Multimodal imaging biomarkers in premanifest and early Huntington's disease: 30-month IMAGE-HD data

Journal article


Dominguez, Juan, Stout, Julie C., Poudel, Govinda, Churchyard, Andrew, Chua, Phyllis, Egan, Gary F. and Georgiou-Karistianis, Nellie. (2016). Multimodal imaging biomarkers in premanifest and early Huntington's disease: 30-month IMAGE-HD data. British Journal of Psychiatry. 208(6), pp. 571 - 578. https://doi.org/10.1192/bjp.bp.114.156588
AuthorsDominguez, Juan, Stout, Julie C., Poudel, Govinda, Churchyard, Andrew, Chua, Phyllis, Egan, Gary F. and Georgiou-Karistianis, Nellie
Abstract

Background The discovery of potential disease-modifying therapies in a neurodegenerative condition like Huntington's disease depends on the availability of sensitive biomarkers that reflect decline across disease stages and that are functionally and clinically relevant. Aims To quantify macrostructural and microstructural changes in participants with premanifest and symptomatic Huntington's disease over 30 months, and to establish their functional and clinical relevance. Method Multimodal magnetic resonance imaging study measuring changes in macrostructural (volume) and microstructural (diffusivity) measures in 40 patients with premanifest Huntington's disease, 36 patients with symptomatic Huntington's disease and 36 healthy control participants over three testing sessions spanning 30 months. Results Relative to controls, there was greater longitudinal atrophy in participants with symptomatic Huntington's disease in whole brain, grey matter, caudate and putamen, as well as increased caudate fractional anisotropy; caudate volume loss was the only measure to differ between premanifest Huntington's disease and control groups. Changes in caudate volume and fractional anisotropy correlated with each other and neurocognitive decline; caudate volume loss also correlated with clinical and disease severity. Conclusions Caudate neurodegeneration, especially atrophy, may be the most suitable candidate surrogate biomarker for consideration in the development of upcoming clinical trials.

Year2016
JournalBritish Journal of Psychiatry
Journal citation208 (6), pp. 571 - 578
PublisherCambridge University Press
ISSN0007-1250
Digital Object Identifier (DOI)https://doi.org/10.1192/bjp.bp.114.156588
Scopus EID2-s2.0-84973438955
Page range571 - 578
Research GroupMary MacKillop Institute for Health Research
Publisher's version
File Access Level
Controlled
Grant IDNHMRC 606650
Place of publicationUnited Kingdom
Permalink -

https://acuresearchbank.acu.edu.au/item/87q0q/multimodal-imaging-biomarkers-in-premanifest-and-early-huntington-s-disease-30-month-image-hd-data

Restricted files

Publisher's version

  • 106
    total views
  • 0
    total downloads
  • 2
    views this month
  • 0
    downloads this month
These values are for the period from 19th October 2020, when this repository was created.

Export as

Related outputs

Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021 : a systematic analysis for the Global Burden of Disease Study 2021
Brauer, Michael, Roth, Gregory A, Aravkin, Aleksandr Y, Zheng, Peng, Abate, Kalkidan Hassen, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasi, Madineh Akram, Abbasian, Mohammadreza, Abbasifard, Mitra, Abbasi-Kangevari, Mohsen, Abd ElHafeez, Samar, Cerin, Ester, Poudel, Govinda, Rahman, Aziz and et. al.. (2024). Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021 : a systematic analysis for the Global Burden of Disease Study 2021. The Lancet. 403(10440), pp. 2162-2203. https://doi.org/10.1016/S0140-6736(24)00933-4
Brain reward function in people who use cannabis : A systematic review
Beyer, E., Poudel, Govinda, Antonopoulos, Stephanie, Thomson, Hannah and Lorenzetti, Valentina. (2023). Brain reward function in people who use cannabis : A systematic review. Frontiers in Behavioral Neuroscience. 17, pp. 1-17. https://doi.org/10.3389/fnbeh.2023.1323609
Associations of neighbourhood environmental attributes and socio-economic status with health-related quality of life in urban mid-aged and older adults : Mediation by physical activity and sedentary behaviour
