Cardiometabolic health impacts of time-restricted eating : Implications for type 2 diabetes, cancer and cardiovascular diseases

Journal article

Kirkham, Amy A., Parr, Evelyn B. and Kleckner, Amber S.. (2022). Cardiometabolic health impacts of time-restricted eating : Implications for type 2 diabetes, cancer and cardiovascular diseases. Current Opinion in Clinical Nutrition and Metabolic Care. 25(6), pp. 378-387. https://doi.org/10.1097/MCO.0000000000000867
AuthorsKirkham, Amy A., Parr, Evelyn B. and Kleckner, Amber S.
Abstract

Purpose of review
Time-restricted eating (TRE) entails consuming energy intake within a 4- to 10-h window, with the remaining time spent fasting. Although studies have reported health benefits from TRE, little is known about the impact of TRE on common chronic diseases such as type 2 diabetes, cancer and cardiovascular disease. This review summarizes and critically evaluates the most recent TRE research findings relevant to managing and treating these chronic diseases.

Recent findings
Most recent TRE studies have been in populations with overweight/obesity or metabolic syndrome; two have been in populations with diabetes, three in cancer survivors and none in populations with cardiovascular disease. Collectively, these studies showed that participants could adhere to TRE and TRE is well tolerated. These studies also showed preliminary efficacy for improved glucose regulation and insulin sensitivity, a reduction in body fat and blood pressure, reduced cardiovascular risk scores and increased quality of life. More research is required to define the most effective TRE protocol (i.e. length and timing of eating window, intervention duration).

Summary
TRE has demonstrated benefits on cardiovascular, metabolic and clinical outcomes relevant to the underlying pathophysiology, but there are limited data on TRE implemented specifically within populations with diabetes, cancer or cardiovascular disease.

Keywordsbehavioural intervention; circadian rhythm; fasting; heart disease; nutrition; oncology
Year2022
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Journal citation25 (6), pp. 378-387
PublisherLippincott Williams & Wilkins
ISSN1363-1950
Digital Object Identifier (DOI)https://doi.org/10.1097/MCO.0000000000000867
Scopus EID2-s2.0-85139377860
Page range378-387
FunderHeart and Stroke Foundation of Canada
University of Maryland, Baltimore
Institute for Clinical and Translational Research
Maryland Department of Health
Diabetes Australia
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online2022
Publication process dates
Deposited21 Oct 2022
Grant IDUL1TR003098
Y20GPARE
Permalink -

https://acuresearchbank.acu.edu.au/item/8y5xw/cardiometabolic-health-impacts-of-time-restricted-eating-implications-for-type-2-diabetes-cancer-and-cardiovascular-diseases

