Mary MacKillop Institute for Health Research


TypeDepartment
FacultyFaculty of Health Sciences

Latest research outputs

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The effect of breaking up prolonged sitting on paired associative stimulation-induced plasticity
Bojsen-Møller, E., Ekblom, M. M., Tarassova, O., Dunstan, D. W. and Ekblom, O.. (2020). The effect of breaking up prolonged sitting on paired associative stimulation-induced plasticity. Experimental Brain Research. 238, pp. 2497-2506. https://doi.org/10.1007/s00221-020-05866-z

Journal article

Sitting at work & waist circumference - A cross-sectional study of Australian worker
Sugiyama, Takemi, Hadgraft, Nyssa, Clark, Bronwyn K., Dunstan, David W. and Owen, Neville. (2020). Sitting at work & waist circumference - A cross-sectional study of Australian worker. Preventive Medicine. 141, p. 106243. https://doi.org/10.1016/j.ypmed.2020.106243

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Reproducibility-optimized detection of differential DNA methylation
Suni, Veronika, Seyednasrollah, Fatemeh, Ghimire, Bishwa, Junttila, Sini, Laiho, Asta and Elo, Laura L.. (2020). Reproducibility-optimized detection of differential DNA methylation. Epigenomics. 12(9), pp. 1-9. https://doi.org/10.2217/epi-2019-0289

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Public health messaging during extreme smoke events: are we hitting the mark?
Marfori, M. Therese, Campbell, Sharon L., Garvey, Kate, McKeown, Scott, Veitch, Mark, WheelerWheeler, Amanda J., A., Borchers-Arriagada, Nicolas and Johnston, Fay H.. (2020). Public health messaging during extreme smoke events: are we hitting the mark? Frontiers in Public Health. 8, p. 465. https://doi.org/10.3389/fpubh.2020.00465

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Protein kinase a negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495
Spengler, Katrin, Zibrova, Darya, Woods, Angela, Langendorf, Christopher G., Scott, John W., Carling, David and Heller, Regine. (2020). Protein kinase a negatively regulates VEGF-induced AMPK activation by phosphorylating CaMKK2 at serine 495. Biochemical Journal. 477(17), pp. 3453-3469. https://doi.org/10.1042/BCJ20200555

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Mammography adherence among high-risk women with breast cancer and either a non-pathogenic mutation identified or untested brca1/2 genetic status
Flehr, Alison, Judd, Fiona, Lindeman, Geoffrey J., Kentwell, Maira, Gibson, Penny, Bryant, Christina, Komiti, Angela, Mann, G. Bruce and Stafford, Lesley. (2020). Mammography adherence among high-risk women with breast cancer and either a non-pathogenic mutation identified or untested brca1/2 genetic status. Journal of Medical Psychology. 22(1), pp. 31-44. https://doi.org/10.3233/JMP-180016

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Hypothesis testing based on a vector of statistics
King, Maxwell L., Zhang, Xibin and Akram, Muhammad. (2020). Hypothesis testing based on a vector of statistics. Journal of Econometrics. 219(2), pp. 425-455. https://doi.org/10.1016/j.jeconom.2020.03.010

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Grade 1 vertebral fractures identified by densitometric lateral spine imaging predict incident major osteoporotic fracture independently of clinical risk factors and bone mineral density in older women
Johansson, Lisa, Sundh, Daniel, Magnusson, Per, Rukmangatharajan, Komagal, Mellström, Dan, Nilsson, Anna G. and Lorentzon, Mattias. (2020). Grade 1 vertebral fractures identified by densitometric lateral spine imaging predict incident major osteoporotic fracture independently of clinical risk factors and bone mineral density in older women. Journal of Bone and Mineral Research. 35(10), pp. 1942-1951. https://doi.org/10.1002/jbmr.4108

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Functional analysis of an R311C variant of Ca2+-calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder
Xy Ling, Naomi, Langendorf, Christopher G., Hoque, Ashfaqul, Galic, Sandra, Loh, Kim, Kemp, Bruce E., Gundlach, Andrew L., Oakhill, Jonathan S. and Scott, John W.. (2020). Functional analysis of an R311C variant of Ca2+-calmodulin-dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder. Bipolar Disorders. 22(8), pp. 841-848. https://doi.org/10.1111/bdi.12901

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Diurnal patterns of objectively measured sedentary time and interruptions to sedentary time are associated with glycaemic indices in type 2 diabetes
Paing, Aye C., McMillan, Kathryn A., Kirk, Alison F., Collier, Andrew, Hewitt, Allan, Dunstan, David, Owen, Neville and Chastin, Sebastien F. M.. (2020). Diurnal patterns of objectively measured sedentary time and interruptions to sedentary time are associated with glycaemic indices in type 2 diabetes. Journal of Science and Medicine in Sport. 23(11), pp. 1074-1079. https://doi.org/10.1016/j.jsams.2020.06.003

