outcomes is warranted.

Keywordsmobility limitation; rehabilitation; exercise therapy; hospitalization; aged; aged, 80 and over
Year2021
JournalBMC Geriatrics
Journal citation21, p. Article 90
PublisherBiomed Central Ltd
ISSN1471-2318
Digital Object Identifier (DOI)https://doi.org/10.1186/s12877-021-02016-0
PubMed ID33517882
Scopus EID2-s2.0-85100304411
PubMed Central IDPMC7847572
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range1-8
FunderNational Health and Medical Research Council (NHMRC)
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online31 Jan 2021
Publication process dates
Accepted10 Jan 2021
Deposited16 Nov 2021
Grant IDNHMRC/1042680
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Kassebaum, Nicholas J., Barber, Ryan M., Bhutta, Zulfiqar A., Dandona, Lalit, Gething, Peter W., Hay, Simon I., Kinfu, Yohannes, Larson, Heidi J., Liang, Xiaofeng, Lim, Stephen S., Lopez, Alan D., Lozano, Rafael, Mensah, George A., Mokdad, Ali H., Naghavi, Mohsen, Pinho, Christine, Salomon, Joshua A., Steiner, Caitlyn, Vos, Theo, ... GBD 2015 Maternal Mortality Collaborators. (2016). Global, regional, and national levels of maternal mortality, 1990-2015: A systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 388(10053), pp. 1775 - 1812. https://doi.org/10.1016/S0140-6736(16)31470-2
Patterns of social engagement in the transition to later life
Burn, Katherine F., Dennerstein, Lorraine, Browning, Colette and Szoeke, Cassandra. (2016). Patterns of social engagement in the transition to later life. Maturitas. https://doi.org/10.1016/j.maturitas.2016.03.016
Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: A systematic analysis for the Global Burden of Disease Study 2015
Wang, Haidong, Bhutta, Zulfiqar A., Coates, Matthew M., Coggeshall, Megan, Dandona, Lalit, Diallo, Khassoum, Franca, Elisabeth Barboza, Fraser, Maya, Fullman, Nancy, Gething, Peter W., Hay, Simon I., Kinfu, Yohannes, Kita, Maaya, Kulikoff, Xie Rachel, Larson, Heidi J., Liang, Juan, Lim, Stephen S., Lind, Margaret, Lopez, Alan D., ... GBD 2015 Child Mortality Collaborators. (2016). Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980-2015: A systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 388(10053), pp. 1725 - 1774. https://doi.org/10.1016/S0140-6736(16)31575-6
The impact of red and processed meat consumption on cardiovascular disease risk in women
Bovalino, Stephen, Charleson, Georgia and Szoeke, Cassandra. (2016). The impact of red and processed meat consumption on cardiovascular disease risk in women. Nutrition. 32(3), pp. 349 - 354. https://doi.org/10.1016/j.nut.2015.09.015
Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: A systematic analysis for the Global Burden of Disease Study 2015
Wang, Haidong, Naghavi, Mohsen, Allen, Christine, Barber, Ryan M., Bhutta, Zulfiqar A., Carter, Austin, Casey, Daniel C., Charlson, Fiona J., Chen, Alan Zian, Coates, Matthew M., Coggeshall, Megan, Dandona, Lalit, Dicker, Daniel J., Erskine, Holly E., Ferrari, Alize J., Fitzmaurice, Christina, Foreman, Kyle, Forouzanfar, Mohammad H., Fraser, Maya S., ... GBD 2015 Mortality and Causes of Death Collaborators. (2016). Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: A systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 388(10053), pp. 1459 - 1544. https://doi.org/10.1016/S0140-6736(16)31012-1
Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990--2015: a systematic analysis for the Global Burden of Disease Study 2015
Vos, Theo, Allen, Christine, Arora, Megha, Barber, Ryan M., Bhutta, Zulfiqar A., Brown, Alexandria, Carter, Austin, Casey, Daniel C., Charlson, Fiona J., Chen, Alan Z., Coggeshall, Megan, Cornaby, Leslie, Dandona, Lalit, Dicker, Daniel J., Dilegge, Tina, Erskine, Holly E., Ferrari, Alize J., Fitzmaurice, Christina, Fleming, Tom, ... Murray, Christopher J. L.. (2016). Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990--2015: a systematic analysis for the Global Burden of Disease Study 2015. The Lancet. 388(10053), pp. 1545 - 1602. https://doi.org/10.1016/S0140-6736(16)31678-6