Log in to edit

Restricted files

Publisher's version

  • 69
    total views
  • 0
    total downloads
  • 2
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates : A randomized control trial
Parr, Evelyn B., Kouw, Imre W. K., Wheeler, Michael J., Radford, Bridget E., Hall, Rebecca C., Senden, Joan M., Goessens, Joy P. B., Van Loon, Luc J. C. and Hawley, John A.. (2023). Eight-hour time-restricted eating does not lower daily myofibrillar protein synthesis rates : A randomized control trial. Obesity. 31(S1), pp. 116-126. https://doi.org/10.1002/oby.23637
High-intensity interval training in polycystic ovary syndrome : A two-center, three-armed randomized
Kiel, Ida A., Lionett, Sofie, Parr, Evelyn B., Jones, Helen, Røset, Maria A. H., Salvesen, Øyvind, Hawley, John A., Vanky, Eszter and Moholdt, Trine. (2022). High-intensity interval training in polycystic ovary syndrome : A two-center, three-armed randomized. Medicine and Science in Sports and Exercise. 54(5), pp. 717-727. https://doi.org/10.1249/MSS.0000000000002849
Perspective : Time-restricted eating—integrating the what with the when
Parr, Evelyn B., Devlin, Brooke L. and Hawley, John A.. (2022). Perspective : Time-restricted eating—integrating the what with the when. Advances in Nutrition. 13(3), pp. 699-711. https://doi.org/10.1093/advances/nmac015
"I want to get myself as fit as I can and not die just yet" - Perceptions of exercise in people with advanced cancer and cachexia : A qualitative study
Bland, Kelcey A., Krishnasamy, Meinir, Parr, Evelyn B., Mulder, Stella, Martin, Peter, van Loon, Luc, Cormie, Prue, Michael, Natasha and Zopf, Eva M.. (2022). "I want to get myself as fit as I can and not die just yet" - Perceptions of exercise in people with advanced cancer and cachexia : A qualitative study. BMC Palliative Care. 21(1), p. Article 75. https://doi.org/10.1186/s12904-022-00948-x
Skeletal muscle adaptive responses to different types of short-term exercise training and detraining in middle-age men
Callahan, Marcus J., Parr, Evelyn B., Snijders, Tim, Conceição, Miguel S., Radford, Bridget E., Timmins, Ryan G., Devlin, Brooke L., Hawley, John A. and Camera, Donny M.. (2021). Skeletal muscle adaptive responses to different types of short-term exercise training and detraining in middle-age men. Medicine and Science in Sports and Exercise. 53(10), pp. 2023-2036. https://doi.org/10.1249/MSS.0000000000002684
Lower nocturnal blood glucose response to a potato-based mixed evening meal compared to rice in individuals with type 2 diabetes
Devlin, Brooke L., Parr, Evelyn B., Radford, Bridget E. and Hawley, John A.. (2021). Lower nocturnal blood glucose response to a potato-based mixed evening meal compared to rice in individuals with type 2 diabetes. Clinical Nutrition. 40(4), pp. 2200-2209. https://doi.org/10.1016/j.clnu.2020.09.049
Can high-intensity interval training promote skeletal muscle anabolism?
Callahan, Marcus J., Parr, Evelyn B., Hawley, John A. and Camera, Donny M.. (2021). Can high-intensity interval training promote skeletal muscle anabolism? Sports Medicine. 51, pp. 405-421. https://doi.org/10.1007/s40279-020-01397-3
Time-restricted eating as a nutrition strategy for individuals with type 3 diabetes : A feasibility study
Parr, Evelyn B., Devlin, Brooke L., Lim, Karen H. C., Moresi, Laura N. Z., Geils, Claudia, Brennan, Leah and Hawley, John A.. (2020). Time-restricted eating as a nutrition strategy for individuals with type 3 diabetes : A feasibility study. Nutrients. 12(11), p. 3228. https://doi.org/10.3390/nu12113228
Circulating and adipose tissue miRNAs in women with polycystic ovary syndrome and responses to high-intensity interval training
Lionett,Sofie, Kiel,Ida A., Camera,Donny M., Vanky,Eszter, Parr, E., Lydersen,Stian, Hawley, J. and Moholdt,Trine. (2020). Circulating and adipose tissue miRNAs in women with polycystic ovary syndrome and responses to high-intensity interval training. Frontiers in Physiology. 11, p. 904. https://doi.org/10.3389/fphys.2020.00904
Improving reproductive function in women with polycystic ovary syndrome with high-intensity interval training (IMPROV-IT): study protocol for a two-centre, three-armed randomised controlled trial
Ida Almenning Kiel, Sofie Lionett, Evelyn Parr, Helen Jones, Maria Aurora Hernandez Roset, Oyvind Salvesen, Eszter Vanky and Trine Moholdt. (2020). Improving reproductive function in women with polycystic ovary syndrome with high-intensity interval training (IMPROV-IT): study protocol for a two-centre, three-armed randomised controlled trial. BMJ Open. 10(2), pp. 1-9. https://doi.org/10.1136/bmjopen-2019-034733
A time to eat and a time to exercise
Parr, Evelyn B., Heilbronn, Leonie K. and Hawley, John A.. (2020). A time to eat and a time to exercise. Exercise and Sport Sciences Reviews. 48(1), pp. 4-10. https://doi.org/10.1249/JES.0000000000000207
Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression
Leonidas S Lundell, Evelyn Parr, Brooke Devlin, Lars R Ingerslev, Ali Altintas, Shogo Sato, Paolo Sassone-Corsi, Romain Barres, Juleen R Zierath and John Hawley. (2020). Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression. Nature Communications. 11(1), pp. 1-11. https://doi.org/10.1038/s41467-020-18412-w
