Protein coingestion with alcohol following strenuous exercise attenuates alcohol-induced intramyocellular apoptosis and inhibition of autophagy

Journal article

Smiles, William J., Parr, Evelyn B., Coffey, Vernon G., Lacham-Kaplan, Orly, Hawley, John Alan and Camera, Donny Michael. (2016). Protein coingestion with alcohol following strenuous exercise attenuates alcohol-induced intramyocellular apoptosis and inhibition of autophagy. American Journal of Physiology - Endocrinology and Metabolism. 311(5), pp. E836 - E849. https://doi.org/10.1152/ajpendo.00303.2016

Authors	Smiles, William J., Parr, Evelyn B., Coffey, Vernon G., Lacham-Kaplan, Orly, Hawley, John Alan and Camera, Donny Michael
Abstract	Alcohol ingestion decreases postexercise rates of muscle protein synthesis, but the mechanism( s ) ( e.g., increased protein breakdown ) underlying this observation is unknown. Autophagy is an intracellular “recycling” system required for homeostatic substrate and organelle turnover; its dysregulation may provoke apoptosis and lead to muscle atrophy. We investigated the acute effects of alcohol ingestion on autophagic cell signaling responses to a bout of concurrent ( combined resistance- and endurance-based ) exercise. In a randomized crossover design, eight physically active males completed three experimental trials of concurrent exercise with either postexercise ingestion of alcohol and carbohydrate ( 12 ± 2 standard drinks; ALC-CHO ), energy-matched alcohol and protein ( ALC-PRO ), or protein ( PRO ) only. Muscle biopsies were taken at rest and 2 and 8 h postexercise. Select autophagy-related gene ( Atg ) proteins decreased compared with rest with ALC-CHO ( P < 0.05 ) but not ALC-PRO. There were parallel increases ( P < 0.05 ) in p62 and PINK1 commensurate with a reduction in BNIP3 content, indicating a diminished capacity for mitochondria-specific autophagy ( mitophagy ) when alcohol and carbohydrate were coingested. DNA fragmentation increased in both alcohol conditions ( P < 0.05 ); however, nuclear AIF accumulation preceded this apoptotic response with ALC-CHO only ( P < 0.05 ). In contrast, increases in the nuclear content of p53, TFEB, and PGC-1α in ALC-PRO were accompanied by markers of mitochondrial biogenesis at the transcriptional ( Tfam, SCO2, and NRF-1 ) and translational ( COX-IV, ATPAF1, and VDAC1 ) level ( P < 0.05 ). We conclude that alcohol ingestion following exercise triggers apoptosis, whereas the anabolic properties of protein coingestion may stimulate mitochondrial biogenesis to protect cellular homeostasis.
Keywords	alcohol; exercise; autophagy; apoptosis; protein
Year	2016
Journal	American Journal of Physiology - Endocrinology and Metabolism
Journal citation	311 (5), pp. E836 - E849
Publisher	American Physiological Society
ISSN	1522-1555
Digital Object Identifier (DOI)	https://doi.org/10.1152/ajpendo.00303.2016
Scopus EID	2-s2.0-84994603238
Page range	E836 - E849
Research Group	Mary MacKillop Institute for Health Research
Publisher's version	File Access Level Controlled
Place of publication	United States

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Murphy, Caoileann, Shankaran, Mahalakshmi, Churchward-Venne, T. A., Mitchell, Cameron J., Kolar, Nathan M., Burke, Louise, Hawley, John, Kassis, Amira, Karagounis, Leonidas G., Li, Kelvin, King, Chelsea, Hellerstein, Marc and Phillips, S. M.. (2018). Effect of resistance training and protein intake pattern on myofibrillar protein synthesis and proteome kinetics in older men in energy restriction. The Journal of Physiology. 596(11), pp. 2091 - 2120. https://doi.org/10.1113/JP275246

Structural determinants for small-molecule activation of skeletal muscle AMPK α2β2γ1 by the glucose importagog sc4

Ngoei, Kevin R.W., Langendorf, Christopher G., Ling, Naomi, Hoque, Ashfaqul, Johnson, Swapna, Camerino, Michelle C., Walker, Scott R., Bozikis, Ylva E., Dite, Toby A., Ovens, Ashley J., Smiles, William, Jacobs, Roxane, Huang, He, Parker, Michael W., Scott, John W., Rider, Mark H., Foitzik, Richard C., Kemp, Bruce, Baell, Jonathan B. and Oakhill, Jonathan S.. (2018). Structural determinants for small-molecule activation of skeletal muscle AMPK α2β2γ1 by the glucose importagog sc4. Cell Chemical Biology. 25(6), pp. 728 - 737. https://doi.org/10.1016/j.chembiol.2018.03.008

Potential roles of n-3 PUFAs during skeletal muscle growth and regeneration

Tachtsis, Bill, Camera, Donny and Lacham-Kaplan, Orly. (2018). Potential roles of n-3 PUFAs during skeletal muscle growth and regeneration. Nutrients. 10(3), pp. 1 - 20. https://doi.org/10.3390/nu10030309

The guardian of the genome p53 regulates exercise-induced mitochondrial plasticity beyond organelle biogenesis

Smiles, William and Camera, Donny. (2018). The guardian of the genome p53 regulates exercise-induced mitochondrial plasticity beyond organelle biogenesis. Acta Physiologica. 222(3), pp. 1 - 13. https://doi.org/10.1111/apha.13004

Protein availability and satellite cell dynamics in skeletal muscle

Shamim, Baubak, Hawley, John and Camera, Donny. (2018). Protein availability and satellite cell dynamics in skeletal muscle. Sports Medicine. 48(6), pp. 1329 - 1343. https://doi.org/10.1007/s40279-018-0883-7

Where do satellite cells orbit? An endomysium space odyssey

Shamim, Baubak, Conceicao, Miguel, Callahan, Marcus J. and Camera, Donny. (2018). Where do satellite cells orbit? An endomysium space odyssey. The Journal of Physiology. 596(10), pp. 1791 - 1792. https://doi.org/10.1113/JP276024

Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle

Sato, Shogo, Evelyn, Parr B., Devlin, Brooke L., Hawley, John A. and Sassone-Corsi, Paolo. (2018). Human metabolomics reveal daily variations under nutritional challenges specific to serum and skeletal muscle. Molecular Metabolism. 16, pp. 1-11. https://doi.org/10.1016/j.molmet.2018.06.008

Toward a common understanding of diet-exercise strategies to manipulate fuel availability for training and competition preparation in endurance sport

Burke, Louise, Hawley, John, Jeukendrup, A. E., Morton, James P., Stellingwerff, T. and Maughan, Ronald J.. (2018). Toward a common understanding of diet-exercise strategies to manipulate fuel availability for training and competition preparation in endurance sport. International Journal of Sport Nutrition and Exercise Metabolism. 28(5), pp. 451 - 463. https://doi.org/10.1123/ijsnem.2018-0289

Muscle fiber hypertrophy and myonuclei addition: a systematic review and meta-analysis

Conceição, Miguel S., Vechin, Felipe C., Lixandrão, Manoel, Damas, Felipe, Libardi, Cleiton A., Tricoli, Valmor, Roschel, Hamilton, Camera, Donny and Ugrinowitsch, Carlos. (2018). Muscle fiber hypertrophy and myonuclei addition: a systematic review and meta-analysis. Medicine and Science in Sports and Exercise. 50(7), pp. 1385 - 1393. https://doi.org/10.1249/MSS.0000000000001593

Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges

Perry, Christopher G. R. and Hawley, John. (2018). Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges. Cold Spring Harbor Perspectives in Medicine. 8(9), pp. 1 - 15. https://doi.org/10.1101/cshperspect.a029686

Adaptations to concurrent training in combination with high protein availability: A comparative trial in healthy, recreationally active men

Shamim, Baubak, Devlin, Brooke L., Timmins, Ryan G., Tofari, Paul, Dow, Connor Lee, Coffey, Vernon G., Hawley, John A. and Camera, Donny M.. (2018). Adaptations to concurrent training in combination with high protein availability: A comparative trial in healthy, recreationally active men. Sports Medicine. 48(12), pp. 2869 - 2883. https://doi.org/10.1007/s40279-018-0999-9

High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans

Leckey, Jill J., Hoffman, Nolan J., Parr, Evelyn B., Devlin, Brooke L., Trewin, Adam J., Stepto, Nigel K., Morton, James P., Burke, Louise M. and Hawley, John A.. (2018). High dietary fat intake increases fat oxidation and reduces skeletal muscle mitochondrial respiration in trained humans. FASEB Journal. 32(6), pp. 2979-2991. https://doi.org/10.1096/fj.201700993R

