A randomized clinical trial to reduce patient prehospital delay to treatment in acute coronary syndrome
Journal article
Dracup, Kathleen, McKinley, Sharon, Riegel, Barbara, Moser, Debra, Meischke, Hendrika, Doering, Lynn, Davidson, Patricia, Paul, Steven M., Baker, Heather and Pelter, Michele M.. (2009). A randomized clinical trial to reduce patient prehospital delay to treatment in acute coronary syndrome. Circulation: Cardiovascular Quality and Outcomes. 2(6), pp. 524-532. https://doi.org/10.1161/CIRCOUTCOMES.109.852608
Authors | Dracup, Kathleen, McKinley, Sharon, Riegel, Barbara, Moser, Debra, Meischke, Hendrika, Doering, Lynn, Davidson, Patricia, Paul, Steven M., Baker, Heather and Pelter, Michele M. |
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Abstract | Background— Delay from onset of acute coronary syndrome (ACS) symptoms to hospital admission continues to be prolonged. To date, community education campaigns on the topic have had disappointing results. Therefore, we conducted a clinical randomized trial to test whether an intervention tailored specifically for patients with ACS and delivered one-on-one would reduce prehospital delay time. Methods and Results— Participants (n=3522) with documented coronary heart disease were randomized to experimental (n=1777) or control (n=1745) groups. Experimental patients received education and counseling about ACS symptoms and actions required. Patients had a mean age of 67±11 years, and 68% were male. Over the 2 years of follow-up, 565 patients (16.0%) were admitted to an emergency department with ACS symptoms a total of 842 times. Neither median prehospital delay time (experimental, 2.20 versus control, 2.25 hours) nor emergency medical system use (experimental, 63.6% versus control, 66.9%) was different between groups, although experimental patients were more likely than control to call the emergency medical system if the symptoms occurred within the first 6 months following the intervention (P=0.036). Experimental patients were significantly more likely to take aspirin after symptom onset than control patients (experimental, 22.3% versus control, 10.1%, P=0.02). The intervention did not result in an increase in emergency department use (experimental, 14.6% versus control, 17.5%). Conclusions— The education and counseling intervention did not lead to reduced prehospital delay or increased ambulance use. Reducing the time from onset of ACS symptoms to arrival at the hospital continues to be a significant public health challenge. Clinical Trial Registration— clinicaltrials.gov. Identifier NCT00734760. |
Keywords | myocardial infarction; acute coronary syndrome |
Year | 2009 |
Journal | Circulation: Cardiovascular Quality and Outcomes |
Journal citation | 2 (6), pp. 524-532 |
Publisher | Lippincott Williams & Wilkins |
ISSN | 1941-7713 |
Digital Object Identifier (DOI) | https://doi.org/10.1161/CIRCOUTCOMES.109.852608 |
PubMed ID | 20031889 |
Scopus EID | 2-s2.0-77649163522 |
PubMed Central ID | PMC2802063 |
Page range | 524-532 |
Funder | National Institute of Nursing Research (NINR), National Institutes of Research |
Research Group | Mary MacKillop Institute for Health Research |
Publisher's version | License All rights reserved File Access Level Controlled |
Output status | Published |
Publication dates | |
Online | 06 Oct 2009 |
Publication process dates | |
Accepted | 14 Aug 2009 |
Grant ID | R01 NR05323 |
https://acuresearchbank.acu.edu.au/item/8v852/a-randomized-clinical-trial-to-reduce-patient-prehospital-delay-to-treatment-in-acute-coronary-syndrome
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