Effects of providing high-fat versus high-carbohydrate meals on daily and postprandial physical activity and glucose patterns: a randomised controlled trial
Parr, Evelyn, Devlin, Brooke, Callahan, Marcus J., Radford, Bridget, Blankenship, Jennifer M., Dunstan, David and Hawley, John. (2018). Effects of providing high-fat versus high-carbohydrate meals on daily and postprandial physical activity and glucose patterns: a randomised controlled trial. Nutrients. 10(5), pp. 1 - 16. https://doi.org/10.3390/nu10050557
Impact of first meal size during prolonged sitting on postprandial glycaemia in individuals with prediabetes: a randomised, crossover study
Parr, Evelyn, Devlin, Brooke, Pinto, Samuel, Dunstan, David and Hawley, John. (2018). Impact of first meal size during prolonged sitting on postprandial glycaemia in individuals with prediabetes: a randomised, crossover study. Nutrients. 10(6), pp. 1 - 15. https://doi.org/10.3390/nu10060733
High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans
Leckey, Jill J., Hoffman, Nolan J., Parr, Evelyn B., Devlin, Brooke L., Trewin, Adam J., Stepto, Nigel K., Morton, James P., Burke, Louise M. and Hawley, John A.. (2018). High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB Journal. 32(6), pp. 2979-2991. https://doi.org/10.1096/fj.201700993R
Single and combined effects of beetroot crystals and sodium bicarbonate on 4-km cycling time trial performance
Callahan, Marcus J., Parr, Evelyn B., Hawley, John A. and Burke, Louise M.. (2017). Single and combined effects of beetroot crystals and sodium bicarbonate on 4-km cycling time trial performance. International Journal of Sport Nutrition and Exercise Metabolism. 27(3), pp. 271-278. https://doi.org/10.1123/ijsnem.2016-0228
Similar metabolic response to lower- versus upper-body interval exercise or endurance exercise
Francois, Monique E., Graham, Matthew J., Parr, Evelyn, Rehrer, Nancy J., Lucas, Samuel J. E., Stavrianeas, Stasinos and Cotter, James D.. (2017). Similar metabolic response to lower- versus upper-body interval exercise or endurance exercise. Metabolism: Clinical and experimental. 68, pp. 1 - 10. https://doi.org/10.1016/j.metabol.2016.11.009
Carbohydrate dependence during prolonged simulated cycling time trials
Torrens, Samuel L., Areta, José L., Parr, Evelyn B. and Hawley, John A.. (2016). Carbohydrate dependence during prolonged simulated cycling time trials. European Journal of Applied Physiology. 116(4), pp. 781-790. https://doi.org/10.1007/s00421-016-3333-y
Low-volume intense exercise elicits post-exercise hypotension and subsequent hypervolemia, irrespective of which limbs are exercised
Graham, Matthew J., Lucas, Samuel J. E., Francois, Monique E., Stavrianeas, Stasinos, Parr, Evelyn B., Thomas, Kate N. and Cotter, James D.. (2016). Low-volume intense exercise elicits post-exercise hypotension and subsequent hypervolemia, irrespective of which limbs are exercised. Frontiers in Physiology. 7(May), pp. 1 - 11. https://doi.org/10.3389/Fphys.2016.00199
Circulating microRNA responses between 'high' and 'low' responders to a 16-wk diet and exercise weight loss intervention
Parr, Evelyn B., Camera, Donny M., Burke, Louise M., Phillips, Stuart M., Coffey, Vernon G. and Hawley, John Alan. (2016). Circulating microRNA responses between 'high' and 'low' responders to a 16-wk diet and exercise weight loss intervention. PLoS ONE. 11(4), pp. 1 - 14. https://doi.org/10.1371/journal.pone.0152545
A randomized trial of high-dairy-protein, variable-carbohydrate diets and exercise on body composition in adults with obesity
Parr, Evelyn B., Coffey, Vernon Glenn, Cato, Louise E., Phillips, Stuart M., Burke, Louise Mary and Hawley, John Alan. (2016). A randomized trial of high-dairy-protein, variable-carbohydrate diets and exercise on body composition in adults with obesity. Obesity. 24(5), pp. 1035 - 1045. https://doi.org/10.1002/oby.21451
Protein coingestion with alcohol following strenuous exercise attenuates alcohol-induced intramyocellular apoptosis and inhibition of autophagy
Smiles, William J., Parr, Evelyn B., Coffey, Vernon G., Lacham-Kaplan, Orly, Hawley, John Alan and Camera, Donny Michael. (2016). Protein coingestion with alcohol following strenuous exercise attenuates alcohol-induced intramyocellular apoptosis and inhibition of autophagy. American Journal of Physiology - Endocrinology and Metabolism. 311(5), pp. E836 - E849. https://doi.org/10.1152/ajpendo.00303.2016
Exercise and nutrient interactions: Effects on skeletal muscle and body fat mass
Parr, Evelyn Bridget. (2015). Exercise and nutrient interactions: Effects on skeletal muscle and body fat mass [Thesis]. https://doi.org/10.4226/66/5a9cbd34b0b99
Alcohol ingestion impairs maximal post-exercise rates of myofibrillar protein synthesis following a single bout of concurrent training
Parr, Evelyn, Camera, Donny, Areta, José, Burke, Louise, Phillips, Stuart, Hawley, John A. and Coffey, Vernon. (2014). Alcohol ingestion impairs maximal post-exercise rates of myofibrillar protein synthesis following a single bout of concurrent training. PLoS ONE. 9(2), pp. 1 - 9. https://doi.org/10.1371/journal.pone.0088384