Maximizing cellular adaptation to endurance exercise in skeletal muscle

Hawley, John, Lundby, Carsten, Cotter, James D. and Burke, Louise. (2018). Maximizing cellular adaptation to endurance exercise in skeletal muscle. Cell Metabolism. 27(5), pp. 962 - 976. https://doi.org/10.1016/j.cmet.2018.04.014

Post-exercise muscle glycogen resynthesis in humans

Burke, Louise M., van Loon, Luc J. C. and Hawley, John A.. (2017). Post-exercise muscle glycogen resynthesis in humans. Journal of Applied Physiology. 122(5), pp. 1055-1067. https://doi.org/0.1152/japplphysiol.00860.2016

Ketone diester ingestion impairs time-trial performance in professional cyclists

Leckey, Jill J., Ross, Megan L., Quod, Marc, Hawley, John A. and Burke, Louise M.. (2017). Ketone diester ingestion impairs time-trial performance in professional cyclists. Frontiers in Physiology. 8(OCT), pp. 1 - 10. https://doi.org/10.3389/fphys.2017.00806

Fenugreek increases insulin-stimulated creatine content in l6C11 muscle myotubes

Tomcik, Kristyen, Smiles, William, Camera, Donny, Hugel, Helmut M., Hawley, John and Watts, Rani. (2017). Fenugreek increases insulin-stimulated creatine content in l6C11 muscle myotubes. European Journal of Nutrition. 56(3), pp. 973 - 979. https://doi.org/10.1007/s00394-015-1145-1

Acute low-intensity cycling with blood-flow restriction has no effect on metabolic signaling in human skeletal muscle compared to traditional exercise

Smiles, William J., Conceição, Miguel S., Telles, Guilherme D., Chacon-Mikahil, Mara P. T., Cavaglieri, Cláudia R., Vechin, Felipe C., Libardi, Cleiton A., Hawley, John A. and Camera, Donny M.. (2017). Acute low-intensity cycling with blood-flow restriction has no effect on metabolic signaling in human skeletal muscle compared to traditional exercise. European Journal of Applied Physiology. 117(2), pp. 345-358. https://doi.org/10.1007/s00421-016-3530-8

Single and combined effects of beetroot crystals and sodium bicarbonate on 4-km cycling time trial performance

Callahan, Marcus J., Parr, Evelyn B., Hawley, John A. and Burke, Louise M.. (2017). Single and combined effects of beetroot crystals and sodium bicarbonate on 4-km cycling time trial performance. International Journal of Sport Nutrition and Exercise Metabolism. 27(3), pp. 271-278. https://doi.org/10.1123/ijsnem.2016-0228

Similar metabolic response to lower- versus upper-body interval exercise or endurance exercise

Francois, Monique E., Graham, Matthew J., Parr, Evelyn, Rehrer, Nancy J., Lucas, Samuel J. E., Stavrianeas, Stasinos and Cotter, James D.. (2017). Similar metabolic response to lower- versus upper-body interval exercise or endurance exercise. Metabolism: Clinical and experimental. 68, pp. 1 - 10. https://doi.org/10.1016/j.metabol.2016.11.009

Postexercise muscle glycogen resynthesis in humans

Burke, Louise, Van Loon, Luc and Hawley, John. (2017). Postexercise muscle glycogen resynthesis in humans. Journal of Applied Physiology. 122(5), pp. 1055 - 1067. https://doi.org/10.1152/japplphysiol.00860.2016

Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges

Perry, Christopher G. R. and Hawley, John. (2017). Molecular basis of exercise-induced skeletal muscle mitochondrial biogenesis: Historical advances, current knowledge, and future challenges. In In J. R. Zierath, M. J. Joyner and J. A. Hawley (Ed.). The biology of exercise: A subject collection from Cold Spring Harbor Persepectives in Medicine pp. 73 - 87 Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/cshperspect.a029686

Concurrent exercise training: Do opposites distract?

Coffey, Vernon and Hawley, John. (2017). Concurrent exercise training: Do opposites distract? The Journal of Physiology. 595(9), pp. 2883 - 2896. https://doi.org/10.1113/JP272270

Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers

Burke, Louise, Ross, Megan L.L., Garvican, Laura A., Welvaert, Marijke, Heikura, Ida A., Forbes, Sara G., Mirtschin, Jo, Cato, Louise E., Strobel, Nicki, Sharma, Avish P. and Hawley, John. (2017). Low carbohydrate, high fat diet impairs exercise economy and negates the performance benefit from intensified training in elite race walkers. The Journal of Physiology. 595(9), pp. 2785 - 2807. https://doi.org/10.1113/JP273230

Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise

Camera, Donny M., Burniston, Jatin G., Pogson, Mark A., Smiles, William J. and Hawley, John A.. (2017). Dynamic proteome profiling of individual proteins in human skeletal muscle after a high-fat diet and resistance exercise. The FASEB Journal. 31(12), pp. 5478-5494. https://doi.org/10.1096/fj.201700531R

Autophagy and Protein Turnover Responses to Exercise-Nutrient Interactions in Human Skeletal Muscle

Smiles, William J.. (2017). Autophagy and Protein Turnover Responses to Exercise-Nutrient Interactions in Human Skeletal Muscle [Thesis]. https://doi.org/10.4226/66/59f29efd01e38

Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans

Laker, R. C., Garde, C., Camera, Donny, Smiles, William, Zierath, J. R., Hawley, John and Barrès, R.. (2017). Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans. Scientific Reports. 7(1), pp. 1 - 12. https://doi.org/10.1038/s41598-017-15420-7

Commentaries on Viewpoint: A time for exercise: the exercise window

Boule, Normand G., Terada, Tasuku, Francois, Monique E., Hawley, John, Cotter, James D., Kruse, Nicholas T., McDonald, Matthew W., Olver, T D., Paoli, Antonio, Sacchetti, Massimo, Di Luigi, Luigi, van Dijk, Jan W., Van Loon, Luc, Yardley, Jane E., DiPietro, Loretta, Gribok, Andrei and Rumpler, William. (2017). Commentaries on Viewpoint: A time for exercise: the exercise window. Journal of Applied Physiology. 122(1), pp. 210 - 213. https://doi.org/10.1152/japplphysiol.00938.2016

Sprinting toward fitness

Gibala, M. J. and Hawley, John. (2017). Sprinting toward fitness. Cell Metabolism. 25(5), pp. 988 - 990. https://doi.org/10.1016/j.cmet.2017.04.030

Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity

Pinto, Samuel K., Lamon, Séverine, Stephenson, Erin J., Kalanon, M., Mikovic, Jasmine, Koch, L G., Britton, S. L., Hawley, John and Camera, Donny. (2017). Expression of microRNAs and target proteins in skeletal muscle of rats selectively bred for high and low running capacity. American Journal of Physiology - Endocrinology and Metabolism. 313(3), pp. 335 - 343. https://doi.org/10.1152/ajpendo.00043.2017

Postexercise high-fat feeding suppresses p70S6K1 activity in human skeletal muscle

Hammond, Kelly M., Impey, Samuel G., Currell, Kevin, Mitchell, Nigel, Shepherd, Sam O., Jeromson, Stewart, Hawley, John A., Close, Graeme L., Hamilton, Lee D., Sharples, Adam P. and Morton, James P.. (2016). Postexercise high-fat feeding suppresses p70S6K1 activity in human skeletal muscle. Medicine and Science in Sports and Exercise. 48(11), pp. 2108-2117. https://doi.org/10.1249/MSS.0000000000001009

Adaptations to prolonged, intense endurance training in human skeletal muscle

Hawley, J. A. (2016). Adaptations to prolonged, intense endurance training in human skeletal muscle. In In I Mujika and Y Le Meur (Ed.). Endurance Training pp. 119-126 Inigo Mujika.