Phenomenological characterization of memory complaints in preclinical and prodromal Alzheimer's disease
Buckley, Rachel F., Ellis, Kathryn A., Ames, David, Rowe, Christopher C., Lautenschlager, Nicola T., Maruff, Paul Thomas, Villemagne, Victor L., Macaulay, S. Lance, Szoeke, Cassandra, Martins, Ralph N., Masters, Colin L., Savage, Greg, Rainey-Smith, Stephanie R., Rembach, Alan R. and Saling, Michael M.. (2015). Phenomenological characterization of memory complaints in preclinical and prodromal Alzheimer's disease. Neuropsychology. https://doi.org/10.1037/neu0000156
Grandparenting predicts late-life cognition: Results from the Women's Healthy Ageing Project
Burn, Katherine F. and Szoeke, Cassandra. (2015). Grandparenting predicts late-life cognition: Results from the Women's Healthy Ageing Project. Maturitas. https://doi.org/10.1016/j.maturitas.2015.03.013
Longitudinal cognitive decline in the AIBL cohort: The role of APOE E4 status
Albrecht, Matthew A., Szoeke, Cassandra, Maruff, Paul Thomas, Savage, Greg, Lautenschlager, Nicola T., Ellis, Kathryn A., Taddei, Kevin, Martins, Ralph N., Masters, Colin L., Ames, David and Foster, Jonathan K.. (2015). Longitudinal cognitive decline in the AIBL cohort: The role of APOE E4 status. Neuropsychologia. https://doi.org/10.1016/j.jalz.2014.04.303
Evaluating the effects of increasing physical activity to optimize rehabilitation outcomes in hospitalized older adults (MOVE Trial): Study protocol for a randomized controlled trial
Said, Catherine M., Morris, Meg E., McGinley, Jennifer L., Szoeke, Cassandra, Workman, Barbara, Liew, Danny, Hill, Keith David, Woodward, Michael Clifford, Wittwer, Joanne E., Churilov, Leonid, Ventura, Cameron and Bernhardt, Julie. (2015). Evaluating the effects of increasing physical activity to optimize rehabilitation outcomes in hospitalized older adults (MOVE Trial): Study protocol for a randomized controlled trial. Trials. 16(1), pp. 1 - 9. https://doi.org/10.1186/s13063-014-0531-y
Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease
Kerestes, Rebecca, Phal, Pramit M., Steward, Chris, Moffat, Bradford A., Salinas, Simon, Cox, Kay L., Ellis, Kathryn A., Cyarto, Elizabeth V., Ames, David, Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Sharman, Matthew J., Salvado, Oliver, Szoeke, Cassandra, Lai, Michelle, Lautenschlager, Nicola T. and Desmond, Patricia M.. (2015). Alterations in dorsal and ventral posterior cingulate connectivity in APOE ε4 carriers at risk of Alzheimer's disease. BJPsych Open. 1(2), pp. 139 - 148. https://doi.org/10.1192/bjpo.bp.115.001339
Is grandparenting a form of social engagement that benefits cognition in ageing?
Burn, Katherine F. and Szoeke, Cassandra. (2015). Is grandparenting a form of social engagement that benefits cognition in ageing? Maturitas. 80(2), pp. 122 - 125. https://doi.org/10.1016/j.maturitas.2014.10.017
Semi-automated hippocampal segmentation in people with cognitive impairment using an age appropriate template for registration
Merkel, Bernd, Steward, Christopher, Vivash, Lucy, Malpas, Charles B., Phal, Pramit, Moffat, Bradford A., Cox, Kay L., Ellis, Kathryn A., Ames, David J., Cyarto, Elizabeth V., Lai, Michelle M. Y., Sharman, Matthew J., Szoeke, Cassandra, Masters, Colin L., Lautenschlager, Nicola T. and Desmond, Patricia. (2015). Semi-automated hippocampal segmentation in people with cognitive impairment using an age appropriate template for registration. Journal of Magnetic Resonance Imaging. https://doi.org/10.1002/jmri.24966
Dietary patterns and cognitive decline in an Australian study of ageing
Gardener, S. L., Rainey-Smith, Stephanie R., Barnes, Margaret, Sohrabi, H. R., Weinborn, M., Lim, Yen Ying, Harrington, Karra D., Taddei, Kevin, Gu, Yian, Rembach, Alan R., Szoeke, Cassandra, Ellis, Kathryn A., Masters, C. L., Macaulay, Stuart Lance, Rowe, Christopher C., Ames, David, Keogh, Jennifer B., Scarmeas, Nikolaos and Martins, Ralph N.. (2015). Dietary patterns and cognitive decline in an Australian study of ageing. Molecular Psychiatry. https://doi.org/10.1038/mp.2014.79
