Does physical inactivity induce significant changes in human gut microbiota? New answers using the dry immersion hypoactivity model

Journal article


Jollet, Maxence, Nay, Kevin, Chopard, Angele, Bareille, Marie-Pierre, Beck, Arnaud, Ollendorff, Vincent, Vernus, Barbara, Bonnieu, Anne, Mariadassou, Mahendra, Rué, Olivier, Derbré, Frédéric, Goustard, Bénédicte and Koechlin-Ramonatxo, Christelle. (2021). Does physical inactivity induce significant changes in human gut microbiota? New answers using the dry immersion hypoactivity model. Nutrients. 13(11), p. Article 3865. https://doi.org/10.3390/nu13113865
AuthorsJollet, Maxence, Nay, Kevin, Chopard, Angele, Bareille, Marie-Pierre, Beck, Arnaud, Ollendorff, Vincent, Vernus, Barbara, Bonnieu, Anne, Mariadassou, Mahendra, Rué, Olivier, Derbré, Frédéric, Goustard, Bénédicte and Koechlin-Ramonatxo, Christelle
Abstract

Gut microbiota, a major contributor to human health, is influenced by physical activity and diet, and displays a functional cross-talk with skeletal muscle. Conversely, few data are available on the impact of hypoactivity, although sedentary lifestyles are widespread and associated with negative health and socio-economic impacts. The study aim was to determine the effect of Dry Immersion (DI), a severe hypoactivity model, on the human gut microbiota composition. Stool samples were collected from 14 healthy men before and after 5 days of DI to determine the gut microbiota taxonomic profiles by 16S metagenomic sequencing in strictly controlled dietary conditions. The α and β diversities indices were unchanged. However, the operational taxonomic units associated with the Clostridiales order and the Lachnospiraceae family, belonging to the Firmicutes phylum, were significantly increased after DI. Propionate, a short-chain fatty acid metabolized by skeletal muscle, was significantly reduced in post-DI stool samples. The finding that intestine bacteria are sensitive to hypoactivity raises questions about their impact and role in chronic sedentary lifestyles.

Keywordshypoactivity; commensal bacteria; flora; phyla; muscle atrophy; disuse; weightlessness; micro-gravity
Year2021
JournalNutrients
Journal citation13 (11), p. Article 3865
PublisherMultidisciplinary Digital Publishing Institute (MDPI AG)
ISSN2072-6643
Digital Object Identifier (DOI)https://doi.org/10.3390/nu13113865
PubMed ID34836120
Scopus EID2-s2.0-85117933928
PubMed Central IDPMC8620432
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range1-17
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online29 Oct 2021
Publication process dates
Accepted25 Oct 2021
Deposited25 Feb 2022
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