Update on the effects of physical activity on insulin sensitivity in humans

Bird, Stephen R. and Hawley, John. (2016). Update on the effects of physical activity on insulin sensitivity in humans. 2(1), pp. 1 - 26. https://doi.org/10.1136/bmjsem-2016-000143

Revisiting the three component synthesis of isoxazolo[5,4-b]pyridines, 4-aryl-3,7,7-trimethyl-isoxazolo[5,4-b]quinolin-5(6H)-ones and related heterocycles

Lingham, Anthony R., Hawley, John A., Greaves, Tamar, Jackson, Neale, Antolasic, Frank and Hugel, Helmut M.. (2016). Revisiting the three component synthesis of isoxazolo[5,4-b]pyridines, 4-aryl-3,7,7-trimethyl-isoxazolo[5,4-b]quinolin-5(6H)-ones and related heterocycles. Polyhedron. 120, pp. 175 - 179. https://doi.org/10.1016/j.poly.2016.09.011

Carbohydrate dependence during prolonged simulated cycling time trials

Torrens, Samuel L., Areta, José L., Parr, Evelyn B. and Hawley, John A.. (2016). Carbohydrate dependence during prolonged simulated cycling time trials. European Journal of Applied Physiology. 116(4), pp. 781-790. https://doi.org/10.1007/s00421-016-3333-y

Low-volume intense exercise elicits post-exercise hypotension and subsequent hypervolemia, irrespective of which limbs are exercised

Graham, Matthew J., Lucas, Samuel J. E., Francois, Monique E., Stavrianeas, Stasinos, Parr, Evelyn B., Thomas, Kate N. and Cotter, James D.. (2016). Low-volume intense exercise elicits post-exercise hypotension and subsequent hypervolemia, irrespective of which limbs are exercised. Frontiers in Physiology. 7(May), pp. 1 - 11. https://doi.org/10.3389/Fphys.2016.00199

Acute endurance exercise induces nuclear p53 abundance in human skeletal muscle

Tachtsis, Bill, Smiles, William, Lane, Steven C., Hawley, John Alan and Camera, Donny Michael. (2016). Acute endurance exercise induces nuclear p53 abundance in human skeletal muscle. Frontiers in Physiology. 7(144), pp. 1 - 10. https://doi.org/10.3389/fphys.2016.00144

Circulating microRNA responses between 'high' and 'low' responders to a 16-wk diet and exercise weight loss intervention

Parr, Evelyn B., Camera, Donny M., Burke, Louise M., Phillips, Stuart M., Coffey, Vernon G. and Hawley, John Alan. (2016). Circulating microRNA responses between 'high' and 'low' responders to a 16-wk diet and exercise weight loss intervention. PLoS ONE. 11(4), pp. 1 - 14. https://doi.org/10.1371/journal.pone.0152545

Altering fatty acid availability does not impair prolonged, continuous running to fatigue: Evidence for carbohydrate dependence

Leckey, Jill, Burke, Louise Mary, Morton, James P. and Hawley, John Alan. (2016). Altering fatty acid availability does not impair prolonged, continuous running to fatigue: Evidence for carbohydrate dependence. Journal of Applied Physiology. 120(2), pp. 107 - 113. https://doi.org/10.1152/japplphysiol.00855.2015

Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough

Camera, Donny and Hawley, John. (2016). Commentaries on Viewpoint: The rigorous study of exercise adaptations: Why mRNA might not be enough. Journal of Applied Physiology. 121(2), pp. 598 - 598. https://doi.org/10.1152/japplphysiol.00509.2016

Exercise-induced skeletal muscle signaling pathways and human athletic performance

Camera, Donny Michael, Smiles, William J. and Hawley, John Alan. (2016). Exercise-induced skeletal muscle signaling pathways and human athletic performance. Free Radical Biology & Medicine. 98, pp. 131 - 143. https://doi.org/10.1016/j.freeradbiomed.2016.02.007

Effects of skeletal muscle energy availability on protein turnover responses to exercise

Smiles, William J., Hawley, John Alan and Camera, Donny Michael. (2016). Effects of skeletal muscle energy availability on protein turnover responses to exercise. Journal of Experimental Biology. 219(Pt 2), pp. 214 - 225. https://doi.org/10.1242/jeb.125104

Periodization of carbohydrate intake: Short-term effect on performance

Marquet, Laurie-Anne, Hausswirth, Christophe, Molle, Odeline, Hawley, John A., Burke, Louise M., Tiollier, Eve and Brisswalter, Jeanick. (2016). Periodization of carbohydrate intake: Short-term effect on performance. Nutrients. 8(12), pp. 1 - 13. https://doi.org/10.3390/nu8120755

A randomized trial of high-dairy-protein, variable-carbohydrate diets and exercise on body composition in adults with obesity

Parr, Evelyn B., Coffey, Vernon Glenn, Cato, Louise E., Phillips, Stuart M., Burke, Louise Mary and Hawley, John Alan. (2016). A randomized trial of high-dairy-protein, variable-carbohydrate diets and exercise on body composition in adults with obesity. Obesity. 24(5), pp. 1035 - 1045. https://doi.org/10.1002/oby.21451

Metabolism: One step forward for exercise

Hawley, John Alan and Krook, Anna. (2016). Metabolism: One step forward for exercise. Nature Reviews Endocrinology. 12(1), pp. 7 - 8. https://doi.org/10.1038/nrendo.2015.201

Attenuated PGC-1α isoforms following endurance exercise with blood flow restriction

Conceição, Miguel Soares, Chacon-Mikahil, Mara Patricia Traina, Telles, Guilherme Defante, Libardi, Cleiton Augusto, Júnior, Edson Manoel Mendes, Vechin, Felipe Cassaro, Lugani de Andrade, André Luis, Gáspari, Arthur Fernandes, Brum, Patrícia Chakur, Cavaglieri, Cláudia Regina, Serag, Sara, Spiegelman, Bruce M., Hawley, John A. and Camera, Donny M.. (2016). Attenuated PGC-1α isoforms following endurance exercise with blood flow restriction. Medicine and Science in Sports and Exercise. 16(4809), pp. 1699-1707. https://doi.org/10.1249/MSS.0000000000000970

SnapShot: Exercise metabolism

Egan, Brendan, Hawley, John Alan and Zierath, Juleen R.. (2016). SnapShot: Exercise metabolism. Cell Metabolism. 24(2), pp. 342 - 342. https://doi.org/10.1016/j.cmet.2016.07.013

Selective modulation of microRNA expression with protein ingestion following concurrent resistance and endurance exercise in human skeletal muscle

Camera, Donny Michael, Ong, Jun N., Coffey, Vernon Glenn and Hawley, John Alan. (2016). Selective modulation of microRNA expression with protein ingestion following concurrent resistance and endurance exercise in human skeletal muscle. Frontiers in Physiology. 7(Mar), pp. 1 - 8. https://doi.org/10.3389/fphys.2016.00087

Enhanced endurance performance by periodization of CHO intake: "Sleep Low" strategy

Marquet, Laurie-Anne, Brisswalter, Jeanick, Louis, Julien, Tiollier, Eve, Burke, Louise Mary, Hawley, John Alan and Hausswirth, Christophe. (2016). Enhanced endurance performance by periodization of CHO intake: "Sleep Low" strategy. Medicine and Science in Sports and Exercise. 48(4), pp. 663 - 672. https://doi.org/10.1249/MSS.0000000000000823

Modulation of autophagy signaling with resistance exercise and protein ingestion following short-term energy deficit

Smiles, William J., Areta, José L., Coffey, Vernon G., Phillips, Stuart M., Moore, Daniel R., Stellingwerff, Trent, Burke, Louise M., Hawley, John A. and Camera, Donny M.. (2015). Modulation of autophagy signaling with resistance exercise and protein ingestion following short-term energy deficit. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 309(5), pp. R603-R612. https://doi.org/10.1152/ajpregu.00413.2014

Exercise and nutrient interactions: Effects on skeletal muscle and body fat mass

Parr, Evelyn Bridget. (2015). Exercise and nutrient interactions: Effects on skeletal muscle and body fat mass [Thesis]. https://doi.org/10.4226/66/5a9cbd34b0b99

Carbohydrate dependence during prolonged, intense endurance exercise

Hawley, John and Leckey, Jill. (2015). Carbohydrate dependence during prolonged, intense endurance exercise. Sports Medicine: reviews of applied medicine and science in sport and exercise. 45, pp. 5 - 12. https://doi.org/10.1007/s40279-015-0400-1

Carbohydrate availability and exercise training adaptation : Too much of a good thing?

Bartlett, Jonathan, Hawley, John and Morton, James. (2015). Carbohydrate availability and exercise training adaptation : Too much of a good thing? European Journal of Sport Science. 15(1), pp. 3 - 12. https://doi.org/10.1080/17461391.2014.920926

Nutritional strategies to enhance fat oxidation during aerobic exercise

Burke, Louise and Hawley, John. (2015). Nutritional strategies to enhance fat oxidation during aerobic exercise. In In L. Burke and V. Deakin (Ed.). Clinical sports nutrition pp. 463 - 492 McGraw-Hill Education (Australia) Pty Ltd.

Need for measures of satellite cell activation along with muscle protein synthesis?

Camera, Donny and Hawley, John. (2015). Need for measures of satellite cell activation along with muscle protein synthesis? Journal of Applied Physiology. 118(4), pp. 500 - 500. https://doi.org/10.1152/japplphysiol.00609.2014.