Barnett, Anthony, Shaw, Jonathan E., Martino, Erika, Knibbs, Luke D., Poudel, Govinda, Owen, Neville and Cerin, Ester. (2023). Associations of neighbourhood environmental attributes and socio-economic status with health-related quality of life in urban mid-aged and older adults : Mediation by physical activity and sedentary behaviour. Cities. 142, p. Article 104538. https://doi.org/10.1016/j.cities.2023.104538
Characteristics of urban neighbourhood environments and cognitive age in mid-age and older adults
Soloveva, Maria V., Poudel, Govinda, Barnett, Anthony, Shaw, Jonathan E., Martino, Erika, Knibbs, Luke D., Anstey, Kaarin J. and Cerin, Ester. (2023). Characteristics of urban neighbourhood environments and cognitive age in mid-age and older adults. Health and Place. 83, p. Article 103077. https://doi.org/10.1016/j.healthplace.2023.103077
Exploring personalized structural connectomics for moderate-to-severe traumatic brain injury
Imms, Phoebe, Clemente, Adam, Deutscher, Evelyn, Radwan, Ahmed M., Akhlaghi, Hamed, Beech, Paul, Wilson, Peter H., Irimia, Andrei, Poudel, Govinda, Domínguez Duque, Juan F. and Caeyenberghs, Karen. (2023). Exploring personalized structural connectomics for moderate-to-severe traumatic brain injury. Network Neuroscience. 7(1), pp. 160-183. https://doi.org/10.1162/netn_a_00277
Individualised profiling of white matter organisation in moderate-to-severe traumatic brain injury patients
Clemente, Adam, Attyé, Arnaud, Renard, Félix, Calamante, Fernando, Burmester, Alex, Imms, Phoebe, Deutscher, Evelyn, Akhlaghi, Hamed, Beech, Paul, Wilson, Peter H., Poudel, Govinda, Dominguez D, Juan F. and Caeyenberghs, Karen. (2023). Individualised profiling of white matter organisation in moderate-to-severe traumatic brain injury patients. Brain Research. 1806, p. Article 148289. https://doi.org/10.1016/j.brainres.2023.148289
Do neighbourhood traffic-related air pollution and socio-economic statusmoderate the associations of the neighbourhood physical environment withcognitive function? Findings from the AusDiab study
Cerin, Ester, Barnett, Anthony, Wu, Yu-Tzu, Martino, Erika, Shaw, Jonathan E., Knibbs, Luke D., Poudel, Govinda, Jalaludin, Bin and Anstey, Kaarin J.. (2023). Do neighbourhood traffic-related air pollution and socio-economic statusmoderate the associations of the neighbourhood physical environment withcognitive function? Findings from the AusDiab study. Science of the Total Environment. 858(Part 3), p. Article 160028. https://doi.org/10.1016/j.scitotenv.2022.160028
Longitudinal mapping of cortical surface changes in Huntington’s disease
Tan, Brendan, Shishegar, Rosita, Fornito, Alex, Poudel, Govinda and Georgiou-Karistianis, Nellie. (2022). Longitudinal mapping of cortical surface changes in Huntington’s disease. Brain Imaging and Behavior. 16(3), pp. 1381-1391. https://doi.org/10.1007/s11682-021-00625-2
Multimodal neuroimaging with simultaneous fMRI and EEG
Poudel, Govinda R. and Jones, Richard D.. (2022). Multimodal neuroimaging with simultaneous fMRI and EEG. In In Thakor, Nitish V. (Ed.). Handbook of neuroengineering pp. 1-23 Springer Singapore. https://doi.org/10.1007/978-981-15-2848-4_81-1
Machine Learning for Prediction of Cognitive Health in Adults Using Sociodemographic, Neighbourhood Environmental, and Lifestyle Factors
Poudel, Govinda, Barnett, Anthony, Akram, Muhammad, Martino, Erika, Knibbs, Luke, Anstey, Kaarin, Shaw, Jonathan and Cerin, Ester. (2022). Machine Learning for Prediction of Cognitive Health in Adults Using Sociodemographic, Neighbourhood Environmental, and Lifestyle Factors. International Journal of Environmental Research and Public Health. 19(17), pp. 1-14. https://doi.org/10.3390/ijerph191710977
Structural-Functional Connectivity Bandwidth of the Human Brain
Parsons, Nicholas, Ugon, Julien, Morgan, Kerri, Shelyag, Sergiy, Hocking, Alex, Chan, Su, Poudel, Govinda, Dominguez Duque, Juan and Caeyenberghs, Karen. (2022). Structural-Functional Connectivity Bandwidth of the Human Brain. NeuroImage. 263, pp. 1-12. https://doi.org/10.1016/j.neuroimage.2022.119659
Network diffusion model predicts neurodegeneration in limb-onset Amyotrophic Lateral Sclerosis
