Movement does not promote recovery of motor output following acute experimental muscle pain

Journal article


Schabrun, Siobhan M., Palsson, Thorvaldur S., Thapa, Tribikram and Graven-Nielsen, Thomas. (2018). Movement does not promote recovery of motor output following acute experimental muscle pain. Pain Medicine. 19(3), pp. 608-614. https://doi.org/10.1093/pm/pnx099
AuthorsSchabrun, Siobhan M., Palsson, Thorvaldur S., Thapa, Tribikram and Graven-Nielsen, Thomas
Abstract

Objective
To examine the effect of motor activity on the magnitude and duration of altered corticomotor output following experimental muscle pain.

Design
Experimental, pre-post test.

Setting
University laboratory.

Subjects
Twenty healthy individuals.

Methods
Participants were randomly allocated to a Rest or Movement group. The Rest group sat quietly without moving for the duration of the experiment. The Movement group repeated a unimanual pattern of five sequential keystrokes as quickly and as accurately as possible immediately following the resolution of pain. Pain was induced into the right extensor carpi radialis brevis muscle by a bolus injection of 0.5 mL hypertonic saline. Corticomotor output was assessed as motor evoked potentials in response to transcranial magnetic stimulation before, immediately after, and at 10, 20, and 30 minutes following pain resolution. Pain intensity was recorded every 30 seconds using an 11-point numerical rating scale.

Results
There was no difference in peak pain intensity (P < 0.09) or duration (P < 0.2) between groups. Corticomotor output was reduced in both groups (P < 0.002) at 10 minutes (P < 0.002), 20 minutes (P < 0.02), and 30 minutes (P < 0.037) following the resolution of pain relative to baseline. There was no difference between groups at any time point.

Conclusions
Performance of motor activity immediately following the resolution of acute muscle pain did not alter the magnitude or duration of corticomotor depression. Understanding corticomotor depression in the postpain period and what factors promote recovery has relevance for clinical pain syndromes where ongoing motor dysfunction, in the absence of pain, may predispose to symptom persistence or recurrence.

Keywordscorticomotor output; experimental muscle pain; motor activity; recovery; transcranial magnetic stimulation
Year2018
JournalPain Medicine
Journal citation19 (3), pp. 608-614
PublisherOxford University Press
ISSN1526-2375
Digital Object Identifier (DOI)https://doi.org/10.1093/pm/pnx099
Scopus EID2-s2.0-85050588501
Research or scholarlyResearch
Page range608-614
FunderNational Health and Medical Research Council (NHMRC)
Danish National Research Foundation
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online19 May 2017
Publication process dates
Deposited18 Aug 2022
Grant ID1105040
DNRF121
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