Alcohol ingestion impairs maximal post-exercise rates of myofibrillar protein synthesis following a single bout of concurrent training

Parr, Evelyn, Camera, Donny, Areta, José, Burke, Louise, Phillips, Stuart, Hawley, John A. and Coffey, Vernon. (2014). Alcohol ingestion impairs maximal post-exercise rates of myofibrillar protein synthesis following a single bout of concurrent training. PLoS ONE. 9(2), pp. 1 - 9. https://doi.org/10.1371/journal.pone.0088384

Ramping up the signal : Promoting endurance training adaptation in skeletal muscle by nutritional manipulation

Hawley, John and Morton, James. (2014). Ramping up the signal : Promoting endurance training adaptation in skeletal muscle by nutritional manipulation. Clinical and Experimental Pharmacology & Physiology. 41(8), pp. 608 - 613. https://doi.org/10.1111/1440-1681.12246

Single and combined effects of beetroot juice and caffeine supplementation on cycling time trial performance

Lane, Stephen C., Hawley, John, Desbrow, Ben, Jones, Andrew M., Blackwell, James R., Ross, Megan L. L., Zemski, Adam J. and Burke, Louise. (2014). Single and combined effects of beetroot juice and caffeine supplementation on cycling time trial performance. 39(9), pp. 1050 - 1057. https://doi.org/10.1139/apnm-2013-0336

'Exercise snacks' before meals: A novel strategy to improve glycaemic control in individuals with insulin resistance

Francois, Monique, Baldi, James, Manning, Patrick, Lucas, Samuel, Hawley, John Alan, Williams, Michael and Cotter, James. (2014). 'Exercise snacks' before meals: A novel strategy to improve glycaemic control in individuals with insulin resistance. Diabetologia. 57(7), pp. 1437 - 1445. https://doi.org/10.1007/s00125-014-3244-6

Mitochondrial function in metabolic health: A genetic and environmental tug of war

Stephenson, Erin and Hawley, John Alan. (2014). Mitochondrial function in metabolic health: A genetic and environmental tug of war. Biochimica et Biophysica Acta. 1840(4), pp. 1285 - 1294. https://doi.org/10.1016/j.bbagen.2013.12.004

Single and combined effects of betroot juice and caffeine supplementation on cycling time trial performance

Lane, Stephen, Hawley, John, Desbrow, Ben, Jones, Andrew, Blackwell, James, Ross, Megan, Zemski, Adam and Burke, Louise. (2014). Single and combined effects of betroot juice and caffeine supplementation on cycling time trial performance. Applied Physiology, Nutrition and Metabolism. 39(9), pp. 1050 - 1057. https://doi.org/10.1139/apnm-2013-0336

Beyond muscle hypertrophy: Why dietary protein is important for endurance athletes

Moore, Daniel, Camera, Donny, Areta, José and Hawley, John A.. (2014). Beyond muscle hypertrophy: Why dietary protein is important for endurance athletes. Applied Physiology, Nutrition and Metabolism. 39(9), pp. 987 - 997. https://doi.org/10.1139/apnm-2013-0591

Integrative Biology of Exercise

Hawley, John A., Hargreaves, Mark, Joyner, Michael J. and Zierath, Juleen R.. (2014). Integrative Biology of Exercise. Cell. 159(4), pp. 738 - 749. https://doi.org/10.1016/j.cell.2014.10.029

The relationship between exercise, nutrition and type 2 diabetes

Stephenson, Erin J., Smiles, William and Hawley, John Alan. (2014). The relationship between exercise, nutrition and type 2 diabetes. Medicine and Sport Science. 60, pp. 1 - 10. https://doi.org/10.1159/000357331

Increasing leucine concentration stimulates mechanistic target of rapamycin signaling an cell growth in C2C12 skeletal muscle cells

Areta, José, Hawley, John A., Ye, Ji-Ming, Chan, M. H. Stanley and Coffey, Vernon. (2014). Increasing leucine concentration stimulates mechanistic target of rapamycin signaling an cell growth in C2C12 skeletal muscle cells. Nutrition Research. 34(11), pp. 1000 - 1007. https://doi.org/10.1016/j.nutres.2014.09.011

Reduced resting skeletal muscle protein synthesis is reduced by resistance exercise and protein ingestion following short-term energy deficit

Areta, José, Burke, Louise, Camera, Donny, West, Daniel, Crawshay, Siobhan, Moore, Daniel, Stellingwerff, Trent, Phillips, Stuart, Hawley, John A. and Coffey, Vernon. (2014). Reduced resting skeletal muscle protein synthesis is reduced by resistance exercise and protein ingestion following short-term energy deficit. American Journal of Physiology - Endocrinology and Metabolism. 306(8), pp. E989 - E997. https://doi.org/10.1152/ajpendo.00590.2013

Ramping up the signal: Promoting endurance training adaptation in skeletal muscle by nutritional manipulation

Hawley, John Alan and Morton, James. (2014). Ramping up the signal: Promoting endurance training adaptation in skeletal muscle by nutritional manipulation. Clinical and Experimental Pharmacology & Physiology. 41(8), pp. 608 - 613. https://doi.org/10.1111/1440-1681.12246

Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis

Rao, Rajesh, Long, Jonathan, White, James, Svensson, Katrin, Lou, Jesse, Lokurkar, Isha, Jedrychowski, Mark, Ruas, Jorge, Wrann, Christiane, Lo, James, Camera, Donny, Lachey, Jenn, Gygi, Steven, Seehra, Jasbir, Hawley, John and Spiegelman, Bruce. (2014). Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell. 157(6), pp. 1279 - 1291. https://doi.org/10.1016/j.cell.2014.03.065

Integrative biology of exercise

Hawley, John A., Hargreaves, Mark, Joyner, Michael J. and Zierath, Juleen R.. (2014). Integrative biology of exercise. Cell. 159(6), pp. 738 - 749. https://doi.org/10.1016/j.cell.2014.10.029

Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis

Rao, Rajesh, Long, Jonathan Z., White, James P., Svensson, Katrin J., Lou, Jesse, Lokurkar, Isha, Jedrychowski, Mark P., Ruas, Jorge L., Wrann, Christine D., Camera, Donny, Lachey, Jenn, Gygi, Steven, Seehra, Jasbir, Hawley, John and Spiegelman, Bruce M.. (2014). Meteorin-like Is a Hormone that Regulates Immune-Adipose Interactions to Increase Beige Fat Thermogenesis. Cell. 157(6), pp. 1279 - 1291. https://doi.org/10.1016/j.cell.2014.03.065

Acute changes to biomarkers as a consequence of prolonged strenuous running

Bird, Stephen R., Linden, Matthew and Hawley, John Alan. (2014). Acute changes to biomarkers as a consequence of prolonged strenuous running. Annals of Clinical Biochemistry. 51(2), pp. 137 - 150. https://doi.org/10.1177/0004563213492147

Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men

Skleryk, J, Karagounis, Leonidas, Hawley, John, Sharman, Matthew, Laursen, Paul and Watson, Greg. (2013). Two weeks of reduced-volume sprint interval or traditional exercise training does not improve metabolic functioning in sedentary obese men. Diabetes, Obesity and Metabolism: a journal of pharmacology and therapeutics. https://doi.org/10.1111/dom.12150

Nutritional strategies to modulate the adaptive response to endurance training

Hawley, John Alan. (2013). Nutritional strategies to modulate the adaptive response to endurance training. Nestle Nutrition Institute Workshop Series. 75, pp. 1 - 14. https://doi.org/10.1159/000345813

Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity

Stephenson, Erin, Lessard, Sarah, Rivas, Donato, Watt, Matthew, Yaspelkis III, Ben, Koch, Lauren, Britton, Steven and Hawley, John. (2013). Exercise training enhances white adipose tissue metabolism in rats selectively bred for low- or high-endurance running capacity. American Journal of Physiology - Endocrinology and Metabolism. https://doi.org/10.1152/ajpendo.00544.2012

Caffeine ingestion and cycling power output in a low or normal muscle glycogen state

Lane, Suzanne, Areta, José, Bird, S, Coffey, Vernon, Burke, Louise, Desbrow, B, Karagounis, L and Hawley, John A.. (2013). Caffeine ingestion and cycling power output in a low or normal muscle glycogen state. Medicine and Science in Sports and Exercise. https://doi.org/10.1249/MSS.0b013e31828af183

Effect of a carbohydrate mouth rinse on simulated cycling time-trial performance commenced in a fed or fasted state

Lane, Stephen, Bird, S, Burke, Louise and Hawley, John. (2013). Effect of a carbohydrate mouth rinse on simulated cycling time-trial performance commenced in a fed or fasted state. Applied Physiology, Nutrition and Metabolism. https://doi.org/10.1139/apnm-2012-0300

ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue

Kosari, Samin, Camera, Donny Michael, Hawley, John Alan, Stebbing, Martin and Badoer, Emilio. (2013). ERK1/2 in the brain mediates the effects of central resistin on reducing thermogenesis in brown adipose tissue. International Journal of Physiology, Pathophysiology and Pharmacology. 5(3), pp. 184 - 189.

Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis

Areta, José, Burke, Louise, Ross, M, Camera, Donny, West, D, Broad, E, Jeacocke, N, Moore, Daniel, Stellingwerff, T and Phillips, S. (2013). Timing and distribution of protein ingestion during prolonged recovery from resistance exercise alters myofibrillar protein synthesis. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2012.244897

Preexercise aminoacidemia and muscle protein synthesis after resistance exercise

Burke, Louise, Hawley, John, Ross, M, Moore, Daniel, Phillips, S, Slater, G, Stellingwerff, T, Tipton, K, Garnham, A and Coffey, Vernon. (2012). Preexercise aminoacidemia and muscle protein synthesis after resistance exercise. Medicine and Science in Sports and Exercise. 44(10), pp. 1968 - 1977. https://doi.org/10.1249/MSS.0b013e31825d28fa

Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet

Stephenson, E, Camera, Donny, Jenkins, T, Kosari, S, Lee, Joohyung, Hawley, John and Stepto, N. (2012). Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet. American Journal of Physiology - Endocrinology and Metabolism. 302(12), pp. E1541 - E1549. https://doi.org/10.1152/ajpendo.00590.2011

What's new since Hippocrates? : Preventing type 2 diabetes by physical exercise and diet

Hawley, John and Gibala, M. (2012). What's new since Hippocrates? : Preventing type 2 diabetes by physical exercise and diet. Diabetologia. 55(3), pp. 535 - 539. https://doi.org/10.1007/s00125-012-2460-1

Daytime pattern of post-exercise protein intake affects whole-body protein turnover in resistance-trained males

Moore, Daniel, Areta, José, Coffey, Vernon, Stellingwerff, Trent, Phillips, Stuart, Burke, Louise, Cleroux, Marilyn, Godin, Jean-Philippe and Hawley, John Alan. (2012). Daytime pattern of post-exercise protein intake affects whole-body protein turnover in resistance-trained males. Nutrition and Metabolism. 9(91), pp. 1 - 5. https://doi.org/10.1186/1743-7075-9-91

Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability : A role for Nor1?

Stephenson, E, Stepto, N, Koch, L, Britton, S and Hawley, John. (2012). Divergent skeletal muscle respiratory capacities in rats artificially selected for high and low running ability : A role for Nor1? Journal of Applied Physiology. 113(9), pp. 1403 - 1412. https://doi.org/10.1152/japplphysiol.00788.2012

Reply from M. J. Gibala, J. P. Little, M. J. MadDonald and J. A. Hawley

Gibala, M. J., Little, John, Macdonald, M. J. and Hawley, John. (2012). Reply from M. J. Gibala, J. P. Little, M. J. MadDonald and J. A. Hawley. The Journal of Physiology. 590(14), pp. 3391 - 3391. https://doi.org/10.1113/jphysiol.2012.235127

Preexercise nutrient timing in endurance activity

Broad, E., Karagounis, L. and Hawley, John Alan. (2012). Preexercise nutrient timing in endurance activity. In In C. M. Kerksick (Ed.). Nutrient Timing: Metabolic Optimization for Health, Performance, and Recovery pp. 118 - 118 Taylor & Francis.

Sex-based comparisons of myofibrillar protein synthesis after resistance exercise in the fed state

West, D, Burd, N, Churchward-Venne, T, Camera, Donny, Mitchell, Cameron, Baker, S, Hawley, John, Coffey, Vernon and Phillips, S. (2012). Sex-based comparisons of myofibrillar protein synthesis after resistance exercise in the fed state. Journal of Applied Physiology. 112(11), pp. 1805 - 1813. https://doi.org/10.1152/japplphysiol.00170.2012

Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise

Camera, Donny, West, D, Burd, N, Phillips, S, Garnham, A, Hawley, John and Coffey, Vernon. (2012). Low muscle glycogen concentration does not suppress the anabolic response to resistance exercise. Journal of Applied Physiology. 113(2), pp. 206 - 214. https://doi.org/10.1152/japplphysiol.00395.2012

Physiological adaptations to low-volume, high-intensity interval training in health and disease

Gibala, M, Little, John, Macdonald, M and Hawley, John. (2012). Physiological adaptations to low-volume, high-intensity interval training in health and disease. The Journal of Physiology. 590(5), pp. 1077 - 1084. https://doi.org/10.1113/jphysiol.2011.224725

Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints

Coffey, Vernon, Moore, Daniel, Burd, N, Rerecich, T, Stellingwerff, T, Garnham, A, Phillips, S and Hawley, John. (2011). Nutrient provision increases signalling and protein synthesis in human skeletal muscle after repeated sprints. European Journal of Applied Physiology. 111(7), pp. 1473 - 1483. https://doi.org/10.1007/s00421-010-1768-0

No role for early IGF-1 signalling in stimulating acute 'muscle building' responses

Burd, Nicholas A., West, D. W., Camera, Donny and Breen, L.. (2011). No role for early IGF-1 signalling in stimulating acute 'muscle building' responses. The Journal of Physiology. https://doi.org/10.1113/jphysiol.2011.207332

Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise

West, D, Burd, N, Coffey, Vernon, Baker, S, Burke, Louise, Hawley, John, Moore, Daniel, Stellingwerff, T and Phillips, S. (2011). Rapid aminoacidemia enhances myofibrillar protein synthesis and anabolic intramuscular signaling responses after resistance exercise. American Journal of Clinical Nutrition: A journal reporting the practical application of our world-wide knowledge of nutrition. 94(3), pp. 795 - 803. https://doi.org/10.3945/ajcn.111.013722

Nutritional modulation of training-induced skeletal muscle adaptations

Hawley, John, Burke, Louise, Phillips, S and Spriet, L. (2011). Nutritional modulation of training-induced skeletal muscle adaptations. Journal of Applied Physiology. 110(3), pp. 834 - 845. https://doi.org/10.1152/japplphysiol.00949.2010

Single-leg cycle training is superior to double-leg cycling in improving the oxidative potential and metabolic profile of trained skeletal muscle

Abbiss, Chris, Karagounis, L, Laursen, P, Peiffer, J, Martin, D, Hawley, John, Fatehee, N and Martin, J.. (2011). Single-leg cycle training is superior to double-leg cycling in improving the oxidative potential and metabolic profile of trained skeletal muscle. Journal of Applied Physiology. 110(5), pp. 1248 - 1255. https://doi.org/10.1152/japplphysiol.01247.2010

Carbohydrates for training and competition

Burke, Louise, Hawley, John, Wong, S and Jeukendrup, A. (2011). Carbohydrates for training and competition. Journal of Sports Sciences. 29(Suppl 1), pp. S17 - S27. https://doi.org/10.1080/02640414.2011.585473

Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity

Lessard, S, Rivas, D, Stephenson, E, Yaspelkis, Koch, L, Britton, S, Hawley, John and III, B Yaspelkis. (2011). Exercise training reverses impaired skeletal muscle metabolism induced by artificial selection for low aerobic capacity. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300(1), pp. R175 - R182. https://doi.org/10.1152/ajpregu.00338.2010

Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle

Rivas, D, Lessard, S, Saito, M, Friedhuber, A, Koch, L, Britton, S, Yaspelkis III, B and Hawley, John. (2011). Low intrinsic running capacity is associated with reduced skeletal muscle substrate oxidation and lower mitochondrial content in white skeletal muscle. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 300(4), pp. 835 - 843. https://doi.org/10.1152/ajpregu.00659.2010

Substrate oxidation

Hawley, John A.. (2010). Substrate oxidation. In In Connes, Philippe, Hue, Olivier and Perrey, Stéphane (Ed.). Exercise physiology : From a cellular to an integrative approach pp. 340-347 IOS Press.

The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet

Mitchell, Todd, Turner, Nigel, Else, Paul, Hulbert, Anthony and Hawley, John. (2010). The effect of exercise on the skeletal muscle phospholipidome of rats fed a high-fat diet. International Journal of Molecular Sciences. 11(10), pp. 3954 - 3964. https://doi.org/10.3390/ijms11103954

Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen : Experimental Physiology-Research Paper

Yeo, W, McGee, S, Carey, A, Paton, C, Garnham, A, Hargreaves, M and Hawley, John. (2010). Acute signalling responses to intense endurance training commenced with low or normal muscle glycogen : Experimental Physiology-Research Paper. Experimental Physiology. 95(2), pp. 351 - 358. https://doi.org/10.1113/expphysiol.2009.049353

Reply

Hawley, John and Martin, David. (2010). Reply. International Journal of Sports Physiology and Performance. 5(4), pp. 434 - 436.

