Mitochondria-targeted antioxidants and skeletal muscle function

Journal article


Broome, Sophie, Woodhead, Jonathan and Merry, Troy. (2018). Mitochondria-targeted antioxidants and skeletal muscle function. Antioxidants. 7(8), p. Article 107. https://doi.org/10.3390/antiox7080107
AuthorsBroome, Sophie, Woodhead, Jonathan and Merry, Troy
Abstract

One of the main sources of reactive oxygen species (ROS) in skeletal muscle is the mitochondria. Prolonged or very high ROS exposure causes oxidative damage, which can be deleterious to muscle function, and as such, there is growing interest in targeting antioxidants to the mitochondria in an effort to prevent or treat muscle dysfunction and damage associated with disease and injury. Paradoxically, however, ROS also act as important signalling molecules in controlling cellular homeostasis, and therefore caution must be taken when supplementing with antioxidants. It is possible that mitochondria-targeted antioxidants may limit oxidative stress without suppressing ROS from non-mitochondrial sources that might be important for cell signalling. Therefore, in this review, we summarise literature relating to the effect of mitochondria-targeted antioxidants on skeletal muscle function. Overall, mitochondria-targeted antioxidants appear to exert beneficial effects on mitochondrial capacity and function, insulin sensitivity and age-related declines in muscle function. However, it seems that this is dependent on the type of mitochondrial-trageted antioxidant employed, and its specific mechanism of action, rather than simply targeting to the mitochondria.

Keywordsmitochondria; reactive oxygen species; oxidative stress; skeletal muscle; antioxidant
Year2018
JournalAntioxidants
Journal citation7 (8), p. Article 107
PublisherMultidisciplinary Digital Publishing Institute (MDPI AG)
ISSN2076-3921
Digital Object Identifier (DOI)https://doi.org/10.3390/antiox7080107
PubMed ID30096848
Scopus EID2-s2.0-85052678015
PubMed Central IDPMC6116009
Open accessPublished as ‘gold’ (paid) open access
Page range1-12
FunderMarsden Fund
Rutherford Discovery Fellowship
Callaghan Innovation
Publisher's version
License
File Access Level
Open
Output statusPublished
Publication dates
Online08 Aug 2018
Publication process dates
Accepted07 Aug 2018
Deposited08 Sep 2023
Grant ID16-UOA-313
15-UOA-020
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