Associations of health-related quality of life, fear of falling and objective measures of physical function with bone health in postmenopausal women with low bone mass

Journal article


Gandham, Anoohya, McMillan, Lachlan B., Ng, Carrie-Anne, Humbert, Ludovic, Bonham, Maxine P., Zengin, Ayse, Ebeling, Peter R. and Scott, David. (2019). Associations of health-related quality of life, fear of falling and objective measures of physical function with bone health in postmenopausal women with low bone mass. Journal of Clinical Medicine. 8(9), p. Article 1370. https://doi.org/10.3390/jcm8091370
AuthorsGandham, Anoohya, McMillan, Lachlan B., Ng, Carrie-Anne, Humbert, Ludovic, Bonham, Maxine P., Zengin, Ayse, Ebeling, Peter R. and Scott, David
Abstract

Health-related quality of life (HRQoL) and physical function deteriorate with age and may adversely impact bone health in older adults. We determined associations of objective measures of physical function and HRQoL with bone health in postmenopausal women with low areal bone mineral density (aBMD). Fifty postmenopausal women (64.4 ± 7.7 years old, mean ± standard deviation) with low spine, hip or femoral neck aBMD (T- or Z-score < −1.0) on dual-energy X-ray absorptiometry (DXA) participated. Femoral surface BMD, trabecular, integral and cortical volumetric BMD (vBMD) measurements were obtained using 3D-SHAPER software on DXA. Distal tibial vBMD and microarchitecture were assessed using high-resolution peripheral quantitative computed tomography (HRpQCT). Participants completed self-administered EuroQol-5D (EQ-5D) and modified falls efficacy scale (MFES) questionnaires, and physical function assessments. Stair climb power was positively associated with bone parameters at the hip, femoral neck, and distal tibia (all p < 0.05) in multivariable linear regression. EQ-5D demonstrated no significant associations with bone parameters and MFES was positively associated only with distal tibial cortical vBMD and cortical von Mises stress (both p < 0.05). Objective measures of physical function, particularly muscle power, are more consistently associated with bone parameters compared with self-administered HRQoL questionnaires.

Keywordsosteoporosis; postmenopausal women; physical function; bone; health-related quality of life
Year2019
JournalJournal of Clinical Medicine
Journal citation8 (9), p. Article 1370
PublisherMultidisciplinary Digital Publishing Institute (MDPI AG)
ISSN2077-0383
Digital Object Identifier (DOI)https://doi.org/10.3390/jcm8091370
PubMed ID31480742
Scopus EID2-s2.0-85114279332
PubMed Central IDPMC6780346
Open accessPublished as ‘gold’ (paid) open access
Research or scholarlyResearch
Page range1-13
FunderMonash University
National Health and Medical Research Council
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online02 Sep 2019
Publication process dates
Accepted30 Aug 2019
Deposited23 Aug 2022
Grant IDSGS16-0388
1123014
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