Prehypertension in midlife is associated with worse cognition a decade later in middle-aged and older women
Chen, Karen, Henderson, Victor, Stolwyk, Rene, Dennerstein, Lorraine and Szoeke, Cassandra. (2015). Prehypertension in midlife is associated with worse cognition a decade later in middle-aged and older women. Age and Ageing. https://doi.org/10.1093/ageing/afv026
Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study
Pietrzak, Robert H., Scott, James, Neumeister, Alexander, Lim, Yen Ying, Ames, David, Ellis, Kathryn A., Harrington, Karra D., Lautenschlager, Nicola T., Szoeke, Cassandra, Martins, Ralph N., Masters, Colin L., Villemagne, Victor L., Rowe, Christopher C. and Maruff, Paul Thomas. (2014). Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study. British Journal of Psychiatry. https://doi.org/10.1192/bjp.bp.113.134239
Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL)
Ellis, Kathryn A., Szoeke, Cassandra, Bush, Ashley I., Darby, David, Graham, Petra, Lautenschlager, Nicola T., Macaulay, S Lance, Martins, Ralph N., Maruff, Paul Thomas, Masters, Colin L., McBride, Simon J., Pike, Kerryn E., Rainey-Smith, Stephanie R., Rembach, Alan R., Robertson, Joanne, Rowe, Christopher C., Savage, Greg, Villemagne, Victor L., Woodward, Michael Clifford, ... Ames, David. (2014). Rates of diagnostic transition and cognitive change at 18-month follow-up among 1,112 participants in the Australian Imaging, Biomarkers and Lifestyle Flagship Study of Ageing (AIBL). International Psychogeriatrics. https://doi.org/10.1017/S1041610213001956
Aß and cognitive change: Examining the preclinical and prodromal stages of Alzheimer's disease
Lim, Yen Ying, Maruff, Paul Thomas, Pietrzak, Robert H., Ellis, Kathryn A., Darby, David, -, David Ames, Harrington, Karra J., Martins, Ralph N., Masters, Colin L., Szoeke, Cassandra, Savage, Greg, Villemagne, Victor L. and Rowe, Christopher C.. (2014). Aß and cognitive change: Examining the preclinical and prodromal stages of Alzheimer's disease. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2013.11.005
Incidence of cerebral microbleeds in preclinical Alzheimer disease
Yates, Paul A., Desmond, Patricia M., Phal, Pramit M., Steward, Christopher, Szoeke, Cassandra, Salvado, Olivier, Ellis, Kathryn A., Martins, Ralph N., Masters, Colin L., Ames, David, Villemagne, Victor L. and Rowe, Christopher C.. (2014). Incidence of cerebral microbleeds in preclinical Alzheimer disease. Neurology. https://doi.org/10.1212/WNL.0000000000000285
Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: Combined data from three cohorts
Moore, Eileen, Ames, David, Mander, Alastair, Carne, Ross, Brodaty, Henry, Woodward, Michael Clifford, Boundy, Karen, Ellis, Kathryn A., Bush, Ashley I., Faux, Noel G., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Szoeke, Cassandra and Watters, David. (2014). Among vitamin B12 deficient older people, high folate levels are associated with worse cognitive function: Combined data from three cohorts. Journal of Alzheimer's Disease. https://doi.org/10.3233/JAD-131265
Associations between gonadotropins, testosterone and ß amyloid in men at risk of Alzheimer's disease
Verdile, G., Laws, S. M., Henley, D., Ames, David, Bush, A. I., Ellis, Kathryn A., Faux, N. G., Gupta, V. B., Li, Q., Masters, C L., Pike, K E., Rowe, C. C., Szoeke, Cassandra, Taddei, K., Villemagne, V. L. and Martins, R. N.. (2014). Associations between gonadotropins, testosterone and ß amyloid in men at risk of Alzheimer's disease. Molecular Psychiatry. https://doi.org/10.1038/mp.2012.147
Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease
Lim, Yen Ying, Maruff, Paul Thomas, Pietrzak, Robert H., Ames, David, Ellis, Kathryn A., Harrington, Karra J., Lautenschlager, Nicola T., Szoeke, Cassandra, Martins, Ralph N., Masters, Colin L., Villemagne, Victor L. and Rowe, Christopher C.. (2014). Effect of amyloid on memory and non-memory decline from preclinical to clinical Alzheimer's disease. Brain. 137(1), pp. 221 - 231. https://doi.org/10.1093/brain/awt286
Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults
Buckley, Rachel F., Saling, Michael M., Irish, Muireann, Ames, David, Rowe, Christopher C., Villemagne, Victor L., Lautenschlager, Nicola T., Maruff, Paul Thomas, Macaulay, S Lance, Martins, Ralph N., Szoeke, Cassandra, Masters, Colin L., Rainey-Smith, Stephanie R., Rembach, Alan R., Savage, Greg and Ellis, Kathryn A.. (2014). Autobiographical narratives relate to Alzheimer's disease biomarkers in older adults. International Psychogeriatrics. https://doi.org/10.1017/S1041610214001136
Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease
Rembach, Alan R., Gaux, Noel G., Watt, Andrew D., Pertile, Kelly Kathleen, Rumble, Rebecca L., Trounson, Brett O., Fowler, Christopher J., Roberts, Blaine R., Perez, Keyla A., Li, Qiaoxin, Laws, Simon M., Taddei, Kevin, Rainey-Smith, Stephanie R., Robertson, Joanne, Vandijck, Manu LJ, Vanderstichele, Hugo M. J., Barnham, Kevin Jeffrey, Ellis, Kathryn A., Szoeke, Cassandra, ... Masters, Colin L.. (2014). Changes in plasma amyloid beta in a longitudinal study of aging and Alzheimer's disease. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2012.12.006
Genetic algorithm with logistic regression for prediction of progression to Alzheimer's disease
Johnson, Piers, Vandewater, Luke, Wilson, William, Maruff, Paul Thomas, Savage, Greg, Graham, Petra, Macaulay, Lance S., Ellis, Kathryn A., Szoeke, Cassandra, Martins, Ralph N., Rowe, Christopher C., Masters, Colin L., Ames, David and Zhang, Ping. (2014). Genetic algorithm with logistic regression for prediction of progression to Alzheimer's disease. BMC Bioinformatics. 15(S11), pp. 1 - 14. https://doi.org/10.1186/1471-2105-15-S16-S11
Dehydroepiandrosterone sulfate and cognition in midlife, post-menopausal women
Chua, Catherine K.Z., Henderson, Victor W., Dennerstein, Lorraine, Ames, David and Szoeke, Cassandra. (2014). Dehydroepiandrosterone sulfate and cognition in midlife, post-menopausal women. Neurobiology of Aging. 35(7), pp. 1654 - 1655. https://doi.org/10.1016/j.neurobiolaging.2014.01.140
The Women's Healthy Ageing Project: Fertile ground for investigation of healthy participants 'at risk' for dementia
Szoeke, Cassandra, Robertson, Joanne, Rowe, Christopher C., Yates, Paul A., Campbell, Katherine, Masters, C. L., Ames, David, Dennerstein, L. and Desmond, P.. (2013). The Women's Healthy Ageing Project: Fertile ground for investigation of healthy participants 'at risk' for dementia. International Review of Psychiatry. https://doi.org/10.3109/09540261.2013.873394
Lack of reliable evidence for a distinctive e4-related cognitive phenotype that is independent from clinical diagnostic status: Findings from the Australian Imaging, Biomarkers and Lifestyle Study
Foster, Jonathan, Albrecht, Matthew A., Savage, Greg, Lautenschlager, Nicola T., Ellis, Kathryn A., Maruff, Paul Thomas, Szoeke, Cassandra, Taddei, Kevin, Martins, Ralph N., Masters, Colin L. and Ames, David. (2013). Lack of reliable evidence for a distinctive e4-related cognitive phenotype that is independent from clinical diagnostic status: Findings from the Australian Imaging, Biomarkers and Lifestyle Study. Brain. https://doi.org/10.1093/brain/awt127
Aß amyloid, cognition, and APOE genotype in healthy older adults
Lim, Yen Ying, Ellis, Kathryn A., Ames, David, Darby, David, Harrington, Karra J., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg, Szoeke, Cassandra, Villemagne, Victor L. and Maruff, Paul Thomas. (2013). Aß amyloid, cognition, and APOE genotype in healthy older adults. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2012.07.004
Physical activity and amyloid-Beta plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing
Brown, Belinda M., Peiffer, J. J., Taddei, Kevin, Lui, J. K., Laws, Simon M., Gupta, V. B., Taddei, Tania, Ward, Vanessa K., Rodrigues, Mark A., Burnham, Samantha, Rainey-Smith, Stephanie R., Villemagne, Victor L., Bush, Ashley I., Ellis, Kathryn A., Masters, Colin L., Ames, David, Macaulay, S. Lance, Szoeke, Cassandra, Rowe, Christopher C. and Martins, Ralph N.. (2013). Physical activity and amyloid-Beta plasma and brain levels: Results from the Australian Imaging, Biomarkers and Lifestyle Study of Ageing. Molecular Psychiatry. https://doi.org/10.1038/mp.2012.107
Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease
Frost, Shaun M., Kanagasinam, Yogesan, Sohrabi, Hamid R., Vignarajan, Janardhan, Bourgeat, Pierrick T., Salvado, Oliver, Villemagne, Victor Luis, Rowe, Christopher C., Macaulay, S. Lance, Szoeke, Cassandra, Ellis, Kathryn A., Ames, David, Masters, Colin L., Rainey-Smith, Stephanie R. and Martins, Ralph N.. (2013). Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease. Translational Psychiatry. https://doi.org/10.1038/tp.2012.150
Normative Data for the Tower Of London Performance in Australian Midlife Women
Lee, Young Eun C., Anderson, Jacqueline F., Dennerstein, Lorraine, Henderson, Victor W. and Szoeke, Cassandra. (2013). Normative Data for the Tower Of London Performance in Australian Midlife Women. Australian Psychologist. https://doi.org/10.1111/ap.12033
Factors affecting subjective memory complaints in the AIBL aging study: Biomarkers, memory, affect, and age
Buckley, Rachel F., Saling, Michael M., Ames, David, Rowe, Christopher C., Lautenschlager, Nicola T., Macaulay, S. Lance, Martins, Ralph N., Masters, Colin L., O'Meara, T., Savage, Greg, Szoeke, Cassandra, Villemagne, Victor L. and Ellis, Kathryn A.. (2013). Factors affecting subjective memory complaints in the AIBL aging study: Biomarkers, memory, affect, and age. International Psychogeriatrics. https://doi.org/10.1017/S1041610213000665
Predicting Alzheimer disease with beta-amyloid imaging: Results from the Australian imaging, biomarkers, and lifestyle study of ageing
Rowe, Christopher C., Bourgeat, Pierrick, Ellis, Kathryn A., Brown, Belinda M., Lim, Yen Ying, Mulligan, Rachel, Jones, Gareth, Maruff, Paul Thomas, Woodward, Michael Clifford, Price, Roger Ian, Robins, Peter, Tochon-Danguy, Henri, O'Keefe, Graeme, Pike, Kerryn E., Yates, Patsy, Szoeke, Cassandra, Salvado, Olivier, Macaulay, S. Lance, O'Meara, Timothy, ... Villemagne, Victor L.. (2013). Predicting Alzheimer disease with beta-amyloid imaging: Results from the Australian imaging, biomarkers, and lifestyle study of ageing. Annals of Neurology. https://doi.org/10.1002/ana.24040
Cognitive consequences of high Aß amyloid in mild cognitive impairment and healthy older adults: Implications for early detection of alzheimer's disease
Lim, Yen Ying, Ellis, Kathryn A., Harrington, Karra J., Kamer, Adrian, Pietrzak, Robert H., Bush, Ashley I., Darby, David G., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg R., Szoeke, Cassandra, Villemagne, Victor L., Ames, David and Maruff, Paul Thomas. (2013). Cognitive consequences of high Aß amyloid in mild cognitive impairment and healthy older adults: Implications for early detection of alzheimer's disease. Neuropsychology. https://doi.org/10.1037/a0032321
Research and standardization in Alzheimer's trials: Reaching international consensus
Carillo, Maria C., Rowe, Christopher C., Szoeke, Cassandra, Masters, Colin L., Ames, David, O'Meara, Timothy, Macaulay, S Lance, Milner, Andrew, Ellis, Kathryn A., Maruff, Paul Thomas, Rainey-Smith, Stephanie R., Martins, Ralph N., Bain, Lisa J. and Head, Richard. (2013). Research and standardization in Alzheimer's trials: Reaching international consensus. Alzheimer's and Dementia. https://doi.org/10.1016/j.jalz.2012.10.006
Cognitive decline in adults with amnestic mild cognitive impairment and high amyloid-: Prodromal Alzheimer's disease?