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Differing effects of zoledronic acid on bone microarchitecture and bone mineral density in men receiving androgen deprivation therapy : A randomized controlled trial
Cheung, Ada S., Hoermann, Rudolf, Ghasem-Zadeh, Ali, Tinson, Alistair J., Ly, Vivian, Milevski, Stefan V., Joon, Daryl Lim, Zajac, Jeffrey D., Seeman, Ego and Grossmann, Mathis. (2020). Differing effects of zoledronic acid on bone microarchitecture and bone mineral density in men receiving androgen deprivation therapy : A randomized controlled trial. Journal of Bone and Mineral Research. 35(10), pp. 1871-1880. https://doi.org/10.1002/jbmr.4106

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Differences in adolescent activity and dietary behaviors across home, school, and other locations warrant location-specific intervention approaches
Ortega, Adrian, Bejarano, Carolina M., Cushing, Christopher C., Staggs, Vincent S., Papa, Amy E., Steel, Chelsea, Shook, Robin P., Sullivan, Debra K., Couch, Sarah C., Conway, Terry L., Saelens, Brian E., Glanz, Karen, Frank, Lawrence D., Cain, Kelli L., Kerr, Jacqueline, Schipperijn, Jasper, Sallis, James F. and Carlson, Jordan A.. (2020). Differences in adolescent activity and dietary behaviors across home, school, and other locations warrant location-specific intervention approaches. International Journal of Behavioral Nutrition and Physical Activity. 17(1), p. 123. https://doi.org/10.1186/s12966-020-01027-1

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Circulating and adipose tissue miRNAs in women with polycystic ovary syndrome and responses to high-intensity interval training
Lionett,Sofie, Kiel,Ida A., Camera,Donny M., Vanky,Eszter, Parr, E., Lydersen,Stian, Hawley, J. and Moholdt,Trine. (2020). Circulating and adipose tissue miRNAs in women with polycystic ovary syndrome and responses to high-intensity interval training. Frontiers in Physiology. 11, p. 904. https://doi.org/10.3389/fphys.2020.00904

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Effect of vitamin d supplementation, omega-3 fatty acid supplementation or a strength-training exercise program on clinical outcomes in older adults : The DO-HEALTH Randomized Clinical Trial
Bischoff-Ferrari, Heike A., Vellas, Bruno, Rizzoli, René, Kressig, Reto W., da Silva, José A. P., Blauth, Michael, Felson, David T., McCloskey, Eugene V., Watzl, Bernhard, Hofbauer, Lorenz C., Felsenberg, Dieter, Willett, Walter C., Dawson-Hughes, Bess, Manson, JoAnn E., Siebert, Uwe, Theiler, Robert, Staehelin, Hannes B., de Godoi Rezende Costa Molino, Caroline, Chocano-Bedoya, Patricia O., ... for the DO-HEALTH Research Group. (2020). Effect of vitamin d supplementation, omega-3 fatty acid supplementation or a strength-training exercise program on clinical outcomes in older adults : The DO-HEALTH Randomized Clinical Trial. JAMA: Journal of the American Medical Association. 324(18), pp. 1855-1868. https://doi.org/10.1001/jama.2020.16909

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Car use and cardiovascular disease risk : Systematic review and implications for transport research
Sugiyama, Takemi, Chandrabose, M., Homer, A., Sugiyama, Masaaki, Dunstan, D. and Owen, Neville. (2020). Car use and cardiovascular disease risk : Systematic review and implications for transport research. Journal of Transport and Health. 19, p. 100930. https://doi.org/10.1016/j.jth.2020.100930

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Bone densitometry worldwide : A global survey by the ISCD and IOF
Clynes, M. A., Westbury, L. D., Dennison, E. M., Kanis, J., Javaid, M. K., Harvey, N. C., Fujita, M., Cooper, C., Leslie, W. D., Shuhart, C. R., The International Society for Clinical Densitometry (ISCD) and The International Osteoporosis Foundation (IOF). (2020). Bone densitometry worldwide : A global survey by the ISCD and IOF. Osteoporosis International. 31, pp. 1779-1786. https://doi.org/10.1007/s00198-020-05435-8

