Associations of health-related quality of life, fear of falling and objective measures of physical function with bone health in postmenopausal women with low bone mass
Journal article
Gandham, Anoohya, McMillan, Lachlan B., Ng, Carrie-Anne, Humbert, Ludovic, Bonham, Maxine P., Zengin, Ayse, Ebeling, Peter R. and Scott, David. (2019). Associations of health-related quality of life, fear of falling and objective measures of physical function with bone health in postmenopausal women with low bone mass. Journal of Clinical Medicine. 8(9), p. Article 1370. https://doi.org/10.3390/jcm8091370
Authors | Gandham, Anoohya, McMillan, Lachlan B., Ng, Carrie-Anne, Humbert, Ludovic, Bonham, Maxine P., Zengin, Ayse, Ebeling, Peter R. and Scott, David |
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Abstract | Health-related quality of life (HRQoL) and physical function deteriorate with age and may adversely impact bone health in older adults. We determined associations of objective measures of physical function and HRQoL with bone health in postmenopausal women with low areal bone mineral density (aBMD). Fifty postmenopausal women (64.4 ± 7.7 years old, mean ± standard deviation) with low spine, hip or femoral neck aBMD (T- or Z-score < −1.0) on dual-energy X-ray absorptiometry (DXA) participated. Femoral surface BMD, trabecular, integral and cortical volumetric BMD (vBMD) measurements were obtained using 3D-SHAPER software on DXA. Distal tibial vBMD and microarchitecture were assessed using high-resolution peripheral quantitative computed tomography (HRpQCT). Participants completed self-administered EuroQol-5D (EQ-5D) and modified falls efficacy scale (MFES) questionnaires, and physical function assessments. Stair climb power was positively associated with bone parameters at the hip, femoral neck, and distal tibia (all p < 0.05) in multivariable linear regression. EQ-5D demonstrated no significant associations with bone parameters and MFES was positively associated only with distal tibial cortical vBMD and cortical von Mises stress (both p < 0.05). Objective measures of physical function, particularly muscle power, are more consistently associated with bone parameters compared with self-administered HRQoL questionnaires. |
Keywords | osteoporosis; postmenopausal women; physical function; bone; health-related quality of life |
Year | 2019 |
Journal | Journal of Clinical Medicine |
Journal citation | 8 (9), p. Article 1370 |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI AG) |
ISSN | 2077-0383 |
Digital Object Identifier (DOI) | https://doi.org/10.3390/jcm8091370 |
PubMed ID | 31480742 |
Scopus EID | 2-s2.0-85114279332 |
PubMed Central ID | PMC6780346 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 1-13 |
Funder | Monash University |
National Health and Medical Research Council (NHMRC) | |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 02 Sep 2019 |
Publication process dates | |
Accepted | 30 Aug 2019 |
Deposited | 23 Aug 2022 |
Grant ID | SGS16-0388 |
1123014 |
https://acuresearchbank.acu.edu.au/item/8y272/associations-of-health-related-quality-of-life-fear-of-falling-and-objective-measures-of-physical-function-with-bone-health-in-postmenopausal-women-with-low-bone-mass
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Publisher's version
OA_Gandham_2019_Associations_of_health_related_quality_of.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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