Does physical inactivity induce significant changes in human gut microbiota? New answers using the dry immersion hypoactivity model
Journal article
Jollet, Maxence, Nay, Kevin, Chopard, Angele, Bareille, Marie-Pierre, Beck, Arnaud, Ollendorff, Vincent, Vernus, Barbara, Bonnieu, Anne, Mariadassou, Mahendra, Rué, Olivier, Derbré, Frédéric, Goustard, Bénédicte and Koechlin-Ramonatxo, Christelle. (2021). Does physical inactivity induce significant changes in human gut microbiota? New answers using the dry immersion hypoactivity model. Nutrients. 13(11), p. Article 3865. https://doi.org/10.3390/nu13113865
Authors | Jollet, Maxence, Nay, Kevin, Chopard, Angele, Bareille, Marie-Pierre, Beck, Arnaud, Ollendorff, Vincent, Vernus, Barbara, Bonnieu, Anne, Mariadassou, Mahendra, Rué, Olivier, Derbré, Frédéric, Goustard, Bénédicte and Koechlin-Ramonatxo, Christelle |
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Abstract | Gut microbiota, a major contributor to human health, is influenced by physical activity and diet, and displays a functional cross-talk with skeletal muscle. Conversely, few data are available on the impact of hypoactivity, although sedentary lifestyles are widespread and associated with negative health and socio-economic impacts. The study aim was to determine the effect of Dry Immersion (DI), a severe hypoactivity model, on the human gut microbiota composition. Stool samples were collected from 14 healthy men before and after 5 days of DI to determine the gut microbiota taxonomic profiles by 16S metagenomic sequencing in strictly controlled dietary conditions. The α and β diversities indices were unchanged. However, the operational taxonomic units associated with the Clostridiales order and the Lachnospiraceae family, belonging to the Firmicutes phylum, were significantly increased after DI. Propionate, a short-chain fatty acid metabolized by skeletal muscle, was significantly reduced in post-DI stool samples. The finding that intestine bacteria are sensitive to hypoactivity raises questions about their impact and role in chronic sedentary lifestyles. |
Keywords | hypoactivity; commensal bacteria; flora; phyla; muscle atrophy; disuse; weightlessness; micro-gravity |
Year | 2021 |
Journal | Nutrients |
Journal citation | 13 (11), p. Article 3865 |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI AG) |
ISSN | 2072-6643 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/nu13113865 |
PubMed ID | 34836120 |
Scopus EID | 2-s2.0-85117933928 |
PubMed Central ID | PMC8620432 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 1-17 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 29 Oct 2021 |
Publication process dates | |
Accepted | 25 Oct 2021 |
Deposited | 25 Feb 2022 |
https://acuresearchbank.acu.edu.au/item/8x5z7/does-physical-inactivity-induce-significant-changes-in-human-gut-microbiota-new-answers-using-the-dry-immersion-hypoactivity-model
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Publisher's version
OA_Jollet_2021_Does_physical_inactivity_induce_significant_changes.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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