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Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures
John Kanis, Helena Johansson, Nicholas C. Harvey, V. Gudnason, Gunnar Sigurdsson, K. Siggeirsdottir, Mattias Lorentzon, E. Liu, Liesbeth Vandenput and Eugene McCloskey. (2020). Adjusting conventional FRAX estimates of fracture probability according to the recency of sentinel fractures. Osteoporosis International. 31(10), pp. 1817-1828. https://doi.org/10.1007/s00198-020-05517-7

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Acute effects of breaking up prolonged sedentary time on cardiovascular disease risk markers in adults with paraplegia
Daniel P. Bailey, Thomas M. Withers, Victoria L. Goosey-Tolfrey, David Dunstan, Christof A. Leicht, Rachael B. Champion, Opie P. Charlett and Louise Ferrandino. (2020). Acute effects of breaking up prolonged sedentary time on cardiovascular disease risk markers in adults with paraplegia. Scandinavian Journal of Medicine & Science in Sports. 30(8), pp. 1398-1408. https://doi.org/10.1111/sms.13671

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Abaloparatide followed by alendronate in women ≥80 years with osteoporosis: post hoc analysis of ACTIVExtend
S L Greenspan, Lorraine A. Fitzpatrick, Bruce Mitlak, Yamei Wang, Nicholas C. Harvey, Chad Deal, F. Cosman and Michael McClung. (2020). Abaloparatide followed by alendronate in women ≥80 years with osteoporosis: post hoc analysis of ACTIVExtend. Menopause: The Journal of the North American Menopause Society. 27(10), pp. 1137-1142. https://doi.org/10.1097/GME.0000000000001593

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A single dose of zoledronate preserves bone mineral density for up to 2 years after a second course of romosozumab
McClung, Michael, Bolognese, Michael A, Brown, Jacques P, Reginster, Jean Yves, Langdahl, Bente Lomholt, Maddox, Judy, Shi, Y., Rojeski, M., Meisner, Paul and Grauer, Andreas. (2020). A single dose of zoledronate preserves bone mineral density for up to 2 years after a second course of romosozumab. Osteoporosis International. 31, pp. 2231-2241. https://doi.org/10.1007/s00198-020-05502-0

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A Community-Wide Walking Promotion Using Maps and Events for Japanese Older Adults
Kubota, Akio, Matsushita, Munehiro, Arao, Takashi, Merom, Dafna, Cerin, Ester and Sugiyama, Takemi. (2020). A Community-Wide Walking Promotion Using Maps and Events for Japanese Older Adults. Journal of Aging and Health. 32(7-8), pp. 735-743. https://doi.org/10.1177/0898264319848868

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Combined effects of continuous exercise and intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides in adults with obesity : A randomized crossover trial
Wheeler, Michael J., Green, Daniel J., Cerin, Ester, Ellis, Kathryn A., Heinonen, Ilkka, Lewis, Jaye, Naylor, Louise H., Cohen, Neale, Larsen, Robyn, Dempsey, Paddy C., Kingwell, Bronwyn A., Owen, Neville and Dunstan, David W.. (2020). Combined effects of continuous exercise and intermittent active interruptions to prolonged sitting on postprandial glucose, insulin, and triglycerides in adults with obesity : A randomized crossover trial. International Journal of Behavioral Nutrition and Physical Activity. 17(1), p. 152. https://doi.org/10.1186/s12966-020-01057-9

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CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins
Langendorf, Christopher G., O'Brien, Matthew T., Ngoei, Kevin R. W., McAloon, Luke M., Dhagat, Urmi, Hoque, Ashfaqul, Ling, Naomi X. Y., Dite, Toby A., Galic, Sandra, Loh, Kim, Parker, Michael W., Oakhill, Jonathan S., Kemp, Bruce E. and Scott, John W.. (2020). CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins. Journal of Biological Chemistry. 295(48), pp. 16239-16250. https://doi.org/10.1074/jbc.RA120.013756

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Automated high-frequency observations of physical activity using computer vision
Carlson, Jordan A., Liu, B. O., Sallis, James F., Hipp, J. Aaron, Staggs, Vincent S., Kerr, Jacqueline, Papa, A. M. Y., Dean, Kelsey and Vasconcelos, Nuno M.. (2020). Automated high-frequency observations of physical activity using computer vision. Medicine & Science in Sports & Exercise. 52(9), pp. 2029-2036. https://doi.org/10.1249/MSS.0000000000002341

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Associations of local social engagement and environmental attributes with walking and sitting among Japanese older adults
Akio, Kubota, Alison, Carver and Takemi, Sugiyama. (2020). Associations of local social engagement and environmental attributes with walking and sitting among Japanese older adults. Journal of Aging and Physical Activity. 28(2), pp. 187-193. https://doi.org/10.1123/japa.2018-0321