Early time course of akt phosphorylation after endurance and resistance exercise

Camera, Donny, Edge, J, Short, M, Hawley, John and Coffey, Vernon. (2010). Early time course of akt phosphorylation after endurance and resistance exercise. Medicine and Science in Sports and Exercise. 42(10), pp. 1843 - 1852. https://doi.org/10.1249/MSS.0b013e3181d964e4

Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue

Camera, Donny, Anderson, Malcolm, Hawley, John and Carey, A. (2010). Short-term endurance training does not alter the oxidative capacity of human subcutaneous adipose tissue. European Journal of Applied Physiology. 109(2), pp. 307 - 316. https://doi.org/10.1007/s00421-010-1356-3

Reprogramming of DNA replication timing

Shufaro, Yoel, Lacham-Kaplan, Orly, Tzuberi, Ben Zion, Mclaughlin, John, Trounson, Alan, Cedar, Howard and Reubinoff, Benjamin E.. (2010). Reprogramming of DNA replication timing. Stem Cells. 28(3), pp. 443 - 449. https://doi.org/10.1002/stem.303

Contraction-induced changes in TNFalpha and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle

Karagounis, L, Yaspelkis III, B, Reeder, D, Lancaster, G, Hawley, John and Coffey, Vernon. (2010). Contraction-induced changes in TNFalpha and Akt-mediated signalling are associated with increased myofibrillar protein in rat skeletal muscle. European Journal of Applied Physiology. 109(5), pp. 839 - 848. https://doi.org/10.1007/s00421-010-1427-5

Gamma tocopherol supplementation prevents exercise induced coagulation and platelet aggregation

Vucinic, L, Singh, I, Spargo, F, Hawley, John and Linden, M. (2010). Gamma tocopherol supplementation prevents exercise induced coagulation and platelet aggregation. Thrombosis Research: vascular obstruction, hemorrhage and hemostasis. 125(2), pp. 196 - 199. https://doi.org/10.1016/j.thromres.2009.11.015

Carbohydrate availability and training adaptation: Effects on cell metabolism

Hawley, John and Burke, Louise. (2010). Carbohydrate availability and training adaptation: Effects on cell metabolism. Exercise and Sport Sciences Reviews. 38(4), pp. 152 - 160. https://doi.org/10.1097/JES.0b013e3181f44dd9

Daily training with high carbohydrate availability increases exogenous carbohydrate oxidation during endurance cycling

Cox, Geoffrey, Clark, Sally, Cox, A, Halson, Shona, Hargreaves, M, Hawley, John, Jeacocke, N, Snow, Rod, Yeo, W and Burke, Louise. (2010). Daily training with high carbohydrate availability increases exogenous carbohydrate oxidation during endurance cycling. Journal of Applied Physiology. 109(1), pp. 126 - 134. https://doi.org/10.1152/japplphysiol.00950.2009

Aerobic training reverses high-fat diet-induced pro-inflammatory signalling in rat skeletal muscle

Yaspelkis III, B, Kvasha, I, Lessard, S, Rivas, D and Hawley, John. (2010). Aerobic training reverses high-fat diet-induced pro-inflammatory signalling in rat skeletal muscle. European Journal of Applied Physiology. 110(4), pp. 779 - 788. https://doi.org/10.1007/s00421-010-1559-7

Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury

Ross, M, Halson, Shona, Suzuki, K, Garnham, A, Hawley, John, Cameron-Smith, David and Peake, J. (2010). Cytokine responses to carbohydrate ingestion during recovery from exercise-induced muscle injury. Journal of Interferon and Cytokine Research. 30(5), pp. 329 - 337. https://doi.org/10.1089/jir.2009.0079

Skeletal muscle : increasing the size of the locomotor cell

Karagounis, L and Hawley, John. (2010). Skeletal muscle : increasing the size of the locomotor cell. The International Journal of Biochemistry and Cell Biology. 42(9), pp. 1376 - 1379. https://doi.org/10.1016/j.biocel.2010.05.013

Global gene expression in skeletal muscle from well-trained strength and endurance athletes

Stepto, Nigel K., Coffey, Vernon Glenn, Carey, Andrew L., Ponnampalam, Anna P., Canny, Benedict J., Powell, David and Hawley, John Alan. (2009). Global gene expression in skeletal muscle from well-trained strength and endurance athletes. Medicine and Science in Sports and Exercise. 41(3), pp. 546 - 565. https://doi.org/10.1249/MSS.0b013e31818c6be9

Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle

Coffey, Vernon Glenn, Jemiolo, Bozena, Edge, Johann, Garnham, Andrew P., Trappe, Scott W. and Hawley, John Alan. (2009). Effect of consecutive repeated sprint and resistance exercise bouts on acute adaptive responses in human skeletal muscle. American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 297(5), pp. 1441 - 1451. https://doi.org/10.1152/ajpregu.00351.2009

Exercise intensity and insulin sensitivity: How low can you go?

Hawley, John Alan and Gibala, M. J.. (2009). Exercise intensity and insulin sensitivity: How low can you go? Diabetologia. 52(9), pp. 1709 - 1713. https://doi.org/10.1007/s00125-009-1425-5

Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside

Rivas, Donato A., Yaspelkis, Ben B., Hawley, John Alan and Lessard, Sarah J.. (2009). Lipid-induced mTOR activation in rat skeletal muscle reversed by exercise and 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside. Journal of Endocrinology. 202(3), pp. 441 - 451. https://doi.org/10.1677/JOE-09-0202

Molecular responses to strength and endurance training: Are they incompatible?

Hawley, John Alan. (2009). Molecular responses to strength and endurance training: Are they incompatible? Applied Physiology, Nutrition and Metabolism. 34(3), pp. 355 - 361. https://doi.org/10.1139/H09-023

The 5' adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics

Karagounis, Leonidas G. and Hawley, John Alan. (2009). The 5' adenosine monophosphate-activated protein kinase: Regulating the ebb and flow of cellular energetics. The International Journal of Biochemistry and Cell Biology. 41(12), pp. 2360 - 2363. https://doi.org/10.1016/j.biocel.2009.07.004

Exercise: It's the real thing!

Hawley, John Alan and Holloszy, J O.. (2009). Exercise: It's the real thing! Nutrition Reviews. 67(3), pp. 172 - 178. https://doi.org/10.1111/j.1753-4887.2009.00185.x

Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity

Lessard, Sarah J., Rivas, Donato A., Chen, Zhu-Ping, van Denderen, Bryce J., Watt, Matthew J., Koch, Lauren G., Britton, Steven L., Kemp, Bruce Ernest and Hawley, John Alan. (2009). Impaired skeletal muscle beta-adrenergic activation and lipolysis are associated with whole-body insulin resistance in rats bred for low intrinsic exercise capacity. Endocrinology. 150(11), pp. 4883 - 4891. https://doi.org/10.1210/en.2009-0158

Spectroscopic correlation analysis of NMR-based metabonomics in exercise science

Kirwan, Gemma M., Coffey, Vernon Glenn, Niere, Julie O., Hawley, John Alan and Adams, Michael J.. (2009). Spectroscopic correlation analysis of NMR-based metabonomics in exercise science. Analytica Chimica Acta. 652(1-2), pp. 173 - 179. https://doi.org/10.1016/j.aca.2009.07.011

Differentiation of germ cells and gametes from stem cells

Marques-Mari, A. I., Lacham-Kaplan, Orly, Medrano, J. V., Pellicer, A. and Simón, C.. (2009). Differentiation of germ cells and gametes from stem cells. Human Reproduction Update. 15(3), pp. 379 - 390. https://doi.org/10.1093/humupd/dmp001

Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle

Coffey, Vernon Glenn, Pilegaard, Henriette, Garnham, Andrew P., O'Brien, Brendan J. and Hawley, John Alan. (2009). Consecutive bouts of diverse contractile activity alter acute responses in human skeletal muscle. Journal of Applied Physiology. 106(4), pp. 1187 - 1197. https://doi.org/10.1152/japplphysiol.91221.2008

Gene expression profiling of human oocytes following in vivo or in vitro maturation

Jones, Gayle M., Cram, David S., Song, Bi, Magli, M. Cristina, Gianaroli, Luca, Lacham-Kaplan, Orly, Findlay, Jock K., Jenkin, Graham and Trounson, Alan. (2008). Gene expression profiling of human oocytes following in vivo or in vitro maturation. Human Reproduction. 23(5), pp. 1138 - 1144. https://doi.org/10.1093/humrep/den085

Specificity of training adaptation: Time for a rethink?