Lim, Yen Ying, Ellis, Kathryn A., Harrington, Karra J., Pietrzak, Robert H., Gale, Joanne, Ames, David, Bush, Ashley I., -, David Darby, Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg, Szoeke, Cassandra, Villemagne, Victor L. and Maruff, Paul Thomas. (2013). Cognitive decline in adults with amnestic mild cognitive impairment and high amyloid-: Prodromal Alzheimer's disease? Journal of Alzheimer's Disease. https://doi.org/10.3233/JAD-121771
Three-month stability of the cogstate brief battery in healthy older adults, mild cognitive impairment, and alzheimer's disease: Results from the Australian imaging, biomarkers, and lifestyle-rate of change substudy (AIBL-ROCS)
Lim, Yen Ying, Jaeger, Judith, Harrington, Karra J., Ashwood, Tim J., Ellis, Kathryn A., Stoffler, Albrecht, Szoeke, Cassandra, -, Rebecca Lachovitzki, Martins, Ralph N., Villemagne, Victor L., Bush, Ashley I., Masters, Colin L., Rowe, Christopher C., Ames, David, Darby, David and Maruff, Paul Thomas. (2013). Three-month stability of the cogstate brief battery in healthy older adults, mild cognitive impairment, and alzheimer's disease: Results from the Australian imaging, biomarkers, and lifestyle-rate of change substudy (AIBL-ROCS). Archives of Clinical Neuropsychology. https://doi.org/10.1093/arclin/act021
Amyloid ß deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study
Villemagne, Victor L., Burnham, Samantha, Bourgeat, Pierrick, Brown, Belinda M., Ellis, Kathryn A., Salvado, Olivier, Szoeke, Cassandra, Macaulay, S. Lance, Martins, Ralph N., Maruff, Paul Thomas, Ames, David, Rowe, Christopher C. and Masters, Colin L.. (2013). Amyloid ß deposition, neurodegeneration, and cognitive decline in sporadic Alzheimer's disease: A prospective cohort study. The Lancet Neurology. https://doi.org/10.1016/S1474-4422(13)70044-9
The association of ABeta amyloid and composite cognitive measures in healthy older adults and MCI
Harrington, Karra J., Lim, Yen Ying, Ellis, Kathryn A., Copolov, Carly, Darby, D, Weinborn, M., Ames, David, Martins, R. N., Savage, G., Szoeke, Cassandra, Rowe, C. C., Villemagne, V. L., Masters, C. L. and Maruff, Paul Thomas. (2013). The association of ABeta amyloid and composite cognitive measures in healthy older adults and MCI. International Psychogeriatrics. https://doi.org/10.1017/S1041610213001087
Increased risk of cognitive impairment in patients with diabetes is associated with metformin
Moore, Eileen, Mander, Alastair, Ames, David, Kotowicz, Mark A., Carne, Ross, Brodaty, Henry, Woodward, Michael Clifford, Boundy, Karen, Ellis, Kathryn A., Bush, Ashley I., Faux, Noel G., Martins, Ralph N., Szoeke, Cassandra, Rowe, Christopher C. and Watters, David. (2013). Increased risk of cognitive impairment in patients with diabetes is associated with metformin. Diabetes Care. https://doi.org/10.2337/dc13-0229
Decline in cognitive function over 18 months in healthy older adults with high amyloid-beta
Ellis, Kathryn A., Lim, Yen Ying, Harrington, Karra J., Ames, David, Bush, Ashley I., Darby, David, Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg, Szoeke, Cassandra, Villemagne, Victor L. and Maruff, Paul Thomas. (2013). Decline in cognitive function over 18 months in healthy older adults with high amyloid-beta. Journal of Alzheimer's Disease. https://doi.org/10.3233/JAD-122170
Intense physical activity is associated with cognitive performance in the elderly
Brown, Belinda M., Peiffer, John, Sohrabi, Hamid R., Mondal, Alinda, Gupta, Veer B. A., Rainey-Smith, Stephanie R., Taddei, Kevin, Burnham, Samantha C., Ellis, Kathryn A., Szoeke, Cassandra, Masters, Colin L., Ames, David, Rowe, Christopher C. and Martins, Ralph N.. (2012). Intense physical activity is associated with cognitive performance in the elderly. Translational Psychiatry. https://doi.org/10.1038/tp.2012.118
Oestrogen alpha-receptor variant and two-year memory decline in midlife Australian women
Bousman, Chad, Szoeke, Cassandra, Chen, Karen, Dennerstein, Lorraine, Henderson, Victor W. and Everall, Ian P.. (2012). Oestrogen alpha-receptor variant and two-year memory decline in midlife Australian women. Neuropsychobiology. https://doi.org/10.1159/000341879
Cortical surface mapping using topology correction, partial flattening and 3D shape context-based non-rigid registration for use in quantifying atrophy in Alzheimer's disease