Bhattarai, Anjan, Chen, Zhaolin, Chua, Phyllis, Talman, Paul, Mathers, Susan, Chapman, Caron, Howe, James, Lee, C. M. Sarah, Lie, Yenni, Poudel, Govinda R. and Egan, Gary F.. (2022). Network diffusion model predicts neurodegeneration in limb-onset Amyotrophic Lateral Sclerosis. PLoS ONE. 17(8), p. Article e0272736. https://doi.org/10.1371/journal.pone.0272736
Investigating longitudinal changes to frontal cortico-striatal tracts in Huntington’s disease : The IMAGE-HD study
Tan, Brendan, Shishegar, Rosita, Oldham, Stuart, Fornito, Alex, Poudel, Govinda and Georgiou-Karistianis, Nellie. (2022). Investigating longitudinal changes to frontal cortico-striatal tracts in Huntington’s disease : The IMAGE-HD study. Brain Imaging and Behavior. 16, pp. 2457-2466. https://doi.org/10.1007/s11682-022-00699-6
RoWDI: rolling window detection of sleep intrusions in the awake brain using fMRI
Poudel, Govinda R., Hawes, Stephanie, Innes, Carrie R. H., Parsons, Nicholas, Drummond, Sean P. A., Caeyensberghs, Karen and Jones, Richard D.. (2021). RoWDI: rolling window detection of sleep intrusions in the awake brain using fMRI. Journal of Neural Engineering. 18(5), p. Article 056063. https://doi.org/10.1088/1741-2552/ac2bb9
Investigating the neural signature of microsleeps using EEG
Zaky, Mohamed H., Shoorangiz, Reza, Poudel, Govinda R., Yang, Le and Jones, Richard D.. (2021). Investigating the neural signature of microsleeps using EEG. 43rd Annual International Conference of the IEEE Engineering in Medicine and Biology Society. 31 Oct - 04 Nov 2021 Institute of Electrical and Electronics Engineers. pp. 6293-6296 https://doi.org/10.1109/EMBC46164.2021.9630401
Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection : A sytematic review
Groff, Destin, Sun, Ashley, Ssentongo, Anna E., Ba, Djibril, Parsons, Nicholas, Poudel, Govinda R., Lekoubou, Alain, Oh, John S., Ericson, Jessica E., Ssentongo, Paddy and Chinchilli, Vernon M.. (2021). Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection : A sytematic review. JAMA Network Open. 4(10), p. Article e2128568. https://doi.org/10.1001/jamanetworkopen.2021.28568
Early white matter pathology in the fornix of the limbic system in Huntington disease
Gabery, Sanaz, Kwa, Jlng, Cheong, Rachel Y., Baldo, Barbara, Bardile, Costanza Ferrari, Tan, Brendan, Mclean, Catriona, Georgiou-Karistianis, Nellie, Poudel, Govinda R., Halliday, Glenda, Pouladi, Mahmoud A. and Petersén, Åsa. (2021). Early white matter pathology in the fornix of the limbic system in Huntington disease. Acta Neuropathologica. 142, pp. 781-806. https://doi.org/10.1007/s00401-021-02362-8
Modelling the anatomic distribution of neurologic events in patients with COVID-19 : A systematic review of MRI findings 
Parsons, N., Outsikas, A., Parish, A., Clohesy, R., D’Aprano, F., Toomey, F., Advani, S. and Poudel, G. R.. (2021). Modelling the anatomic distribution of neurologic events in patients with COVID-19 : A systematic review of MRI findings . American Journal of Neuroradiology. 42(7), pp. 1190-1195. https://doi.org/10.3174/ajnr.A7113
Individual differences in attentional lapses are associated with fiber-specific white matter microstructure in healthy adults
Clemente, Adam, Dominguez D, Juan F., Imms, Phoebe, Burmester, Alex, Dhollander, Thijs, Wilson, Peter., Poudel, Govinda and Caeyenberghs, Karen. (2021). Individual differences in attentional lapses are associated with fiber-specific white matter microstructure in healthy adults. Psychophysiology. 58(9), p. e13871. https://doi.org/10.1111/psyp.13871
ENIGMA-Sleep : Challenges, opportunities, and the road map
Tahmasian, Masoud, Aleman, André, Andreassen, Ole A., Arab, Zahra, Baillet, Marion, Benedetti, Francesco, Bresser, Tom, Bright, Joanna, Chee, Michael W. L., Chylinski, Daphne, Cheng, Wei, Deantoni, Michele, Dresler, Martin, Eickhoff, Simon B., Eickhoff, Claudia R., Elvsåshagen, Torbjørn, Feng, Jianfeng, Foster-Dingley, Jessica C., Ganjgahi, Habib, ... Zarei, Mojtaba. (2021). ENIGMA-Sleep : Challenges, opportunities, and the road map. Journal of Sleep Research. 30(6), p. Article e13347. https://doi.org/10.1111/jsr.13347
Tracking Huntingtonʼs disease progression using motor, functional, cognitive, and imaging markers
