Impact of heart rate on admission on mortality and morbidity in acute ischaemic stroke patients – results from VISTA

Journal article


Nolte, C. H., Erdur, H., Grittner, U., Schneider, A., Piper, S. K., Scheitz, J. F., Wellwood, I., Bath, P. M. W., Diener, H.-C., Lees, K. R. and Endres, M.. (2016). Impact of heart rate on admission on mortality and morbidity in acute ischaemic stroke patients – results from VISTA. European Journal of Neurology. 23(12), pp. 1750-1756. https://doi.org/10.1111/ene.13115
AuthorsNolte, C. H., Erdur, H., Grittner, U., Schneider, A., Piper, S. K., Scheitz, J. F., Wellwood, I., Bath, P. M. W., Diener, H.-C., Lees, K. R. and Endres, M.
Abstract

Background and purpose
Elevated heart rate (HR) is associated with worse outcomes in patients with cardiovascular disease. Its predictive value in acute stroke patients is less well established. We investigated the effects of HR on admission in acute ischaemic stroke patients.

Methods
Using the Virtual International Stroke Trials Archive (VISTA) database, the association between HR in acute stroke patients without atrial fibrillation and the pre-defined composite end-point of (recurrent) ischaemic stroke, transient ischaemic attack (TIA), myocardial infarction (MI) and vascular death within 90 days was analysed. Pre-defined secondary outcomes were the composite end-point components and any death, decompensated heart failure and degree of functional dependence according to the modified Rankin Scale after 90 days. HR was analysed as a categorical variable (quartiles).

Results
In all, 5606 patients were available for analysis (mean National Institutes of Health Stroke Scale 13; mean age 67 years; mean HR 77 bpm; 44% female) amongst whom the composite end-point occurred in 620 patients (11.1%). Higher HR was not associated with the composite end-point. The frequencies of secondary outcomes were 3.2% recurrent stroke (n = 179), 0.6% TIA (n = 35), 1.8% MI (n = 100), 6.8% vascular death (n = 384), 15.0% any death (n = 841) and 2.2% decompensated heart failure (n = 124). Patients in the highest quartile (HR> 86 bpm) were at increased risk for any death [adjusted hazard ratio (95% confidence interval) 1.40 (1.11–1.75)], decompensated heart failure [adjusted hazard ratio 2.20 (1.11–4.37)] and worse modified Rankin Scale [adjusted odds ratio 1.29 (1.14–1.52)].

Conclusions
In acute stroke patients, higher HR (>86 bpm) is linked to mortality, heart failure and higher degree of dependence after 90 days but not to recurrent stroke, TIA or MI.

Keywordsacute stroke; heart failure; heart rate; mortality; recurrent stroke
Year2016
JournalEuropean Journal of Neurology
Journal citation23 (12), pp. 1750-1756
PublisherWiley
ISSN1351-5101
Digital Object Identifier (DOI)https://doi.org/10.1111/ene.13115
Scopus EID2-s2.0-84992455342
Open accessPublished as green open access
Research or scholarlyResearch
Page range1750-1756
Author's accepted manuscript
License
All rights reserved
File Access Level
Open
Publisher's version
License
All rights reserved
File Access Level
Controlled
Output statusPublished
Publication dates
Online12 Aug 2016
Publication process dates
Accepted27 Jun 2016
Deposited25 Aug 2022
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