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FRAX and ethnicity
Kanis, J. A., Cooper, C., Dawson-Hughes, B., Harvey, N. C., Johansson, H., Lorentzon, M., McCloskey, E. V., Reginster, J. Y., Rizzoli, R. and International Osteoporosis Foundation. (2020). FRAX and ethnicity. Osteoporosis International. 31(11), pp. 2063-2067. https://doi.org/10.1007/s00198-020-05631-6

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DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy
Puustinen, Pietri, Keldsbo, Anne, Corcelle-Termeau, Elisabeth, Ngoei, Kevin, Sønder, Stine L., Farkas, Thomas, Kaae Andersen, Klaus, Oakhill, Jon S. and Jäättelä, Marja. (2020). DNA-dependent protein kinase regulates lysosomal AMP-dependent protein kinase activation and autophagy. Autophagy. 16(10), pp. 1871-1888. https://doi.org/10.1080/15548627.2019.1710430

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Assessment of cardiovascular safety of anti-osteoporosis drugs
Fuggle, N. R., Cooper, C., Harvey, N. C., Al-Daghri, N., Brandi, M. L., Bruyere, O., Cano, A., Dennison, E. M., Diez-Perez, A., Kaufman, J. M., Palacios, S., Prieto-Alhambra, D., Rozenberg, S., Thomas, T., Tremollieres, F., Rizzoli, R., Kanis, J. A. and Reginster, J. Y.. (2020). Assessment of cardiovascular safety of anti-osteoporosis drugs. Drugs: Education, Prevention and Policy. 80(15), pp. 1537-1552. https://doi.org/10.1007/s40265-020-01364-2

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American Association of Clinical Endocrinologists/American College Of Endocrinology Clinical Practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis — 2020 update executive summary
Camacho, Pauline M., Petak, Steven M., Binkley, Neil, Diab, Dima L., Eldeiry, Leslie S., Farooki, Azeez, Harris, Steven T., Hurley, Daniel L., Kelly, Jennifer, Lewiecki, E. Michael, Pessah-Pollack, Rachel, McClung, Michael, Wimalawansa, Sunil J. and Watts, Nelson B.. (2020). American Association of Clinical Endocrinologists/American College Of Endocrinology Clinical Practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis — 2020 update executive summary. Endocrine Practice. 26(5), pp. 564-570. https://doi.org/10.4158/GL-2020-0524

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Alternative and complementary therapies in osteoarthritis and cartilage repair
Fuggle, N. R., Cooper, C., Oreffo, R. O. C., Price, A. J., Kaux, J. F., Maheu, E., Cutolo, M., Honvo, G., Conaghan, P. G., Berenbaum, F., Branco, J., Brandi, M. L., Cortet, B., Veronese, N., Kurth, A. A., Matijevic, R., Roth, R., Pelletier, J. P., Martel-Pelletier, J., ... Reginster, J. Y.. (2020). Alternative and complementary therapies in osteoarthritis and cartilage repair. Aging Clinical and Experimental Research. 32(4), pp. 547-560. https://doi.org/10.1007/s40520-020-01515-1

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What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs
Heraud-Farlow, Jacki E. and Walkley, Carl R.. (2020). What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs. Open Biology. 10(7), p. 200085. https://doi.org/10.1098/rsob.200085

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Vertebral Fractures in Ankylosing Spondylitis Are Associated with Lower Bone Mineral Density in Both Central and Peripheral Skeleton
Bakker, Esmée A., Hartman, Yvonne A. W., Hopman, Maria T. E., Hopkins, Nicola D., Graves, Lee E. F., Dunstan, David W., Healy, Genevieve N., Eijsvogels, Thijs M. H. and Thijssen, Dick H. J.. (2020). Vertebral Fractures in Ankylosing Spondylitis Are Associated with Lower Bone Mineral Density in Both Central and Peripheral Skeleton. International Journal of Behavioral Nutrition and Physical Activity. 17(1), p. 75. https://doi.org/10.1186/s12966-020-00972-1

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Using methylome data to inform exposome-health association studies : An application to the identification of environmental drivers of child body mass index
Cadiou, Solène, Bustamante, Mariona, Agier, Lydiane, Andrusaityte, Sandra, Basagaña, Xavier, Carracedo, Angel, Chatzi, Leda, Grazuleviciene, Regina, Gonzalez, Juan R., Gutzkow, Kristine B., Maitre, Léa, Mason, Dan, Millot, Frédéric, Nieuwenhuijsen, Mark, Papadopoulou, Eleni, Santorelli, Gillian, Saulnier, Pierre-Jean, Vives, Marta, Wright, John, ... Slama, Rémy. (2020). Using methylome data to inform exposome-health association studies : An application to the identification of environmental drivers of child body mass index. Environment International. 138, p. 105622. https://doi.org/10.1016/j.envint.2020.105622