Abeyasinghe, Pubu M., Long, Jeffrey D., Razi, Adeel, Pustina, Dorian, Paulsen, Jane S., Tabrizi, Sarah J., Poudel, Govinda R. and Georgiou-Karistianis, Nellie. (2021). Tracking Huntingtonʼs disease progression using motor, functional, cognitive, and imaging markers. Movement Disorders. 36(10), pp. 2282-2292. https://doi.org/10.1002/mds.28650
Afraid of the dark : Light acutely suppresses activity in the human amygdala
McGlashan, Elise M., Poudel, Govinda R., Jamadar, Sharna D., Phillips, Andrew J. K. and Cain, Sean W.. (2021). Afraid of the dark : Light acutely suppresses activity in the human amygdala. PLoS ONE. 16(6), p. Article e0252350. https://doi.org/10.1371/journal.pone.0252350
Patterns of brain function associated with cannabis cue-reactivity in regular cannabis users : A systematic review of fMRI studies
Sehl, Hannah, Terrett, Gill, Greenwood, Lisa-Marie, Kowalczyk, Magdalena, Thomson, Hannah, Poudel, Govinda, Manning, Victoria and Lorenzetti, Valentina. (2021). Patterns of brain function associated with cannabis cue-reactivity in regular cannabis users : A systematic review of fMRI studies. Psychopharmacology. 238(10), pp. 2709-2728. https://doi.org/10.1007/s00213-021-05973-x
OA Dhollander 2021 Fixel based Analysis of Diffusion MRI
Dhollander, Thijs, Clemente, Adam, Singh, Mervyn, Boonstra, Frederique, Civier, Oren, Duque, Juan Dominguez, Egorova, Natalia, Enticott, Peter, Fuelscher, Ian, Gajamange, Sanuji, Genc, Sila, Gottlieb, Elie, Hyde, Christian, Imms, Phoebe, Kelly, Claire, Kirkovski, Melissa, Kolbe, Scott, Liang, Xiaoyun, Malhotra, Atul, ... Caeyenberghs, Karen. (2021). OA Dhollander 2021 Fixel based Analysis of Diffusion MRI. NeuroImage. 241, p. Article: 118417. https://doi.org/10.1016/j.neuroimage.2021.118417
Navigating the link between processing speed and network communication in the human brain
Imms, Phoebe, Domínguez D, Juan F., Burmester, Alex, Seguin, Caio, Clemente, Adam, Dhollander, Thijs, Wilson, Peter H., Poudel, Govinda and Caeyenberghs, Karen. (2021). Navigating the link between processing speed and network communication in the human brain. Brain Structure and Function. 226, pp. 1281-1302. https://doi.org/10.1007/s00429-021-02241-8
Neural responses to food cues in middle to older aged adults : A scoping review of fMRI studies
Bennett, Christie, Burrows, Tracy, Pursey, Kirrilly, Poudel, Govinda, Ng, Ker Wei, Nguo, Kay, Walker, Karen and Porter, Judi. (2021). Neural responses to food cues in middle to older aged adults : A scoping review of fMRI studies. Nutrition and Dietetics. 78(3), pp. 343-364. https://doi.org/10.1111/1747-0080.12644
Cortical thickness and resting-state cardiac function across the lifespan : A cross-sectional pooled mega-analysis
Koenig, Julian, Abler, Birgit, Agartz, Ingrid, Åkerstedt, Torbjörn, Andreassen, Ole A., Anthony, Mia, Bär, Karl-Jürgen, Bertsch, Katja, Brown, Rebecca C., Brunner, Romuald, Carnevali, Luca, Critchley, Hugo D., Cullen, Kathryn R., de Geus, Eco J. C., de la Cruz, Feliberto, Dziobek, Isabel, Ferger, Marc D., Fischer, Håkan, Flor, Herta, ... Quintana, Daniel S.. (2021). Cortical thickness and resting-state cardiac function across the lifespan : A cross-sectional pooled mega-analysis. Psychophysiology. 58(7), p. e13688. https://doi.org/10.1111/psyp.13688
Longtidunial fixed-based analysis reveals rstoration of white matter-alterations following balance training in young brain injured patients
Liang, Xiaoyun, Yeh, Chun-Hung, Domínguez D., Juan F., Poudel, Govinda, Swinnen, Stephan P. and Caeyenberghs, Karen. (2021). Longtidunial fixed-based analysis reveals rstoration of white matter-alterations following balance training in young brain injured patients. NeuroImage: Clinical. 30, p. 102621. https://doi.org/10.1016/j.nicl.2021.102621
Cortical morphometry and neural dysfunction in Huntington’s disease : A review
Tan, Brendan, Shishegar, Rosita, Poudel, Govinda R., Fornito, Alex and Georgiou-Karistianis, Nellie. (2021). Cortical morphometry and neural dysfunction in Huntington’s disease : A review. European Journal of Neurology. 28(4), pp. 1406-1419. https://doi.org/10.1111/ene.14648
