Cardiometabolic health impacts of time-restricted eating : Implications for type 2 diabetes, cancer and cardiovascular diseases

Journal article

Kirkham, Amy A., Parr, Evelyn B. and Kleckner, Amber S.. (2022). Cardiometabolic health impacts of time-restricted eating : Implications for type 2 diabetes, cancer and cardiovascular diseases. Current Opinion in Clinical Nutrition and Metabolic Care. 25(6), pp. 378-387. https://doi.org/10.1097/MCO.0000000000000867
AuthorsKirkham, Amy A., Parr, Evelyn B. and Kleckner, Amber S.
Abstract

Purpose of review
Time-restricted eating (TRE) entails consuming energy intake within a 4- to 10-h window, with the remaining time spent fasting. Although studies have reported health benefits from TRE, little is known about the impact of TRE on common chronic diseases such as type 2 diabetes, cancer and cardiovascular disease. This review summarizes and critically evaluates the most recent TRE research findings relevant to managing and treating these chronic diseases.

Recent findings
Most recent TRE studies have been in populations with overweight/obesity or metabolic syndrome; two have been in populations with diabetes, three in cancer survivors and none in populations with cardiovascular disease. Collectively, these studies showed that participants could adhere to TRE and TRE is well tolerated. These studies also showed preliminary efficacy for improved glucose regulation and insulin sensitivity, a reduction in body fat and blood pressure, reduced cardiovascular risk scores and increased quality of life. More research is required to define the most effective TRE protocol (i.e. length and timing of eating window, intervention duration).

Summary
TRE has demonstrated benefits on cardiovascular, metabolic and clinical outcomes relevant to the underlying pathophysiology, but there are limited data on TRE implemented specifically within populations with diabetes, cancer or cardiovascular disease.

Keywordsbehavioural intervention; circadian rhythm; fasting; heart disease; nutrition; oncology
Year2022
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Journal citation25 (6), pp. 378-387
PublisherLippincott Williams & Wilkins
ISSN1363-1950
Digital Object Identifier (DOI)https://doi.org/10.1097/MCO.0000000000000867
Scopus EID2-s2.0-85139377860
Page range378-387
FunderHeart and Stroke Foundation of Canada
University of Maryland, Baltimore
Institute for Clinical and Translational Research
Maryland Department of Health
Diabetes Australia
Publisher's version
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All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online2022
Publication process dates
Deposited21 Oct 2022
Grant IDUL1TR003098
Y20GPARE
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