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Urban environments and objectively-assessed physical activity and sedentary time in older Belgian and Chinese community dwellers: potential pathways of influence and the moderating role of physical function
Cerin, Ester, Van Dyck, Delfien, Zhang, Casper J. P., Van Cauwenberg, Jelle, Lai, Poh-chin and Barnett, Anthony. (2020). Urban environments and objectively-assessed physical activity and sedentary time in older Belgian and Chinese community dwellers: potential pathways of influence and the moderating role of physical function. International Journal of Behavioral Nutrition and Physical Activity. 17(1), p. 73. https://doi.org/10.1186/s12966-020-00979-8

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Urban and transport planning pathways to carbon neutral, liveable and healthy cities : A review of the current evidence
Nieuwenhuijsen, Mark J.. (2020). Urban and transport planning pathways to carbon neutral, liveable and healthy cities : A review of the current evidence. Environment International. 140, p. 105661. https://doi.org/10.1016/j.envint.2020.105661

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The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKa2
Lee, Jung Ok, Byun, Won Seok, Kang, Min Ju, Han, Jeong Ah, Moon, Jiyoung, Shin, Min-Jeong, Lee, Ho Jun, Chung, Ji Hyung, Lee, Jin-Seok, Son, Chang-Gue, Song, Kwon-Ho, Kim, Tae Woo, Lee, Eun-Soo, Kim, Hong Min, Chung, Choon Hee, Ngoei, Kevin R. W., Ling, Naomi X. Y., Oakhill, Jonathan S., Galic, Sandra, ... Kim, Hyeon Soo. (2020). The myokine meteorin-like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKa2. The FEBS Journal. 287(10), pp. 2087-2104. https://doi.org/10.1111/FEBS.15301

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The eEF2 kinase-induced STAT3 inactivation inhibits lung cancer cell proliferation by phosphorylation of PKM2
Xiao, Min, Xie, Jianling, Wu, Yu, Wang, Genzhu, Qi, Xin, Liu, Zailiang, Wang, Yuying, Wang, Xuemin, Hoque, Ashfaqul, Oakhill, Jon, Proud, Christopher G. and Li, Jing. (2020). The eEF2 kinase-induced STAT3 inactivation inhibits lung cancer cell proliferation by phosphorylation of PKM2. Cell Communication and Signaling. 18(1), p. 25.

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The association between natural outdoor environments and common somatic symptoms
Watson, C., Nieuwenhuijsen, M. J., Triguero-Mas, M., Cirach, M., Maas, J., Gidlow, C., Kruize, H., Andrusaityte, S., Grazuleviciene, R. and Zijlema, W. L.. (2020). The association between natural outdoor environments and common somatic symptoms. Health and Place. 64, pp. 1-13. https://doi.org/10.1016/j.healthplace.2020.102381

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Systematic screening using FRAX® leads to increased use of, and adherence to, anti-osteoporosis medications: an analysis of the UK SCOOP trial
Parsons, C. M., Harvey, N., Shepstone, L., Kanis, J. A., Lenaghan, E., Clarke, S., Fordham, R., Gittoes, N., Harvey, I., Holland, R., Redmond, N. M., Howe, A., Marshall, T., Peters, T. J., Torgerson, D., O’Neill, T. W., McCloskey, E., Cooper, C., Crabtree, N., ... the Scoop Trial Group. (2020). Systematic screening using FRAX® leads to increased use of, and adherence to, anti-osteoporosis medications: an analysis of the UK SCOOP trial. Osteoporosis International. 31(1), pp. 67-75. https://doi.org/10.1007/s00198-019-05142-z

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Stand out in class : Restructuring the classroom environment to reduce sitting time - findings from a pilot cluster randomised controlled trial
Clemes, Stacy A., Bingham, Daniel D., Pearson, Natalie, Chen, Yu-Ling, Edwardson, Charlotte L., McEachan, Rosemary R. C., Tolfrey, Keith, Cale, Lorraine, Richardson, Gerry, Fray, Mike, Altunkaya, James, Bandelow, Stephan, Jaicim, Nishal Bhupendra, Salmon, Jo, Dunstan, David W. and Barber, Sally E.. (2020). Stand out in class : Restructuring the classroom environment to reduce sitting time - findings from a pilot cluster randomised controlled trial. International Journal of Behavioral Nutrition and Physical Activity. 17(1), pp. 1-16. https://doi.org/10.1186/s12966-020-00958-z

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