Fluency and rule breaking behaviour in the frontal cortex
Cipolotti, Lisa, Molenberghs, Pascal, Dominguez, Juan, Smith, Nicola, Smirni, Daniela, Xu, Tianbo, Shallice, Tim and Chan, Edgar. (2020). Fluency and rule breaking behaviour in the frontal cortex. Neuropsychologia. 137, p. Article 107308. https://doi.org/10.1016/j.neuropsychologia.2019.107308
Multidisciplinary rehabilitation reduces hypothalamic grey matter volume loss in individuals with preclinical Huntington's disease : A nine-month pilot study
Bartlett, Danielle M., Dominguez D, Juan F., Lazar, Alpar S., Kordsachia, Catarina C., Rankin, Tim J., Lo, Johnny, Govus, Andrew D., Power, Brian D., Lampit, Amit, Eastwood, Peter R., Ziman, Mel R. and Cruickshank, Travis M.. (2020). Multidisciplinary rehabilitation reduces hypothalamic grey matter volume loss in individuals with preclinical Huntington's disease : A nine-month pilot study. Journal of the Neurological Sciences. 408, p. Article 116522. https://doi.org/10.1016/j.jns.2019.116522
Robust markers and sample sizes for multicenter trials of Huntington disease
Wijeratne, Peter A., Johnson, Eileanoir B., Eshaghi, Arman, Aksman, Leon, Gregory, Sarah, Johnson, Hans J., Poudel, Govinda R., Mohan, Amrita, Sampaio, Cristina, Georgiou-Karistianis, Nellie, Paulsen, Jane S., Tabrizi, Sarah J., Scahill, Rachael I., the Image-Hd, Predict-Hd Track-Hd investigators and Alexander, Daniel C.. (2020). Robust markers and sample sizes for multicenter trials of Huntington disease. Annals of Neurology. 87(5), pp. 751-762. https://doi.org/10.1002/ana.25709
Network diffusion modeling predicts neurodegeneration in traumatic brain injury
Poudel, Govinda R., Dominguez D, Juan F., Verhelst, Helena, Vander Linden, Catharine, Deblaere, Karel, Jones, Derek K., Cerin, Ester, Vingerhoets, Guy and Caeyenberghs, Karen. (2020). Network diffusion modeling predicts neurodegeneration in traumatic brain injury. Annals of Clinical and Translational Neurology. 7(3), pp. 270-279. https://doi.org/10.1002/acn3.50984
International Mind, Activities and Urban Places (iMAP) study: methods of a cohort study on environmental and lifestyle influences on brain and cognitive health
Ester Cerin, Anthony Barnett, Basile Chaix, Mark Nieuwenhuijsen, Karen Caeyenberghs, Bin Jalaludin, Takemi Sugiyama, James Sallis, Nicola T. Lautenschlager, Michael Y Ni, Govinda Poudel, David Donaire Gonzalez, Rachel Tham, Amanda Wheeler, Luke Knibbs, Linwei Tian, Kai Chan, David Dunstan, Alison Carver and Kaarin Anstey. (2020). International Mind, Activities and Urban Places (iMAP) study: methods of a cohort study on environmental and lifestyle influences on brain and cognitive health. BMJ Open. 10(3), pp. 1-15. https://doi.org/10.1136/bmjopen-2019-036607
Rate of torque development and striatal shape in individuals with prodromal Huntington's disease
Travis M. Cruickshank, Alvaro P. Reyes, Timothy S. Pulverenti, Tim J. Rankin, Danielle M. Bartlett, Anthony Blazevich, Govinda Poudel, Mel R. Ziman and Gabriel S Trajano. (2020). Rate of torque development and striatal shape in individuals with prodromal Huntington's disease. Scientific Reports. 10(1), pp. 1-8. https://doi.org/10.1038/s41598-020-72042-2
The effects of multidisciplinary rehabilitation on neuroimaging, biological, cognitive and motor outcomes in individuals with premanifest Huntington's disease
Danielle M. Bartlett, Andrew D. Govus, Tim J. Rankin, A. Lampit, Kirk W. Feindel, Govinda Poudel, Wei Peng Teo, Johnny Lo, Nellie Georgiou-Karistianis, Mel R. Ziman and Travis M. Cruickshank. (2020). The effects of multidisciplinary rehabilitation on neuroimaging, biological, cognitive and motor outcomes in individuals with premanifest Huntington's disease. Journal of the Neurological Sciences. 416, pp. 1-9. https://doi.org/10.1016/j.jns.2020.117022
Exploring the brain-body composition relationship in Huntington's disease
Mitchell Turner, Alvaro Reyes, Danielle M. Bartlett, Scott Culpin, Nicolas H. Hart, Luca Hardt, Kirk Feindel, Govinda R. Poudel, Mel Ziman and Travis M. Cruickshank. (2020). Exploring the brain-body composition relationship in Huntington's disease. The Journal of Musculoskeletal and Neuronal Interactions. 20(3), pp. 332-338.