Hawley, John Alan. (2008). Specificity of training adaptation: Time for a rethink? The Journal of Physiology. 586(1), pp. 1 - 2. https://doi.org/10.1113/jphysiol.2007.147397

Evidence for presribing exercise as a therapy for treating patients with type 2 diabetes

Lessard, Sarah J. and Hawley, John Alan. (2008). Evidence for presribing exercise as a therapy for treating patients with type 2 diabetes. In In J.A. Hawley and J. R. Zierath (Ed.). Physical activity and type 2 diabetes: Therapeutic effects and mechanisms of action pp. 203 - 214 Human Kinetics Publishers Inc..

The effects of polyphenols in olive leaves on platelet function

Singh, Indu, Mok, Michelle, Christensen, Anne-Marie, Turner, Alan H. and Hawley, John Alan. (2008). The effects of polyphenols in olive leaves on platelet function. Nutrition Metabolism and Cardiovascular Diseases. 18(2), pp. 127 - 132. https://doi.org/10.1016/j.numecd.2006.09.001

Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens

Yeo, Wee Kian, Paton, Carl D., Garnham, Andrew P., Burke, Louise M., Carey, Andrew L. and Hawley, John Alan. (2008). Skeletal muscle adaptation and performance responses to once a day versus twice every second day endurance training regimens. Journal of Applied Physiology. 105(5), pp. 1462 - 1470. https://doi.org/10.1152/japplphysiol.90882.2008

Density gradients for the isolation of germ cells from embryoid bodies

Saiti, Deshira and Lacham-Kaplan, Orly. (2008). Density gradients for the isolation of germ cells from embryoid bodies. Reproductive Biomedicine Online. 16(5), pp. 730 - 740. https://doi.org/10.1016/S1472-6483(10)60489-0

Commentary on viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise?

Reid, Julianne J. and Hawley, John Alan. (2008). Commentary on viewpoint: Exercise and cardiovascular risk reduction: Time to update the rationale for exercise? Journal of Applied Physiology. 105(2), pp. 772 - 772. https://doi.org/10.1152/japplphysiol.90362.2008

Metabolic adaptations to training

Hawley, John Alan and Nader, Gustavo A.. (2008). Metabolic adaptations to training. In In M.P. Schwellnus (Ed.). Olympic textbook of medicine in sport pp. 78 - 87 Wiley-Blackwell.

Exercise training-induced improvements in insulin action

Hawley, John Alan and Lessard, S. J.. (2008). Exercise training-induced improvements in insulin action. Acta Physiologica. 192(1), pp. 127 - 135. https://doi.org/10.1111/j.1748-1716.2007.01783.x

Exercise-induced phospho-proteins in skeletal muscle

Deshmukh, A. S., Hawley, John Alan and Zierath, J. R.. (2008). Exercise-induced phospho-proteins in skeletal muscle. International Journal of Obesity. 32(SUPPL.4), pp. S18 - S23. https://doi.org/10.1038/ijo.2008.118

Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle

Saito, Misato, Lessard, S. J., Rivas, Donato A., Reeder, Donald W., Hawley, John Alan and Yaspelkis, Ben B.. (2008). Activation of atypical protein kinase Czeta toward TC10 is regulated by high-fat diet and aerobic exercise in skeletal muscle. Metabolism: Clinical and experimental. 57(9), pp. 1173 - 1180. https://doi.org/10.1016/j.metabol.2008.03.023

Commentary on viewpoint: Perspective on the future use of genomics in exercise prescription

Hawley, John Alan. (2008). Commentary on viewpoint: Perspective on the future use of genomics in exercise prescription. Journal of Applied Physiology. 104(4), pp. 1249 - 1249. https://doi.org/10.1152/japplphysiol.00047.2008

Oxidative stress-induced insulin resistance in skeletal muscle cells is ameliorated by gamma-tocopherol treatment

Singh, Indu, Carey, Andrew L., Watson, Nadine, Febbraio, Mark A. and Hawley, John Alan. (2008). Oxidative stress-induced insulin resistance in skeletal muscle cells is ameliorated by gamma-tocopherol treatment. European Journal of Nutrition. 47(7), pp. 387 - 392. https://doi.org/10.1007/s00394-008-0739-2

High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine

Pedersen, David J., Lessard, Sarah J., Coffey, Vernon Glenn, Churchley, Emmanuel G., Wootton, Andrew M., Ng, They, Watt, Matthew J. and Hawley, John Alan. (2008). High rates of muscle glycogen resynthesis after exhaustive exercise when carbohydrate is coingested with caffeine. Journal of Applied Physiology. 105(1), pp. 7 - 13. https://doi.org/10.1152/japplphysiol.01121.2007

Overweight and obesity in Australia

Hawley, John Alan and Dunstan, David Wayne. (2008). Overweight and obesity in Australia. Medical Journal of Australia. 188(11), pp. 678 - 679.

Reduced developmental competence of immature, in-vitro matured and postovulatory aged mouse oocytes following IVF and ICSI

Lacham-Kaplan, Orly and Trounson, Alan. (2008). Reduced developmental competence of immature, in-vitro matured and postovulatory aged mouse oocytes following IVF and ICSI. Reproductive Biology and Endocrinology. 6(1). https://doi.org/10.1186/1477-7827-6-58

Shedding new light on the molecular architecture of oocytes using a combination of synchrotron fourier transform-infrared and raman spectroscopic mapping

Wood, Bayden R., Chernenko, Tatyana, Matthäus, Christian, Diem, Max, Chong, Connie, Bernhard, Uditha, Jene, Cassandra, Brandli, Alice A., McNaughton, Don, Tobin, Mark J., Trounson, Alan and Lacham-Kaplan, Orly. (2008). Shedding new light on the molecular architecture of oocytes using a combination of synchrotron fourier transform-infrared and raman spectroscopic mapping. Analytical Chemistry. 80(23), pp. 9065 - 9072. https://doi.org/10.1021/ac8015483

Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans

Yeo, Wee Kian, Lessard, Sarah J., Chen, Zhi-Ping, Garnham, Andrew P., Burke, Louise, Rivas, Donato A., Kemp, Bruce Ernest and Hawley, John Alan. (2008). Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans. Journal of Applied Physiology. 105(5), pp. 1519 - 1526. https://doi.org/10.1152/japplphysiol.90540.2008

The battle against obesity - Attacking physical inactivity as a primary means of defense

Hawley, John and Dunstan, David. (2008). The battle against obesity - Attacking physical inactivity as a primary means of defense. Nature Reviews Endocrinology. 4(10), pp. 548 - 549. https://doi.org/10.1038/ncpendmet0918

In vitro maturation and intracytoplasmic sperm injection of oocytes collected from hormonally stimulated common wombats, Vombatus ursinus

West, M., Lacham-Kaplan, Orly, Cleary, M., Galloway, D., Shaw, J., Trounson, Alan and Paris, M. C. J.. (2007). In vitro maturation and intracytoplasmic sperm injection of oocytes collected from hormonally stimulated common wombats, Vombatus ursinus. Animal Reproduction Science. 98(43924), pp. 311 - 321. https://doi.org/10.1016/j.anireprosci.2006.03.005

Comparison of mice born after intracytoplasmic sperm injection with in vitro fertilization and natural mating

Wilson, Trevor J., Lacham-Kaplan, Orly, Gould, Jodee, Holloway, Andrew, Bertoncello, Ivan, Hertzog, Paul J. and Trounson, Alan. (2007). Comparison of mice born after intracytoplasmic sperm injection with in vitro fertilization and natural mating. Molecular Reproduction and Development. 74(4), pp. 512 - 519. https://doi.org/10.1002/mrd.20644

The employment of strontium to activate mouse oocytes: Effects on spermatid-injection outcome

Loren, Jean and Lacham-Kaplan, Orly. (2006). The employment of strontium to activate mouse oocytes: Effects on spermatid-injection outcome. Reproduction. 131(2), pp. 259 - 267. https://doi.org/10.1530/rep.1.00894

Testicular cell conditioned medium supports differentiation of embryonic stem cells into ovarian structures containing oocytes

Lacham-Kaplan, Orly, Chy, Hun and Trounson, Alan. (2006). Testicular cell conditioned medium supports differentiation of embryonic stem cells into ovarian structures containing oocytes. Stem Cells. 24(2), pp. 266 - 273. https://doi.org/10.1634/stemcells.2005-0204

In vivo and in vitro differentiation of male germ cells in the mouse

Lacham-Kaplan, Orly. (2004). In vivo and in vitro differentiation of male germ cells in the mouse. Reproduction. 128(2), pp. 147 - 152. https://doi.org/10.1530/rep.1.00220

