Exercise-regulated mitochondrial and nuclear signalling networks in skeletal muscle
Journal article
Reisman, Elizabeth G., Hawley, John A. and Hoffman, Nolan J.. (2024). Exercise-regulated mitochondrial and nuclear signalling networks in skeletal muscle. Sports Medicine. 54, pp. 1097-1119. https://doi.org/10.1007/s40279-024-02007-2
Authors | Reisman, Elizabeth G., Hawley, John A. and Hoffman, Nolan J. |
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Abstract | Exercise perturbs energy homeostasis in skeletal muscle and engages integrated cellular signalling networks to help meet the contraction-induced increases in skeletal muscle energy and oxygen demand. Investigating exercise-associated perturbations in skeletal muscle signalling networks has uncovered novel mechanisms by which exercise stimulates skeletal muscle mitochondrial biogenesis and promotes whole-body health and fitness. While acute exercise regulates a complex network of protein post-translational modifications (e.g. phosphorylation) in skeletal muscle, previous investigations of exercise signalling in human and rodent skeletal muscle have primarily focused on a select group of exercise-regulated protein kinases [i.e. 5ʹ adenosine monophosphate-activated protein kinase (AMPK), protein kinase A (PKA), Ca2+/calmodulin-dependent protein kinase (CaMK) and mitogen-activated protein kinase (MAPK)] and only a small subset of their respective protein substrates. Recently, global mass spectrometry-based phosphoproteomic approaches have helped unravel the extensive complexity and interconnection of exercise signalling pathways and kinases beyond this select group and phosphorylation and/or translocation of exercise-regulated mitochondrial and nuclear protein substrates. This review provides an overview of recent advances in our understanding of the molecular events associated with acute endurance exercise-regulated signalling pathways and kinases in skeletal muscle with a focus on phosphorylation. We critically appraise recent evidence highlighting the involvement of mitochondrial and nuclear protein phosphorylation and/or translocation in skeletal muscle adaptive responses to an acute bout of endurance exercise that ultimately stimulate mitochondrial biogenesis and contribute to exercise’s wider health and fitness benefits. |
Keywords | endurance exercise; sketetal muscle exercise |
Year | 01 Jan 2024 |
Journal | Sports Medicine |
Journal citation | 54, pp. 1097-1119 |
Publisher | Springer Nature |
ISSN | 0112-1642 |
Digital Object Identifier (DOI) | https://doi.org/10.1007/s40279-024-02007-2 |
Web address (URL) | https://link.springer.com/article/10.1007/s40279-024-02007-2#Sec22 |
Open access | Published as ‘gold’ (paid) open access |
Research or scholarly | Research |
Page range | 1097-1119 |
Publisher's version | License File Access Level Open |
Output status | Published |
Publication dates | |
Online | 25 Mar 2024 |
Publication process dates | |
Accepted | 18 Feb 2024 |
Deposited | 15 Nov 2024 |
Supplemental file | License File Access Level Open |
ARC Funded Research | This output has been funded, wholly or partially, under the Australian Research Council Act 2001 |
Grant ID | DP200103542 |
Additional information | Open Access funding enabled and organized by CAUL and its Member Institutions. The authors’ research is partially funded by the Australian Government through the Australian Research Council (ARC) Discovery Project grant DP200103542, ‘Molecular networks underlying exercise-induced mitochondrial biogenesis in humans’. |
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. | |
Place of publication | New Zealand |
https://acuresearchbank.acu.edu.au/item/9112v/exercise-regulated-mitochondrial-and-nuclear-signalling-networks-in-skeletal-muscle
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Publisher's version
OA_Hawley_2024_Exercise_regulated_mitochondrial_and_nuclear_signalling.pdf | |
License: CC BY 4.0 | |
File access level: Open |
Supplemental file
SM_Hawley_2024_Exercise_regulated_mitochondrial_and_nuclear_signalling.pdf | |
License: CC BY 4.0 | |
File access level: Open |
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