Dual tasking impairments are associated with striatal pathology in Huntington’s disease
Johnny Lo, Alvaro Reyes, Timothy S. Pulverenti, Timothy J. Rankin, Danielle M. Bartlett, Pauline Zaenker, Grant Rowe, Kirk Feindel, Govinda Poudel, Nellie Georgiou-Karistianis, Mel R. Ziman and Travis M. Cruickshank. (2020). Dual tasking impairments are associated with striatal pathology in Huntington’s disease. Annals of Clinical and Translational Neurology. 7(9), pp. 1608-1619. https://doi.org/10.1002/acn3.51142
Oxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers
Izelle Labuschagne, Govinda Poudel, Catarina C. Kordsachia, Qizhu Wu, Hannah Thomson, Nellie Georgiou-Karistianis and Julie C Stout. (2018). Oxytocin selectively modulates brain processing of disgust in Huntington's disease gene carriers. Progress in Neuropsychopharmacology and Biological Psychiatry. 81, pp. 11-16. https://doi.org/10.1016/j.pnpbp.2017.09.023
Neurosocialities: Anthropological Engagements with the Neurosciences
John Gardner, Narelle Warren, Paul H Mason and Juan F. Dominguez D.. (2018). Neurosocialities: Anthropological Engagements with the Neurosciences. Medical Anthropology: cross-cultural studies in health and illness. 37(3), pp. 189-193. https://doi.org/10.1080/01459740.2018.1439488
A critical review of brain and cognitive reserve in Huntington's disease
Soloveva, Maria V., Jamadar, Sharna D., Poudel, Govinda and Georgiou-Karistianis, Nellie. (2018). A critical review of brain and cognitive reserve in Huntington's disease. Neuroscience and Biobehavioral Reviews. 88, pp. 155 - 169. https://doi.org/10.1016/j.neubiorev.2018.03.003
Temporal evolution of neutral activity and connectivity during microsleeps when rested and following sleep restriction
Poudel, Govinda, Innes, Carrie R. H. and Jones, Richard. (2018). Temporal evolution of neutral activity and connectivity during microsleeps when rested and following sleep restriction. NeuroImage. 174, pp. 263 - 273. https://doi.org/10.1016/j.neuroimage.2018.03.031
Neural correlates of decision-making during a Bayesian choice task
Poudel, Govinda, Bhattarai, Anjan, Dickinson, David L. and Drummond, Sean P. A.. (2017). Neural correlates of decision-making during a Bayesian choice task. NeuroReport. 28(4), pp. 193 - 199. https://doi.org/10.1097/WNR.0000000000000730
Emotion processing in persons who respond vicariously towards others in pain: Disinhibited left-lateralized neural activity for threatening expressions
Giummarra, Melita J., Poudel, Govinda, Niu, P. Amanda, Nicholls, Michael E. R., Fielding, Joanne, Verdejo-Garcia, Antonio and Labuschagne, Izelle. (2017). Emotion processing in persons who respond vicariously towards others in pain: Disinhibited left-lateralized neural activity for threatening expressions. Laterality: Assymetries of body, brain and cognition. 23(2), pp. 184 - 208. https://doi.org/10.1080/1357650X.2017.1349781
Longitudinal changes in the fronto-striatal network are associated with executive dysfunction and behavioral dysregulation in Huntington's disease: 30 months IMAGE-HD data
Dominguez, Juan F., Poudel, Govinda, Stout, Julie C., Gray, Marcus, Chua, Phyllis, Borowsky, Beth, Egan, Gary F. and Georgiou-Karistianis, Nellie. (2017). Longitudinal changes in the fronto-striatal network are associated with executive dysfunction and behavioral dysregulation in Huntington's disease: 30 months IMAGE-HD data. Cortex. 92, pp. 139 - 149. https://doi.org/10.1016/j.cortex.2017.04.001
Fronto-cerebellar dysfunction and dysconnectivity underlying cognition in Friedreich Ataxia: The IMAGE-FRDA Study
Harding, Ian H., Corben, Louise A., Storey, Elsdon, Egan, Gary F., Stagnitti, Monique R., Poudel, Govinda, Delatycki, Martin B. and Georgiou-Karistianis, Nellie. (2016). Fronto-cerebellar dysfunction and dysconnectivity underlying cognition in Friedreich Ataxia: The IMAGE-FRDA Study. Human Brain Mapping. 37(1), pp. 338 - 350. https://doi.org/10.1002/hbm.23034
Large-scale comparative visualisation of sets of multidimensional data