Acosta, Oscar, Fripp, Jurgen, Dore, Vincent, Bourgeat, Pierrick, Favreau, Jean-Marie, Chetelat, Gael, Rueda, Andrea, Villemagne, Victor L., Szoeke, Cassandra, Ames, David, Ellis, Kathryn A., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Bonner, Erik, Gris, Florence, Xiao, Di, Raniga, Parnesh, Barra, Vincent and Salvado, Olivier. (2012). Cortical surface mapping using topology correction, partial flattening and 3D shape context-based non-rigid registration for use in quantifying atrophy in Alzheimer's disease. Journal of Neuroscience Methods. https://doi.org/10.1016/j.jneumeth.2011.12.011
Blood-based protein biomarkers for diagnosis of Alzheimer disease
Doecke, James D., Laws, Simon M., Faux, Noel G., Wilson, William, Burnham, Samantha, Lam, Chiou Peng, Mondal, Alinda, Bedo, Justin, Bush, Ashley I., Brown, Belinda M., De Ruyck, Karl, Ellis, Kathryn A., Fowler, Christopher J., Gupta, V. B., Head, Richard, Macaulay, S. Lance, Pertile, Kelly K., Rowe, Christopher C., Rembach, Alan R., ... Martins, Ralph N.. (2012). Blood-based protein biomarkers for diagnosis of Alzheimer disease. Archives of Neurology. https://doi.org/10.1001/archneurol.2012.1282
Predictors of rapid cognitive decline in Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing
Sona, Alessano, Zhang, Ping, Ames, David, Bush, Ashley I., Lautenschlager, Nicola T., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Szoeke, Cassandra, Taddei, Kevin and Ellis, Kathryn A.. (2012). Predictors of rapid cognitive decline in Alzheimer's disease: Results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of ageing. International Psychogeriatrics. https://doi.org/10.1017/S1041610211001335
Hormone levels and cognitive function in postmenopausal midlife women
Ryan, Joanne L., Stanczyk, Frank Z., Dennerstein, Lorraine, Mack, Wendy J., Clark, Margaret S., Szoeke, Cassandra, Kildea, Daniel George and Henderson, Victor W.. (2012). Hormone levels and cognitive function in postmenopausal midlife women. Neurobiology of Aging. 33(3), pp. 617.e11 - 617.e22. https://doi.org/10.1016/j.neurobiolaging.2010.07.014
Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults
Lim, Yen Ying, Ellis, Kathryn A., Pietrzak, Robert H., Ames, David, Darby, David, Harrington, Karra J., Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg, Szoeke, Cassandra, Villemagne, Victor L. and Maruff, Paul Thomas. (2012). Stronger effect of amyloid load than APOE genotype on cognitive decline in healthy older adults. Neurology. https://doi.org/10.1212/WNL.0b013e31826e9ae6
Use of the CogState Brief Battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study
Lim, Yen Ying, Ellis, Kathryn A., Harrington, Karra J., Ames, David, Martins, Ralph N., Masters, Colin L., Rowe, Christopher C., Savage, Greg, Szoeke, Cassandra, Darby, David and Maruff, Paul Thomas. (2012). Use of the CogState Brief Battery in the assessment of Alzheimer's disease related cognitive impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study. Journal of Clinical and Experimental Neuropsychology. https://doi.org/10.1080/13803395.2011.643227
Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population
Gardener, Samantha L., Gu, Yian, Rainey-Smith, Stephanie R., Keogh, Jennifer B., Clifton, Peter Marshall, Mathieson, S. L., Taddei, Kevin, Mondal, Alinda, Ward, Vanessa K., Scarmeas, Nikolaos, Barnes, Margaret, Ellis, Kathryn A., Head, Richard, Masters, Colin L., Ames, David, Macaulay, Stuart Lance, Rowe, Christopher C., Szoeke, Cassandra and Martins, Ralph N.. (2012). Adherence to a Mediterranean diet and Alzheimer's disease risk in an Australian population. Translational Psychiatry. https://doi.org/10.1038/tp.2012.91
Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study
Pike, Kerryn E., Ellis, Kathryn A., Villemagne, Victor L., Good, Norm, Chetelat, Gael, Ames, David, Szoeke, Cassandra, Laws, Simon M., Verdile, Giuseppe, Martins, Ralph N., Masters, Colin L. and Rowe, Christopher C.. (2011). Cognition and beta-amyloid in preclinical Alzheimer's disease: Data from the AIBL study. Neuropsychologia. https://doi.org/10.1016/j.neuropsychologia.2011.04.012
Advances in structural and molecular neuroimaging in Alzheimer's disease
Ellis, Kathryn A., Rowe, Christopher C., Szoeke, Cassandra E. I., Villemagne, Victor L., Ames, David, Chetelat, Gael, Martins, Ralph N., Masters, Colin L., Fripp, Jurgen, Acosta, Oscar, Raniga, Parnesh, Bourgeat, Pierrick T. and Salvado, Olivier. (2011). Advances in structural and molecular neuroimaging in Alzheimer's disease. Medical Journal of Australia.