Oocyte Activation after Intracytoplasmic Injection with Sperm Frozen Without Cryoprotectants Results in Live Offspring from Inbred and Hybrid Mouse Strains

Lacham-Kaplan, Orly, Shaw, J., Sanchez-Partida, L. Gabriel and Trounson, Alan. (2003). Oocyte Activation after Intracytoplasmic Injection with Sperm Frozen Without Cryoprotectants Results in Live Offspring from Inbred and Hybrid Mouse Strains. Biology of Reproduction. 69(5), pp. 1683 - 1689. https://doi.org/10.1095/biolreprod.103.018184

Effects of electrical stimulation and seminal plasma on the motility of mouse sperm

Tecirlio¿lu, R. T., Lacham-Kaplan, Orly and Trounson, Alan. (2002). Effects of electrical stimulation and seminal plasma on the motility of mouse sperm. Reproduction Fertility and Development. 14(44050), pp. 471 - 478. https://doi.org/10.1071/RD02050

Cell synchronization for the purposes of nuclear transfer in the bovine

Korfiatis, Natasha, Trounson, Alan and Lacham-Kaplan, Orly. (2001). Cell synchronization for the purposes of nuclear transfer in the bovine. Cellular Reprogramming. 3(3), pp. 125 - 138. https://doi.org/10.1089/153623001753205089

Fertilization of mouse oocytes using somatic cells as male germ cells

Lacham-Kaplan, Orly, Daniels, Rob and Trounson, Alan. (2001). Fertilization of mouse oocytes using somatic cells as male germ cells. Reproductive Biomedicine Online. 3(3), pp. 205 - 211. https://doi.org/10.1016/S1472-6483(10)62037-8

Characterization of the fertility of male aromatase knockout mice

Robertson, K. M., Simpson, Evan, Lacham-Kaplan, Orly and Jones, Margaret. (2001). Characterization of the fertility of male aromatase knockout mice. Journal of Andrology. 22(5), pp. 825 - 830.

Nuclear transfer of adult and genetically modified fetal cells of the rat

Hayes, Eric, Galea, Sandra, Verkuylen, Amanda, Pera, Martin, Morrison, John, Lacham-Kaplan, Orly and Trounson, Alan. (2001). Nuclear transfer of adult and genetically modified fetal cells of the rat. Physiological Genomics. 5(4), pp. 193 - 203.

Pregnancies produced from fertile and infertile stallions by intracytoplasmic sperm injection (ICSI) of single frozen-thawed spermatozoa into in vivo matured mare oocytes.

McKinnon, A. O., Lacham-Kaplan, Orly and Trounson, Alan. (2000). Pregnancies produced from fertile and infertile stallions by intracytoplasmic sperm injection (ICSI) of single frozen-thawed spermatozoa into in vivo matured mare oocytes. Reproduction: Supplement.

Developmental competence of nuclear transfer cow oocytes after direct injection of fetal fibroblast nuclei

Lacham-Kaplan, Orly, Diamente, Maria, Pushett, David, Lewis, Ian and Trounson, Alan. (2000). Developmental competence of nuclear transfer cow oocytes after direct injection of fetal fibroblast nuclei. Cloning. 2(2), pp. 55 - 62. https://doi.org/10.1089/152045500436078

Intracytoplasmic sperm injection, zona drilling and zona removal of the human oocyte and embryo

Okuma, Y., Lacham-Kaplan, Orly and Trounson, Alan. (1998). Intracytoplasmic sperm injection, zona drilling and zona removal of the human oocyte and embryo. Zygote. 6(Supplement 1), pp. 51 - 51.

Is the acrosome reaction a prerequisite for sperm incorporation after intra-cytoplasmic sperm injection (ICSI)?

Sathananthan, A. H., Szell, A., Ng, S. C., Kausche, A., Lacham-Kaplan, Orly and Trounson, Alan. (1997). Is the acrosome reaction a prerequisite for sperm incorporation after intra-cytoplasmic sperm injection (ICSI)? Reproduction Fertility and Development. 9(7), pp. 703 - 709. https://doi.org/10.1071/R97028

Fertilization and embryonic developmental capacity of epididymal and testicular sperm and immature spermatids and spermatocytes

Lacham-Kaplan, Orly and Trounson, Alan. (1997). Fertilization and embryonic developmental capacity of epididymal and testicular sperm and immature spermatids and spermatocytes. Reproductive Medicine Review. 6(1), pp. 55 - 68.

Blastocyst development and birth after in-vitro maturation of human primary oocytes, intracytoplasmic sperm injection and assisted hatching

Barnes, Frank L., Crombie, Amanda, Gardner, David K., Kausche, A., Lacham-Kaplan, Orly, Suikkari, Anne Maria, Tiglias, Jennifer, Wood, Carl and Trounson, Alan. (1995). Blastocyst development and birth after in-vitro maturation of human primary oocytes, intracytoplasmic sperm injection and assisted hatching. Human Reproduction. 10(12), pp. 3243 - 3247. https://doi.org/10.1093/oxfordjournals.humrep.a135896

Intracytoplasmic sperm injection in mice: Increased fertilization and development to term after induction of the acrosome reaction

Lacham-Kaplan, Orly and Trounson, Alan. (1995). Intracytoplasmic sperm injection in mice: Increased fertilization and development to term after induction of the acrosome reaction. Human Reproduction. 10(10), pp. 2642 - 2649. https://doi.org/10.1093/oxfordjournals.humrep.a135760

Embryo development capacity of oocytes fertilized by immature sperm and sperm treated with motility stimulants

Lacham-Kaplan, Orly and Trounson, Alan. (1994). Embryo development capacity of oocytes fertilized by immature sperm and sperm treated with motility stimulants. Reproduction Fertility and Development. 6(1), pp. 113 - 116. https://doi.org/10.1071/RD9940113

Microinjection: Choice of embryo transfer technique

McLachlan, Robert I., Fuscaldo, Giuliana, Calderon, Ilan, Lacham-Kaplan, Orly, Poulos, Christine, Rho, Hwan, Trounson, Alan and Wood, Carl. (1994). Microinjection: Choice of embryo transfer technique. Reproduction Fertility and Development. 6(1), pp. 57 - 61. https://doi.org/10.1071/RD9940057

The effects of the sperm motility activators 2-deoxyadenosine and pentoxifylline used for sperm micro-injection on mouse and human embryo development

Lacham-Kaplan, Orly and Trounson, Alan. (1993). The effects of the sperm motility activators 2-deoxyadenosine and pentoxifylline used for sperm micro-injection on mouse and human embryo development. Human Reproduction. 8(6), pp. 945 - 952. https://doi.org/10.1093/oxfordjournals.humrep.a138172

Subzonal sperm microinjection in cases of severe male factor infertility and repeated in vitro fertilization failure

Sakkas, D., Lacham-Kaplan, Orly, Gianaroli, Luca and Trounson, Alan. (1992). Subzonal sperm microinjection in cases of severe male factor infertility and repeated in vitro fertilization failure. Fertility and Sterility. 57(6), pp. 1279 - 1288.

Fertilizing capacity of epididymal and testicular spermatozoa microinjected under the zona pellucida of the mouse oocyte

Lacham-Kaplan, Orly and Trounson, Alan. (1991). Fertilizing capacity of epididymal and testicular spermatozoa microinjected under the zona pellucida of the mouse oocyte. Molecular Reproduction and Development. 29(1), pp. 85 - 93. https://doi.org/10.1002/mrd.1080290113

Chromosomal analysis of human oocytes fertilized by microinjection of spermatozoa into the perivitelline space

Kola, Ismail, Lacham-Kaplan, Orly, Jansen, Robert P. S., Turner, Marie and Trounson, Alan. (1990). Chromosomal analysis of human oocytes fertilized by microinjection of spermatozoa into the perivitelline space. Human Reproduction. 5(5), pp. 575 - 577. https://doi.org/10.1093/oxfordjournals.humrep.a137147

Fertilization and development of mouse eggs injected under the zona pellucida with single spermatozoa treated to induce the acrosome reaction

Lacham-Kaplan, Orly, Trounson, Alan, Holden, Carol, Mann, Jeff and Sathananthan, Henry. (1989). Fertilization and development of mouse eggs injected under the zona pellucida with single spermatozoa treated to induce the acrosome reaction. Gamete Research. 23(2), pp. 233 - 243. https://doi.org/10.1002/mrd.1120230210

Fertilization of mouse and human eggs by microinjection of single spermatozoa under the zona pellucida.

Trounson, Alan, Peura, A. and Lacham-Kaplan, Orly. (1989). Fertilization of mouse and human eggs by microinjection of single spermatozoa under the zona pellucida. Reproduction: Supplement. 38, pp. 145 - 152.