Hippocampal morphology in Huntington's disease, implications for plasticity and pathogenesis : The IMAGE-HD study
Journal article
Wilkes, Fiona A., Jakabek, David, Walterfang, Mark, Velakoulis, Dennis, Poudel, Govinda R., Stout, Julie C., Chua, Phyllis, Egan, Gary F., Looi, Jeffrey C. L. and Georgiou-Karistianis, Nellie. (2023). Hippocampal morphology in Huntington's disease, implications for plasticity and pathogenesis : The IMAGE-HD study. Psychiatry Research: Neuroimaging. 335, p. Article 111694. https://doi.org/10.1016/j.pscychresns.2023.111694
Authors | Wilkes, Fiona A., Jakabek, David, Walterfang, Mark, Velakoulis, Dennis, Poudel, Govinda R., Stout, Julie C., Chua, Phyllis, Egan, Gary F., Looi, Jeffrey C. L. and Georgiou-Karistianis, Nellie |
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Abstract | While striatal changes in Huntington's Disease (HD) are well established, few studies have investigated changes in the hippocampus, a key neuronal hub. Using MRI scans obtained from the IMAGE-HD study, hippocampi were manually traced and then analysed with the Spherical Harmonic Point Distribution Method (SPHARM-PDM) in 36 individuals with presymptomatic-HD, 37 with early symptomatic-HD, and 36 healthy matched controls. There were no significant differences in overall hippocampal volume between groups. Interestingly we found decreased bilateral hippocampal volume in people with symptomatic-HD who took selective serotonin reuptake inhibitors compared to those who did not, despite no significant differences in anxiety, depressive symptoms, or motor incapacity between the two groups. In symptomatic-HD, there was also significant shape deflation in the right hippocampal head, showing the utility of using manual tracing and SPHARM-PDM to characterise subtle shape changes which may be missed by other methods. This study confirms previous findings of the lack of hippocampal volumetric differentiation in presymptomatic-HD and symptomatic-HD compared to controls. We also find novel shape and volume findings in those with symptomatic-HD, especially in relation to decreased hippocampal volume in those treated with SSRIs. |
Keywords | Huntington’s disease; hippocampus; SSRIs; depression |
Year | 2023 |
Journal | Psychiatry Research: Neuroimaging |
Journal citation | 335, p. Article 111694 |
Publisher | Elsevier B.V. |
ISSN | 0925-4927 |
Digital Object Identifier (DOI) | https://doi.org/10.1016/j.pscychresns.2023.111694 |
PubMed ID | 37598529 |
Scopus EID | 2-s2.0-85168089527 |
Open access | Published as ‘gold’ (paid) open access |
Page range | 1-7 |
Funder | CHDI Foundation |
National Health and Medical Research Council (NHMRC) | |
RANZCP | |
University of Melbourne | |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 02 Aug 2023 |
Publication process dates | |
Accepted | 26 Jul 2023 |
Deposited | 04 Apr 2025 |
Grant ID | 3433 |
606650 | |
Additional information | © 2023 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). |
https://acuresearchbank.acu.edu.au/item/91940/hippocampal-morphology-in-huntington-s-disease-implications-for-plasticity-and-pathogenesis-the-image-hd-study
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OA_Wilkes_2023_Hippocampal_morphology_in_Huntingtons_disease_implications.pdf | |
License: CC BY-NC-ND 4.0 | |
File access level: Open |
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