Combined effects of exercise and different levels of acute hypoxic severity : A randomized crossover study on glucose regulation in adults with overweight
Journal article
Tee, Chris Chow Li, Parr, Evelyn B., Cooke, Matthew B., Chong, Mee Chee, Rahmat, Nurhamizah, Md Razali, Mohd Rizal, Yeo, Wee Kian and Camera, Donny M.. (2023). Combined effects of exercise and different levels of acute hypoxic severity : A randomized crossover study on glucose regulation in adults with overweight. Frontiers in Physiology. 14, p. Article 1174926. https://doi.org/10.3389/fphys.2023.1174926
Authors | Tee, Chris Chow Li, Parr, Evelyn B., Cooke, Matthew B., Chong, Mee Chee, Rahmat, Nurhamizah, Md Razali, Mohd Rizal, Yeo, Wee Kian and Camera, Donny M. |
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Abstract | Purpose: The aim of this study was to investigate the influence of manipulating hypoxic severity with low-intensity exercise on glucose regulation in healthy overweight adults. Methods: In a randomized crossover design, 14 males with overweight (age: 27 ± 5 years; body mass index (BMI) 27.1 ± 1.8 kg⋅m2) completed three exercise trials involving 60 min aerobic exercise cycling at 90% lactate threshold in normoxia (NM, FiO2 = 20.9%), moderate hypoxia (MH, FiO2 = 16.5%) and high hypoxia (HH, FiO2 = 14.8%). A post-exercise oral glucose tolerance test (OGTT) was performed. Venous blood samples were analyzed for incremental area under the curve (iAUC), plasma glucose and insulin, as well as exerkine concentrations (plasma apelin and fibroblast growth factor 21 [FGF-21]) pre- and post-exercise. A 24-h continuous glucose monitoring (CGM) was used to determine interstitial glucose concentrations. Heart rate, oxygen saturation (SpO2) and perceptual measures were recorded during exercise. Results: Post-exercise OGTT iAUC for plasma glucose and insulin concentrations were lower in MH vs. control (p = 0.02). Post-exercise interstitial glucose iAUC, plasma apelin and FGF-21 were not different between conditions. Heart rate was higher in HH vs. NM and MH, and MH vs. NM (p < 0.001), while SpO2 was lower in HH vs. NM and MH, and MH vs. NM (p < 0.001). Overall perceived discomfort and leg discomfort were higher in HH vs. NM and MH (p < 0.05), while perceived breathing difficulty was higher in HH vs. NM only (p = 0.003). Conclusion: Compared to higher hypoxic conditions, performing acute aerobic-based exercise under moderate hypoxia provided a more effective stimulus for improving post-exercise glucose regulation while concomitantly preventing excessive physiological and perceptual stress in healthy overweight adults. |
Keywords | hypoxia; low-intensity exercise; exerkines; apelin; FGF-21 |
Year | 2023 |
Journal | Frontiers in Physiology |
Journal citation | 14, p. Article 1174926 |
Publisher | Frontiers Media S.A. |
ISSN | 1664-042X |
Digital Object Identifier (DOI) | https://doi.org/10.3389/fphys.2023.1174926 |
PubMed ID | 37123278 |
Scopus EID | 2-s2.0-85153779410 |
PubMed Central ID | PMC10133678 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1-9 |
Funder | National Sports Institute of Malaysia |
Swinburne University of Technology | |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 13 Apr 2023 |
Publication process dates | |
Accepted | 05 Apr 2023 |
Deposited | 29 Apr 2025 |
Grant ID | ISNRG 003/2020 |
Additional information | © 2023 Tee, Parr, Cooke, Chong, Rahmat, Md Razali, Yeo and Camera. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
https://acuresearchbank.acu.edu.au/item/91qz6/combined-effects-of-exercise-and-different-levels-of-acute-hypoxic-severity-a-randomized-crossover-study-on-glucose-regulation-in-adults-with-overweight
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OA_Tee_2023_Combined_effects_of_exercise_and_different.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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