Effects of anticholinergic drugs on cognitive function in older Australians: Results from the AIBL study
Sittironnarit, Gobhathai, Ames, David, Bush, Ashley I., Faux, Noel G., Flicker, Leon, Foster, Jonathan, Hilmer, Sarah, Lautenschlager, Nicola T., Maruff, Paul Thomas, Masters, Colin L., Martins, Ralph N., Rowe, Christopher C., Szoeke, Cassandra and Ellis, Kathryn A.. (2011). Effects of anticholinergic drugs on cognitive function in older Australians: Results from the AIBL study. Dementia and Geriatric Cognitive Disorders. https://doi.org/10.1159/000325171
Plasma apolipoprotein E and Alzheimer disease risk: The AIBL study of aging
Gupta, V. B., Laws, Simon M., Villemagne, Victor L., Ames, David, Bush, Ashley I., Ellis, Kathryn A., Lui, J. K., Masters, Colin L., Rowe, Christopher C., Szoeke, Cassandra, Taddei, K. and Martins, Ralph N.. (2011). Plasma apolipoprotein E and Alzheimer disease risk: The AIBL study of aging. Neurology. https://doi.org/10.1212/WNL.0b013e318211c352
Association of plasma Aß peptides with blood pressure in the elderly
Lambert, Jean C., Dallongeville, Jean, Ellis, Kathryn A., Schraen-Maschke, Susanna, Lui, James, Laws, Simon M., Dumont, Julie, Richard, Florence, Cottel, Dominique C., Berr, Claudine, Ames, David, Masters, Colin L., Rowe, Christopher C., Szoeke, Cassandra, Tzourio, Christophe, Dartigues, Jean-Francois, Buee, Luc, Martins, Ralph N. and Amouyel, Phillippe. (2011). Association of plasma Aß peptides with blood pressure in the elderly. PLoS ONE. 6(4), pp. 1 - 6. https://doi.org/10.1371/journal.pone.0018536
Executive functions in recently postmenopausal women: Absence of strong association with serum gonadal steroids
Ryan, Joanne L., Stanczyk, Frank Z., Dennerstein, Lorraine, Mack, Wendy J., Clark, Margaret S., Szoeke, Cassandra and Henderson, Victor W.. (2011). Executive functions in recently postmenopausal women: Absence of strong association with serum gonadal steroids. Brain Research. https://doi.org/10.1016/j.brainres.2010.10.093
Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: Baseline characteristics in subjects of the Australian imaging biomarker lifestyle study
Faux, Noel G., Ellis, Kathryn A., Porter, Lorine, Fowler, Chris J., Laws, Simon M., Martins, Ralph N., Pertile, Kelly K., Rembach, Alan R., Rowe, Christopher C., Rumble, Rebecca L., Szoeke, Cassandra, Taddei, Kevin, Taddei, Tania, Trounson, Brett, Villemagne, Victor L., Ward, Vanessa R., Ames, David, Masters, Colin L. and Bush, Ashley I.. (2011). Homocysteine, vitamin B12, and folic acid levels in Alzheimer's disease, mild cognitive impairment, and healthy elderly: Baseline characteristics in subjects of the Australian imaging biomarker lifestyle study. Journal of Alzheimer's Disease. https://doi.org/10.3233/JAD-2011-110752
A web-based normative data tool for assessing cognitive performance in healthy older Australians
McBride, Simon J., Szoeke, Cassandra E. I., Good, Norm M., Ames, David, Martins, Ralph N., Masters, Colin L., Maruff, Paul Thomas, Rowe, Christopher C., Savage, Greg and Ellis, Kathryn A.. (2011). A web-based normative data tool for assessing cognitive performance in healthy older Australians. Medical Journal of Australia.
Independent contribution of temporal beta-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease
Chetelat, Gael, Villemagne, Victor L., Pike, Kerryn E., Ellis, Kathryn A., Bourgeat, Pierrick, Jones, Gareth, O'Keefe, Graeme, Salvado, Olivier, Szoeke, Cassandra, Martins, Ralph N., Ames, David, Masters, Colin L. and Rowe, Christopher C.. (2011). Independent contribution of temporal beta-amyloid deposition to memory decline in the pre-dementia phase of Alzheimer's disease. Brain. 134(3), pp. 798 - 807. https://doi.org/10.1093/brain/awq383