Vohl, Dany, Barnes, David G., Fluke, Christopher J., Poudel, Govinda, Georgiou-Karistianis, Nellie, Hassan, Amr H., Benovitski, Yuri, Wong, Tsz Ho, Kaluza, Owen L., Nguyen, Toan D. and Bonnington, C. Paul. (2016). Large-scale comparative visualisation of sets of multidimensional data. PeerJ. 2016(10), pp. 1 - 36. https://doi.org/10.7717/peerj-cs.88
Iron accumulation in the basal ganglia in Huntington's disease: Cross-sectional data from the IMAGE-HD study
Dominguez, Juan F., Ng, Amanda C. L., Poudel, Govinda, Stout, Julie C., Churchyard, A., Chua, Phyllis, Egan, Gary F. and Georgiou-Karistianis, Nellie. (2016). Iron accumulation in the basal ganglia in Huntington's disease: Cross-sectional data from the IMAGE-HD study. Journal of Neurology, Neurosurgery and Psychiatry. 87(5), pp. 545 - 549. https://doi.org/10.1136/jnnp-2014-310183
Subjective sleep problems in Huntington's disease: A pilot investigation of the relationship to brain structure, neurocognitive, and neuropsychiatric function
Baker, Chaya Rochel, Dominguez, Juan F., Stout, Julie C., Gabery, Sanaz, Churchyard, A., Chua, Phyllis, Egan, Gary F., Petersen, Asa, Georgiou-Karistianis, Nellie and Poudel, Govinda. (2016). Subjective sleep problems in Huntington's disease: A pilot investigation of the relationship to brain structure, neurocognitive, and neuropsychiatric function. Journal of the Neurological Sciences. 364, pp. 148 - 153. https://doi.org/10.1016/j.jns.2016.03.021
Microsleeps are associated with stage-2 sleep spindles from hippocampal-temporal network
Jonmohamadi, Yaqub, Poudel, Govinda, Innes, Carrie C. R. H. and Jones, Richard. (2016). Microsleeps are associated with stage-2 sleep spindles from hippocampal-temporal network. International Journal of Neural Systems. 26(4), pp. 1 - 12. https://doi.org/10.1142/S0129065716500155
Time-varying effective connectivity of the cortical neuroelectric activity associated with behavioural microsleeps
Toppi, Jlenia, Astolfi, Laura, Poudel, Govinda, H., Babiloni, Fabio, Jones, Richard and Innes, Carrie R. H.. (2016). Time-varying effective connectivity of the cortical neuroelectric activity associated with behavioural microsleeps. NeuroImage. 124, pp. 421 - 432. https://doi.org/10.1016/j.neuroimage.2015.08.059
Characterising upper limb movements in Huntington's Disease and the impact of restricted visual cues
Despard, Jessica, Ternes, Anne-Marie, Dimech-Betancourt, Bleydy, Poudel, Govinda, Churchyard, Andrew and Georgiou-Karistianis, Nellie. (2015). Characterising upper limb movements in Huntington's Disease and the impact of restricted visual cues. PLoS ONE. 10(8), pp. 1 - 18. https://doi.org/10.1371/journal.pone.0133709
Longitudinal change in white matter microstructure in Huntington's disease: The IMAGE-HD study
Poudel, Govinda R., Stout, Julie C., Dominguez, Juan F., Churchyard, Andrew, Chua, Phyllis, Egan, Gary F. and Georgiou-Karistianis, Nellie. (2015). Longitudinal change in white matter microstructure in Huntington's disease: The IMAGE-HD study. Neurobiology of Disease. 74(1), pp. 406 - 412. https://doi.org/10.1016/j.nbd.2014.12.009
Comparison of beamformers for EEG source signal reconstruction
Jonmohamadi, Yaqub, Poudel, Govinda, Innes, Carrie, Weiss, Daniel, Krueger, Rejko and Jones, Richard. (2014). Comparison of beamformers for EEG source signal reconstruction. Biomedical Signal Processing and Control. 14(1), pp. 175 - 188. https://doi.org/10.1016/j.bspc.2014.07.014
Source-space ICA for EEG source separation, localization, and time-course reconstruction
Jonmohamadi, Yaqub, Poudel, Govinda, Innes, Carrie and Jones, Richard. (2014). Source-space ICA for EEG source separation, localization, and time-course reconstruction. NeuroImage. 101(November), pp. 720 - 737. https://doi.org/10.1016/j.neuroimage.2014.07.052
The Multi-modal Australian ScienceS Imaging and Visualization Environment (MASSIVE) high performance computing infrastructure: Applications in neuroscience and neuroinformatics research
Goscinski, Wojtek J., McIntosh, Paul, Felzmann, Ulrich, Maksimenko, Anton, Hall, Christopher J., Gureyev, Timur, Thompson, Darren, Janke, Andrew, Galloway, Graham, Killeen, Neil E. B., Raniga, Parnesh, Kaluza, Owen, Ng, Amanda, Poudel, Govinda, Barnes, David G., Nguyen, Toan, Bonnington, Paul and Egan, Gary F.. (2014). The Multi-modal Australian ScienceS Imaging and Visualization Environment (MASSIVE) high performance computing infrastructure: Applications in neuroscience and neuroinformatics research. Frontiers in Neuroinformatics. 8(March), pp. 1 - 13. https://doi.org/10.3389/fninf.2014.00030
Functional magnetic resonance imaging of working memory in Huntington's disease: Cross-sectional data from the IMAGE-HD study
Georgiou-Karistianis, Nellie, Stout, Julie C., Domínguez, Juan F., Carron, Sarah P., Ando, Ayaka, Churchyard, Andrew, Chua, Phyllis, Bohanna, India, Dymowski, Alicia R., Poudel, Govinda and Egan, Gary F.. (2014). Functional magnetic resonance imaging of working memory in Huntington's disease: Cross-sectional data from the IMAGE-HD study. Human Brain Mapping. 35(5), pp. 1847 - 1864. https://doi.org/10.1002/hbm.22296
Voxel-ICA for reconstruction of source signal time-series and orientation in EEG and MEG
Jonmohamadi, Yaqub, Poudel, Govinda, Innes, Carrie and Jones, Richard. (2014). Voxel-ICA for reconstruction of source signal time-series and orientation in EEG and MEG. Australasian Physical and Engineering Sciences in Medicine. 37(2), pp. 457 - 464. https://doi.org/10.1007/s13246-014-0265-x
Multi-modal neuroimaging in premanifest and early Huntington's disease : 18 month longitudinal data from the IMAGE-HD study
Domínguez D, Juan F., Egan, Gary F., Gray, Marcus A., Poudel, Govinda R., Churchyard, Andrew, Chua, Phyllis, Stout, Julie C. and Georgiou-Karistianis, Nellie. (2013). Multi-modal neuroimaging in premanifest and early Huntington's disease : 18 month longitudinal data from the IMAGE-HD study. PLoS ONE. 8(9), pp. 1-10. https://doi.org/10.1371/journal.pone.0074131
Functional and connectivity changes during working memory in Huntington's disease : 18 month longitudinal data from the IMAGE-HD study
Georgiou-Karistianis, Nellie, Poudel, Govinda R., Domínguez D, Juan F., Langmaid, Rebecca, Gray, Marcus A., Churchyard, Andrew, Chua, Phyllis, Borowsky, Beth, Egan, Gary F. and Stout, Julie C.. (2013). Functional and connectivity changes during working memory in Huntington's disease : 18 month longitudinal data from the IMAGE-HD study. Brain and Cognition. 83(1), pp. 80-91. https://doi.org/10.1016/j.bandc.2013.07.004
Efficient and regular patterns of nighttime sleep are related to increased vulnerability to microsleeps following a single night of sleep restriction
Innes, Carrie R. H., Poudel, Govinda R. and Jones, Richard D.. (2013). Efficient and regular patterns of nighttime sleep are related to increased vulnerability to microsleeps following a single night of sleep restriction. Chronobiology International. 30(9), pp. 1187-1196. https://doi.org/10.3109/07420528.2013.810222
Distinct neural correlates of time-on-task and transient errors during a visuomotor tracking task after sleep restriction
Poudel, Govinda R., Innes, Carrie R. H. and Jones, Richard D.. (2013). Distinct neural correlates of time-on-task and transient errors during a visuomotor tracking task after sleep restriction. NeuroImage. 77, pp. 105-113. https://doi.org/10.1016/j.neuroimage.2013.03.054
Time-Varying Functional Connectivity for Understanding the Neural Basis of Behavioral Microsleeps
J Toppi, L Astolfi, GR Poudel, F Babiloni, L Macchiusi, D Mattia, S Salinari and RD Jones. (2012). Time-Varying Functional Connectivity for Understanding the Neural Basis of Behavioral Microsleeps. 34th Annual International Conference of the IEEE EMBS. IEEE, Institute of Electrical and Electronics Engineers. pp. 4708-4711 https://doi.org/10.1109/EMBC.2012.6347018
Performance of Beamformers on EEG Source Reconstruction
Yaqub Jon Mohamadi, Govinda Poudel, Carrie R H Innes and Richard Jones. (2012). Performance of Beamformers on EEG Source Reconstruction. 34th Annual International Conference of the IEEE EMBS. IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/EMBC.2012.6346476
Cerebral perfusion differences between drowsy and nondrowsy individuals after acute sleep restriction
Poudel, Govinda R., Innes, Carrie R. H. and Jones, Richard D.. (2012). Cerebral perfusion differences between drowsy and nondrowsy individuals after acute sleep restriction. Sleep. 35(8), pp. 1085-1096. https://doi.org/10.5665/sleep.1994